JP2018517415A5 - - Google Patents
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- JP2018517415A5 JP2018517415A5 JP2017564059A JP2017564059A JP2018517415A5 JP 2018517415 A5 JP2018517415 A5 JP 2018517415A5 JP 2017564059 A JP2017564059 A JP 2017564059A JP 2017564059 A JP2017564059 A JP 2017564059A JP 2018517415 A5 JP2018517415 A5 JP 2018517415A5
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- Prior art keywords
- monoclonal antibody
- cell
- cells
- receptor
- cell line
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021036808A JP7275178B2 (ja) | 2015-06-10 | 2021-03-09 | がんを処置するための改変ｎｋ－９２細胞 |
| JP2023025723A JP7836780B2 (ja) | 2015-06-10 | 2023-02-22 | がんを処置するための改変ｎｋ－９２細胞 |
| JP2025048124A JP2025089426A (ja) | 2015-06-10 | 2025-03-24 | がんを処置するための改変ｎｋ－９２細胞 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562173701P | 2015-06-10 | 2015-06-10 | |
| US62/173,701 | 2015-06-10 | ||
| US201662337044P | 2016-05-16 | 2016-05-16 | |
| US62/337,044 | 2016-05-16 | ||
| PCT/US2016/036991 WO2016201304A1 (en) | 2015-06-10 | 2016-06-10 | Modified nk-92 cells for treating cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021036808A Division JP7275178B2 (ja) | 2015-06-10 | 2021-03-09 | がんを処置するための改変ｎｋ－９２細胞 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018517415A JP2018517415A (ja) | 2018-07-05 |
| JP2018517415A5 true JP2018517415A5 (enExample) | 2019-06-27 |
Family
ID=57504144
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017564059A Pending JP2018517415A (ja) | 2015-06-10 | 2016-06-10 | がんを処置するための改変ｎｋ−９２細胞 |
| JP2021036808A Active JP7275178B2 (ja) | 2015-06-10 | 2021-03-09 | がんを処置するための改変ｎｋ－９２細胞 |
| JP2023025723A Active JP7836780B2 (ja) | 2015-06-10 | 2023-02-22 | がんを処置するための改変ｎｋ－９２細胞 |
| JP2025048124A Pending JP2025089426A (ja) | 2015-06-10 | 2025-03-24 | がんを処置するための改変ｎｋ－９２細胞 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021036808A Active JP7275178B2 (ja) | 2015-06-10 | 2021-03-09 | がんを処置するための改変ｎｋ－９２細胞 |
| JP2023025723A Active JP7836780B2 (ja) | 2015-06-10 | 2023-02-22 | がんを処置するための改変ｎｋ－９２細胞 |
| JP2025048124A Pending JP2025089426A (ja) | 2015-06-10 | 2025-03-24 | がんを処置するための改変ｎｋ－９２細胞 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10738279B2 (enExample) |
| EP (3) | EP4424326A3 (enExample) |
| JP (4) | JP2018517415A (enExample) |
| KR (4) | KR102526538B1 (enExample) |
| CN (2) | CN113502270B (enExample) |
| AU (1) | AU2016275030B2 (enExample) |
| CA (1) | CA2987290C (enExample) |
| ES (1) | ES2958720T3 (enExample) |
| IL (3) | IL328383A (enExample) |
| WO (1) | WO2016201304A1 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201808811QA (en) | 2014-04-10 | 2018-11-29 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Method and compositions for cellular immunotherapy |
| EP3805371A1 (en) | 2014-05-15 | 2021-04-14 | National University of Singapore | Modified natural killer cells and uses thereof |
| ES2958720T3 (es) * | 2015-06-10 | 2024-02-13 | Immunitybio Inc | Células NK-92 modificadas para tratar el cáncer |
| MX2018001568A (es) | 2015-08-07 | 2019-04-25 | Seattle Children´S Hospital Dba Seattle Children´S Res Institute | Celulas t biespecificas de receptor quimerico de antigeno (car) para focalizacion a tumores solidos. |
| CN118652336A (zh) | 2016-06-08 | 2024-09-17 | 普瑞赛格恩公司 | Cd33特异性嵌合抗原受体 |
| CN110168078B (zh) * | 2017-01-06 | 2024-05-14 | 免疫生物公司 | 具有降低的cd96/tigit表达的遗传修饰的nk-92细胞 |
| CA3049652A1 (en) * | 2017-01-10 | 2018-07-19 | Intrexon Corporation | Modulating expression of polypeptides via new gene switch expression systems |
| CA3051866A1 (en) * | 2017-02-01 | 2018-08-09 | Nant Holdings Ip, Llc | Calreticulin-mediated cancer treatment |
| AU2018220734B2 (en) * | 2017-02-20 | 2025-03-06 | Dragonfly Therapeutics, Inc. | Proteins binding CD33, NKG2D and CD16 |
| AU2018231193B2 (en) | 2017-03-08 | 2021-07-22 | Immunitybio, Inc. | Modified NK-92 haNK003 cells for the clinic |
| BR112019018915A2 (pt) | 2017-03-15 | 2020-04-14 | Pandion Therapeutics Inc | imunotolerância direcionada |
| CA3058144A1 (en) * | 2017-03-27 | 2018-10-04 | Nantcell, Inc. | Ank and il-12 compositions and methods |
| CN117363636A (zh) | 2017-03-27 | 2024-01-09 | 新加坡国立大学 | 一种编码嵌合受体的多核苷酸 |
| MX2019011570A (es) | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
| KR102009040B1 (ko) * | 2017-04-05 | 2019-08-08 | 한국생명공학연구원 | Nk 세포 활성화 융합 단백질, nk 세포 및 이들을 포함하는 약제학적 조성물 |
| KR20190141695A (ko) * | 2017-04-13 | 2019-12-24 | 센티 바이오사이언시스, 인코포레이티드 | 병용 암 면역요법 |
| AU2018273914A1 (en) | 2017-05-24 | 2019-11-14 | Pandion Operations, Inc. | Targeted immunotolerance |
| TWI676483B (zh) * | 2017-08-06 | 2019-11-11 | 強普生技股份有限公司 | 醫藥套組及其用途 |
| KR102742741B1 (ko) | 2017-10-18 | 2024-12-16 | 프레시전 인코포레이티드 | 스페이서를 포함하는 폴리펩타이드 조성물 |
| WO2019084234A1 (en) * | 2017-10-26 | 2019-05-02 | St. Jude Childen's Research Hospital, Inc. | METHODS AND COMPOSITIONS FOR TREATING CD33 + CANCERS AND IMPROVING IN VIVO PERSISTENCE OF CHIMERIC ANTIGEN RECEPTOR T CELLS |
| US20210187024A1 (en) * | 2017-11-01 | 2021-06-24 | Nantkwest, Inc. | NK-92 Cells to Stimulate Anti-Cancer Vaccine |
| US20200392458A1 (en) * | 2017-11-24 | 2020-12-17 | Onk Therapeutics Limited | Modified natural killer cells and natural killer cell lines targetting tumour cells |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| WO2019127215A1 (en) * | 2017-12-28 | 2019-07-04 | Nanjing Legend Biotech Co., Ltd. | Multispecific chimeric receptors comprising an nkg2d domain and methods of use thereof |
| CN110028589B (zh) * | 2018-02-07 | 2023-07-21 | 阿思科力(苏州)生物科技有限公司 | 嵌合抗原受体、表达该嵌合抗原受体的nkg2d car-nk细胞及其制备方法和应用 |
| JP7360174B2 (ja) | 2018-02-09 | 2023-10-12 | ナショナル ユニヴァーシティー オブ シンガポール | ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用 |
| CN112004829A (zh) * | 2018-03-12 | 2020-11-27 | 南克维斯特公司 | Cd33car修饰的高亲和力nk细胞(t-hank)用于降低髓系衍生的抑制细胞的抑制活性(或降低对nk细胞活性的负面影响)的用途 |
| WO2019182425A1 (ko) * | 2018-03-23 | 2019-09-26 | 주식회사 에스엘바이젠 | 신규 키메라 항원 수용체 암호화 유전자가 형질도입된 유전자 변형 nk 세포주 및 그의 용도 |
| US12441787B2 (en) | 2018-04-02 | 2025-10-14 | National University Of Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| IL321548A (en) | 2018-05-22 | 2025-08-01 | Immunitybio Inc | Recombinant NK cells expressing a chimeric antigen receptor (CAR) for epsilon-FC and uses thereof |
| KR102907902B1 (ko) * | 2018-08-01 | 2026-01-02 | 난트퀘스트, 인크. | 면역 요법의 안정한 유전적 변형을 위한 귀소 수용체 또는 사이토카인, 및 키메라 항원 수용체를 포함하는 4 시스트론 시스템 |
| WO2020028654A1 (en) | 2018-08-01 | 2020-02-06 | Nantkwest, Inc. | Combined invasion and cytotoxicity assay using chemokine secreting target cells |
| WO2020044239A1 (en) | 2018-08-29 | 2020-03-05 | National University Of Singapore | A method to specifically stimulate survival and expansion of genetically-modified immune cells |
| KR20240162586A (ko) * | 2018-10-31 | 2024-11-15 | 난트퀘스트, 인크. | Pd-l1 키메라 항원 수용체-발현 nk 세포에 의한 pd-l1-양성 악성종양의 제거 |
| KR20200119892A (ko) * | 2018-10-31 | 2020-10-20 | 난트퀘스트, 인크. | Cd19-car 발현 nk 세포에 의한 cd19-양성 림프성 악성종양의 제거(elimination of cd19-positive lymphoid malignancies by cd19-car expressing nk cells) |
| EP3743513A4 (en) | 2018-11-06 | 2021-11-24 | Nantkwest, Inc. | NK-92 CELLS MODIFIED BY CHIMERIC ANTIGEN RECEPTOR |
| US12109238B2 (en) * | 2018-11-06 | 2024-10-08 | Immunitybio, Inc. | Chimeric antigen receptor-modified NK-92 cells |
| AU2019388876A1 (en) * | 2018-11-26 | 2021-05-20 | Immunitybio, Inc. | IL-2 Dependent NK-92 cells with stable Fc receptor expression |
| CN113226340A (zh) | 2018-11-26 | 2021-08-06 | 恩卡尔塔公司 | 同时扩增多种免疫细胞类型的方法、相关组合物及其在癌症免疫疗法中的用途 |
| KR20210137085A (ko) | 2019-03-05 | 2021-11-17 | 엔카르타, 인크. | Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도 |
| WO2020205100A1 (en) * | 2019-03-15 | 2020-10-08 | Nantcell, Inc. | Recombinant eril-15 nk cells |
| AU2020279240A1 (en) | 2019-05-20 | 2021-12-23 | Pandion Operations, Inc. | MAdCAM targeted immunotolerance |
| US20220265716A1 (en) * | 2019-07-26 | 2022-08-25 | Nantkwest, Inc. | Antibody pre-loaded cd16+nk-92 cells as an effective therapeutic product for tumor lysis |
| IL283568B2 (en) * | 2019-08-01 | 2025-01-01 | Immunitybio Inc | NK–92 cells modified with a chimeric antigen receptor against B7–H4 |
| KR20210033436A (ko) * | 2019-09-18 | 2021-03-26 | 주식회사 에스엘바이젠 | 신규 키메라 항원 수용체 암호화 유전자가 형질도입된 유전자 변형 nk 세포주 및 그의 용도 |
| US20210106619A1 (en) * | 2019-10-10 | 2021-04-15 | Nantkwest, Inc. | NK-92 Bone and Brain targeting |
| EP4061385A4 (en) * | 2019-11-19 | 2024-08-14 | Acibadem Mehmet Ali Aydinlar Üniversitesi | METHOD FOR REDESIGNING AND EXPANDING NK92 CELLS FOR USE IN IMMUNOTHERAPY |
| AU2020387167B2 (en) * | 2019-11-20 | 2024-10-24 | Immunitybio, Inc. | Cell-mediated transient delivery of immune-enhancing molecules into the tumor microenvironment |
| WO2021116913A1 (en) | 2019-12-09 | 2021-06-17 | Nantkwest, Inc. | Screening of cell clones expressing polygenic transgenes through non-antibiotic dependent positive selection |
| US11230699B2 (en) | 2020-01-28 | 2022-01-25 | Immunitybio, Inc. | Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors |
| WO2021154218A1 (en) | 2020-01-28 | 2021-08-05 | Nantkwest, Inc. | Chimeric antigen receptor-modified nk-92 cells targeting egfr super-family receptors |
| EP4097220A4 (en) * | 2020-01-30 | 2024-03-20 | ImmunityBio, Inc. | ELIMINATION OF BCMA-POSITIVE MALIGNANCIES BY CAR-EXPRESSING NK CELLS |
| US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
| JP7773789B2 (ja) * | 2020-03-28 | 2025-11-20 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 癌の治療のための細胞免疫療法 |
| KR102594083B1 (ko) | 2020-07-07 | 2023-10-25 | 칸큐어 엘엘씨 | Mic 항체 및 결합제 및 이의 사용 방법 |
| AU2021372458A1 (en) * | 2020-10-26 | 2023-06-15 | Research Institute At Nationwide Children's Hospital | Chimeric antigen receptor (car) nk cells and uses thereof |
| US11459372B2 (en) | 2020-11-30 | 2022-10-04 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| EP4271798A1 (en) | 2020-12-30 | 2023-11-08 | CRISPR Therapeutics AG | Compositions and methods for differentiating stem cells into nk cells |
| WO2024236557A1 (en) | 2023-05-12 | 2024-11-21 | Gilboa Therapeutics LTD | Compositions comprising an fc domain for the treatment of medical conditions |
| EP4739323A1 (en) | 2023-07-05 | 2026-05-13 | ImmunityBio, Inc. | <smallcaps/>? ? ?ex vivo? ? ? ? ?generation of immune effector cells from apheresis material intermediates |
| WO2025158400A1 (en) * | 2024-01-24 | 2025-07-31 | Yale University | Compositions and methods of natural killer cell hyperboosts for enhancement of nk cell therapy |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69834257T2 (de) | 1997-04-30 | 2007-01-04 | Klingemann, Hans | Natürliche killerzelllinien und verfahren zu ihrer verwendung |
| US8034332B2 (en) | 1997-04-30 | 2011-10-11 | Conkwest, Inc. | Interleukin-secreting natural killer cell lines and methods of use |
| WO1999024566A1 (en) | 1997-11-06 | 1999-05-20 | Roche Diagnostics Gmbh | Tumor-specific antigens, methods for their production and their use for immunization and diagnosis |
| WO2000020460A1 (en) | 1998-10-05 | 2000-04-13 | Ludwig Institute For Cancer Research | Methods for producing human tumor antigen specific antibodies |
| US7098008B2 (en) | 2000-04-25 | 2006-08-29 | Ic&G Do. Ltd. | Selected primers for detection of MAGE or GAGE genes for diagnosis of cancer and methods of use |
| SE526227C2 (sv) * | 2002-05-15 | 2005-08-02 | North China Pharmaceutical Group | Metod för rening av rekombinant humant serumalbumin |
| CA2487932A1 (en) | 2002-05-30 | 2003-12-11 | Macrogenics, Inc. | Cd16a binding proteins and use for the treatment of immune disorders |
| JP2008505071A (ja) * | 2004-07-02 | 2008-02-21 | アヴァリス・アクチエボラーグ | 細胞を遺伝学的に活性化する方法、および、該細胞の使用 |
| ES2678094T3 (es) | 2004-07-10 | 2018-08-08 | Fox Chase Cancer Center | Líneas de células asesinas naturales genéticamente modificadas |
| EP2123754B1 (en) * | 2007-01-30 | 2011-04-06 | Forerunner Pharma Research Co., Ltd. | CHIMERIC Fc GAMMA RECEPTOR AND METHOD FOR DETERMINATION OF ADCC ACTIVITY BY USING THE RECEPTOR |
| EP2161339A1 (en) * | 2008-08-29 | 2010-03-10 | F. Hoffmann-La Roche Ag | ADCC with modified NK92 cells |
| CA2803391C (en) | 2010-06-22 | 2021-11-09 | Neogenix Oncology, Inc. | Npc1 antibodies that bind a muc5ac epitope |
| EP3115373B1 (en) | 2010-09-08 | 2019-08-28 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Chimeric antigen receptors with an optimized hinge region |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| JP6053688B2 (ja) | 2011-10-07 | 2016-12-27 | 国立大学法人三重大学 | キメラ抗原受容体 |
| JP6267644B2 (ja) | 2011-10-20 | 2018-01-24 | アメリカ合衆国 | 抗ｃｄ２２キメラ抗原受容体 |
| CN103483452B (zh) * | 2012-06-12 | 2021-08-13 | 上海细胞治疗集团有限公司 | 双信号独立的嵌合抗原受体及其用途 |
| AU2013312838B2 (en) | 2012-09-04 | 2018-11-29 | Cellectis | Multi-chain chimeric antigen receptor and uses thereof |
| RU2729401C2 (ru) * | 2012-10-02 | 2020-08-06 | Мемориал Слоан-Кеттеринг Кэнсер Сентер | Композиции и способы для иммунотерапии |
| US20150329640A1 (en) | 2012-12-20 | 2015-11-19 | Bluebird Bio, Inc. | Chimeric antigen receptors and immune cells targeting b cell malignancies |
| US20160015749A1 (en) | 2013-03-05 | 2016-01-21 | Baylor College Of Medicine | Engager cells for immunotherapy |
| ES2769574T3 (es) * | 2013-03-15 | 2020-06-26 | Michael C Milone | Reconocimiento de células citotóxicas con receptores quiméricos para inmunoterapia adoptiva |
| DK2992020T3 (da) * | 2013-05-03 | 2020-02-10 | Ohio State Innovation Foundation | Cs1-specifik kimær antigenreceptor-manipulerede immuneffektorceller |
| CN104561069A (zh) * | 2013-10-23 | 2015-04-29 | 深圳先进技术研究院 | 含重组嵌合抗原受体基因表达盒的微环dna重组母质粒、含该表达盒的微环dna及应用 |
| EP3701957B1 (en) * | 2013-11-01 | 2022-12-28 | ImmunityBio, Inc. | Tumoricidal and antimicrobial compositions and methods |
| EP3858379A1 (en) * | 2013-11-21 | 2021-08-04 | Autolus Limited | Cell |
| ES2958720T3 (es) * | 2015-06-10 | 2024-02-13 | Immunitybio Inc | Células NK-92 modificadas para tratar el cáncer |
| KR20200119892A (ko) * | 2018-10-31 | 2020-10-20 | 난트퀘스트, 인크. | Cd19-car 발현 nk 세포에 의한 cd19-양성 림프성 악성종양의 제거(elimination of cd19-positive lymphoid malignancies by cd19-car expressing nk cells) |
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2016
- 2016-06-10 ES ES16808427T patent/ES2958720T3/es active Active
- 2016-06-10 KR KR1020187000382A patent/KR102526538B1/ko active Active
- 2016-06-10 US US15/531,109 patent/US10738279B2/en active Active
- 2016-06-10 IL IL328383A patent/IL328383A/en unknown
- 2016-06-10 IL IL255884A patent/IL255884B2/en unknown
- 2016-06-10 CN CN202110790574.3A patent/CN113502270B/zh active Active
- 2016-06-10 KR KR1020257004508A patent/KR20250027585A/ko active Pending
- 2016-06-10 AU AU2016275030A patent/AU2016275030B2/en active Active
- 2016-06-10 KR KR1020247001893A patent/KR20240013282A/ko not_active Ceased
- 2016-06-10 CA CA2987290A patent/CA2987290C/en active Active
- 2016-06-10 EP EP24185893.5A patent/EP4424326A3/en active Pending
- 2016-06-10 IL IL309167A patent/IL309167B1/en unknown
- 2016-06-10 CN CN201680033667.9A patent/CN107709552B/zh active Active
- 2016-06-10 WO PCT/US2016/036991 patent/WO2016201304A1/en not_active Ceased
- 2016-06-10 JP JP2017564059A patent/JP2018517415A/ja active Pending
- 2016-06-10 EP EP16808427.5A patent/EP3307876B1/en active Active
- 2016-06-10 EP EP23176181.8A patent/EP4272757A3/en active Pending
- 2016-06-10 KR KR1020237013832A patent/KR102627811B1/ko active Active
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2020
- 2020-07-27 US US16/940,018 patent/US11788059B2/en active Active
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2021
- 2021-03-09 JP JP2021036808A patent/JP7275178B2/ja active Active
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2023
- 2023-02-22 JP JP2023025723A patent/JP7836780B2/ja active Active
- 2023-09-07 US US18/463,213 patent/US20240002802A1/en active Pending
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2025
- 2025-03-24 JP JP2025048124A patent/JP2025089426A/ja active Pending