JP2018520996A5 - - Google Patents
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- JP2018520996A5 JP2018520996A5 JP2017558454A JP2017558454A JP2018520996A5 JP 2018520996 A5 JP2018520996 A5 JP 2018520996A5 JP 2017558454 A JP2017558454 A JP 2017558454A JP 2017558454 A JP2017558454 A JP 2017558454A JP 2018520996 A5 JP2018520996 A5 JP 2018520996A5
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- tumor
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- binding antagonist
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- 108010074708 B7-H1 Antigen Proteins 0.000 claims 78
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 78
- 206010028980 Neoplasm Diseases 0.000 claims 76
- 230000014509 gene expression Effects 0.000 claims 48
- 238000000034 method Methods 0.000 claims 43
- 239000005557 antagonist Substances 0.000 claims 42
- 239000003814 drug Substances 0.000 claims 29
- 210000004881 tumor cell Anatomy 0.000 claims 17
- 210000002865 immune cell Anatomy 0.000 claims 16
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 14
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 14
- 108090000623 proteins and genes Proteins 0.000 claims 14
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 12
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 10
- 238000002560 therapeutic procedure Methods 0.000 claims 7
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 6
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 6
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 238000003753 real-time PCR Methods 0.000 claims 6
- 108091006020 Fc-tagged proteins Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 210000003719 b-lymphocyte Anatomy 0.000 claims 4
- 230000008878 coupling Effects 0.000 claims 4
- 238000010168 coupling process Methods 0.000 claims 4
- 238000005859 coupling reaction Methods 0.000 claims 4
- 229950009791 durvalumab Drugs 0.000 claims 4
- 238000003364 immunohistochemistry Methods 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 108020004999 messenger RNA Proteins 0.000 claims 4
- 229960003301 nivolumab Drugs 0.000 claims 4
- 102000008186 Collagen Human genes 0.000 claims 3
- 108010035532 Collagen Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 229920001436 collagen Polymers 0.000 claims 3
- 102100027205 B-cell antigen receptor complex-associated protein alpha chain Human genes 0.000 claims 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 2
- 101000914489 Homo sapiens B-cell antigen receptor complex-associated protein alpha chain Proteins 0.000 claims 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 2
- 101000945371 Homo sapiens Killer cell immunoglobulin-like receptor 2DL2 Proteins 0.000 claims 2
- 101000945333 Homo sapiens Killer cell immunoglobulin-like receptor 2DL3 Proteins 0.000 claims 2
- 101000945331 Homo sapiens Killer cell immunoglobulin-like receptor 2DL4 Proteins 0.000 claims 2
- 101000945339 Homo sapiens Killer cell immunoglobulin-like receptor 2DS2 Proteins 0.000 claims 2
- 101000945351 Homo sapiens Killer cell immunoglobulin-like receptor 3DL1 Proteins 0.000 claims 2
- 101001049181 Homo sapiens Killer cell lectin-like receptor subfamily B member 1 Proteins 0.000 claims 2
- 101000971538 Homo sapiens Killer cell lectin-like receptor subfamily F member 1 Proteins 0.000 claims 2
- 101000971533 Homo sapiens Killer cell lectin-like receptor subfamily G member 1 Proteins 0.000 claims 2
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 2
- 101000991061 Homo sapiens MHC class I polypeptide-related sequence B Proteins 0.000 claims 2
- 101001109508 Homo sapiens NKG2-A/NKG2-B type II integral membrane protein Proteins 0.000 claims 2
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims 2
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 2
- 101001109470 Homo sapiens NKG2-E type II integral membrane protein Proteins 0.000 claims 2
- 101000589301 Homo sapiens Natural cytotoxicity triggering receptor 1 Proteins 0.000 claims 2
- 101000971513 Homo sapiens Natural killer cells antigen CD94 Proteins 0.000 claims 2
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 2
- 101000987581 Homo sapiens Perforin-1 Proteins 0.000 claims 2
- 108020003285 Isocitrate lyase Proteins 0.000 claims 2
- 102100033599 Killer cell immunoglobulin-like receptor 2DL2 Human genes 0.000 claims 2
- 102100033634 Killer cell immunoglobulin-like receptor 2DL3 Human genes 0.000 claims 2
- 102100033633 Killer cell immunoglobulin-like receptor 2DL4 Human genes 0.000 claims 2
- 102100033630 Killer cell immunoglobulin-like receptor 2DS2 Human genes 0.000 claims 2
- 102100033627 Killer cell immunoglobulin-like receptor 3DL1 Human genes 0.000 claims 2
- 102100023678 Killer cell lectin-like receptor subfamily B member 1 Human genes 0.000 claims 2
- 102100021458 Killer cell lectin-like receptor subfamily F member 1 Human genes 0.000 claims 2
- 102100021457 Killer cell lectin-like receptor subfamily G member 1 Human genes 0.000 claims 2
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 2
- 102100030301 MHC class I polypeptide-related sequence A Human genes 0.000 claims 2
- 102100030300 MHC class I polypeptide-related sequence B Human genes 0.000 claims 2
- 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 claims 2
- 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 claims 2
- 102100022682 NKG2-A/NKG2-B type II integral membrane protein Human genes 0.000 claims 2
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims 2
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 2
- 102100022701 NKG2-E type II integral membrane protein Human genes 0.000 claims 2
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims 2
- 102100021462 Natural killer cells antigen CD94 Human genes 0.000 claims 2
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 2
- 102100028467 Perforin-1 Human genes 0.000 claims 2
- 238000003559 RNA-seq method Methods 0.000 claims 2
- 108010044012 STAT1 Transcription Factor Proteins 0.000 claims 2
- 102000006381 STAT1 Transcription Factor Human genes 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 229960003852 atezolizumab Drugs 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 238000000684 flow cytometry Methods 0.000 claims 2
- 238000010166 immunofluorescence Methods 0.000 claims 2
- 238000007901 in situ hybridization Methods 0.000 claims 2
- 230000001394 metastastic effect Effects 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- 239000010445 mica Substances 0.000 claims 2
- 229910052618 mica group Inorganic materials 0.000 claims 2
- 238000010208 microarray analysis Methods 0.000 claims 2
- 210000000651 myofibroblast Anatomy 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- 238000010839 reverse transcription Methods 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 229950007213 spartalizumab Drugs 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 238000001262 western blot Methods 0.000 claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001086 cytosolic effect Effects 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000003966 growth inhibitor Substances 0.000 claims 1
- 239000012188 paraffin wax Substances 0.000 claims 1
- 230000003439 radiotherapeutic effect Effects 0.000 claims 1
- 238000003860 storage Methods 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022013871A JP7534344B2 (ja) | 2015-05-12 | 2022-02-01 | 癌のための治療方法及び診断方法 |
| JP2024125652A JP2024170394A (ja) | 2015-05-12 | 2024-08-01 | 癌のための治療方法及び診断方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562160561P | 2015-05-12 | 2015-05-12 | |
| US62/160,561 | 2015-05-12 | ||
| US201562168700P | 2015-05-29 | 2015-05-29 | |
| US62/168,700 | 2015-05-29 | ||
| PCT/US2016/032112 WO2016183326A1 (en) | 2015-05-12 | 2016-05-12 | Therapeutic and diagnostic methods for cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022013871A Division JP7534344B2 (ja) | 2015-05-12 | 2022-02-01 | 癌のための治療方法及び診断方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018520996A JP2018520996A (ja) | 2018-08-02 |
| JP2018520996A5 true JP2018520996A5 (enExample) | 2019-06-13 |
| JP7048319B2 JP7048319B2 (ja) | 2022-04-05 |
Family
ID=56072467
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017558454A Active JP7048319B2 (ja) | 2015-05-12 | 2016-05-12 | 癌のための治療方法及び診断方法 |
| JP2022013871A Active JP7534344B2 (ja) | 2015-05-12 | 2022-02-01 | 癌のための治療方法及び診断方法 |
| JP2024125652A Pending JP2024170394A (ja) | 2015-05-12 | 2024-08-01 | 癌のための治療方法及び診断方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022013871A Active JP7534344B2 (ja) | 2015-05-12 | 2022-02-01 | 癌のための治療方法及び診断方法 |
| JP2024125652A Pending JP2024170394A (ja) | 2015-05-12 | 2024-08-01 | 癌のための治療方法及び診断方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20180030138A1 (enExample) |
| EP (2) | EP3783029A1 (enExample) |
| JP (3) | JP7048319B2 (enExample) |
| KR (2) | KR20250021621A (enExample) |
| CN (1) | CN107667119A (enExample) |
| AU (2) | AU2016262074A1 (enExample) |
| CA (1) | CA2983282A1 (enExample) |
| DK (1) | DK3294770T4 (enExample) |
| ES (1) | ES2835866T5 (enExample) |
| FI (1) | FI3294770T4 (enExample) |
| HK (1) | HK1250376A1 (enExample) |
| HR (1) | HRP20201900T4 (enExample) |
| HU (1) | HUE051815T2 (enExample) |
| IL (2) | IL255312B (enExample) |
| LT (1) | LT3294770T (enExample) |
| MX (2) | MX2017014381A (enExample) |
| PL (1) | PL3294770T5 (enExample) |
| PT (1) | PT3294770T (enExample) |
| RS (1) | RS61152B2 (enExample) |
| SI (1) | SI3294770T2 (enExample) |
| WO (1) | WO2016183326A1 (enExample) |
Families Citing this family (43)
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| EP3808349B1 (en) | 2014-08-07 | 2022-10-05 | Mayo Foundation for Medical Education and Research | Compounds and methods for treating cancer |
| MX2017011644A (es) | 2015-03-13 | 2017-12-04 | Cytomx Therapeutics Inc | Anticuerpos anti-pdl1, anticuerpos anti-pdl1 activables y metodos de uso de los mismos. |
| WO2016183326A1 (en) | 2015-05-12 | 2016-11-17 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
| CA2994544C (en) | 2015-08-03 | 2021-03-30 | Enb Therapeutics, Llc | Compositions and methods for treating cancers associated with etbr activation |
| CN107787373B (zh) * | 2015-08-17 | 2021-11-26 | 库拉肿瘤学公司 | 法尼基转移酶抑制剂在制备用于治疗癌症的药物中的用途 |
| KR20180097615A (ko) | 2016-01-08 | 2018-08-31 | 에프. 호프만-라 로슈 아게 | Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법 |
| JP7235508B2 (ja) * | 2016-11-24 | 2023-03-08 | 第一三共株式会社 | Ｐｄ－１免疫チェックポイント阻害剤による治療に対するがんの感受性を予測する方法 |
| CA3048646A1 (en) * | 2017-01-07 | 2018-07-12 | Merck Patent Gmbh | Dosing regimens and dosage forms for targeted tgf-b inhibition |
| WO2018136553A1 (en) * | 2017-01-18 | 2018-07-26 | Genentech, Inc. | Idiotypic antibodies against anti-pd-l1 antibodies and uses thereof |
| WO2018151601A1 (en) * | 2017-02-17 | 2018-08-23 | Stichting Vumc | Swarm intelligence-enhanced diagnosis and therapy selection for cancer using tumor- educated platelets |
| US11292842B2 (en) * | 2017-02-21 | 2022-04-05 | Regeneron Pharmaceuticals, Inc. | Anti-PD-1 antibodies for treatment of lung cancer |
| ES3036483T3 (en) * | 2017-02-28 | 2025-09-19 | Mayo Found Medical Education & Res | Combinations for use in the treatment of cancer |
| CN110546277B (zh) | 2017-03-01 | 2024-06-11 | 豪夫迈·罗氏有限公司 | 用于癌症的诊断和治疗方法 |
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| IL271888B2 (en) | 2017-07-21 | 2024-09-01 | Genentech Inc | Therapeutic and diagnostic methods for cancer |
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| US11243207B2 (en) | 2018-03-29 | 2022-02-08 | Mayo Foundation For Medical Education And Research | Assessing and treating cancer |
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| CN112771177A (zh) * | 2018-05-21 | 2021-05-07 | 纳米线科技公司 | 分子基因标签及其使用方法 |
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| KR102084196B1 (ko) * | 2018-08-29 | 2020-03-03 | 연세대학교 산학협력단 | 면역 항암 요법의 치료 반응에 관한 정보 제공 방법 및 이를 이용한 키트 |
| AU2019342133B8 (en) | 2018-09-21 | 2025-08-07 | Genentech, Inc. | Diagnostic methods for triple-negative breast cancer |
| MX2021004348A (es) | 2018-10-18 | 2021-05-28 | Genentech Inc | Procedimientos de diagnóstico y terapéuticos para el cáncer de riñón sarcomatoide. |
| CN113164599B (zh) * | 2018-12-24 | 2023-08-01 | 正大天晴药业集团股份有限公司 | 抗pd-l1单克隆抗体治疗癌症的用途 |
| BR112021022084A2 (pt) * | 2019-05-03 | 2022-02-08 | Univ Cornell | Marcadores para identificar e quantificar a mutação da sequência de ácido nucleico, expressão, variante de splice, translocação, número de cópias ou alterações de metilação |
| CN111973739B (zh) * | 2019-05-23 | 2024-02-13 | 正大天晴药业集团股份有限公司 | 抗pd-l1单克隆抗体治疗癌症的用途 |
| US20210030868A1 (en) * | 2019-07-29 | 2021-02-04 | Cai Gu Huang | Formulation of antibody based drugs for treating lung cancer by inhalation |
| EP3792632A1 (en) * | 2019-09-16 | 2021-03-17 | Vito NV | Immunotherapy markers |
| JP2023511595A (ja) | 2020-01-27 | 2023-03-20 | ジェネンテック， インコーポレイテッド | 抗ｔｉｇｉｔアンタゴニスト抗体を用いたがんを処置するための方法 |
| CN115698717A (zh) * | 2020-04-03 | 2023-02-03 | 基因泰克公司 | 癌症的治疗和诊断方法 |
| JP2023524257A (ja) * | 2020-05-05 | 2023-06-09 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | Ｐｄ－１軸阻害剤に対する応答の予測 |
| EP4164627A1 (en) | 2020-06-16 | 2023-04-19 | Genentech, Inc. | Methods and compositions for treating triple-negative breast cancer |
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| EP4384276A4 (en) * | 2021-08-10 | 2025-06-25 | Apexigen, Inc. | Biomarkers for cd40 agonist therapy |
| JP2025516649A (ja) | 2022-05-12 | 2025-05-30 | ジェネンテック， インコーポレイテッド | Ｓｈｐ２阻害剤およびｐｄ－ｌ１結合アンタゴニストを含む方法および組成物 |
| JP2025523387A (ja) | 2022-06-07 | 2025-07-23 | ジェネンテック， インコーポレイテッド | 抗ｐｄ－ｌ１アンタゴニストおよび抗ｔｉｇｉｔアンタゴニスト抗体を含む、肺がん治療の有効性を判定するための方法 |
| WO2024163009A1 (en) | 2023-01-31 | 2024-08-08 | Genentech, Inc. | Methods and compositions for treating urothelial bladder cancer |
| TW202436339A (zh) | 2023-01-31 | 2024-09-16 | 瑞士商赫孚孟拉羅股份公司 | 治療選自非小細胞肺癌或三陰性乳癌的癌症之用途 |
| CN120826478A (zh) | 2023-03-06 | 2025-10-21 | 基因泰克公司 | 用于非小细胞肺癌的预后和治疗方法 |
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