JP2018529780A5 - - Google Patents

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Publication number
JP2018529780A5
JP2018529780A5 JP2018536710A JP2018536710A JP2018529780A5 JP 2018529780 A5 JP2018529780 A5 JP 2018529780A5 JP 2018536710 A JP2018536710 A JP 2018536710A JP 2018536710 A JP2018536710 A JP 2018536710A JP 2018529780 A5 JP2018529780 A5 JP 2018529780A5
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Japan
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cancer
independently
substituted
arylalkyl
alkyl
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JP2018536710A
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English (en)
Japanese (ja)
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JP2018529780A (ja
JP6971239B2 (ja
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Priority claimed from PCT/US2016/055316 external-priority patent/WO2017062354A1/en
Publication of JP2018529780A publication Critical patent/JP2018529780A/ja
Publication of JP2018529780A5 publication Critical patent/JP2018529780A5/ja
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Publication of JP6971239B2 publication Critical patent/JP6971239B2/ja
Expired - Fee Related legal-status Critical Current
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JP2018536710A 2015-10-05 2016-10-04 グルタミナーゼ阻害剤とイムノオンコロジー薬剤との併用療法 Expired - Fee Related JP6971239B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562237287P 2015-10-05 2015-10-05
US62/237,287 2015-10-05
US201662323179P 2016-04-15 2016-04-15
US62/323,179 2016-04-15
PCT/US2016/055316 WO2017062354A1 (en) 2015-10-05 2016-10-04 Combination therapy with glutaminase inhibitors and immuno-oncology agents

Publications (3)

Publication Number Publication Date
JP2018529780A JP2018529780A (ja) 2018-10-11
JP2018529780A5 true JP2018529780A5 (enExample) 2019-11-07
JP6971239B2 JP6971239B2 (ja) 2021-11-24

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ID=58447081

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018536710A Expired - Fee Related JP6971239B2 (ja) 2015-10-05 2016-10-04 グルタミナーゼ阻害剤とイムノオンコロジー薬剤との併用療法

Country Status (10)

Country Link
US (3) US10258619B2 (enExample)
EP (1) EP3359150A4 (enExample)
JP (1) JP6971239B2 (enExample)
KR (1) KR20180059544A (enExample)
CN (1) CN108601767A (enExample)
AU (1) AU2016335991A1 (enExample)
CA (1) CA3000996A1 (enExample)
IL (1) IL258500A (enExample)
SG (1) SG11201802830QA (enExample)
WO (1) WO2017062354A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2920168T (lt) 2012-11-16 2021-10-25 Calithera Biosciences, Inc. Heterociklinis gliutaminazės inhibitorius
US10441654B2 (en) 2014-01-24 2019-10-15 Children's Hospital Of Eastern Ontario Research Institute Inc. SMC combination therapy for the treatment of cancer
EA037738B1 (ru) 2014-08-07 2021-05-17 Калитера Байосайенсиз, Инк. Кристаллические формы ингибиторов глутаминазы
CA3000996A1 (en) 2015-10-05 2017-04-13 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors and immuno-oncology agents
WO2019055786A1 (en) * 2017-09-14 2019-03-21 Lankenau Institute For Medical Research METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
US20210177841A1 (en) * 2017-11-03 2021-06-17 Calithera Biosciences, Inc. Conjoint therapy with glutaminase inhibitors
WO2020014611A1 (en) * 2018-07-12 2020-01-16 Cedars-Sinai Medical Center Compositions and methods targeting glutamine and its metabolism for diagnosing and treating cancer and therapy-associated side effects
CA3149049A1 (en) * 2019-08-30 2021-03-04 Vestlandets Innovasjonsselskap As Method for the treatment of chronic fatigue syndrome using an inhibitory or cytotoxic agent against plasma cells
CN111643669A (zh) * 2020-06-30 2020-09-11 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) 谷氨酰胺酶抑制剂在制备治疗银屑病的药物中的应用
US11839659B2 (en) 2020-07-02 2023-12-12 Northwestern University Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of indoleamine 2,3-dioxygenase (IDO) protein
US20250281609A1 (en) * 2021-10-19 2025-09-11 Organoidsciences Ltd. Composition for treating or preventing cancer
TW202406539A (zh) * 2022-04-21 2024-02-16 大陸商北京加科思新藥研發有限公司 藥物組合及其用途
CN116284398A (zh) * 2023-01-30 2023-06-23 中山大学附属第五医院 一种表达pd-l1抗体的细胞囊泡及其制备方法和应用

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1019519A (en) 1911-07-11 1912-03-05 Oscar Martin Polin Apparatus for making backing for teeth.
US4172896A (en) 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
GB9217295D0 (en) 1992-08-14 1992-09-30 Wellcome Found Controlled released tablets
US5541231A (en) 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
GB9315856D0 (en) 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
US5358970A (en) 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
ATE391492T1 (de) 1997-07-29 2008-04-15 Alcon Lab Inc Ophthalmische zusammensetzungen enthaltend galaktomannanpolymere und borat
WO1999038504A1 (en) 1998-01-29 1999-08-05 Sepracor Inc. Pharmaceutical uses of optically pure (-)-bupropion
US8889112B2 (en) 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
US6451828B1 (en) 2000-08-10 2002-09-17 Elan Pharmaceuticals, Inc. Selective inhibition of glutaminase by bis-thiadiazoles
AU2002305926A1 (en) 2001-02-05 2002-10-08 Exegenics Inc. Cysteine protease inhibitors
CA2520172C (en) * 2003-03-27 2012-10-02 Lankenau Institute For Medical Research Novel methods for the treatment of cancer with an indoleamine 2, 3-dioxygenase inhibitor
US6933289B2 (en) 2003-07-01 2005-08-23 Allergan, Inc. Inhibition of irritating side effects associated with use of a topical ophthalmic medication
DE602004023516D1 (de) 2003-08-07 2009-11-19 Allergan Inc Zusammensetzungen zur abgabe von therapeutika in die augen und verfahren zu ihrer herstellung und verwendung
US20050059744A1 (en) 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
ES2367311T3 (es) 2004-04-15 2011-11-02 University Of Florida Research Foundation, Inc. Productos de degradación proteolítica de map-2 como biomarcadores de diagnóstico para las lesiones neurales.
US7928140B2 (en) 2007-08-02 2011-04-19 Amgen Inc. Benzothiazole PI3 kinase modulators for cancer treatment
CN101932325B (zh) * 2007-11-30 2014-05-28 新联基因公司 Ido抑制剂
WO2009104696A1 (ja) 2008-02-19 2009-08-27 株式会社アーネストメディスン 身体機能の回復に有用な経口又は経腸組成物
TR201910726T4 (tr) * 2009-01-26 2019-08-21 Astrazeneca Uk Ltd Arginaz inhibitörleri ve kullanım yöntemleri.
US20130109643A1 (en) 2010-05-10 2013-05-02 The Johns Hopkins University Metabolic inhibitor against tumors having an idh mutation
WO2012006506A1 (en) 2010-07-09 2012-01-12 Massachusetts Institute Of Technology Metabolic gene, enzyme, and flux targets for cancer therapy
AU2011329619A1 (en) 2010-11-18 2013-05-02 Deuteria Pharmaceuticals, Inc. 3-deutero-pomalidomide
CN103402549A (zh) * 2010-12-31 2013-11-20 考瑞多制药公司 精氨酸酶抑制剂及其使用方法
CA2742342A1 (en) 2011-02-12 2012-08-12 Baylor Research Institute Msh3 expression status determines the responsiveness of cancer cells to the chemotherapeutic treatment with parp inhibitors and platinum drugs
FI20115876A0 (fi) 2011-09-06 2011-09-06 Turun Yliopisto Yhdistelmähoito
CN103030597B (zh) 2011-09-30 2014-10-01 南昌滨西科技有限公司 肾脏型谷氨酰胺酶抑制剂及其制备方法和用途
AU2012326109A1 (en) * 2011-10-19 2014-05-29 Mars, Incorporated Inhibitors of arginase and their therapeutic applications
EA026656B1 (ru) * 2011-11-21 2017-05-31 Калитера Байосайенсиз Инк. Гетероциклические ингибиторы глютаминазы
US8604016B2 (en) 2011-11-21 2013-12-10 Calithera Biosciences Inc. Heterocyclic inhibitors of glutaminase
AU2013266243A1 (en) 2012-05-24 2014-12-18 Beth Israel Deaconess Medical Center, Inc. Targeting the glutamine to pyruvate pathway for treatment of oncogenic Kras-associated cancer
US9694015B2 (en) 2012-09-10 2017-07-04 Celgene Corporation Methods for the treatment of locally advanced breast cancer
US9618514B2 (en) 2012-09-17 2017-04-11 Agios Pharmaceuticals, Inc Methods of evaluating patients using E-cadherin and vimentin
LT2920168T (lt) 2012-11-16 2021-10-25 Calithera Biosciences, Inc. Heterociklinis gliutaminazės inhibitorius
KR20150085078A (ko) 2012-11-21 2015-07-22 아지오스 파마슈티컬스 아이엔씨. 글루타마제 억제제 및 사용 방법
WO2014079011A1 (en) 2012-11-22 2014-05-30 Agios Pharmaceuticals, Inc. Heterocyclic compounds for inhibiting glutaminase and their methods of use
KR20150091389A (ko) * 2012-12-03 2015-08-10 칼리테라 바이오사이언시즈 인코포레이티드 글루타미나제의 헤테로사이클릭 억제제에 의한 암 치료
CN105324362B (zh) * 2013-03-15 2017-05-24 百时美施贵宝公司 Ido抑制剂
WO2015061432A1 (en) 2013-10-25 2015-04-30 Calithera Biosciences, Inc. Treatment of viral infections with inhibitors of glutaminase
TWI617309B (zh) * 2013-10-25 2018-03-11 製藥公司 使用布魯頓氏酪胺酸激酶抑制劑之治療及免疫療法
GB201322725D0 (en) * 2013-12-20 2014-02-05 Immodulon Therapeutics Ltd Cancer therapy
US20170165364A1 (en) * 2014-02-21 2017-06-15 Idac Theranostics, Inc. Therapeutic agent for solid cancer
US20150258082A1 (en) 2014-03-14 2015-09-17 Francesco Parlati Combination therapy with glutaminase inhibitors
US10221459B2 (en) 2014-05-13 2019-03-05 Case Western Reserve University Compositions and methods of treating cancer harboring PIKC3A mutations
EP3154590B1 (en) 2014-06-13 2021-04-14 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors
WO2016004413A2 (en) 2014-07-03 2016-01-07 Board Of Regents, University Of Texas System Gls1 inhibitors for treating disease
WO2016004418A1 (en) 2014-07-03 2016-01-07 Board Of Regents, University Of Texas System Glutaminase inhibitor therapy
WO2016014890A1 (en) 2014-07-24 2016-01-28 Calithera Biosciences, Inc. Treatment of multiple myeloma with heterocyclic inhibitors of glutaminase
EA037738B1 (ru) 2014-08-07 2021-05-17 Калитера Байосайенсиз, Инк. Кристаллические формы ингибиторов глутаминазы
WO2016054388A1 (en) 2014-10-03 2016-04-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Glutaminase inhibitors
WO2016077632A2 (en) 2014-11-13 2016-05-19 Buck Institute For Research On Aging Inhibition of proline catabolism for the treatment of cancer and other therapeutic applications
EA037152B1 (ru) * 2015-03-30 2021-02-11 Калитера Байосайенсиз, Инк. Способ лечения рака
EP3280415A4 (en) 2015-04-06 2018-12-26 Calithera Biosciences Inc. Treatment of lung cancer with inhibitors of glutaminase
CA2994165A1 (en) 2015-07-31 2017-02-09 The Johns Hopkins University Methods for cancer and immunotherapy using glutamine analogues, including don
EP3355875B1 (en) 2015-10-01 2021-09-29 Gilead Sciences, Inc. Combination of a btk inhibitor and a checkpoint inhibitor for treating cancers
CA3000996A1 (en) 2015-10-05 2017-04-13 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors and immuno-oncology agents
IL292302B2 (en) 2016-05-20 2023-10-01 Biohaven Pharm Holding Co Ltd Use of glutamate modulating factors in cancer immunotherapy
WO2018039441A1 (en) 2016-08-25 2018-03-01 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors
WO2018039442A1 (en) 2016-08-25 2018-03-01 Calithera Biosciences, Inc. Treatment of cancer with inhibitors of glutaminase
MX2019002108A (es) 2016-08-25 2019-07-08 Calithera Biosciences Inc Terapia de combinacion con inhibidores de glutaminasa.
CN110730664A (zh) 2017-03-10 2020-01-24 卡利泰拉生物科技公司 含谷氨酰胺酶抑制剂的组合疗法
US20210177841A1 (en) * 2017-11-03 2021-06-17 Calithera Biosciences, Inc. Conjoint therapy with glutaminase inhibitors

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