|
US3598122A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US4144317A
(en)
|
1975-05-30 |
1979-03-13 |
Alza Corporation |
Device consisting of copolymer having acetoxy groups for delivering drugs
|
|
US4262003A
(en)
|
1975-12-08 |
1981-04-14 |
Alza Corporation |
Method and therapeutic system for administering scopolamine transdermally
|
|
US4201211A
(en)
|
1977-07-12 |
1980-05-06 |
Alza Corporation |
Therapeutic system for administering clonidine transdermally
|
|
US4338457A
(en)
|
1980-02-28 |
1982-07-06 |
The Upjohn Company |
Composition and process
|
|
US4525586A
(en)
|
1980-02-28 |
1985-06-25 |
The Upjohn Company |
Composition and process
|
|
US4306075A
(en)
|
1980-03-28 |
1981-12-15 |
The Upjohn Company |
Composition and process
|
|
US4420632A
(en)
|
1980-04-15 |
1983-12-13 |
The Upjohn Company |
Composition and process
|
|
US4306076A
(en)
|
1980-04-23 |
1981-12-15 |
The Upjohn Company |
Inter-phenylene CBA compounds
|
|
US4349689A
(en)
|
1980-12-22 |
1982-09-14 |
The Upjohn Company |
Methano carbacyclin analogs
|
|
US4379454A
(en)
|
1981-02-17 |
1983-04-12 |
Alza Corporation |
Dosage for coadministering drug and percutaneous absorption enhancer
|
|
DE3333240A1
(de)
|
1983-09-12 |
1985-03-28 |
Schering AG, 1000 Berlin und 4709 Bergkamen |
Mittel zur transdermalen applikation von arzneimittelwirkstoffen
|
|
US4668814A
(en)
|
1984-03-08 |
1987-05-26 |
The Upjohn Company |
Interphenylene carbacyclin derivatives
|
|
US4683330A
(en)
|
1984-03-08 |
1987-07-28 |
The Upjohn Company |
Interphenylene carbacyclin derivatives
|
|
GB8814438D0
(en)
|
1988-06-17 |
1988-07-20 |
Wellcome Found |
Compounds for use in medicine
|
|
GB8824187D0
(en)
|
1988-10-14 |
1988-11-23 |
Wellcome Found |
Compounds for use in medicine
|
|
US5088977A
(en)
|
1988-12-21 |
1992-02-18 |
Drug Delivery Systems Inc. |
Electrical transdermal drug applicator with counteractor and method of drug delivery
|
|
CA2056039A1
(en)
|
1991-01-22 |
1992-07-23 |
Philip L. Fuchs |
Carbacyclin analogs
|
|
US5234690A
(en)
|
1991-08-23 |
1993-08-10 |
Cygnus Therapeutic Systems |
Transdermal drug delivery device using an unfilled microporous membrane to achieve delayed onset
|
|
US5869505A
(en)
|
1993-02-02 |
1999-02-09 |
Keenan; Robert M. |
Nicotine metabolites and nicotine dependence
|
|
US5853751A
(en)
|
1993-06-23 |
1998-12-29 |
Masiz; John J. |
Molecular transdermal transport system
|
|
US5797898A
(en)
|
1996-07-02 |
1998-08-25 |
Massachusetts Institute Of Technology |
Microchip drug delivery devices
|
|
IN184589B
(cg-RX-API-DMAC7.html)
|
1996-10-16 |
2000-09-09 |
Alza Corp |
|
|
CN1354622A
(zh)
|
1999-03-31 |
2002-06-19 |
联合治疗公司 |
前列腺素类化合物、组合物和治疗外周血管疾病和肺动脉高压的方法
|
|
WO2001052823A2
(en)
|
2000-01-20 |
2001-07-26 |
Noven Pharmaceuticals, Inc. |
Compositions to effect the release profile in the transdermal administration of drugs
|
|
US6242482B1
(en)
|
2000-06-05 |
2001-06-05 |
United Therapeutics Corporation |
Prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of congestive heart failure
|
|
US6635274B1
(en)
|
2000-10-27 |
2003-10-21 |
Biochemics, Inc. |
Solution-based transdermal drug delivery system
|
|
US6700025B2
(en)
|
2001-01-05 |
2004-03-02 |
United Therapeutics Corporation |
Process for stereoselective synthesis of prostacyclin derivatives
|
|
US20030108512A1
(en)
|
2001-12-10 |
2003-06-12 |
Robert Shorr |
Modified prostaglandin compounds and analogs thereof, compositions containing the same useful for the treatment of cancer
|
|
US8246979B2
(en)
|
2002-07-30 |
2012-08-21 |
Ucb Pharma Gmbh |
Transdermal delivery system for the administration of rotigotine
|
|
CA2959852A1
(en)
|
2003-05-22 |
2005-01-27 |
United Therapeutics Corporation |
Compounds and methods for delivery of prostacyclin analogs
|
|
CA2530407A1
(en)
*
|
2003-07-23 |
2005-02-03 |
The Regents Of The University Of California |
Penetration enhancer combinations for transdermal delivery
|
|
US7375139B2
(en)
|
2003-08-18 |
2008-05-20 |
Aldred Katherine M |
Transdermal method and apparatus
|
|
JP2005120069A
(ja)
|
2003-10-13 |
2005-05-12 |
Anges Mg Inc |
炎症性疾患治療薬
|
|
JP4906514B2
(ja)
|
2003-12-16 |
2012-03-28 |
ユナイテッド セラピューティクス コーポレイション |
腎臓機能改善のためのトレプロスチニルの用途
|
|
ATE473736T1
(de)
|
2003-12-16 |
2010-07-15 |
United Therapeutics Corp |
Verwendung von treprostinil zur behandlung von ischämischen läsionen
|
|
DE602005020269D1
(de)
|
2004-04-12 |
2010-05-12 |
United Therapeutics Corp |
Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren
|
|
WO2006015299A2
(en)
|
2004-07-30 |
2006-02-09 |
Microchips, Inc. |
Multi-reservoir device for transdermal drug delivery and sensing
|
|
WO2006044206A2
(en)
|
2004-10-08 |
2006-04-27 |
Noven Pharmaceuticals, Inc. |
Transdermal drug delivery device including an occlusive backing
|
|
CN101212975A
(zh)
|
2005-06-03 |
2008-07-02 |
艾克若克斯Dds有限公司 |
用于透皮给药的方法和组合物
|
|
EA200801369A1
(ru)
|
2005-12-20 |
2009-02-27 |
ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. |
Способы трансдермального введения агониста рецептора индолсеротонина и трансдермальные лекарственные формы для применения этого способа
|
|
PT1988910T
(pt)
|
2006-02-28 |
2018-02-07 |
Kodiak Sciences Inc |
Acriloiloxietilfosforilcolina contendo conjugados de polímeros e sua preparação
|
|
US8747897B2
(en)
|
2006-04-27 |
2014-06-10 |
Supernus Pharmaceuticals, Inc. |
Osmotic drug delivery system
|
|
US20080200449A1
(en)
|
2006-05-15 |
2008-08-21 |
United Therapeutics Corporation |
Treprostinil administration using a metered dose inhaler
|
|
WO2008002929A2
(en)
|
2006-06-26 |
2008-01-03 |
Inverseon, Inc. |
Heterologous cross-sensitization for improved agonist activity
|
|
US20090036465A1
(en)
|
2006-10-18 |
2009-02-05 |
United Therapeutics Corporation |
Combination therapy for pulmonary arterial hypertension
|
|
CA2678258A1
(en)
|
2007-02-09 |
2008-08-14 |
United Therapeutics Corporation |
Treprostinil treatment for interstitial lung disease and asthma
|
|
BRPI0814105A2
(pt)
|
2007-07-11 |
2015-02-03 |
Lexicon Pharmaceuticals Inc |
Métodos e composições para o tratamento de hipertensão pulmonar e doenças e distúrbios relacionados
|
|
KR101898407B1
(ko)
|
2007-12-17 |
2018-09-12 |
유나이티드 세러퓨틱스 코오포레이션 |
레모둘린®의 활성 성분인 트레프로스티닐의 개선된 제조 방법
|
|
WO2009152160A1
(en)
|
2008-06-10 |
2009-12-17 |
Gilead Sciences, Inc. |
Inhaled carbaprostacyclin and prostacyclin prodrugs for the treatment of pulmonary arterial hypertension
|
|
WO2009158010A1
(en)
|
2008-06-27 |
2009-12-30 |
Concert Pharmaceuticals, Inc. |
Prostacyclin analogs
|
|
PT2315587T
(pt)
|
2008-08-13 |
2018-01-31 |
Actelion Pharmaceuticals Ltd |
Produto que contém macitentan, composição farmacêutica que o contém e uso de macitentan
|
|
CN106075455A
(zh)
|
2008-12-30 |
2016-11-09 |
丹麦国家医院 |
鉴定发展成器官功能衰竭的风险提高的危重患者的方法及用于其治疗的化合物
|
|
JP5649645B2
(ja)
|
2009-05-07 |
2015-01-07 |
ユナイテッド セラピューティクス コーポレイション |
プロスタサイクリンアナログの固形製剤
|
|
WO2011005505A2
(en)
|
2009-06-22 |
2011-01-13 |
Johnson Matthey Public Limited Company |
Method for the purification of prostaglandins
|
|
PT2461812E
(pt)
|
2009-08-07 |
2014-04-07 |
Scipharm S Rl |
Composição para o tratamento da fibrose cística
|
|
US9327105B2
(en)
*
|
2010-03-26 |
2016-05-03 |
Itrace Biomedical Inc. |
Active transdermal drug delivery system and the method thereof
|
|
EP2552967A4
(en)
|
2010-04-02 |
2014-10-08 |
Amunix Operating Inc |
BINDING FUSION PROTEINS, BINDING FUSION PROTEIN MEDICINAL CONJUGATES, XTEN MEDICAMENT CONJUGATES, AND METHOD FOR THEIR PREPARATION AND USE
|
|
WO2011123830A2
(en)
|
2010-04-02 |
2011-10-06 |
Amunix Operating Inc. |
Alpha 1-antitrypsin compositions and methods of making and using same
|
|
WO2011134478A2
(en)
|
2010-04-29 |
2011-11-03 |
Thrombologic Aps |
Methods of treatment of patients at increased risk of development of ischemic events and compounds hereof
|
|
CA3029711A1
(en)
|
2010-06-03 |
2011-12-08 |
United Therapeutics Corporation |
Treprostinil production
|
|
WO2012006273A1
(en)
|
2010-07-09 |
2012-01-12 |
United Therapeutics Corporation |
Combination therapies with cox-2 inhibitors and treprostinil
|
|
CA2710726C
(en)
|
2010-07-22 |
2016-02-23 |
Alphora Research Inc. |
Synthesis of treprostinil and intermediates useful therein
|
|
CA2726599C
(en)
|
2010-12-30 |
2017-07-25 |
Alphora Research Inc. |
Process for treprostinil salt preparation
|
|
EP2663313B1
(en)
|
2011-01-13 |
2018-08-08 |
SciPharm S.à r.l. |
Method for enhancing engraftment of haematopoetic stem cells
|
|
BR112013019335B1
(pt)
|
2011-02-07 |
2022-05-31 |
Scipharm Sàrl |
Nova composição, método para aumentar o nível de camp em um célula e combinação terapêutica, para o tratamento da fibrose cística
|
|
WO2012107364A1
(en)
|
2011-02-07 |
2012-08-16 |
Scipharm Sàrl |
Novel composition for the treatment of cystic fibrosis
|
|
KR20140053881A
(ko)
|
2011-04-19 |
2014-05-08 |
릭스하스피탈렛 |
모세관 누출의 예방 및 치료를 위한 수술 동안 투여되는 프로스타시클린 및 그 유사체
|
|
CN103987704A
(zh)
|
2011-08-05 |
2014-08-13 |
卡德尔治疗公司 |
类黄酮化合物
|
|
WO2013024051A1
(en)
|
2011-08-12 |
2013-02-21 |
Ascendis Pharma A/S |
Sustained release composition of prostacyclin
|
|
US20140249093A1
(en)
|
2011-08-12 |
2014-09-04 |
Ascendis Pharma A/S |
Carrier-Linked Prodrugs Having Reversible Carboxylic Ester Linkages
|
|
CA2843883C
(en)
*
|
2011-08-12 |
2020-04-28 |
Ascendis Pharma A/S |
Carrier-linked treprostinil prodrugs
|
|
US8524939B2
(en)
|
2011-08-24 |
2013-09-03 |
Chirogate International Inc. |
Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
|
|
CN103193627B
(zh)
|
2012-01-10 |
2016-04-20 |
上海天伟生物制药有限公司 |
一种前列腺素类似物的晶型及其制备方法和用途
|
|
US9387214B2
(en)
|
2012-01-13 |
2016-07-12 |
United Therapeutics Corporation |
Method of identifying therapies for pulmonary hypertension
|
|
US20150057325A1
(en)
|
2012-03-30 |
2015-02-26 |
Rigshospitalet |
Compounds capable of modulating/preserving endothelial integrity for use in prevention or treatment of acute traumatic coagulopathy and resuscitated cardiac arrest
|
|
US20150087688A1
(en)
|
2012-04-25 |
2015-03-26 |
Ascendis Pharma A/S |
Prodrugs of hydroxyl-comprising drugs
|
|
SMT201700496T1
(it)
|
2012-06-15 |
2017-11-15 |
Scipharm Sarl |
Processo per la preparazione di treprostinil e suoi derivati
|
|
IN2015DN00934A
(cg-RX-API-DMAC7.html)
|
2012-08-01 |
2015-06-12 |
United Therapeutics Corp |
|
|
KR20150091170A
(ko)
|
2012-12-07 |
2015-08-07 |
카이맨 케미칼 컴파니 인코포레이티드 |
프로스타사이클린 유사체의 합성 방법
|
|
US10080730B2
(en)
|
2013-01-09 |
2018-09-25 |
United Therapeutics Corporation |
Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
|
|
JP6542128B2
(ja)
|
2013-01-11 |
2019-07-10 |
コルセア ファーマ インコーポレイテッド |
トレプロスチニルのプロドラッグ
|
|
US9505737B2
(en)
|
2013-01-11 |
2016-11-29 |
Corsair Pharma, Inc. |
Treprostinil derivative compounds and methods of using same
|
|
KR102405650B1
(ko)
|
2013-03-15 |
2022-06-03 |
유나이티드 세러퓨틱스 코오포레이션 |
트레프로스티닐의 염
|
|
ES2676447T3
(es)
|
2013-03-25 |
2018-07-19 |
United Therapeutics Corporation |
Procedimiento de fabricación de compuestos de prostaciclina con tiol de unión y formas pegiladas
|
|
JP6594857B2
(ja)
|
2013-04-30 |
2019-10-23 |
ユナイテッド セラピューティクス コーポレイション |
放出制御製剤
|
|
WO2014203278A2
(en)
|
2013-06-19 |
2014-12-24 |
Msn Laboratories Private Limited |
NOVEL PROCESS FOR THE PREPARATION OF (1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-HEXAHYDRO-2-HYDROXY-1-[(3S)-3-HYDROXYOCTYL]-1H-BENZ[f]INDEN-5-YL]OXY]ACETIC ACID
|
|
MX382833B
(es)
|
2013-10-25 |
2025-03-13 |
Insmed Inc |
Compuestos derivados de prostaciclinas, y el uso de los mismo para el tratamiento de la hipertension pulmonar
|
|
EP3068752A1
(en)
|
2013-11-13 |
2016-09-21 |
Cayman Chemical Company Incorporated |
Amine salts of a prostacyclin analog
|
|
WO2015138423A1
(en)
|
2014-03-11 |
2015-09-17 |
Insmed Incorporated |
Prostacylin compositions and methods for using the same
|
|
EP3169660A1
(en)
|
2014-07-16 |
2017-05-24 |
Corsair Pharma, Inc. |
Treprostinil derivative compounds and methods of using same
|
|
HU231186B1
(hu)
|
2014-10-08 |
2021-06-28 |
CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. |
Új eljárás treprostinil és sói előállítására
|
|
JP6866043B2
(ja)
|
2014-11-18 |
2021-04-28 |
インスメッド インコーポレイテッド |
トレプロスチニルプロドラッグおよびトレプロスチニル誘導体プロドラッグの製造方法
|
|
TWI540121B
(zh)
|
2014-12-01 |
2016-07-01 |
臺灣永光化學工業股份有限公司 |
曲前列環素二乙醇胺之合成方法及新穎中間體
|
|
CA2973147A1
(en)
|
2015-01-27 |
2016-08-04 |
Scipharm Sarl |
Composition for the treatment of hepatic veno-occlusive disease
|
|
US20160243064A1
(en)
|
2015-02-21 |
2016-08-25 |
Gavis Pharmaceuticals |
Novel oral pharmaceutical compositions of treprostinil
|
|
WO2016176555A1
(en)
|
2015-04-29 |
2016-11-03 |
Insmed Incorporated |
Prostacyclin compounds, compositions and methods of use thereof
|
|
US9394227B1
(en)
|
2015-06-17 |
2016-07-19 |
Corsair Pharma, Inc. |
Treprostinil derivatives and compositions and uses thereof
|
|
US9643911B2
(en)
|
2015-06-17 |
2017-05-09 |
Corsair Pharma, Inc. |
Treprostinil derivatives and compositions and uses thereof
|
|
KR20230119035A
(ko)
|
2016-12-05 |
2023-08-14 |
코세어 파마 인코포레이티드 |
트레프로스티닐 및 이의 염의 피부 및 경피 투여
|