JP2018521976A5 - - Google Patents
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- JP2018521976A5 JP2018521976A5 JP2017561797A JP2017561797A JP2018521976A5 JP 2018521976 A5 JP2018521976 A5 JP 2018521976A5 JP 2017561797 A JP2017561797 A JP 2017561797A JP 2017561797 A JP2017561797 A JP 2017561797A JP 2018521976 A5 JP2018521976 A5 JP 2018521976A5
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- patient
- tumor
- antagonist
- tumor sample
- bladder cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 206010028980 Neoplasm Diseases 0.000 claims 79
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 77
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 77
- 239000005557 antagonist Substances 0.000 claims 59
- 230000014509 gene expression Effects 0.000 claims 42
- 239000003814 drug Substances 0.000 claims 38
- 238000000034 method Methods 0.000 claims 37
- 206010005003 Bladder cancer Diseases 0.000 claims 28
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 28
- 201000005112 urinary bladder cancer Diseases 0.000 claims 28
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 20
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 20
- 210000002865 immune cell Anatomy 0.000 claims 16
- 108090000623 proteins and genes Proteins 0.000 claims 14
- 230000008878 coupling Effects 0.000 claims 12
- 238000010168 coupling process Methods 0.000 claims 12
- 238000005859 coupling reaction Methods 0.000 claims 12
- 238000002560 therapeutic procedure Methods 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 238000003753 real-time PCR Methods 0.000 claims 6
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 5
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 5
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 5
- 108091006020 Fc-tagged proteins Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- 229950009791 durvalumab Drugs 0.000 claims 4
- 238000003364 immunohistochemistry Methods 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 108020004999 messenger RNA Proteins 0.000 claims 4
- 229960003301 nivolumab Drugs 0.000 claims 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 4
- 230000004044 response Effects 0.000 claims 4
- 230000004043 responsiveness Effects 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 108010009392 Cyclin-Dependent Kinase Inhibitor p16 Proteins 0.000 claims 3
- 102100024458 Cyclin-dependent kinase inhibitor 2A Human genes 0.000 claims 3
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims 3
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims 3
- 102100029283 Hepatocyte nuclear factor 3-alpha Human genes 0.000 claims 3
- 101001062353 Homo sapiens Hepatocyte nuclear factor 3-alpha Proteins 0.000 claims 3
- 101000614436 Homo sapiens Keratin, type I cytoskeletal 14 Proteins 0.000 claims 3
- 101001056473 Homo sapiens Keratin, type II cytoskeletal 5 Proteins 0.000 claims 3
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 3
- 101000819111 Homo sapiens Trans-acting T-cell-specific transcription factor GATA-3 Proteins 0.000 claims 3
- 102100040445 Keratin, type I cytoskeletal 14 Human genes 0.000 claims 3
- 102100025756 Keratin, type II cytoskeletal 5 Human genes 0.000 claims 3
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 3
- 102100021386 Trans-acting T-cell-specific transcription factor GATA-3 Human genes 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 3
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 3
- 108091070501 miRNA Proteins 0.000 claims 3
- 239000002679 microRNA Substances 0.000 claims 3
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 3
- 229960002621 pembrolizumab Drugs 0.000 claims 3
- 230000004083 survival effect Effects 0.000 claims 3
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 claims 2
- 102100036170 C-X-C motif chemokine 9 Human genes 0.000 claims 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 2
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 claims 2
- 101000947172 Homo sapiens C-X-C motif chemokine 9 Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 2
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 229960003852 atezolizumab Drugs 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 238000000684 flow cytometry Methods 0.000 claims 2
- 238000010166 immunofluorescence Methods 0.000 claims 2
- 238000007901 in situ hybridization Methods 0.000 claims 2
- 230000001394 metastastic effect Effects 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- 108091092072 miR-100 stem-loop Proteins 0.000 claims 2
- 108091024975 miR-100-1 stem-loop Proteins 0.000 claims 2
- 108091041879 miR-100-2 stem-loop Proteins 0.000 claims 2
- 108091076732 miR-99a stem-loop Proteins 0.000 claims 2
- 238000010208 microarray analysis Methods 0.000 claims 2
- 229910052697 platinum Inorganic materials 0.000 claims 2
- 230000003439 radiotherapeutic effect Effects 0.000 claims 2
- 230000002829 reductive effect Effects 0.000 claims 2
- 238000010839 reverse transcription Methods 0.000 claims 2
- 238000012882 sequential analysis Methods 0.000 claims 2
- 229950007213 spartalizumab Drugs 0.000 claims 2
- 238000001262 western blot Methods 0.000 claims 2
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 1
- 102100030386 Granzyme A Human genes 0.000 claims 1
- 102100030385 Granzyme B Human genes 0.000 claims 1
- 101001009599 Homo sapiens Granzyme A Proteins 0.000 claims 1
- 101001009603 Homo sapiens Granzyme B Proteins 0.000 claims 1
- 101000599940 Homo sapiens Interferon gamma Proteins 0.000 claims 1
- 101000987581 Homo sapiens Perforin-1 Proteins 0.000 claims 1
- 101000713602 Homo sapiens T-box transcription factor TBX21 Proteins 0.000 claims 1
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 102100028467 Perforin-1 Human genes 0.000 claims 1
- 102100036840 T-box transcription factor TBX21 Human genes 0.000 claims 1
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000003966 growth inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012188 paraffin wax Substances 0.000 claims 1
- 238000003860 storage Methods 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022122906A JP2022172083A (ja) | 2015-05-29 | 2022-08-01 | 癌のための治療方法及び診断方法 |
| JP2024159272A JP2025003997A (ja) | 2015-05-29 | 2024-09-13 | 癌のための治療方法及び診断方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562168669P | 2015-05-29 | 2015-05-29 | |
| US62/168,669 | 2015-05-29 | ||
| US201662301599P | 2016-02-29 | 2016-02-29 | |
| US62/301,599 | 2016-02-29 | ||
| PCT/US2016/034664 WO2016196298A1 (en) | 2015-05-29 | 2016-05-27 | Therapeutic and diagnolstic methods for cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022122906A Division JP2022172083A (ja) | 2015-05-29 | 2022-08-01 | 癌のための治療方法及び診断方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521976A JP2018521976A (ja) | 2018-08-09 |
| JP2018521976A5 true JP2018521976A5 (enExample) | 2019-06-27 |
| JP7144935B2 JP7144935B2 (ja) | 2022-09-30 |
Family
ID=56236061
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017561797A Active JP7144935B2 (ja) | 2015-05-29 | 2016-05-27 | 癌のための治療方法及び診断方法 |
| JP2022122906A Withdrawn JP2022172083A (ja) | 2015-05-29 | 2022-08-01 | 癌のための治療方法及び診断方法 |
| JP2024159272A Pending JP2025003997A (ja) | 2015-05-29 | 2024-09-13 | 癌のための治療方法及び診断方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022122906A Withdrawn JP2022172083A (ja) | 2015-05-29 | 2022-08-01 | 癌のための治療方法及び診断方法 |
| JP2024159272A Pending JP2025003997A (ja) | 2015-05-29 | 2024-09-13 | 癌のための治療方法及び診断方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20180037655A1 (enExample) |
| EP (3) | EP4335931A3 (enExample) |
| JP (3) | JP7144935B2 (enExample) |
| KR (2) | KR20250151554A (enExample) |
| CN (1) | CN107532217A (enExample) |
| AU (3) | AU2016270625B2 (enExample) |
| CA (1) | CA2984003A1 (enExample) |
| ES (1) | ES2789500T5 (enExample) |
| HK (1) | HK1248773A1 (enExample) |
| IL (2) | IL255372B (enExample) |
| MX (2) | MX392671B (enExample) |
| PL (1) | PL3303632T5 (enExample) |
| WO (1) | WO2016196298A1 (enExample) |
Families Citing this family (55)
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| CN112552401B (zh) | 2013-09-13 | 2023-08-25 | 广州百济神州生物制药有限公司 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
| CN106604742B (zh) | 2014-07-03 | 2019-01-11 | 百济神州有限公司 | 抗pd-l1抗体及其作为治疗剂及诊断剂的用途 |
| ES2789500T5 (es) | 2015-05-29 | 2023-09-20 | Hoffmann La Roche | Procedimientos terapéuticos y de diagnóstico para el cáncer |
| JP6903055B2 (ja) | 2015-08-03 | 2021-07-14 | イーエヌビー・セラピューティクス・インク | Ｅｔｂｒ活性化に関連した癌を治療するための組成物及び方法 |
| KR20180097615A (ko) | 2016-01-08 | 2018-08-31 | 에프. 호프만-라 로슈 아게 | Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법 |
| CN107459578B (zh) * | 2016-05-31 | 2021-11-26 | 泰州迈博太科药业有限公司 | 一种靶向cd47与pd-l1的双功能融合蛋白 |
| US10864203B2 (en) | 2016-07-05 | 2020-12-15 | Beigene, Ltd. | Combination of a PD-1 antagonist and a RAF inhibitor for treating cancer |
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