JP2014533699A5 - - Google Patents
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- JP2014533699A5 JP2014533699A5 JP2014542546A JP2014542546A JP2014533699A5 JP 2014533699 A5 JP2014533699 A5 JP 2014533699A5 JP 2014542546 A JP2014542546 A JP 2014542546A JP 2014542546 A JP2014542546 A JP 2014542546A JP 2014533699 A5 JP2014533699 A5 JP 2014533699A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- independently
- substituted
- cycloalkyl
- heteroarylalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims description 67
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 58
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 54
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 49
- 150000001875 compounds Chemical class 0.000 claims description 47
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 46
- 125000003545 alkoxy group Chemical group 0.000 claims description 45
- 125000001072 heteroaryl group Chemical group 0.000 claims description 40
- 125000003118 aryl group Chemical group 0.000 claims description 39
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 39
- 239000008194 pharmaceutical composition Substances 0.000 claims description 35
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 30
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 30
- 125000000623 heterocyclic group Chemical group 0.000 claims description 30
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 30
- 125000004945 acylaminoalkyl group Chemical group 0.000 claims description 24
- 125000003342 alkenyl group Chemical group 0.000 claims description 24
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims description 24
- 125000004104 aryloxy group Chemical group 0.000 claims description 24
- 125000005326 heteroaryloxy alkyl group Chemical group 0.000 claims description 24
- 125000005553 heteroaryloxy group Chemical group 0.000 claims description 24
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 22
- 206010028980 Neoplasm Diseases 0.000 claims description 21
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 19
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 18
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 125000002252 acyl group Chemical group 0.000 claims description 6
- 125000004442 acylamino group Chemical group 0.000 claims description 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 6
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims description 6
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims description 6
- 125000002837 carbocyclic group Chemical group 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 229910052760 oxygen Inorganic materials 0.000 claims description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
- 229910052717 sulfur Inorganic materials 0.000 claims description 6
- 125000005415 substituted alkoxy group Chemical group 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
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| BR112015010955A2 (pt) | 2012-11-16 | 2017-07-11 | Calithera Biosciences Inc | inibidores de glutaminase heterocíclica |
| MX369691B (es) | 2012-11-21 | 2019-11-19 | Agios Pharmaceuticals Inc | Inhibidores de glutaminasa y métodos de empleo. |
| WO2014079011A1 (en) * | 2012-11-22 | 2014-05-30 | Agios Pharmaceuticals, Inc. | Heterocyclic compounds for inhibiting glutaminase and their methods of use |
| CA2892817A1 (en) * | 2012-12-03 | 2014-06-12 | Calithera Biosciences Inc. | Treatment of cancer with heterocyclic inhibitors of glutaminase |
| US9457016B2 (en) | 2013-08-29 | 2016-10-04 | New York University | Methods for treating polycystic kidney disease |
| WO2015061432A1 (en) * | 2013-10-25 | 2015-04-30 | Calithera Biosciences, Inc. | Treatment of viral infections with inhibitors of glutaminase |
| KR20160100408A (ko) * | 2014-01-06 | 2016-08-23 | 리젠 파마슈티컬스 소시에떼 아노님 | 신규한 글루타미나제 저해제 |
| CN103880777B (zh) * | 2014-03-06 | 2015-12-30 | 陕西科技大学 | 一种制备双噻二唑二胺的方法 |
| US20150258082A1 (en) * | 2014-03-14 | 2015-09-17 | Francesco Parlati | Combination therapy with glutaminase inhibitors |
| BR112016021620A2 (pt) * | 2014-03-21 | 2018-07-10 | Agios Pharmaceuticals Inc | compostos e seus métodos de uso |
| CR20160497A (es) * | 2014-04-30 | 2016-12-20 | Pfizer | Derivados de diheterociclo enlazado a cicloalquilo |
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| SG11201610333VA (en) * | 2014-06-13 | 2017-01-27 | Calithera Biosciences Inc | Combination therapy with glutaminase inhibitors |
| AU2015283850B2 (en) | 2014-07-03 | 2020-06-04 | Board Of Regents, University Of Texas System | GLS1 inhibitors for treating disease |
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| WO2016054388A1 (en) | 2014-10-03 | 2016-04-07 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Glutaminase inhibitors |
| BR112017020780A2 (pt) * | 2015-03-30 | 2018-06-26 | Calithera Biosciences Inc | métodos de administração de inibidores de glutaminase |
| AU2016246521B2 (en) * | 2015-04-06 | 2020-07-09 | Calithera Biosciences, Inc. | Treatment of lung cancer with inhibitors of glutaminase |
| ES2794868T3 (es) * | 2015-06-30 | 2020-11-19 | Univ Texas | Inhibidores de GLS1 para el tratamiento de enfermedades |
| EP3359150A4 (en) * | 2015-10-05 | 2019-11-06 | Calithera Biosciences, Inc. | COMBINATION THERAPY WITH GLUTAMINASE INHIBITORS AND IMMUNO-ONCOLOGICAL AGENTS |
| GB201520959D0 (en) * | 2015-11-27 | 2016-01-13 | Astrazeneca Ab And Cancer Res Technology Ltd | Bis-pyridazine compounds and their use in treating cancer |
| TW201730188A (zh) * | 2015-11-30 | 2017-09-01 | 阿斯特捷利康公司 | 1,3,4-噻二唑化合物及其在治療癌症中之用途 |
| TW201731511A (zh) * | 2015-11-30 | 2017-09-16 | 阿斯特捷利康公司 | １，３，４-噻二唑化合物及其在治療癌症中之用途 |
| TW201733587A (zh) * | 2015-11-30 | 2017-10-01 | 阿斯特捷利康公司 | 1,3,4-噻二唑化合物及其在治療癌症中之用途 |
| JP6976248B2 (ja) | 2015-12-22 | 2021-12-08 | ボード オブ リージェンツ、ザ ユニバーシテイ オブ テキサス システム | （ｒ）−１−（４−（６−（２−（４−（３，３−ジフルオロシクロブトキシ）−６−メチルピリジン−２−イル）アセトアミド）ピリダジン−３−イル）−２−フルオロブチル）−ｎ−メチル−１ｈ−１，２，３−トリアゾール−４−カルボキサミドの塩形態および多形体 |
| KR20190040302A (ko) | 2016-08-25 | 2019-04-17 | 칼리테라 바이오사이언시즈, 인코포레이티드 | 글루타미나제 억제제와의 병용 요법 |
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| CN107137401A (zh) * | 2017-03-28 | 2017-09-08 | 刘纪君 | 一种治疗产后抑郁症的药物组合物 |
| CN106860460B (zh) * | 2017-03-29 | 2019-04-23 | 上海市第一人民医院 | 谷氨酰胺酶抑制剂cb-839在制备治疗雌激素敏感型子宫内膜癌的药物中的应用 |
| EP3640250B1 (en) | 2017-06-13 | 2021-12-15 | Medshine Discovery Inc. | Compound as gls1 inhibitor |
| RU2020112558A (ru) | 2017-10-18 | 2021-11-18 | Боард Оф Регентс, Зе Юниверсити Оф Тексас Систем | Терапия на основе ингибитора глутаминазы |
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2014
- 2014-05-18 IL IL232665A patent/IL232665A0/en unknown
- 2014-06-19 ZA ZA2014/04518A patent/ZA201404518B/en unknown
-
2016
- 2016-03-10 ZA ZA2016/01655A patent/ZA201601655B/en unknown
- 2016-09-13 JP JP2016178240A patent/JP6329226B2/ja not_active Expired - Fee Related
-
2018
- 2018-04-19 JP JP2018080830A patent/JP6577623B2/ja not_active Expired - Fee Related
- 2018-06-12 IL IL259958A patent/IL259958B/en active IP Right Grant
-
2019
- 2019-12-16 CY CY20191101318T patent/CY1122707T1/el unknown
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