|
US10323236B2
(en)
|
2011-07-22 |
2019-06-18 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
WO2015066119A1
(en)
|
2013-10-30 |
2015-05-07 |
North Carolina State University |
Compositions and methods related to a type-ii crispr-cas system in lactobacillus buchneri
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
US10787654B2
(en)
|
2014-01-24 |
2020-09-29 |
North Carolina State University |
Methods and compositions for sequence guiding Cas9 targeting
|
|
JP2017512481A
(ja)
|
2014-04-08 |
2017-05-25 |
ノースカロライナ ステート ユニバーシティーＮｏｒｔｈ Ｃａｒｏｌｉｎａ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ |
Ｃｒｉｓｐｒ関連遺伝子を用いた、ｒｎａ依存性の転写抑制のための方法および組成物
|
|
US10077453B2
(en)
|
2014-07-30 |
2018-09-18 |
President And Fellows Of Harvard College |
CAS9 proteins including ligand-dependent inteins
|
|
EP3186375A4
(en)
|
2014-08-28 |
2019-03-13 |
North Carolina State University |
Novel CAS9 PROTEINS AND CHARACTERISTICS FOR DNA TARGETING AND GENOME EDITING
|
|
EA201792663A1
(ru)
|
2015-05-29 |
2018-04-30 |
Норт Каролина Стейт Юниверсити |
Способы скрининга бактерий, архей, водорослей и дрожжей с использованием нуклеиновых кислот crispr
|
|
WO2016205276A1
(en)
|
2015-06-15 |
2016-12-22 |
North Carolina State University |
Methods and compositions for efficient delivery of nucleic acids and rna-based antimicrobials
|
|
US9580727B1
(en)
*
|
2015-08-07 |
2017-02-28 |
Caribou Biosciences, Inc. |
Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
|
|
WO2017040511A1
(en)
*
|
2015-08-31 |
2017-03-09 |
Agilent Technologies, Inc. |
Compounds and methods for crispr/cas-based genome editing by homologous recombination
|
|
EP3356533A1
(en)
|
2015-09-28 |
2018-08-08 |
North Carolina State University |
Methods and compositions for sequence specific antimicrobials
|
|
WO2017070598A1
(en)
|
2015-10-23 |
2017-04-27 |
Caribou Biosciences, Inc. |
Engineered crispr class 2 cross-type nucleic-acid targeting nucleic acids
|
|
IL310721B2
(en)
|
2015-10-23 |
2025-11-01 |
Harvard College |
Nucleobase editors and uses thereof
|
|
CN108473981B
(zh)
*
|
2015-12-04 |
2022-04-12 |
卡里布生物科学公司 |
工程化靶向核酸的核酸
|
|
US11542466B2
(en)
|
2015-12-22 |
2023-01-03 |
North Carolina State University |
Methods and compositions for delivery of CRISPR based antimicrobials
|
|
US20200340011A1
(en)
*
|
2016-06-10 |
2020-10-29 |
University Of Wyoming |
Recombinant insect vectors and methods of use
|
|
US10337051B2
(en)
|
2016-06-16 |
2019-07-02 |
The Regents Of The University Of California |
Methods and compositions for detecting a target RNA
|
|
CN110214183A
(zh)
|
2016-08-03 |
2019-09-06 |
哈佛大学的校长及成员们 |
腺苷核碱基编辑器及其用途
|
|
WO2018031683A1
(en)
|
2016-08-09 |
2018-02-15 |
President And Fellows Of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
|
WO2018031950A1
(en)
|
2016-08-12 |
2018-02-15 |
Caribou Biosciences, Inc. |
Protein engineering methods
|
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
CA3034931A1
(en)
|
2016-09-23 |
2018-03-29 |
Board Of Trustees Of Southern Illinois University |
Tuning crispr/cas9 activity with chemically modified nucleotide substitutions
|
|
BR112019006388A2
(pt)
|
2016-09-30 |
2019-06-25 |
Univ California |
enzimas modificadoras de ácido nucleico guiadas por rna e métodos de uso das mesmas
|
|
MX2019003674A
(es)
|
2016-09-30 |
2021-01-08 |
Univ California |
Enzimas modificadoras de ácido nucleico guiadas por arn y métodos de uso de estas.
|
|
KR102622411B1
(ko)
|
2016-10-14 |
2024-01-10 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵염기 에디터의 aav 전달
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
US11859219B1
(en)
*
|
2016-12-30 |
2024-01-02 |
Flagship Pioneering Innovations V, Inc. |
Methods of altering a target nucleotide sequence with an RNA-guided nuclease and a single guide RNA
|
|
WO2018140899A1
(en)
|
2017-01-28 |
2018-08-02 |
Inari Agriculture, Inc. |
Novel plant cells, plants, and seeds
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
US12390514B2
(en)
|
2017-03-09 |
2025-08-19 |
President And Fellows Of Harvard College |
Cancer vaccine
|
|
US11542496B2
(en)
|
2017-03-10 |
2023-01-03 |
President And Fellows Of Harvard College |
Cytosine to guanine base editor
|
|
KR20240116572A
(ko)
|
2017-03-23 |
2024-07-29 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
|
|
US10876101B2
(en)
|
2017-03-28 |
2020-12-29 |
Locanabio, Inc. |
CRISPR-associated (Cas) protein
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
EP3630975B1
(en)
|
2017-05-26 |
2025-11-19 |
North Carolina State University |
Altered guide rnas for modulating cas9 activity and methods of use
|
|
US11866726B2
(en)
|
2017-07-14 |
2024-01-09 |
Editas Medicine, Inc. |
Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
|
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
EP3678680A4
(en)
|
2017-09-05 |
2021-12-01 |
Regeneron Pharmaceuticals, Inc. |
ADMINISTRATION OF A GENE EDITING SYSTEM CONTAINING A SINGLE RETROVIRAL PARTICLE AND METHODS OF GENERATION AND USE
|
|
US11603536B2
(en)
*
|
2017-09-29 |
2023-03-14 |
Inari Agriculture Technology, Inc. |
Methods for efficient maize genome editing
|
|
KR20250107288A
(ko)
|
2017-10-16 |
2025-07-11 |
더 브로드 인스티튜트, 인코퍼레이티드 |
아데노신 염기 편집제의 용도
|
|
AU2018358051B2
(en)
*
|
2017-11-01 |
2025-01-09 |
The Regents Of The University Of California |
CasZ compositions and methods of use
|
|
US11970719B2
(en)
|
2017-11-01 |
2024-04-30 |
The Regents Of The University Of California |
Class 2 CRISPR/Cas compositions and methods of use
|
|
WO2019089804A1
(en)
|
2017-11-01 |
2019-05-09 |
The Regents Of The University Of California |
Casy compositions and methods of use
|
|
US20210002609A1
(en)
|
2017-12-05 |
2021-01-07 |
Caribou Biosciences, Inc. |
Modified lymphocytes
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
EP3502262A1
(en)
|
2017-12-22 |
2019-06-26 |
Rhodia Operations |
Process for the hydroxylation of phenolic derivatives catalyzed by hpab monooxygenase
|
|
US20200318106A1
(en)
*
|
2017-12-22 |
2020-10-08 |
Bio-Rad Laboratories, Inc. |
Controlling phenotype of organisms with crispr/cas gene targeting
|
|
US11220694B1
(en)
|
2018-01-29 |
2022-01-11 |
Inari Agriculture, Inc. |
Rice cells and rice plants
|
|
US11802288B1
(en)
|
2018-01-29 |
2023-10-31 |
Inari Agriculture Technology, Inc. |
Methods for efficient soybean genome editing
|
|
US11926835B1
(en)
|
2018-01-29 |
2024-03-12 |
Inari Agriculture Technology, Inc. |
Methods for efficient tomato genome editing
|
|
WO2019152941A1
(en)
|
2018-02-05 |
2019-08-08 |
Caribou Biosciences, Inc. |
Engineered gut microbes for reduction of reactivation of detoxified drugs
|
|
WO2019173248A1
(en)
|
2018-03-07 |
2019-09-12 |
Caribou Biosciences, Inc. |
Engineered nucleic acid-targeting nucleic acids
|
|
CN108588128A
(zh)
*
|
2018-04-26 |
2018-09-28 |
南昌大学 |
一种高效率大豆CRISPR/Cas9系统的构建方法及应用
|
|
EP3788155A1
(en)
*
|
2018-05-01 |
2021-03-10 |
Wake Forest University Health Sciences |
Lentiviral-based vectors and related systems and methods for eukaryotic gene editing
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
US11866719B1
(en)
|
2018-06-04 |
2024-01-09 |
Inari Agriculture Technology, Inc. |
Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants
|
|
CN108795990B
(zh)
*
|
2018-06-27 |
2019-06-11 |
海南大学 |
一种构建桔小实蝇白眼品系的方法
|
|
EP3823633A4
(en)
|
2018-06-29 |
2023-05-03 |
Editas Medicine, Inc. |
SYNTHETIC LEAD MOLECULES, COMPOSITIONS AND METHODS RELATED THERETO
|
|
US12522807B2
(en)
|
2018-07-09 |
2026-01-13 |
The Broad Institute, Inc. |
RNA programmable epigenetic RNA modifiers and uses thereof
|
|
EP3830301B1
(en)
|
2018-08-01 |
2024-05-22 |
Mammoth Biosciences, Inc. |
Programmable nuclease compositions and methods of use thereof
|
|
WO2020072248A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system
|
|
US12203123B2
(en)
|
2018-10-01 |
2025-01-21 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for screening for variant cells
|
|
WO2020072254A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system and uses thereof for killing target cells
|
|
WO2020072250A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system and uses thereof for genome modification and alteration of expression
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
EP3931313A2
(en)
|
2019-01-04 |
2022-01-05 |
Mammoth Biosciences, Inc. |
Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
WO2020176389A1
(en)
|
2019-02-25 |
2020-09-03 |
Caribou Biosciences, Inc. |
Plasmids for gene editing
|
|
WO2020191233A1
(en)
|
2019-03-19 |
2020-09-24 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
CN110305899A
(zh)
*
|
2019-06-25 |
2019-10-08 |
华中农业大学 |
外源基因定点整合至gapdh基因下游的打靶载体构建方法及其应用
|
|
CN110551761B
(zh)
*
|
2019-08-08 |
2022-11-18 |
复旦大学 |
CRISPR/Sa-SepCas9基因编辑系统及其应用
|
|
JP7689949B2
(ja)
*
|
2019-10-03 |
2025-06-09 |
アーティサン ディベロップメント ラブズ インコーポレイテッド |
操作されたデュアルガイド核酸を有するｃｒｉｓｐｒシステム
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
WO2021076876A1
(en)
*
|
2019-10-18 |
2021-04-22 |
Zymergen Inc. |
Genotyping edited microbial strains
|
|
IL297761A
(en)
|
2020-05-08 |
2022-12-01 |
Broad Inst Inc |
Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence
|
|
EP4158019A1
(en)
*
|
2020-05-26 |
2023-04-05 |
Shape Therapeutics Inc. |
Methods and compositions relating to engineered guide systems for adenosine deaminase acting on rna editing
|
|
KR102674574B1
(ko)
*
|
2020-09-02 |
2024-06-13 |
한국과학기술연구원 |
Cas9을 위한 신규 tracrRNA 시스템
|
|
CN117203244A
(zh)
*
|
2021-01-26 |
2023-12-08 |
国立大学法人熊本大学 |
功能性核酸以及蛋白质引入用载体
|
|
WO2022164796A1
(en)
|
2021-01-26 |
2022-08-04 |
California Institute Of Technology |
Allosteric conditional guide rnas for cell-selective regulation of crispr/cas
|
|
CN117729926A
(zh)
*
|
2021-05-28 |
2024-03-19 |
比姆医疗股份有限公司 |
用于使碱基编辑器自失活的组合物和方法
|
|
EP4347818A2
(en)
|
2021-06-01 |
2024-04-10 |
Arbor Biotechnologies, Inc. |
Gene editing systems comprising a crispr nuclease and uses thereof
|
|
WO2023035011A1
(en)
|
2021-09-03 |
2023-03-09 |
North Carolina State University |
Compositions and methods for conferring resistance to geminivirus
|
|
US20250302925A1
(en)
*
|
2022-01-27 |
2025-10-02 |
Synthego Corporation |
Conjugated crispr-cas complexes
|
|
EP4490288A2
(en)
*
|
2022-03-11 |
2025-01-15 |
Intima Bioscience, Inc. |
Nucleic acid editing systems, methods, and uses thereof
|
|
CN116144769B
(zh)
*
|
2022-09-09 |
2023-09-01 |
广州医科大学附属第一医院（广州呼吸中心） |
一种基于PCA3、PSA双基因的sgRNA引物、检测试剂及其应用
|
|
WO2024112036A1
(ko)
*
|
2022-11-21 |
2024-05-30 |
고려대학교 산학협력단 |
Ｃａｓ９ 단백질을 이용한 고효율 어댑터 연결 반응에서 어댑터 이합체의 제거 방법
|
|
KR20250151430A
(ko)
|
2023-02-15 |
2025-10-21 |
아버 바이오테크놀로지스, 인크. |
스타스민 2(stmn2) 전사체에서 비정상적인 스플라이싱을 억제하는 유전자 편집 방법
|
|
WO2025019273A1
(en)
*
|
2023-07-14 |
2025-01-23 |
Epicrispr Biotechnologies, Inc. |
Engineered nucleases and guide rna spacer sequences therefor, and compositions, and methods of use thereof
|
|
WO2025171210A1
(en)
|
2024-02-09 |
2025-08-14 |
Arbor Biotechnologies, Inc. |
Compositions and methods for gene editing via homology-mediated end joining
|
|
WO2026015832A2
(en)
|
2024-07-12 |
2026-01-15 |
Arbor Biotechnologies, Inc. |
Reverse transcriptases and gene editing systems comprising such
|
|
WO2026015829A2
(en)
|
2024-07-12 |
2026-01-15 |
Arbor Biotechnologies, Inc. |
Small reverse transcriptases and gene editing systems comprising such
|
|
US12605394B2
(en)
|
2024-07-25 |
2026-04-21 |
Visionary Assets, Llc |
Compositions containing cannabinoid nanoparticles
|
|
CN119278904B
(zh)
*
|
2024-11-19 |
2026-04-17 |
江苏科技大学 |
稳定表达Cas9-gfp融合蛋白的二化性家蚕品种的育种方法及应用
|
|
CN120210216B
(zh)
*
|
2025-04-09 |
2025-09-19 |
广东海洋大学 |
一种rna适配体及其在提高水稻耐盐性中的应用
|