JP2018520668A5 - - Google Patents
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- JP2018520668A5 JP2018520668A5 JP2017565174A JP2017565174A JP2018520668A5 JP 2018520668 A5 JP2018520668 A5 JP 2018520668A5 JP 2017565174 A JP2017565174 A JP 2017565174A JP 2017565174 A JP2017565174 A JP 2017565174A JP 2018520668 A5 JP2018520668 A5 JP 2018520668A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- seq
- tnf superfamily
- antibody
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 37
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims 35
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 34
- 102000005962 receptors Human genes 0.000 claims 21
- 108020003175 receptors Proteins 0.000 claims 21
- 239000013638 trimer Substances 0.000 claims 13
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 8
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 239000000523 sample Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 239000013068 control sample Substances 0.000 claims 3
- 230000019491 signal transduction Effects 0.000 claims 3
- 230000011664 signaling Effects 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 claims 1
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 102000057041 human TNF Human genes 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 238000000159 protein binding assay Methods 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
- 102000003390 tumor necrosis factor Human genes 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021155537A JP7159420B2 (ja) | 2015-06-18 | 2021-09-24 | 抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1510758.4A GB201510758D0 (en) | 2015-06-18 | 2015-06-18 | Novel TNFa structure for use in therapy |
| GB1510758.4 | 2015-06-18 | ||
| PCT/EP2015/074527 WO2016202414A1 (en) | 2015-06-18 | 2015-10-22 | Antibody |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021155537A Division JP7159420B2 (ja) | 2015-06-18 | 2021-09-24 | 抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018520668A JP2018520668A (ja) | 2018-08-02 |
| JP2018520668A5 true JP2018520668A5 (OSRAM) | 2018-11-29 |
| JP6951256B2 JP6951256B2 (ja) | 2021-10-20 |
Family
ID=53784155
Family Applications (12)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017565114A Active JP7336178B2 (ja) | 2015-06-18 | 2015-10-22 | 治療における使用のための新規のＴＮＦα構造 |
| JP2017565173A Active JP6659030B2 (ja) | 2015-06-18 | 2015-10-22 | 作用機構 |
| JP2017565155A Active JP6781718B2 (ja) | 2015-06-18 | 2015-10-22 | モジュレータアッセイ |
| JP2017565174A Active JP6951256B2 (ja) | 2015-06-18 | 2015-10-22 | 抗体 |
| JP2017565189A Active JP6948954B2 (ja) | 2015-06-18 | 2015-10-22 | 抗体エピトープ |
| JP2019154528A Active JP6752344B2 (ja) | 2015-06-18 | 2019-08-27 | 作用機構 |
| JP2020174314A Pending JP2021038222A (ja) | 2015-06-18 | 2020-10-16 | モジュレータアッセイ |
| JP2021020352A Pending JP2021109880A (ja) | 2015-06-18 | 2021-02-12 | 治療における使用のための新規のＴＮＦα構造 |
| JP2021095909A Abandoned JP2021153592A (ja) | 2015-06-18 | 2021-06-08 | 抗体エピトープ |
| JP2021155537A Active JP7159420B2 (ja) | 2015-06-18 | 2021-09-24 | 抗体 |
| JP2023001089A Pending JP2023052250A (ja) | 2015-06-18 | 2023-01-06 | モジュレータアッセイ |
| JP2023046164A Pending JP2023100010A (ja) | 2015-06-18 | 2023-03-23 | 治療における使用のための新規のＴＮＦα構造 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017565114A Active JP7336178B2 (ja) | 2015-06-18 | 2015-10-22 | 治療における使用のための新規のＴＮＦα構造 |
| JP2017565173A Active JP6659030B2 (ja) | 2015-06-18 | 2015-10-22 | 作用機構 |
| JP2017565155A Active JP6781718B2 (ja) | 2015-06-18 | 2015-10-22 | モジュレータアッセイ |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017565189A Active JP6948954B2 (ja) | 2015-06-18 | 2015-10-22 | 抗体エピトープ |
| JP2019154528A Active JP6752344B2 (ja) | 2015-06-18 | 2019-08-27 | 作用機構 |
| JP2020174314A Pending JP2021038222A (ja) | 2015-06-18 | 2020-10-16 | モジュレータアッセイ |
| JP2021020352A Pending JP2021109880A (ja) | 2015-06-18 | 2021-02-12 | 治療における使用のための新規のＴＮＦα構造 |
| JP2021095909A Abandoned JP2021153592A (ja) | 2015-06-18 | 2021-06-08 | 抗体エピトープ |
| JP2021155537A Active JP7159420B2 (ja) | 2015-06-18 | 2021-09-24 | 抗体 |
| JP2023001089A Pending JP2023052250A (ja) | 2015-06-18 | 2023-01-06 | モジュレータアッセイ |
| JP2023046164A Pending JP2023100010A (ja) | 2015-06-18 | 2023-03-23 | 治療における使用のための新規のＴＮＦα構造 |
Country Status (16)
| Country | Link |
|---|---|
| US (12) | US10969393B2 (OSRAM) |
| EP (8) | EP3311169B1 (OSRAM) |
| JP (12) | JP7336178B2 (OSRAM) |
| KR (2) | KR20180048571A (OSRAM) |
| CN (6) | CN108055865B (OSRAM) |
| AU (2) | AU2015398984B2 (OSRAM) |
| CA (5) | CA2988516A1 (OSRAM) |
| CL (2) | CL2017003189A1 (OSRAM) |
| EA (4) | EA201890080A1 (OSRAM) |
| ES (5) | ES2948915T3 (OSRAM) |
| GB (1) | GB201510758D0 (OSRAM) |
| IL (2) | IL256099B2 (OSRAM) |
| MX (2) | MX2017015481A (OSRAM) |
| PL (4) | PL3311170T3 (OSRAM) |
| PT (4) | PT3311168T (OSRAM) |
| WO (5) | WO2016202411A1 (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016156466A1 (en) | 2015-03-31 | 2016-10-06 | Vhsquared Limited | Peptide construct having a protease-cleavable linker |
| JP2018511346A (ja) | 2015-03-31 | 2018-04-26 | ブイエイチスクエアード リミテッド | ポリペプチド |
| CA3255406A1 (en) | 2015-03-31 | 2025-07-03 | Sorriso Pharmaceuticals, Inc. | Tnf-alpha binding polypeptides |
| AR104293A1 (es) | 2015-04-17 | 2017-07-12 | Abbvie Inc | Indazolonas como moduladores de la señalización de tnf |
| US20160304496A1 (en) | 2015-04-17 | 2016-10-20 | Abbvie Inc. | Indazolones as modulators of tnf signaling |
| US9856253B2 (en) | 2015-04-17 | 2018-01-02 | Abbvie, Inc. | Tricyclic modulators of TNF signaling |
| GB201510758D0 (en) | 2015-06-18 | 2015-08-05 | Ucb Biopharma Sprl | Novel TNFa structure for use in therapy |
| GB201522394D0 (en) | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
| WO2018060453A1 (en) | 2016-09-30 | 2018-04-05 | Vhsquared Limited | Compositions |
| GB201621907D0 (en) | 2016-12-21 | 2017-02-01 | Ucb Biopharma Sprl And Sanofi | Antibody epitope |
| EP4467565A3 (en) | 2016-12-21 | 2025-03-12 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| WO2018130537A1 (en) * | 2017-01-10 | 2018-07-19 | ETH Zürich | Cell-protective compounds and their use |
| JP7680377B2 (ja) | 2019-06-21 | 2025-05-20 | ソリッソ ファーマシューティカルズ，インク． | ポリペプチド |
| CN114466864B (zh) | 2019-06-21 | 2024-12-27 | 索瑞索制药公司 | 多肽 |
| JP7561364B2 (ja) * | 2020-04-30 | 2024-10-04 | 国立大学法人東北大学 | 蛍光偏光免疫分析法 |
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