JP2009541262A5 - - Google Patents
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- Publication number
- JP2009541262A5 JP2009541262A5 JP2009515865A JP2009515865A JP2009541262A5 JP 2009541262 A5 JP2009541262 A5 JP 2009541262A5 JP 2009515865 A JP2009515865 A JP 2009515865A JP 2009515865 A JP2009515865 A JP 2009515865A JP 2009541262 A5 JP2009541262 A5 JP 2009541262A5
- Authority
- JP
- Japan
- Prior art keywords
- glyt1
- compound according
- mammals
- imaging
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102100023145 Sodium- and chloride-dependent glycine transporter 1 Human genes 0.000 claims 14
- 101710083171 Sodium- and chloride-dependent glycine transporter 1 Proteins 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 11
- 241000124008 Mammalia Species 0.000 claims 9
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
- 238000003384 imaging method Methods 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 239000004471 Glycine Substances 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 210000005171 mammalian brain Anatomy 0.000 claims 2
- 235000020004 porter Nutrition 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- QUNUKALKQQJGKN-UHFFFAOYSA-N 2,6-dimethyl-n-[[1-(methylamino)cyclopentyl]-phenylmethyl]benzamide Chemical compound CC=1C=CC=C(C)C=1C(=O)NC(C=1C=CC=CC=1)C1(NC)CCCC1 QUNUKALKQQJGKN-UHFFFAOYSA-N 0.000 claims 1
- PESPSVOBFYJFOT-UHFFFAOYSA-N 3-[[1-(dimethylamino)cyclopentyl]-phenylmethyl]-2,6-dimethylbenzamide Chemical compound C=1C=CC=CC=1C(C=1C(=C(C(N)=O)C(C)=CC=1)C)C1(N(C)C)CCCC1 PESPSVOBFYJFOT-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000000926 neurological effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000000163 radioactive labelling Methods 0.000 claims 1
- 238000002603 single-photon emission computed tomography Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 0 Cc1cccc(C)c1C(NC(C1(CCCC1)N(C)*)c1ccccc1)=O Chemical compound Cc1cccc(C)c1C(NC(C1(CCCC1)N(C)*)c1ccccc1)=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0612435.8A GB0612435D0 (en) | 2006-06-22 | 2006-06-22 | Compounds |
| PCT/EP2007/056117 WO2007147838A1 (en) | 2006-06-22 | 2007-06-20 | Radiolabelled ligand for the glycine 1 transporter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009541262A JP2009541262A (ja) | 2009-11-26 |
| JP2009541262A5 true JP2009541262A5 (enExample) | 2010-08-12 |
Family
ID=36803746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009515865A Withdrawn JP2009541262A (ja) | 2006-06-22 | 2007-06-20 | グリシン１トランスポーターの放射標識リガンド |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090175788A1 (enExample) |
| EP (1) | EP2032512A1 (enExample) |
| JP (1) | JP2009541262A (enExample) |
| GB (1) | GB0612435D0 (enExample) |
| WO (1) | WO2007147838A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5618047B2 (ja) * | 2010-01-29 | 2014-11-05 | 国立大学法人千葉大学 | ポジトロン断層撮影法およびポジトロン放出化合物 |
| SG186885A1 (en) | 2010-06-04 | 2013-02-28 | Albany Molecular Res Inc | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20061156A1 (es) * | 2004-12-23 | 2006-12-16 | Glaxo Group Ltd | Derivados de benzamida como agentes inhibidores del transportador de glicina |
-
2006
- 2006-06-22 GB GBGB0612435.8A patent/GB0612435D0/en not_active Ceased
-
2007
- 2007-06-20 EP EP07730259A patent/EP2032512A1/en not_active Withdrawn
- 2007-06-20 WO PCT/EP2007/056117 patent/WO2007147838A1/en not_active Ceased
- 2007-06-20 US US12/304,136 patent/US20090175788A1/en not_active Abandoned
- 2007-06-20 JP JP2009515865A patent/JP2009541262A/ja not_active Withdrawn
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