JP2018521017A5 - - Google Patents

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JP2018521017A5
JP2018521017A5 JP2017562733A JP2017562733A JP2018521017A5 JP 2018521017 A5 JP2018521017 A5 JP 2018521017A5 JP 2017562733 A JP2017562733 A JP 2017562733A JP 2017562733 A JP2017562733 A JP 2017562733A JP 2018521017 A5 JP2018521017 A5 JP 2018521017A5
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tetraazacyclododecane
amino
carboxylatomethyl
tris
bis
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JP2017562733A
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JP6703012B2 (ja
JP2018521017A (ja
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Priority claimed from EP15170658.7A external-priority patent/EP3101012A1/en
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JP2017562733A 2015-06-04 2016-05-30 磁気共鳴画像法における使用のための新規ガドリニウムキレート化合物 Active JP6703012B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15170658.7 2015-06-04
EP15170658.7A EP3101012A1 (en) 2015-06-04 2015-06-04 New gadolinium chelate compounds for use in magnetic resonance imaging
PCT/EP2016/062105 WO2016193190A1 (en) 2015-06-04 2016-05-30 New gadolinium chelate compounds for use in magnetic resonance imaging

Publications (3)

Publication Number Publication Date
JP2018521017A JP2018521017A (ja) 2018-08-02
JP2018521017A5 true JP2018521017A5 (enExample) 2019-05-30
JP6703012B2 JP6703012B2 (ja) 2020-06-03

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JP2017562733A Active JP6703012B2 (ja) 2015-06-04 2016-05-30 磁気共鳴画像法における使用のための新規ガドリニウムキレート化合物

Country Status (42)

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US (5) US10137209B2 (enExample)
EP (3) EP3101012A1 (enExample)
JP (1) JP6703012B2 (enExample)
KR (1) KR102162742B1 (enExample)
CN (1) CN107667096B (enExample)
AR (1) AR104897A1 (enExample)
AU (1) AU2016272602B2 (enExample)
CA (1) CA2987993C (enExample)
CL (1) CL2017003083A1 (enExample)
CO (1) CO2017012490A2 (enExample)
CU (1) CU24467B1 (enExample)
CY (2) CY1122323T1 (enExample)
DK (2) DK3611169T3 (enExample)
DO (1) DOP2017000282A (enExample)
EA (1) EA033612B1 (enExample)
EC (1) ECSP17080394A (enExample)
ES (2) ES2893244T3 (enExample)
GE (1) GEP20207146B (enExample)
HR (2) HRP20211467T1 (enExample)
HU (2) HUE045967T2 (enExample)
IL (1) IL255945B (enExample)
JO (1) JO3702B1 (enExample)
LT (2) LT3303307T (enExample)
MA (2) MA43146B1 (enExample)
MX (1) MX374249B (enExample)
NI (1) NI201700149A (enExample)
NZ (1) NZ737707A (enExample)
PE (1) PE20180261A1 (enExample)
PH (1) PH12017502205B1 (enExample)
PL (2) PL3303307T3 (enExample)
PT (2) PT3611169T (enExample)
RS (2) RS62353B1 (enExample)
SA (1) SA517390476B1 (enExample)
SI (2) SI3611169T1 (enExample)
SM (1) SMT202100569T1 (enExample)
SV (1) SV2017005578A (enExample)
TN (1) TN2017000505A1 (enExample)
TW (1) TWI699358B (enExample)
UA (1) UA123313C2 (enExample)
UY (1) UY36711A (enExample)
WO (1) WO2016193190A1 (enExample)
ZA (1) ZA201800024B (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
KR102464647B1 (ko) 2016-11-28 2022-11-08 바이엘 파마 악티엔게젤샤프트 자기 공명 영상화에 사용하기 위한 높은 이완도 가돌리늄 킬레이트 화합물
US12262983B2 (en) * 2018-02-07 2025-04-01 University Of Cincinnati System and method for detecting small blood-tissue barrier disruption
AU2019382881B2 (en) * 2018-11-23 2025-06-12 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof
CN110396122B (zh) * 2019-08-13 2020-10-27 牡丹江医学院 一种核磁共振造影剂、制备方法及其用于肿瘤诊断中的用途
US20220370646A1 (en) * 2019-10-25 2022-11-24 Bracco Imaging S.P.A. Pharmaceutical compositions of gd-based contrast agents
KR102386595B1 (ko) * 2019-10-29 2022-04-14 경북대학교 산학협력단 신규한 가돌리늄계 화합물, 이의 제조 방법, 및 이를 함유하는 mri 조영제
CN111393544A (zh) * 2020-03-02 2020-07-10 合肥工业大学 一种具有靶向核磁共振造影和荧光成像功能的聚合物、制备方法及应用
KR102548998B1 (ko) * 2020-03-31 2023-06-29 재단법인 아산사회복지재단 혈전영상을 위한 방사성의약품 및 조성물
CN114181233B (zh) * 2021-11-24 2023-10-31 复旦大学 一种钆基T1磁共振造影剂FD-Gd-123及其制备方法和应用
CN114276309B (zh) * 2021-12-24 2023-08-11 南京科技职业学院 一类含乙氧基芳环的钆磁共振造影剂及其制备方法与应用
WO2024046833A1 (de) 2022-08-30 2024-03-07 Bayer Aktiengesellschaft Erzeugen von synthetischen radiologischen aufnahmen
WO2024046831A1 (de) 2022-08-30 2024-03-07 Bayer Aktiengesellschaft Erzeugen von synthetischen radiologischen aufnahmen
EP4581641A1 (de) 2022-08-30 2025-07-09 Bayer Aktiengesellschaft Erzeugen von synthetischen radiologischen aufnahmen
WO2024052156A1 (de) 2022-09-05 2024-03-14 Bayer Aktiengesellschaft Erzeugen von künstlichen kontrastverstärkten radiologischen aufnahmen
EP4335461A1 (en) 2022-09-09 2024-03-13 Bayer AG Combinations of contrast agents
WO2024063529A1 (ko) * 2022-09-20 2024-03-28 주식회사 테라노큐어 신규 화합물 및 이를 포함하는 염증성 질환과 암에 대한 진단 및 치료에 사용되는 mri 조영제
WO2024083466A1 (de) 2022-10-17 2024-04-25 Bayer Aktiengesellschaft Automatisches analysieren von radiologischen aufnahmen
EP4360660A1 (en) 2022-10-24 2024-05-01 Bayer AG Process for the preparation of a gadolinium contrast agent
EP4369353A1 (de) 2022-11-12 2024-05-15 Bayer Aktiengesellschaft Erzeugung von künstlichen kontrastmittelverstärkten radiologischen aufnahmen
EP4369285A1 (de) 2022-11-12 2024-05-15 Bayer AG Erzeugung von künstlichen kontrastmittelverstärkten radiologischen aufnahmen
KR102875030B1 (ko) * 2022-12-09 2025-10-22 재단법인 대구경북첨단의료산업진흥재단 신규한 가돌리늄계 화합물 및 이를 포함하는 mri 조영제
EP4471710B1 (de) 2023-05-30 2025-12-17 Bayer Aktiengesellschaft Erkennen von artefakten in synthetischen medizinischen aufnahmen
WO2024251601A1 (de) 2023-06-05 2024-12-12 Bayer Aktiengesellschaft Erzeugen von künstlichen kontrastverstärkten radiologischen aufnahmen
EP4475137B1 (de) 2023-06-05 2025-12-03 Bayer Aktiengesellschaft Erzeugen von künstlichen kontrastverstärkten radiologischen aufnahmen
EP4498324A1 (de) 2023-07-25 2025-01-29 Bayer AG Erkennen von artefakten in synthetischen bildern
EP4567716A1 (en) 2023-12-06 2025-06-11 Bayer Aktiengesellschaft Generating synthetic representations
EP4567715A1 (en) 2023-12-06 2025-06-11 Bayer Aktiengesellschaft Generating synthetic representations
WO2025190828A1 (en) 2024-03-15 2025-09-18 Bayer Aktiengesellschaft Correction of an mri image
EP4664393A1 (de) 2024-06-10 2025-12-17 Bayer Aktiengesellschaft Erzeugen von synthetischen kontrastverstärkten radiologischen aufnahmen

Family Cites Families (185)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US5560903A (en) 1981-07-24 1996-10-01 Schering Aktiengesellschaft Method of enhancing paramagnetism in chelates for MRI
US4485237A (en) 1983-03-08 1984-11-27 The United States Of America As Represented By The Secretary Of The Navy Insensitive polynitramine compound
DE3625417C2 (de) 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
US5039512A (en) 1986-08-04 1991-08-13 Salutar, Inc. NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes
DE3640708C2 (de) 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
DE3728525A1 (de) 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US5284647A (en) 1988-03-18 1994-02-08 Schering Aktiengesellschaft Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them
DE4001655A1 (de) 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5334371A (en) 1988-07-20 1994-08-02 Schering Aktiengesellschaft Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
US5138923A (en) 1988-11-18 1992-08-18 Atlas Die, Inc. Rotary die cutter
US5011925A (en) 1989-03-09 1991-04-30 Mallinckrodt, Inc. Morpholinoamido EDTA derivatives
ATE173336T1 (de) 1989-08-28 1998-11-15 Gen Hospital Corp Hydroxy-aryl metallchelate für bildformung zur nmr diagnose
ES2116291T3 (es) * 1989-10-23 1998-07-16 Nycomed Salutar Inc Agentes quelantes de metales en sitios multiples.
GB8923843D0 (en) 1989-10-23 1989-12-13 Salutar Inc Compounds
US5650133A (en) 1990-01-19 1997-07-22 Nycomed Salutar Macrocyclic polyaza dichelates linked through ring nitrogens via an amide or ester functionality
GB9320277D0 (en) 1993-10-01 1993-11-17 Nycomed Salutar Inc Chelants
US5679810A (en) 1990-01-19 1997-10-21 Salutar, Inc. Linear oligomeric polychelant compounds
US7385041B2 (en) 1990-04-25 2008-06-10 Bracco International B.V. Dual functioning excipient for metal chelate contrast agents
CA2039399C (en) 1990-04-25 2000-09-05 C. Allen Chang Dual functioning excipient for metal chelate contrast agents
US5141740A (en) 1990-11-21 1992-08-25 Mallinckrodt Medical, Inc. Complexes and compositions for magnetic resonance imaging and usage methods
US5167942A (en) 1990-11-21 1992-12-01 Board Of Regents, The University Of Texas System Methods for the preparation of molecular sieves, including zeolites, using metal chelate complexes
AU656355B2 (en) 1990-11-21 1995-02-02 Mallinckrodt Medical, Inc. Alkoxyamide derivatized chelates for MRI
ATE186550T1 (de) 1991-04-22 1999-11-15 Mallinckrodt Medical Inc Verbindungen und pharmazeutische zusammensetzungen zum nachweis und zur lokalisierung von geweben mit neurokinin-1- rezeptoren
AU660033B2 (en) 1991-05-23 1995-06-08 Imarx Pharmaceutical Corp. Liposoluble compounds for magnetic resonance imaging
US6875864B2 (en) 1991-08-01 2005-04-05 Bracco International B.V. Aminocarboxylate ligands having substituted aromatic amide moieties
WO1993011120A1 (en) 1991-11-27 1993-06-10 Zynaxis Technologies, Incorporated Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles
ZA929575B (en) 1991-12-10 1994-06-10 Dow Chemical Co Bicyclopolyazamacrocyclocarboxyclic acid complexes,their conjugates,processes for their preparation,and use as contrast agents
US5324503A (en) 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
DE4232925A1 (de) 1992-09-28 1994-03-31 Diagnostikforschung Inst 3-,8-substituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel und Verfahren zu ihrer Herstellung
WO1994027644A1 (en) 1993-06-02 1994-12-08 Bracco S.P.A. Iodinated paramagnetic chelates, and their use as contrast agents
IT1264690B1 (it) 1993-07-08 1996-10-04 Bracco Spa Compositi oligomeri iodurati e composizioni diagnostiche contenenti gli stessi
AU1694895A (en) 1994-01-28 1995-08-15 Mallinckrodt Medical, Inc. Functionalized aza-bimacrocyclic ligands for imaging applications
US6693190B1 (en) 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
DE4425857A1 (de) 1994-07-07 1996-01-11 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US5863518A (en) 1994-10-21 1999-01-26 Nihon Medi-Physics Co., Ltd. Diagnostic imaging agent with backbone with modified sugar chain end
US5672335A (en) 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
US5707605A (en) 1995-06-02 1998-01-13 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
DE19525924A1 (de) 1995-07-04 1997-01-09 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US5739313A (en) 1995-11-13 1998-04-14 Regents Of The University Of Minnesota Radionuclide labeling of vitamin B12 and coenzymes thereof
DE19549286A1 (de) 1995-12-22 1997-06-26 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE19603033A1 (de) 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
DE19608278A1 (de) 1996-02-23 1997-08-28 Schering Ag Pharmazeutische Mittel enthaltend perfluoralkylhaltige Metallkomplexe, und ihre Verwendung in der Tumortherapie und interventioniellen Radiologie
IT1283218B1 (it) * 1996-03-08 1998-04-16 Bracco Spa Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi
US5866562A (en) 1996-10-25 1999-02-02 Bayer Aktiengesellschaft Ring-bridged bis-quinolines
DE19652387A1 (de) 1996-12-04 1998-06-10 Schering Ag Macrocyclische Metallkomplexcarbonsäuren, ihre Verwendung sowie Verfahren zu ihrer Herstellung
US6045776A (en) 1996-12-04 2000-04-04 Schering Aktiengesellschaft Process for the production of metal-complex carboxylic acid amides
DE19652386A1 (de) * 1996-12-04 1998-06-10 Schering Ag Verfahren zur Herstellung von Metallkomplexcarbonsäureamiden
US5919433A (en) 1996-12-04 1999-07-06 Schering Aktiengesellschaft Macrocyclic metal complex carboxylic acids, their use as well as process for their production
DE19729013A1 (de) 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6019959A (en) 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
DE19744003B4 (de) 1997-09-26 2004-07-08 Schering Ag Kontrastmittel für das Infarkt- und Nekroseimaging
JP2001521011A (ja) 1997-10-27 2001-11-06 カリフォルニア・インスティテュート・オブ・テクノロジー 治療成分送達のための磁気共鳴イメージング剤
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
DE19831217A1 (de) 1998-07-03 2000-01-05 Schering Ag Neue Porphyrinderivate, diese enthaltende pharmazeutische Mittel und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik
EP0998946A1 (en) 1998-08-14 2000-05-10 K.U. Leuven Research & Development Non-porphyrin compound for use as a diagnosticum and/or pharmaceutical
US6056939A (en) 1998-08-28 2000-05-02 Desreux; Jean F. Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals
US6511649B1 (en) 1998-12-18 2003-01-28 Thomas D. Harris Vitronectin receptor antagonist pharmaceuticals
FR2794744B1 (fr) 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
US6232265B1 (en) 1999-06-11 2001-05-15 Ibc Advanced Technologies, Inc. Particulate solid supports functionalized with polyhydroxypyridinone ligands
US6221476B1 (en) 1999-06-11 2001-04-24 Ibc Advanced Technologies, Inc. Polymeric membranes functionalized with polyhydroxypyridinone ligands
DE19930177B4 (de) 1999-06-30 2007-02-08 Nikolai Vladimirovich Bovin Intermolekular assoziierende Verbindungen und deren Verwendung
EP1088559A3 (de) 1999-09-29 2002-10-02 INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN Galenische Formulierungen
DE19948651B4 (de) 1999-09-29 2006-10-05 Schering Ag Para- und diamagnetische perfluorhaltige Verbindungen enthaltende galenische Formulierungen, deren Herstellung und Verwendung
DE10002939C1 (de) 2000-01-13 2001-09-20 Schering Ag Paramagnetische DOTA-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung für die Herstellung von pharmazeutischen Mitteln
WO2001052906A2 (en) 2000-01-22 2001-07-26 Epix Medical, Inc. Magnetic resonance imaging using contrast agents prodrugs bioactivated by enzymatic cleavage
US20020052354A1 (en) 2000-01-27 2002-05-02 Schering Ag Paramagnetic DOTA derivatives, pharmaceutical agents that contain the latter, process for their production, and their use for MR imaging of necrosis and infarction
IT1317862B1 (it) 2000-02-29 2003-07-15 Bracco Spa Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso.
EP1311302A2 (en) 2000-06-21 2003-05-21 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
NZ522925A (en) 2000-06-21 2006-08-31 Bristol Myers Squibb Pharma Co Vitronectin receptor antagonist pharmaceuticals for use in combination therapy
DE10040858C2 (de) 2000-08-11 2003-12-18 Schering Ag Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung
DE10066210B4 (de) 2000-08-11 2008-02-28 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques
DE10040381C1 (de) 2000-08-11 2002-06-06 Schering Ag Perfluoralkylhaltige Komplexe mit Zuckerresten, Verfahren zu deren Herstellung und ihre Verwendung
IL145723A0 (en) 2000-10-11 2002-07-25 Nihon Mediphysics Co Ltd Process for producing an amide compound
US20030050452A1 (en) 2000-12-26 2003-03-13 Yuji Hashiguchi Process for producing metal complex of aminooligosaccharide derivative
US20030004236A1 (en) 2001-04-20 2003-01-02 Meade Thomas J. Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
DE10135356C1 (de) 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
DE10135355C1 (de) 2001-07-20 2003-04-17 Schering Ag Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie
TWI240632B (en) 2001-07-30 2005-10-01 Epix Medical Inc Purified peptides for peptide-based multimeric targeted contrast agents
ITMI20011708A1 (it) 2001-08-03 2003-02-03 Bracco Imaging Spa Coniugati di peptidi, loro derivati con complessi metallici e utilizzo per i'indagine diagnostica tramite imaging per risonanza magnetica(m
FR2836916B1 (fr) 2002-03-05 2004-06-11 Guerbet Sa Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese
US20030198597A1 (en) 2002-04-22 2003-10-23 Meade Thomas J. Novel macrocyclic activatible magnetic resonance imaging contrast agents
DE10231799B4 (de) 2002-07-10 2006-10-05 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
DE10307759B3 (de) 2003-02-19 2004-11-18 Schering Ag Trimere makrocyclisch substituierte Benzolderivate, deren Herstellung und Verwendung als Kontrastmittel sowie diese enthaltende pharmazeutische Mittel
WO2005001415A2 (en) 2003-05-23 2005-01-06 Epix Pharmaceuticals, Inc. Optically pure and enriched isomers of chelating ligands and contrast agents
AR047692A1 (es) 2003-07-10 2006-02-08 Epix Medical Inc Imagenes de blancos estacionarios
US7211237B2 (en) 2003-11-26 2007-05-01 3M Innovative Properties Company Solid state synthesis of lithium ion battery cathode material
DE102004023093B3 (de) 2004-05-05 2006-03-02 Schering Ag Trimere makrocyclisch substituierte Halogen-Benzolderivate
DE102004026103A1 (de) 2004-05-25 2005-12-22 Schering Ag Trimere makrocyclisch substituierte Aminoisophthalsäure-Halogen-Benzolderivate
JP5106107B2 (ja) 2004-07-02 2012-12-26 ブラッコ・イメージング・ソシエタ・ペル・アチオニ ポリヒドロキシル化置換基を有するキレート化部分を含む磁気共鳴画像法(mri)用高緩和能造影剤
US8153784B2 (en) 2004-07-07 2012-04-10 The General Hospital Corporation Imaging of enzyme activity
US7507748B2 (en) 2004-07-22 2009-03-24 Amgen Inc. Substituted aryl-amine derivatives and methods of use
US20060057071A1 (en) 2004-09-14 2006-03-16 Wing-Tak Wong Paramagnetic complexes with pendant crown compounds showing improved targeting-specificity as MRI contrast agents
US7205385B2 (en) 2004-11-12 2007-04-17 General Electric Company Polymerization method for the synthesis of polypeptide imaging agents
WO2006080022A2 (en) 2005-01-31 2006-08-03 Yeda Research And Development Co. Ltd. Mri contrast agents for diagnosis and prognosis of tumors
GB0512751D0 (en) 2005-06-22 2005-07-27 Glaxo Group Ltd New adjuvant
FR2891830B1 (fr) 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
US8951502B2 (en) 2005-12-01 2015-02-10 Ge Healthcare As Method of dynamic nuclear polarisation (DNP)
KR20080073728A (ko) 2005-12-02 2008-08-11 지이 헬스케어 에이에스 멀티머 자기 공명 조영제
JP5102221B2 (ja) 2005-12-16 2012-12-19 ジーイー・ヘルスケア・アクスイェ・セルスカプ 過分極カルボン酸塩の製造方法
WO2007084264A2 (en) 2005-12-29 2007-07-26 Epix Pharmaceuticals, Inc. Methods for myocardial imaging
US20070202047A1 (en) * 2006-01-05 2007-08-30 Markus Wolf Polyamine-substituted ligands for use as contrast agents
EP1815870A1 (en) 2006-02-01 2007-08-08 DKFZ Deutsches Krebsforschungszentrum Cyanine dye compounds linked to metal chelator for bi-modal diagnostic imaging
JP2009527559A (ja) 2006-02-24 2009-07-30 マリンクロッド・インコーポレイテッド 二官能性レソルシノール、チオレソルシノールおよびジチオレソルシノール誘導体金属キレート形成性結合体
WO2007112100A2 (en) 2006-03-24 2007-10-04 The University Of Utah Research Foundation Highly fluorinated oils and surfactants and methods of making and using same
US20090110640A1 (en) 2006-03-29 2009-04-30 Oskar Axelsson Contrast agents for magnetic resonance imaging and spectroscopy consisting of a cyclic oligoamid core of 3 to 4 identicial monomer units with 3 to 4 paramagnetic chelate side chains
EP1998813A2 (en) 2006-03-29 2008-12-10 GE Healthcare AS Method to produce hyperpolarised carboxylates and sulphonates in the presence of inorganic cations
WO2007128873A1 (en) 2006-05-05 2007-11-15 Wallac Oy A method for the preparation of maleimido derivatives of biomolecule labeling reactants and conjugates derived thereof
DE102006021495A1 (de) 2006-05-09 2007-11-15 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit
US20110207771A1 (en) 2006-06-08 2011-08-25 Syngenta Crop Protection, Inc. N-(l-alkyl-2-phenylethyl)-carboxamide derivatives and use thereof as fungicides
JP2008012596A (ja) 2006-07-03 2008-01-24 Aji Kk 把持装置
US9127130B2 (en) * 2006-08-11 2015-09-08 Starpharma Pty Ltd. Polylysine dendrimer contrast agent
CA2660717A1 (en) 2006-08-17 2008-02-21 Epix Pharmaceuticals, Inc. Methods for lymph system imaging
DE102007002726A1 (de) 2007-01-18 2008-07-31 Bayer Schering Pharma Aktiengesellschaft Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
EP1980251A1 (en) 2007-04-13 2008-10-15 Glaxo Group Limited Pyrrolo[3,2,1-ij]quinoline-4-one derivatives for treating tuberculosis
JP2010534498A (ja) 2007-07-26 2010-11-11 ジーイー・ヘルスケア・ユーケイ・リミテッド 方法及び該方法で使用するためのイメージング媒体
US20110250138A1 (en) 2007-08-01 2011-10-13 Alnylam Pharmaceuticals, Inc. Single-stranded and double-stranded oligonucleotides comprising a metal-chelating ligand
ATE534408T1 (de) 2007-08-27 2011-12-15 Ge Healthcare Ltd Bildgebungsmedium mit hyperpolarisiertem uüc- acetat und seine verwendung
WO2009030735A1 (en) 2007-09-07 2009-03-12 Ge Healthcare Limited Method of determination of pdh activity and imaging media for use in said method
EP2042491A1 (de) 2007-09-14 2009-04-01 Bayer CropScience AG Pyridazine als Fungizide
FR2921929B1 (fr) 2007-10-08 2013-01-11 Commissariat Energie Atomique Procede de preparation de materiaux polymeriques dopes par des elements metalliques et materiaux obtenus par ce procede
DE102007058220A1 (de) 2007-12-03 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Dimere macrocyclisch substituierte Benzolderivate
EP2902041A1 (en) 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
JP5351172B2 (ja) 2007-12-21 2013-11-27 ジーイー・ヘルスケア・リミテッド Mr造影剤、造影製剤及び該造影製剤を用いた画像検査法
GB0801199D0 (en) 2008-01-23 2008-02-27 Acal Energy Ltd Fuel cells
US8545813B2 (en) 2008-01-25 2013-10-01 Northwestern University Pre-templated macromolecular architectures with multiple Gd(III) complexes and methods of use as MRI contrast agents
US20110008261A1 (en) 2008-02-04 2011-01-13 Ge Healthcare Limited Method to produce hyperpolarised amino acids and aminosulphonic acids
JP2011511775A (ja) 2008-02-04 2011-04-14 ジーイー・ヘルスケア・リミテッド 過分極13c−アラニンを含むmr造影剤、又は画像媒体、及びそのような画像媒体を使用する画像検査法
US20090208421A1 (en) 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
US20110038805A1 (en) 2008-04-18 2011-02-17 Andreas Meijer Compounds comprising paramagnetic chelates arranged around a central core and their use in magneto resonance imaging and spectroscopy
WO2009143101A2 (en) 2008-05-19 2009-11-26 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
JP2010034528A (ja) 2008-06-23 2010-02-12 Sumitomo Chemical Co Ltd 組成物及び該組成物を用いてなる発光素子
EP2149567A1 (en) 2008-07-18 2010-02-03 Bayer Schering Pharma Aktiengesellschaft Cyclic polyamines for binding phosphatidylserine
EP2341944B1 (en) 2008-09-30 2019-06-26 Curium US LLC Conjugates of hexose and metal coordinating compounds for imaging purposes
US20110217241A1 (en) 2008-11-14 2011-09-08 University Of Maryland, Baltimore Conjugates of 19f mr imaging tracers for use in multi-chromic mri imaging
FR2939318B1 (fr) 2008-12-10 2012-07-13 Guerbet Sa Systeme d'encapsulation pour imagerie cest avec quelate q superieur ou egal a 2
EP3222617B1 (en) 2009-03-19 2022-07-06 The Johns Hopkins University Psma-targeting compounds and uses thereof
WO2010147666A1 (en) 2009-06-19 2010-12-23 Memorial Sloan-Kettering Cancer Center Compounds useful as carbonic anhydrase modulators and uses thereof
WO2011031740A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
US20110081428A1 (en) 2009-09-16 2011-04-07 The Buck Institute For Age Research Use of thioflavin-like compounds to increase life span and/or health span
DE102009053171B4 (de) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
NO331773B1 (no) 2009-12-18 2012-03-26 Ge Healthcare As Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR)
WO2011088193A2 (en) 2010-01-13 2011-07-21 University Of Medicine And Dentistry Of New Jersey Fluorophore chelated lanthanide luminiscent probes with improved quantum efficiency
GB201004739D0 (en) 2010-03-22 2010-05-05 Prosidion Ltd Receptor modulators
EP2555803B1 (en) 2010-04-08 2018-09-12 Bracco Imaging S.p.A Process for preparing hyperpolarized substrates and method for mri
EP2397466B1 (en) 2010-06-15 2012-11-28 Centre National De La Recherche Scientifique CNRS X-ray and gamma-photon activatable organic compounds, their preparation and their uses
KR101236142B1 (ko) * 2010-09-30 2013-02-21 경북대학교 산학협력단 가돌리늄 착물을 함유하는 mri조영제
EP2457594A1 (en) 2010-11-05 2012-05-30 Bracco Imaging S.p.A Cest systems exhibiting a concentration independent responsiveness
US9011816B2 (en) 2011-03-25 2015-04-21 Case Western Reserve University Fibronectin targeting contrast agent
CN103547290A (zh) 2011-04-20 2014-01-29 Rf医疗公司 靶向造影剂及其用途
EA201600272A1 (ru) 2011-04-21 2016-12-30 Байер Интеллектчуал Проперти Гмбх Получение гадобутрола высокой чистоты
EP2739316B1 (en) 2011-08-05 2019-04-10 Molecular Insight Pharmaceuticals, Inc. Radiolabeled prostate specific membrane antigen inhibitors
CN102973955B (zh) 2011-09-06 2016-03-23 中国科学院福建物质结构研究所 一种含三价铝的磁共振成像造影剂
CN102442996B (zh) 2011-09-16 2014-09-24 中山大学附属第一医院 多胺类小分子显像剂、其生产方法及其应用
ES2414291B2 (es) 2011-12-16 2014-02-13 Universitat De Valencia Compuestos macrocíclicos de tipo escorpiando y su uso como antiparasitarios.
KR101336071B1 (ko) 2012-01-04 2013-12-05 한국원자력의학원 암 진단용 mri/ct 이중 조영제 및 그 제조방법
CN102614531B (zh) 2012-04-06 2013-06-05 中国科学院长春应用化学研究所 以二乙酰基苯或三乙酰基苯为连接体的多核非离子型磁共振成像造影剂
US9585975B2 (en) 2012-04-27 2017-03-07 Northwestern University MRI contrast agents
WO2013189801A1 (en) 2012-06-20 2013-12-27 Basf Se Pyrazole compound and pesticidal mixtures comprising a pyrazole compound
KR101456234B1 (ko) 2012-08-09 2014-11-04 한국원자력의학원 아미노시클로헥산카르복실산-함유 시클로 rgd 유도체, 그 제조방법 및 그것을 포함하는 mri 조영제
KR101456233B1 (ko) 2012-08-09 2014-11-04 한국원자력의학원 아미노시클로펜탄카르복실산-함유 시클로 rgd 유도체, 그 제조방법 및 그것을 포함하는 mri 조영제
PL2900279T3 (pl) 2012-09-25 2020-05-18 Advanced Accelerator Applications Usa, Inc. Antagonisty grpr do wykrywania, diagnostyki i leczenia raka grpr-pozytywnego
US20150297761A1 (en) 2012-11-12 2015-10-22 The General Hospital Corporation Peptidic structures incorporating an amino acid metal complex and applications in magnetic resonance imaging
JP6468602B2 (ja) 2013-01-14 2019-02-13 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド トリアジン系放射性医薬品及び放射線造影剤
CA2900595A1 (en) * 2013-02-12 2014-08-21 Bayer Pharma Aktiengesellschaft Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia
JP6608805B2 (ja) 2013-04-26 2019-11-20 ゲルベ 造影製剤および関連する調製方法
WO2014197763A1 (en) 2013-06-07 2014-12-11 The Board Of Regents Of The University Of Teas System Molecular design toward dual-modality probes for radioisotope-based imaging (pet or spect) and mri
CN103554185A (zh) 2013-07-04 2014-02-05 上海工程技术大学 一类大环多胺类多齿配体及其合成方法
EP2873679A1 (en) 2013-11-13 2015-05-20 F.Hoffmann-La Roche Ag Camelid single-domain antibody directed against amyloid bêta and methods for producing conjugates thereof
EP2873680A1 (en) 2013-11-13 2015-05-20 F.Hoffmann-La Roche Ag Oligopeptide and methods for producing conjugates thereof
CN103611171B (zh) 2013-11-25 2015-03-25 中国科学院长春应用化学研究所 以四苯酰基甲烷为连接体的非离子型多核磁共振成像造影剂及其制备方法
EP3140282B1 (en) 2014-05-06 2019-07-10 The Johns Hopkins University Metal/radiometal-labeled psma inhibitors for psma-targeted imaging and radiotherapy
US11324827B2 (en) 2014-10-01 2022-05-10 Xiamen Sinopeg Biotech Co., Ltd. Multifunctionalized polyethylene glycol derivative and preparation method therefor
US20180221513A1 (en) 2015-03-16 2018-08-09 Northwestern University Contrast-agent-labeled peptide amphiphile nanofibers
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
US20160375155A1 (en) 2015-06-29 2016-12-29 Collagen Medical, LLC Collagen Imaging Compositions
US10927108B2 (en) 2015-08-17 2021-02-23 Southwestern Oklahoma State University Compositions comprising macrocycle derivatives incorporating bridged macrocycles and methods of producing and using same
JP7049993B2 (ja) 2015-11-30 2022-04-07 ジーイー・ヘルスケア・アクスイェ・セルスカプ Mri造影剤の併用を含む製剤
US10407412B2 (en) 2015-12-10 2019-09-10 Bracco Imaging S.P.A. Dimeric contrast agents
CN108290849B (zh) 2015-12-10 2022-03-22 伯拉考成像股份公司 造影剂
US10656229B2 (en) 2016-04-06 2020-05-19 Northwestern University Magnetic barcode imaging
WO2017178301A1 (en) 2016-04-13 2017-10-19 Bracco Imaging Spa Contrast agents
KR102464647B1 (ko) * 2016-11-28 2022-11-08 바이엘 파마 악티엔게젤샤프트 자기 공명 영상화에 사용하기 위한 높은 이완도 가돌리늄 킬레이트 화합물
AU2017375728B2 (en) 2016-12-12 2021-05-27 Bracco Imaging Spa Dimeric contrast agents

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