JP2018516911A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018516911A5 JP2018516911A5 JP2017561621A JP2017561621A JP2018516911A5 JP 2018516911 A5 JP2018516911 A5 JP 2018516911A5 JP 2017561621 A JP2017561621 A JP 2017561621A JP 2017561621 A JP2017561621 A JP 2017561621A JP 2018516911 A5 JP2018516911 A5 JP 2018516911A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- seq
- antagonist
- cancer
- cpg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 39
- 108091034117 Oligonucleotide Proteins 0.000 claims 21
- 229940124060 PD-1 antagonist Drugs 0.000 claims 20
- 229940044655 toll-like receptor 9 agonist Drugs 0.000 claims 12
- 239000002777 nucleoside Substances 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 125000003835 nucleoside group Chemical group 0.000 claims 6
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 4
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 4
- 108091081548 Palindromic sequence Proteins 0.000 claims 4
- 238000002648 combination therapy Methods 0.000 claims 4
- 102000048776 human CD274 Human genes 0.000 claims 4
- 102000048362 human PDCD1 Human genes 0.000 claims 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 4
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 4
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 3
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 3
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical group OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 claims 3
- 239000005557 antagonist Substances 0.000 claims 3
- 208000021039 metastatic melanoma Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 229940046166 oligodeoxynucleotide Drugs 0.000 claims 3
- 229960002621 pembrolizumab Drugs 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000030808 Clear cell renal carcinoma Diseases 0.000 claims 1
- 101001117312 Homo sapiens Programmed cell death 1 ligand 2 Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000033749 Small cell carcinoma of the bladder Diseases 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 1
- 206010073251 clear cell renal cell carcinoma Diseases 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 102000048119 human PDCD1LG2 Human genes 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005243 lung squamous cell carcinoma Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 1
- 201000007710 urinary bladder small cell neuroendocrine carcinoma Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021041014A JP7236483B2 (ja) | 2015-05-29 | 2021-03-15 | がんの処置のためのＰＤ－１アンタゴニストとＣｐＧ－Ｃ型オリゴヌクレオチドの併用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562168449P | 2015-05-29 | 2015-05-29 | |
| US62/168,449 | 2015-05-29 | ||
| US201562169309P | 2015-06-01 | 2015-06-01 | |
| US62/169,309 | 2015-06-01 | ||
| PCT/US2016/034275 WO2016196173A1 (en) | 2015-05-29 | 2016-05-26 | Combination of a pd-1 antagonist and cpg-c type oligonucleotide for treating cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021041014A Division JP7236483B2 (ja) | 2015-05-29 | 2021-03-15 | がんの処置のためのＰＤ－１アンタゴニストとＣｐＧ－Ｃ型オリゴヌクレオチドの併用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516911A JP2018516911A (ja) | 2018-06-28 |
| JP2018516911A5 true JP2018516911A5 (enExample) | 2019-06-27 |
| JP6893608B2 JP6893608B2 (ja) | 2021-06-23 |
Family
ID=57441888
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017561621A Active JP6893608B2 (ja) | 2015-05-29 | 2016-05-26 | がんの処置のためのＰＤ−１アンタゴニストとＣｐＧ−Ｃ型オリゴヌクレオチドの併用 |
| JP2021041014A Active JP7236483B2 (ja) | 2015-05-29 | 2021-03-15 | がんの処置のためのＰＤ－１アンタゴニストとＣｐＧ－Ｃ型オリゴヌクレオチドの併用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021041014A Active JP7236483B2 (ja) | 2015-05-29 | 2021-03-15 | がんの処置のためのＰＤ－１アンタゴニストとＣｐＧ－Ｃ型オリゴヌクレオチドの併用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10751412B2 (enExample) |
| EP (2) | EP3892284B1 (enExample) |
| JP (2) | JP6893608B2 (enExample) |
| KR (1) | KR20180014009A (enExample) |
| CN (1) | CN108025018B (enExample) |
| AU (1) | AU2016271018A1 (enExample) |
| BR (1) | BR112017025562A2 (enExample) |
| CA (1) | CA2986126A1 (enExample) |
| ES (1) | ES2985394T3 (enExample) |
| MA (1) | MA44699A (enExample) |
| MX (1) | MX2017015308A (enExample) |
| RU (1) | RU2017145558A (enExample) |
| WO (1) | WO2016196173A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8158768B2 (en) | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
| NZ600758A (en) | 2007-06-18 | 2013-09-27 | Merck Sharp & Dohme | Antibodies to human programmed death receptor pd-1 |
| WO2014159662A1 (en) | 2013-03-13 | 2014-10-02 | University Of Miami | Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids |
| IL251669B2 (en) | 2014-10-10 | 2023-02-01 | Idera Pharmaceuticals Inc | Cancer treatment using a tlr9 agonist with checkpoint inhibitors |
| CA2968531A1 (en) | 2014-11-21 | 2016-05-26 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| EP3240801B1 (en) * | 2014-12-31 | 2021-01-20 | Checkmate Pharmaceuticals, Inc. | Combination tumor immunotherapy |
| KR20180014009A (ko) | 2015-05-29 | 2018-02-07 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 cpg-c 유형 올리고뉴클레오티드의 조합 |
| WO2017220989A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anti-pd-l1 and il-2 cytokines |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| KR20190096936A (ko) | 2016-09-15 | 2019-08-20 | 이데라 파마슈티칼즈, 인코포레이티드 | 암 치료를 위하여 tlr9 작용제를 사용한 면역 조정 |
| AR111432A1 (es) | 2017-04-28 | 2019-07-10 | Merck Sharp & Dohme | Biomarcadores para agentes terapéuticos contra el cáncer |
| US11845798B2 (en) | 2017-05-02 | 2023-12-19 | Merck Sharp & Dohme Llc | Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| US20200262919A1 (en) | 2017-10-13 | 2020-08-20 | Merck Sharp & Dohme Corp. | Compositions and methods for treating diffuse large b cell lymphoma |
| CN111278448A (zh) | 2017-10-27 | 2020-06-12 | 美国默沙东药厂 | 用于治疗肝癌的组合物和方法 |
| US12246031B2 (en) | 2018-02-13 | 2025-03-11 | Checkmate Pharmaceuticals, Inc. | Compositions and methods for tumor immunotherapy |
| AU2019251421B2 (en) | 2018-04-09 | 2025-05-01 | Checkmate Pharmaceuticals | Packaging oligonucleotides into virus-like particles |
| TW202011959A (zh) | 2018-04-14 | 2020-04-01 | 美商戴納瓦克斯技術公司 | 用於治療癌症之包括CpG-C 型寡核苷酸及組蛋白去乙醯酶抑制劑之組合 |
| WO2020081398A1 (en) * | 2018-10-14 | 2020-04-23 | Dynavax Technologies Corporation | Combination including a cpg-c type oligonucleotide and a pd-1 antagonist for treating breast cancer |
| KR20210089215A (ko) | 2018-11-07 | 2021-07-15 | 머크 샤프 앤드 돔 코포레이션 | 항-lag3 항체 및 항-pd-1 항체의 공동-제제 |
| CN113366016B (zh) * | 2018-12-12 | 2022-12-16 | 上海开拓者生物医药有限公司 | 抗人白细胞介素5(il-5)单克隆抗体及其应用 |
| CN111321159B (zh) * | 2018-12-14 | 2023-12-12 | 中天(上海)生物科技有限公司 | 用于免疫调节的嵌合核酸分子及其应用 |
| EP3845649B1 (en) * | 2019-12-31 | 2025-09-24 | Industrial Technology Research Institute | Nucleic acid-drug complex and use thereof |
| CA3161956A1 (en) * | 2020-01-10 | 2021-07-15 | Sbi Biotech Co., Ltd. | Novel tlr9 agonists |
| US20230374523A1 (en) * | 2020-09-22 | 2023-11-23 | Trisalus Life Sciences, Inc. | Cancer therapy using toll-like receptor agonists |
| CN116685330A (zh) * | 2020-09-22 | 2023-09-01 | 特萨乐斯生命科学公司 | 使用toll样受体激动剂的癌症疗法 |
| EP4217064A4 (en) * | 2020-09-22 | 2024-08-07 | TriSalus Life Sciences, Inc. | CANCER THERAPY WITH TOLL-LIKE RECEPTOR AGONISTS |
| WO2022110010A1 (zh) * | 2020-11-27 | 2022-06-02 | 苏州吉玛基因股份有限公司 | 免疫激活剂、抗原和抗体在制备预防、治疗肿瘤产品中的应用 |
| CA3215582A1 (en) * | 2021-04-01 | 2022-10-06 | Trisalus Life Sciences, Inc. | Cancer therapy using toll-like receptor agonists |
| GB202107994D0 (en) | 2021-06-04 | 2021-07-21 | Kymab Ltd | Treatment of cancer |
| WO2023081486A1 (en) | 2021-11-08 | 2023-05-11 | Nurix Therapeutics, Inc. | Toll-like receptor therapy combinations with cbl-b inhibitor compounds |
| EP4658310A1 (en) | 2023-01-30 | 2025-12-10 | Kymab Limited | Antibodies |
| WO2025233224A1 (en) | 2024-05-09 | 2025-11-13 | F. Hoffmann-La Roche Ag | Use of atr inhibitors in combination with anti-pd(l)1 therapy |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6217857B1 (en) | 1989-06-28 | 2001-04-17 | Schering Corporation | Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof |
| CA2244946C (en) | 1996-01-30 | 2010-04-13 | The Regents Of The University Of California | Gene expression vectors which generate an antigen specific immune response and methods of using the same |
| US6610661B1 (en) | 1996-10-11 | 2003-08-26 | The Regents Of The University Of California | Immunostimulatory polynucleotide/immunomodulatory molecule conjugates |
| EP2085090A3 (en) | 1997-06-06 | 2012-05-02 | The Regents of the University of California | Inhibitors of DNA immunostimulatory sequence activity |
| PT1009413E (pt) | 1997-09-05 | 2007-05-31 | Univ California | Utilização de oligonucleótidos imumoestimulantes para a prevenção ou tratamento da asma. |
| WO2000032634A1 (en) | 1998-12-01 | 2000-06-08 | Protein Design Labs, Inc. | Humanized antibodies to gamma-interferon |
| EP1176966B1 (en) | 1999-04-12 | 2013-04-03 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Oligodeoxynucleotide and its use to induce an immune response |
| KR100881923B1 (ko) | 2000-12-27 | 2009-02-04 | 다이나박스 테크놀로지 코퍼레이션 | 면역자극 폴리뉴클레오티드 및 그것의 사용 방법 |
| US7595048B2 (en) | 2002-07-03 | 2009-09-29 | Ono Pharmaceutical Co., Ltd. | Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1 |
| BR0316880A (pt) | 2002-12-23 | 2005-10-25 | Wyeth Corp | Anticorpos contra pd-1 e usos dos mesmos |
| US8158768B2 (en) | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
| CN101693890B (zh) | 2002-12-23 | 2012-09-05 | 戴纳伐克斯技术股份有限公司 | 免疫刺激序列寡核苷酸和使用方法 |
| WO2004072286A1 (ja) | 2003-01-23 | 2004-08-26 | Ono Pharmaceutical Co., Ltd. | ヒトｐｄ−１に対し特異性を有する物質 |
| AR046833A1 (es) | 2003-11-10 | 2005-12-28 | Schering Corp | Anticuerpos anti-interleuquina-10 |
| MY159370A (en) | 2004-10-20 | 2016-12-30 | Coley Pharm Group Inc | Semi-soft-class immunostimulatory oligonucleotides |
| EP2439273B1 (en) | 2005-05-09 | 2019-02-27 | Ono Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
| KR101888321B1 (ko) | 2005-07-01 | 2018-08-13 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
| CN101490085A (zh) * | 2006-06-12 | 2009-07-22 | 特鲁比昂药品公司 | 具有效应功能的单链多价结合蛋白 |
| NZ600758A (en) | 2007-06-18 | 2013-09-27 | Merck Sharp & Dohme | Antibodies to human programmed death receptor pd-1 |
| US8168757B2 (en) | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
| MX2011002250A (es) | 2008-08-25 | 2011-08-17 | Amplimmune Inc | Antagonistas de muerte celular programada-1 y métodos de uso de los mismos. |
| MX2011003195A (es) | 2008-09-26 | 2011-08-12 | Dana Farber Cancer Inst Inc | Anticuerpos anti-pd-1, pd-l1 y pd-l2 humanos y usos de los mismos. |
| KR101050829B1 (ko) | 2008-10-02 | 2011-07-20 | 서울대학교산학협력단 | 항 ｐｄ-1 항체 또는 항 ｐｄ-ｌ1 항체를 포함하는 항암제 |
| US8217149B2 (en) | 2008-12-09 | 2012-07-10 | Genentech, Inc. | Anti-PD-L1 antibodies, compositions and articles of manufacture |
| EP3903829B1 (en) * | 2009-02-13 | 2023-05-03 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
| JP2013512251A (ja) | 2009-11-24 | 2013-04-11 | アンプリミューン、インコーポレーテッド | Ｐｄ−ｌ１／ｐｄ−ｌ２の同時阻害 |
| WO2012006634A2 (en) | 2010-07-09 | 2012-01-12 | The Board Of Trustees Of The University Of Illiniois | Prostate specific antigen (psa) peptide therapy |
| AU2012236479B2 (en) | 2011-03-31 | 2016-10-20 | Merck Sharp & Dohme Llc | Stable formulations of antibodies to human programmed death receptor PD-1 and related treatments |
| MY193562A (en) | 2011-08-01 | 2022-10-19 | Genentech Inc | Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors |
| KR102129636B1 (ko) * | 2012-05-31 | 2020-07-03 | 제넨테크, 인크. | Pd-l1 축 결합 길항제 및 vegf 길항제를 사용하여 암을 치료하는 방법 |
| AR093984A1 (es) | 2012-12-21 | 2015-07-01 | Merck Sharp & Dohme | Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano |
| EP2981821B2 (en) * | 2013-04-02 | 2021-11-03 | Merck Sharp & Dohme Corp. | Immunohistochemical assay for detecting expression of programmed death ligand 1 (pd-l1) in tumor tissue |
| CN105682683A (zh) | 2013-08-02 | 2016-06-15 | 阿杜罗生物科技控股有限公司 | 结合cd27激动剂以及免疫检查点抑制以用于免疫刺激 |
| WO2015054642A2 (en) | 2013-10-11 | 2015-04-16 | Genentech, Inc. | Use of cbp/ep300 bromodomain inhibitors for cancer immunotherapy |
| WO2015167616A1 (en) | 2014-05-02 | 2015-11-05 | Nitor Therapeutics | Guanosine as an immunepotentiator mediated through toll receptors |
| IL251669B2 (en) | 2014-10-10 | 2023-02-01 | Idera Pharmaceuticals Inc | Cancer treatment using a tlr9 agonist with checkpoint inhibitors |
| EP3240801B1 (en) * | 2014-12-31 | 2021-01-20 | Checkmate Pharmaceuticals, Inc. | Combination tumor immunotherapy |
| CN107949399A (zh) | 2015-05-29 | 2018-04-20 | 默沙东公司 | 用于治疗癌症的抗‑IL‑10抗体和CpG‑C型寡核苷酸的组合产品 |
| KR20180014009A (ko) | 2015-05-29 | 2018-02-07 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 cpg-c 유형 올리고뉴클레오티드의 조합 |
-
2016
- 2016-05-26 KR KR1020177037185A patent/KR20180014009A/ko not_active Withdrawn
- 2016-05-26 MX MX2017015308A patent/MX2017015308A/es unknown
- 2016-05-26 CA CA2986126A patent/CA2986126A1/en not_active Abandoned
- 2016-05-26 CN CN201680043989.1A patent/CN108025018B/zh active Active
- 2016-05-26 MA MA044699A patent/MA44699A/fr unknown
- 2016-05-26 RU RU2017145558A patent/RU2017145558A/ru not_active Application Discontinuation
- 2016-05-26 EP EP21159163.1A patent/EP3892284B1/en active Active
- 2016-05-26 BR BR112017025562A patent/BR112017025562A2/pt not_active Application Discontinuation
- 2016-05-26 WO PCT/US2016/034275 patent/WO2016196173A1/en not_active Ceased
- 2016-05-26 AU AU2016271018A patent/AU2016271018A1/en not_active Abandoned
- 2016-05-26 US US15/577,369 patent/US10751412B2/en active Active
- 2016-05-26 ES ES21159163T patent/ES2985394T3/es active Active
- 2016-05-26 EP EP16804054.1A patent/EP3302501B1/en active Active
- 2016-05-26 JP JP2017561621A patent/JP6893608B2/ja active Active
-
2020
- 2020-08-21 US US17/000,149 patent/US11918648B2/en active Active
-
2021
- 2021-03-15 JP JP2021041014A patent/JP7236483B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018516911A5 (enExample) | ||
| JP2021102627A5 (enExample) | ||
| RU2017145558A (ru) | Комбинация антагониста pd-1 и олигонуклеотида типа cpg-c для лечения рака | |
| JP2017524715A5 (enExample) | ||
| JP2017537070A5 (enExample) | ||
| RU2017117664A (ru) | Комбинация | |
| MX2020008882A (es) | Dosificación para tratamiento con anticuerpos antagonistas anti-tigit y anti-pd-l1. | |
| JP2015532292A5 (enExample) | ||
| MX2021011500A (es) | Anticuerpos multiespecificos egfr x cd28. | |
| WO2015112805A8 (en) | Human antibodies to pd-l1 | |
| JP2017506264A5 (enExample) | ||
| JP2019524701A5 (enExample) | ||
| NZ752294A (en) | Cd3 binding antibodies | |
| JP2018008963A5 (enExample) | ||
| IL276515B1 (en) | PD–L1-specific antibodies and methods of using them | |
| IL292193B2 (en) | Anti-b7-h1 antibodies for treating tumors | |
| FI3799885T3 (fi) | Lymfosyyttien estoreittien neutralointi | |
| JP2020515637A5 (enExample) | ||
| HRP20210440T1 (hr) | Kombinirana terapija za rak | |
| JP2018518454A5 (enExample) | ||
| RU2016104880A (ru) | Способы лечения рака с использованием антагонистов, связывающих с осью pd-1, и ингибиторов tigit | |
| JP2013166763A5 (enExample) | ||
| HRP20220399T1 (hr) | Režim doziranja imunokonjugata protutijela i sn-38 za poboljšanu učinkovitost i smanjenu toksičnost | |
| HRP20212033T1 (hr) | Anti-lag-3 antitijela za liječenje hematoloških maligniteta | |
| HRP20171758T1 (hr) | Kombinacija dr5 agonista i anti-pd-1 antagonista i načini primjene |