CN108025018B - 用于治疗癌症的pd-1拮抗剂和cpg-c型寡核苷酸的组合产品 - Google Patents

用于治疗癌症的pd-1拮抗剂和cpg-c型寡核苷酸的组合产品 Download PDF

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CN108025018B
CN108025018B CN201680043989.1A CN201680043989A CN108025018B CN 108025018 B CN108025018 B CN 108025018B CN 201680043989 A CN201680043989 A CN 201680043989A CN 108025018 B CN108025018 B CN 108025018B
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cancer
tumor
seq
cpg
oligonucleotide
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Chinese (zh)
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CN108025018A (zh
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Y.于
A.E.登克
S.萨德科瓦
U.T.范
R.A.卡斯特莱因
D.R.考夫曼
R.L.科夫曼
C.奎杜奇
R.S.詹森
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Tesalas Life Sciences
Merck Sharp and Dohme BV
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Texales Life Sciences Shenhuo Pharmaceutical Co ltd
Merck and Co Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CN201680043989.1A 2015-05-29 2016-05-26 用于治疗癌症的pd-1拮抗剂和cpg-c型寡核苷酸的组合产品 Active CN108025018B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562168449P 2015-05-29 2015-05-29
US62/168449 2015-05-29
US201562169309P 2015-06-01 2015-06-01
US62/169309 2015-06-01
PCT/US2016/034275 WO2016196173A1 (en) 2015-05-29 2016-05-26 Combination of a pd-1 antagonist and cpg-c type oligonucleotide for treating cancer

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CN108025018A CN108025018A (zh) 2018-05-11
CN108025018B true CN108025018B (zh) 2021-08-17

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US (2) US10751412B2 (enExample)
EP (2) EP3892284B1 (enExample)
JP (2) JP6893608B2 (enExample)
KR (1) KR20180014009A (enExample)
CN (1) CN108025018B (enExample)
AU (1) AU2016271018A1 (enExample)
BR (1) BR112017025562A2 (enExample)
CA (1) CA2986126A1 (enExample)
ES (1) ES2985394T3 (enExample)
MA (1) MA44699A (enExample)
MX (1) MX2017015308A (enExample)
RU (1) RU2017145558A (enExample)
WO (1) WO2016196173A1 (enExample)

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EP3302501A1 (en) 2018-04-11
US20180169229A1 (en) 2018-06-21
EP3892284B1 (en) 2024-05-22
BR112017025562A2 (pt) 2018-08-07
ES2985394T3 (es) 2024-11-05
KR20180014009A (ko) 2018-02-07
US11918648B2 (en) 2024-03-05
JP2021102627A (ja) 2021-07-15
US10751412B2 (en) 2020-08-25
EP3302501B1 (en) 2021-09-22
CA2986126A1 (en) 2016-12-08
WO2016196173A1 (en) 2016-12-08
CN108025018A (zh) 2018-05-11
MX2017015308A (es) 2018-07-06
JP7236483B2 (ja) 2023-03-09
AU2016271018A1 (en) 2017-11-30
EP3302501A4 (en) 2019-02-27
US20210196819A1 (en) 2021-07-01
JP6893608B2 (ja) 2021-06-23
JP2018516911A (ja) 2018-06-28
HK1252652A1 (zh) 2019-05-31
RU2017145558A (ru) 2019-07-01
MA44699A (fr) 2021-05-05
EP3892284A1 (en) 2021-10-13

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