BR112019022488A2 - Biomarcadores para terapêutica do câncer - Google Patents
Biomarcadores para terapêutica do câncer Download PDFInfo
- Publication number
- BR112019022488A2 BR112019022488A2 BR112019022488-2A BR112019022488A BR112019022488A2 BR 112019022488 A2 BR112019022488 A2 BR 112019022488A2 BR 112019022488 A BR112019022488 A BR 112019022488A BR 112019022488 A2 BR112019022488 A2 BR 112019022488A2
- Authority
- BR
- Brazil
- Prior art keywords
- pembrolizumab
- low
- biomarchers
- antigen
- methods
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/763—Herpes virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/5743—Specifically defined cancers of skin, e.g. melanoma
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
Abstract
são fornecidos biomarcadores úteis para identificar uma variedade de cânceres que respondem ao tratamento com uma terapia de combinação compreendendo pembrolizumabe, uma variante de pembrolizumabe ou um fragmento de ligação a antígeno do mesmo e talimogene laherparepvec. são fornecidos métodos de tratamento de cânceres resistentes à monoterapia com pembrolizumabe, uma variante de pembrolizumabe ou um fragmento de ligação a antígeno do mesmo. também são fornecidos métodos de tratamento de um câncer em um indivíduo com um tumor com uma baixa densidade de cd8+, uma assinatura de interferon gama baixa ou negativa e/ou um status pd-l1 baixo ou negativo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762491746P | 2017-04-28 | 2017-04-28 | |
US62/491,746 | 2017-04-28 | ||
PCT/US2018/029915 WO2018201028A1 (en) | 2017-04-28 | 2018-04-27 | Biomarkers for cancer therapeutics |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112019022488A2 true BR112019022488A2 (pt) | 2020-06-16 |
Family
ID=62244544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019022488-2A BR112019022488A2 (pt) | 2017-04-28 | 2018-04-27 | Biomarcadores para terapêutica do câncer |
Country Status (15)
Country | Link |
---|---|
US (1) | US20210008135A1 (pt) |
EP (2) | EP3615934A1 (pt) |
JP (1) | JP2020517715A (pt) |
KR (1) | KR20190139225A (pt) |
CN (1) | CN110678750A (pt) |
AR (1) | AR111432A1 (pt) |
AU (1) | AU2018260777A1 (pt) |
BR (1) | BR112019022488A2 (pt) |
CA (1) | CA3057157A1 (pt) |
CL (1) | CL2019002904A1 (pt) |
EA (1) | EA201992575A1 (pt) |
MX (1) | MX2019012741A (pt) |
SG (2) | SG10202110526WA (pt) |
TW (1) | TW201900193A (pt) |
WO (1) | WO2018201028A1 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2008266951B2 (en) | 2007-06-18 | 2013-12-12 | Merck Sharp & Dohme B.V. | Antibodies to human programmed death receptor PD-1 |
KR20200078483A (ko) * | 2017-10-27 | 2020-07-01 | 머크 샤프 앤드 돔 코포레이션 | 간암 치료를 위한 조성물 및 방법 |
TW202102543A (zh) * | 2019-03-29 | 2021-01-16 | 美商安進公司 | 溶瘤病毒在癌症新輔助療法中之用途 |
US20220018844A1 (en) * | 2020-07-20 | 2022-01-20 | University Of Baltimore, Maryland | Method for Treating a Cancer Based on Inflammatory Subtype Thereof |
CN111766125A (zh) * | 2020-07-29 | 2020-10-13 | 广州金域医学检验中心有限公司 | 利用荧光淬灭时间差进行的染色方法及自动染色装置、设备和介质 |
US20230303700A1 (en) * | 2020-08-31 | 2023-09-28 | Bristol-Myers Squibb Company | Cell localization signature and immunotherapy |
KR102524548B1 (ko) * | 2020-11-06 | 2023-04-20 | 사회복지법인 삼성생명공익재단 | 항암제 반응성 예측용 바이오마커 및 이의 용도 |
WO2022271033A1 (en) * | 2021-06-24 | 2022-12-29 | Seljelid, Rolf | Combination of an oncolytic virus, an anti-pd-1 inhibitor and an activator of the innate immune system for use in the treatment of prostate cancer |
Family Cites Families (49)
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US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
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BR112017025562A2 (pt) | 2015-05-29 | 2018-08-07 | Merck Sharp & Dohme Corp. | métodos para tratar câncer em um indivíduo e para tratar um indivíduo humano diagnosticado com câncer |
KR20200078483A (ko) * | 2017-10-27 | 2020-07-01 | 머크 샤프 앤드 돔 코포레이션 | 간암 치료를 위한 조성물 및 방법 |
-
2018
- 2018-04-27 JP JP2019558526A patent/JP2020517715A/ja active Pending
- 2018-04-27 EA EA201992575A patent/EA201992575A1/ru unknown
- 2018-04-27 AR ARP180101096A patent/AR111432A1/es unknown
- 2018-04-27 CN CN201880026945.7A patent/CN110678750A/zh active Pending
- 2018-04-27 BR BR112019022488-2A patent/BR112019022488A2/pt unknown
- 2018-04-27 KR KR1020197030511A patent/KR20190139225A/ko not_active Application Discontinuation
- 2018-04-27 EP EP18727090.5A patent/EP3615934A1/en not_active Ceased
- 2018-04-27 TW TW107114398A patent/TW201900193A/zh unknown
- 2018-04-27 MX MX2019012741A patent/MX2019012741A/es unknown
- 2018-04-27 CA CA3057157A patent/CA3057157A1/en active Pending
- 2018-04-27 AU AU2018260777A patent/AU2018260777A1/en active Pending
- 2018-04-27 SG SG10202110526WA patent/SG10202110526WA/en unknown
- 2018-04-27 SG SG11201908296V patent/SG11201908296VA/en unknown
- 2018-04-27 WO PCT/US2018/029915 patent/WO2018201028A1/en active Application Filing
- 2018-04-27 EP EP22163106.2A patent/EP4063859A1/en active Pending
- 2018-04-27 US US16/499,095 patent/US20210008135A1/en active Pending
-
2019
- 2019-10-11 CL CL2019002904A patent/CL2019002904A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2018201028A1 (en) | 2018-11-01 |
TW201900193A (zh) | 2019-01-01 |
AU2018260777A1 (en) | 2019-10-17 |
EA201992575A1 (ru) | 2020-04-13 |
SG10202110526WA (en) | 2021-11-29 |
JP2020517715A (ja) | 2020-06-18 |
KR20190139225A (ko) | 2019-12-17 |
EP4063859A1 (en) | 2022-09-28 |
SG11201908296VA (en) | 2019-10-30 |
CA3057157A1 (en) | 2018-11-01 |
US20210008135A1 (en) | 2021-01-14 |
CL2019002904A1 (es) | 2020-01-17 |
AR111432A1 (es) | 2019-07-10 |
EP3615934A1 (en) | 2020-03-04 |
CN110678750A (zh) | 2020-01-10 |
MX2019012741A (es) | 2020-01-21 |
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