MX369691B - Inhibidores de glutaminasa y métodos de empleo. - Google Patents

Inhibidores de glutaminasa y métodos de empleo.

Info

Publication number
MX369691B
MX369691B MX2015006478A MX2015006478A MX369691B MX 369691 B MX369691 B MX 369691B MX 2015006478 A MX2015006478 A MX 2015006478A MX 2015006478 A MX2015006478 A MX 2015006478A MX 369691 B MX369691 B MX 369691B
Authority
MX
Mexico
Prior art keywords
glutamase
inhibitors
compounds
inhibit glutaminase
cancer
Prior art date
Application number
MX2015006478A
Other languages
English (en)
Other versions
MX2015006478A (es
Inventor
M Lemieux Rene
G Salituro Francesco
Travins Jeremy
Yan Shunqi
Popovici-Muller Janeta
O Saunders Jeffrey
Original Assignee
Agios Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agios Pharmaceuticals Inc filed Critical Agios Pharmaceuticals Inc
Publication of MX2015006478A publication Critical patent/MX2015006478A/es
Publication of MX369691B publication Critical patent/MX369691B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Epidemiology (AREA)
  • Pyridine Compounds (AREA)

Abstract

En la presente se describen compuestos y composiciones que comprenden compuestos que inhiben la glutaminasa. También se describen en la presente métodos de empleo de los compuestos que inhiben la glutaminasa en el tratamiento del cáncer.
MX2015006478A 2012-11-21 2013-11-21 Inhibidores de glutaminasa y métodos de empleo. MX369691B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261729321P 2012-11-21 2012-11-21
PCT/US2013/071212 WO2014081925A1 (en) 2012-11-21 2013-11-21 Glutamase inhibitors and method of use

Publications (2)

Publication Number Publication Date
MX2015006478A MX2015006478A (es) 2015-12-03
MX369691B true MX369691B (es) 2019-11-19

Family

ID=49780330

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015006478A MX369691B (es) 2012-11-21 2013-11-21 Inhibidores de glutaminasa y métodos de empleo.

Country Status (15)

Country Link
US (3) US9303002B2 (es)
EP (1) EP2922832B1 (es)
JP (1) JP6333280B2 (es)
KR (1) KR20150085078A (es)
CN (1) CN105263915B (es)
AU (2) AU2013347933C1 (es)
BR (1) BR112015011756A2 (es)
CA (1) CA2892089A1 (es)
EA (1) EA029531B1 (es)
ES (1) ES2761951T3 (es)
HK (1) HK1213889A1 (es)
IL (1) IL238959A (es)
MX (1) MX369691B (es)
SG (1) SG11201504022RA (es)
WO (1) WO2014081925A1 (es)

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CN105960405B (zh) 2014-01-06 2021-02-19 理森制药股份公司 谷氨酰胺酶抑制剂
BR112016021620A2 (pt) 2014-03-21 2018-07-10 Agios Pharmaceuticals Inc compostos e seus métodos de uso
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GB201409624D0 (en) 2014-05-30 2014-07-16 Astrazeneca Ab 1,3,4-thiadiazole compounds and their use in treating cancer
KR20170012562A (ko) 2014-06-13 2017-02-02 칼리테라 바이오사이언시즈 인코포레이티드 글루타미나제 억제제를 사용하는 병용 요법
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EP3697764B1 (en) 2017-10-18 2025-06-11 Board Of Regents, The University Of Texas System Gls-1 inhibitors for use in the treatment of cancer
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CN114805346A (zh) * 2021-07-08 2022-07-29 成都硕德药业有限公司 杂环类衍生物、其制备方法及用途
WO2025080100A1 (ko) * 2023-10-11 2025-04-17 한국화학연구원 신규한 디-아미드 화합물, 이의 제조방법, 이를 유효성분으로 포함하는 암 또는 자가면역질환의 예방 또는 치료용 약학적 조성물

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Also Published As

Publication number Publication date
EA201590997A1 (ru) 2015-11-30
AU2013347933A1 (en) 2015-06-11
AU2013347933B2 (en) 2018-03-29
CN105263915B (zh) 2019-04-12
HK1213889A1 (zh) 2016-07-15
EA029531B1 (ru) 2018-04-30
US20150299152A1 (en) 2015-10-22
CA2892089A1 (en) 2014-05-30
CN105263915A (zh) 2016-01-20
BR112015011756A2 (pt) 2017-07-11
AU2013347933C1 (en) 2018-10-04
JP6333280B2 (ja) 2018-05-30
US10414740B2 (en) 2019-09-17
ES2761951T3 (es) 2020-05-21
US10011574B2 (en) 2018-07-03
MX2015006478A (es) 2015-12-03
JP2016500107A (ja) 2016-01-07
EP2922832A1 (en) 2015-09-30
US20180370930A1 (en) 2018-12-27
WO2014081925A1 (en) 2014-05-30
KR20150085078A (ko) 2015-07-22
AU2018204692A1 (en) 2018-07-19
US9303002B2 (en) 2016-04-05
AU2013347933A2 (en) 2015-07-09
IL238959A0 (en) 2015-07-30
IL238959A (en) 2017-12-31
EP2922832B1 (en) 2019-10-09
US20140142146A1 (en) 2014-05-22
SG11201504022RA (en) 2015-06-29

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