JP2018519351A - オキシステロールおよびそれらの使用の方法 - Google Patents
オキシステロールおよびそれらの使用の方法 Download PDFInfo
- Publication number
- JP2018519351A JP2018519351A JP2018500417A JP2018500417A JP2018519351A JP 2018519351 A JP2018519351 A JP 2018519351A JP 2018500417 A JP2018500417 A JP 2018500417A JP 2018500417 A JP2018500417 A JP 2018500417A JP 2018519351 A JP2018519351 A JP 2018519351A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- alkyl
- pharmaceutically acceptable
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 C[C@](CCCC(*)(*)O)[C@@](CC1)[C@@](C)(CC2)[C@]1[C@](C)(CC1)[C@]2[C@@](C)(CC2)[C@]1C[C@@]2(*)O Chemical compound C[C@](CCCC(*)(*)O)[C@@](CC1)[C@@](C)(CC2)[C@]1[C@](C)(CC1)[C@]2[C@@](C)(CC2)[C@]1C[C@@]2(*)O 0.000 description 13
- AEHSZDXQXDLGCG-MZLNBKIZSA-N CC(C)C(C)(CCC[C@@H](C)C(CC1)[C@@](C)(CC[C@@]2([C@@](C)(CC[C@@](C)(C3)O)C3=CC3)I)[C@@H]1C23N)O Chemical compound CC(C)C(C)(CCC[C@@H](C)C(CC1)[C@@](C)(CC[C@@]2([C@@](C)(CC[C@@](C)(C3)O)C3=CC3)I)[C@@H]1C23N)O AEHSZDXQXDLGCG-MZLNBKIZSA-N 0.000 description 1
- LWTHEKRHBBWPMZ-HSCDOQPESA-N CC[C@H](CC[C@H](CCC[C@@H]1[C@@](C)(CC[C@@](C)(C2)O)C2=CC2)C12N)[C@H](C)CCCC(C)O Chemical compound CC[C@H](CC[C@H](CCC[C@@H]1[C@@](C)(CC[C@@](C)(C2)O)C2=CC2)C12N)[C@H](C)CCCC(C)O LWTHEKRHBBWPMZ-HSCDOQPESA-N 0.000 description 1
- BSWDPHACJZZFRD-SRBAREEQSA-N C[C@H](CCCC(C)(C)O)[C@@H](CC1)C(C)(CC2)[C@@H]1C1[C@H]2[C@@](C)(CC[C@@](C)(C2)O)C2=CC1 Chemical compound C[C@H](CCCC(C)(C)O)[C@@H](CC1)C(C)(CC2)[C@@H]1C1[C@H]2[C@@](C)(CC[C@@](C)(C2)O)C2=CC1 BSWDPHACJZZFRD-SRBAREEQSA-N 0.000 description 1
- QOAKPJIJMMVMPJ-RNPQCOGNSA-N C[C@H](CCCC(C)(C)O)[C@@H](CC1)[C@@](C)(CC2)[C@@H]1C(CC1)C2[C@@](C)(CC2)C1C[C@@]2(C)O Chemical compound C[C@H](CCCC(C)(C)O)[C@@H](CC1)[C@@](C)(CC2)[C@@H]1C(CC1)C2[C@@](C)(CC2)C1C[C@@]2(C)O QOAKPJIJMMVMPJ-RNPQCOGNSA-N 0.000 description 1
- QOAKPJIJMMVMPJ-JXNZKVSASA-N C[C@H](CCCC(C)(C)O)[C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2[C@@](C)(CC2)[C@@H]1C[C@@]2(C)O Chemical compound C[C@H](CCCC(C)(C)O)[C@@H](CC1)[C@@](C)(CC2)[C@@H]1[C@H](CC1)[C@H]2[C@@](C)(CC2)[C@@H]1C[C@@]2(C)O QOAKPJIJMMVMPJ-JXNZKVSASA-N 0.000 description 1
- FDMVAGWFPHCLNX-QHFORYHTSA-N C[C@H](CCCC(C)=O)[C@@H](CC1)[C@@](C)(CC[C@@H]2[C@@](C)(CC[C@@](C)(C3)O)C3=CC3)[C@@H]1[C@@]23C=C Chemical compound C[C@H](CCCC(C)=O)[C@@H](CC1)[C@@](C)(CC[C@@H]2[C@@](C)(CC[C@@](C)(C3)O)C3=CC3)[C@@H]1[C@@]23C=C FDMVAGWFPHCLNX-QHFORYHTSA-N 0.000 description 1
- GDPLZBJXJSPTAZ-LTITYAFTSA-N C[C@H](CCCCO)[C@@H](CC1)[C@@](C)(CC2)[C@@H]1C1[C@H]2[C@@](C)(CC[C@@](C)(C2)O)C2=CC1 Chemical compound C[C@H](CCCCO)[C@@H](CC1)[C@@](C)(CC2)[C@@H]1C1[C@H]2[C@@](C)(CC[C@@](C)(C2)O)C2=CC1 GDPLZBJXJSPTAZ-LTITYAFTSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562189048P | 2015-07-06 | 2015-07-06 | |
| US62/189,048 | 2015-07-06 | ||
| US201662280394P | 2016-01-19 | 2016-01-19 | |
| US62/280,394 | 2016-01-19 | ||
| PCT/US2016/041168 WO2017007836A1 (en) | 2015-07-06 | 2016-07-06 | Oxysterols and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021002172A Division JP2021054864A (ja) | 2015-07-06 | 2021-01-08 | オキシステロールおよびそれらの使用の方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018519351A true JP2018519351A (ja) | 2018-07-19 |
| JP2018519351A5 JP2018519351A5 (enExample) | 2019-07-25 |
Family
ID=57686105
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018500417A Withdrawn JP2018519351A (ja) | 2015-07-06 | 2016-07-06 | オキシステロールおよびそれらの使用の方法 |
| JP2021002172A Withdrawn JP2021054864A (ja) | 2015-07-06 | 2021-01-08 | オキシステロールおよびそれらの使用の方法 |
| JP2022093073A Active JP7602513B2 (ja) | 2015-07-06 | 2022-06-08 | オキシステロールおよびそれらの使用の方法 |
| JP2024213240A Pending JP2025026573A (ja) | 2015-07-06 | 2024-12-06 | オキシステロールおよびそれらの使用の方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021002172A Withdrawn JP2021054864A (ja) | 2015-07-06 | 2021-01-08 | オキシステロールおよびそれらの使用の方法 |
| JP2022093073A Active JP7602513B2 (ja) | 2015-07-06 | 2022-06-08 | オキシステロールおよびそれらの使用の方法 |
| JP2024213240A Pending JP2025026573A (ja) | 2015-07-06 | 2024-12-06 | オキシステロールおよびそれらの使用の方法 |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US10201550B2 (enExample) |
| EP (3) | EP3319611B1 (enExample) |
| JP (4) | JP2018519351A (enExample) |
| KR (2) | KR20240137111A (enExample) |
| CN (2) | CN108135912B (enExample) |
| AU (3) | AU2016289967B2 (enExample) |
| BR (2) | BR122021005552B1 (enExample) |
| CA (1) | CA2991214C (enExample) |
| CO (1) | CO2018000660A2 (enExample) |
| CY (1) | CY1124496T1 (enExample) |
| DK (2) | DK3319611T3 (enExample) |
| ES (2) | ES2865258T3 (enExample) |
| FI (1) | FI3828194T3 (enExample) |
| HR (1) | HRP20210526T8 (enExample) |
| HU (1) | HUE053778T2 (enExample) |
| IL (2) | IL305404A (enExample) |
| LT (1) | LT3319611T (enExample) |
| MA (2) | MA42410B1 (enExample) |
| MD (1) | MD3319611T2 (enExample) |
| MX (2) | MX390302B (enExample) |
| PE (1) | PE20180483A1 (enExample) |
| PH (2) | PH12018500065B1 (enExample) |
| PL (2) | PL3319611T3 (enExample) |
| PT (2) | PT3828194T (enExample) |
| RS (1) | RS61718B1 (enExample) |
| RU (2) | RU2744267C2 (enExample) |
| SG (1) | SG10202010553XA (enExample) |
| SI (1) | SI3319611T1 (enExample) |
| SM (1) | SMT202100226T1 (enExample) |
| WO (1) | WO2017007836A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS64332B1 (sr) | 2011-09-08 | 2023-08-31 | Sage Therapeutics Inc | Neuroaktivni steroidi, kompozicije i njihova upotreba |
| RU2684103C2 (ru) | 2013-03-13 | 2019-04-04 | Сейдж Терапьютикс, Инк. | Нейроактивные стероиды и способы их применения |
| US10259840B2 (en) | 2014-06-18 | 2019-04-16 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| EP3166613A4 (en) | 2014-07-09 | 2018-02-21 | Duke University | Compositions and methods for the repair of myelin |
| JP2018519328A (ja) | 2015-07-06 | 2018-07-19 | セージ セラピューティクス， インコーポレイテッド | オキシステロールおよびそれらの使用の方法 |
| CA2991311C (en) | 2015-07-06 | 2025-05-06 | Sage Therapeutics, Inc. | OXYSTEROLS AND THEIR METHODS OF USE |
| BR122021005552B1 (pt) | 2015-07-06 | 2024-01-02 | Sage Therapeutics, Inc | Compostos oxiesteróis, seus usos e composição farmacêutica |
| PT3436022T (pt) | 2016-04-01 | 2022-07-04 | Sage Therapeutics Inc | Oxisteróis e métodos de utilização dos mesmos |
| WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| HUE055263T2 (hu) | 2016-07-07 | 2021-11-29 | Sage Therapeutics Inc | 11-Szubsztituált 24-hidroxiszterolok NMDA-hoz kapcsolódó állapotok kezelésére |
| ES2935057T3 (es) | 2016-09-30 | 2023-03-01 | Sage Therapeutics Inc | C7 oxisteroles sustituidos y estos compuestos para su uso como moduladores de la NMDA |
| JP7118957B2 (ja) | 2016-10-18 | 2022-08-16 | セージ セラピューティクス， インコーポレイテッド | オキシステロールおよびその使用方法 |
| EP4616908A3 (en) | 2016-10-18 | 2025-11-26 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| WO2018132676A1 (en) | 2017-01-13 | 2018-07-19 | Duke University | Compositions and methods for the treatment of myelin related and inflammation related diseases or disorders |
| US10857163B1 (en) | 2019-09-30 | 2020-12-08 | Athenen Therapeutics, Inc. | Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof |
| AU2022291395A1 (en) | 2021-06-11 | 2024-01-04 | Sage Therapeutics, Inc. | Neuroactive steroid for the treatment of alzheimer's disease |
| CN113667734B (zh) * | 2021-07-16 | 2022-05-24 | 四川大学华西医院 | Shank3片段序列甲基化检测试剂在制备精神分裂症诊断试剂盒中的用途 |
| US20240368214A1 (en) * | 2021-08-25 | 2024-11-07 | Sage Therapeutics, Inc. | Positive nmda-modulating compounds and methods of use thereof |
| EP4430056A1 (en) * | 2021-11-10 | 2024-09-18 | Umecrine AB | 3.beta.-hydroxy, 3.alpha.-ethyl steroids for modulation of the alpha-3 subtype of the gaba-a receptor |
| US20250064833A1 (en) | 2021-12-13 | 2025-02-27 | Sage Therapeutics, Inc. | Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators |
| US20250154193A1 (en) * | 2022-01-28 | 2025-05-15 | Cholesgen (Shanghai) Co., Ltd. | Steroid compound, and preparation method therefor and application thereof |
| WO2024229297A1 (en) * | 2023-05-02 | 2024-11-07 | Sage Therapeutics, Inc. | Lymphatic system-targeting compounds |
| WO2025020190A1 (zh) * | 2023-07-27 | 2025-01-30 | 珂阑(上海)医药科技有限公司 | 甾类化合物、其制备方法和应用 |
| WO2025021195A1 (zh) * | 2023-07-27 | 2025-01-30 | 珂阑(上海)医药科技有限公司 | 甾类化合物、其制备方法和应用 |
| CN119371475B (zh) * | 2023-07-27 | 2025-11-04 | 珂阑(上海)医药科技有限公司 | 甾类化合物、其制备方法和应用 |
| WO2025221732A1 (en) * | 2024-04-15 | 2025-10-23 | Sage Therapeutics, Inc. | Nmda receptor-modulating compounds and methods of use thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014160480A1 (en) * | 2013-03-13 | 2014-10-02 | Sage Therapeutics, Inc. | Neuroactive steroids and methods of use thereof |
| WO2014160441A1 (en) * | 2013-03-13 | 2014-10-02 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| JP2014526469A (ja) * | 2011-09-08 | 2014-10-06 | セージ セラピューティクス， インコーポレイテッド | 神経刺激性のステロイド、組成物、およびそれらの使用 |
| WO2016054551A1 (en) * | 2014-10-03 | 2016-04-07 | Progressive International Corporation | Salad spinner |
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