KR20180014009A - 암을 치료하기 위한 pd-1 길항제 및 cpg-c 유형 올리고뉴클레오티드의 조합 - Google Patents
암을 치료하기 위한 pd-1 길항제 및 cpg-c 유형 올리고뉴클레오티드의 조합 Download PDFInfo
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
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- Epidemiology (AREA)
- Molecular Biology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
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| US201562168449P | 2015-05-29 | 2015-05-29 | |
| US62/168,449 | 2015-05-29 | ||
| US201562169309P | 2015-06-01 | 2015-06-01 | |
| US62/169,309 | 2015-06-01 | ||
| PCT/US2016/034275 WO2016196173A1 (en) | 2015-05-29 | 2016-05-26 | Combination of a pd-1 antagonist and cpg-c type oligonucleotide for treating cancer |
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| JP (2) | JP6893608B2 (enExample) |
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| US10500231B2 (en) | 2013-03-13 | 2019-12-10 | University Of Miami | Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids |
| KR20170072244A (ko) * | 2014-10-10 | 2017-06-26 | 이데라 파마슈티칼즈, 인코포레이티드 | 관문 억제제를 가지는 tlr9 효능제를 이용한 암 치료 |
| EP3220895B1 (en) | 2014-11-21 | 2022-08-31 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| MX393750B (es) * | 2014-12-31 | 2025-03-24 | Checkmate Pharmaceuticals Inc | Inmunoterapia antitumoral combinada. |
| WO2016196173A1 (en) | 2015-05-29 | 2016-12-08 | Merck Sharp & Dohme Corp. | Combination of a pd-1 antagonist and cpg-c type oligonucleotide for treating cancer |
| CA3026474A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anti-pd-l1 and il-2 cytokines |
| US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
| KR20190096936A (ko) | 2016-09-15 | 2019-08-20 | 이데라 파마슈티칼즈, 인코포레이티드 | 암 치료를 위하여 tlr9 작용제를 사용한 면역 조정 |
| BR112019022488A2 (pt) | 2017-04-28 | 2020-06-16 | Merck Sharp & Dohme Corp. | Biomarcadores para terapêutica do câncer |
| CA3060581A1 (en) | 2017-05-02 | 2018-11-08 | Merck Sharp & Dohme Corp. | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies |
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| CA3075294A1 (en) | 2017-10-27 | 2019-05-02 | Merck Sharp & Dohme Corp. | Compositions and methods for treating liver cancer |
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| CN113122541A (zh) * | 2019-12-31 | 2021-07-16 | 财团法人工业技术研究院 | 核酸药物复合体以及其用途 |
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| KR20230121995A (ko) * | 2020-09-22 | 2023-08-22 | 트라이살루스 라이프 사이언시즈, 인크. | 톨-유사 수용체 작용제를 사용한 암 요법 |
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| WO2016196173A1 (en) | 2015-05-29 | 2016-12-08 | Merck Sharp & Dohme Corp. | Combination of a pd-1 antagonist and cpg-c type oligonucleotide for treating cancer |
| CA2986232A1 (en) | 2015-05-29 | 2016-12-08 | Merck Sharp & Dohme Corp. | Combination of an anti-il-10 antibody and a cpg-c type oligonucleotide for treating cancer |
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2016
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- 2016-05-26 US US15/577,369 patent/US10751412B2/en active Active
- 2016-05-26 MA MA044699A patent/MA44699A/fr unknown
- 2016-05-26 RU RU2017145558A patent/RU2017145558A/ru not_active Application Discontinuation
- 2016-05-26 KR KR1020177037185A patent/KR20180014009A/ko not_active Withdrawn
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2020
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2021
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| EP3302501A1 (en) | 2018-04-11 |
| US20180169229A1 (en) | 2018-06-21 |
| EP3892284B1 (en) | 2024-05-22 |
| BR112017025562A2 (pt) | 2018-08-07 |
| ES2985394T3 (es) | 2024-11-05 |
| US11918648B2 (en) | 2024-03-05 |
| JP2021102627A (ja) | 2021-07-15 |
| US10751412B2 (en) | 2020-08-25 |
| CN108025018B (zh) | 2021-08-17 |
| EP3302501B1 (en) | 2021-09-22 |
| CA2986126A1 (en) | 2016-12-08 |
| WO2016196173A1 (en) | 2016-12-08 |
| CN108025018A (zh) | 2018-05-11 |
| MX2017015308A (es) | 2018-07-06 |
| JP7236483B2 (ja) | 2023-03-09 |
| AU2016271018A1 (en) | 2017-11-30 |
| EP3302501A4 (en) | 2019-02-27 |
| US20210196819A1 (en) | 2021-07-01 |
| JP6893608B2 (ja) | 2021-06-23 |
| JP2018516911A (ja) | 2018-06-28 |
| HK1252652A1 (zh) | 2019-05-31 |
| RU2017145558A (ru) | 2019-07-01 |
| MA44699A (fr) | 2021-05-05 |
| EP3892284A1 (en) | 2021-10-13 |
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