JP2018514794A5 - - Google Patents
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- JP2018514794A5 JP2018514794A5 JP2018509734A JP2018509734A JP2018514794A5 JP 2018514794 A5 JP2018514794 A5 JP 2018514794A5 JP 2018509734 A JP2018509734 A JP 2018509734A JP 2018509734 A JP2018509734 A JP 2018509734A JP 2018514794 A5 JP2018514794 A5 JP 2018514794A5
- Authority
- JP
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- Prior art keywords
- particle
- optionally
- targeted
- biomolecule
- magnetic core
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002245 particle Substances 0.000 claims description 67
- 239000007771 core particle Substances 0.000 claims description 26
- 239000000203 mixture Substances 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 22
- 230000008685 targeting Effects 0.000 claims description 22
- 235000018102 proteins Nutrition 0.000 claims description 16
- 102000004169 proteins and genes Human genes 0.000 claims description 16
- 108090000623 proteins and genes Proteins 0.000 claims description 16
- 241000894007 species Species 0.000 claims description 16
- 239000002131 composite material Substances 0.000 claims description 14
- 229920000642 polymer Polymers 0.000 claims description 14
- 239000011521 glass Substances 0.000 claims description 12
- 239000012472 biological sample Substances 0.000 claims description 10
- 239000011541 reaction mixture Substances 0.000 claims description 10
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 8
- 108010001857 Cell Surface Receptors Proteins 0.000 claims description 8
- 239000013078 crystal Substances 0.000 claims description 8
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 claims description 8
- 239000003446 ligand Substances 0.000 claims description 8
- 102000006240 membrane receptors Human genes 0.000 claims description 8
- 239000002122 magnetic nanoparticle Substances 0.000 claims description 5
- 108090001008 Avidin Proteins 0.000 claims description 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 4
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 4
- 108010090804 Streptavidin Proteins 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- 229960002685 biotin Drugs 0.000 claims description 4
- 235000020958 biotin Nutrition 0.000 claims description 4
- 239000011616 biotin Substances 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 241000283690 Bos taurus Species 0.000 claims description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
- 229910052692 Dysprosium Inorganic materials 0.000 claims description 2
- 229910052688 Gadolinium Inorganic materials 0.000 claims description 2
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 2
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 2
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims description 2
- 108010071390 Serum Albumin Proteins 0.000 claims description 2
- 102000007562 Serum Albumin Human genes 0.000 claims description 2
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical group [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims description 2
- WGLPBDUCMAPZCE-UHFFFAOYSA-N Trioxochromium Chemical compound O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 claims description 2
- -1 amino, sulfhydryl Chemical group 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 239000005018 casein Substances 0.000 claims description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 2
- 235000021240 caseins Nutrition 0.000 claims description 2
- 229910000423 chromium oxide Inorganic materials 0.000 claims description 2
- 230000002939 deleterious effect Effects 0.000 claims description 2
- 238000012377 drug delivery Methods 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 238000005339 levitation Methods 0.000 claims description 2
- 230000005389 magnetism Effects 0.000 claims description 2
- 229910052748 manganese Inorganic materials 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229910021645 metal ion Inorganic materials 0.000 claims description 2
- 229910044991 metal oxide Inorganic materials 0.000 claims description 2
- 150000004706 metal oxides Chemical class 0.000 claims description 2
- 239000011859 microparticle Substances 0.000 claims description 2
- 229910052759 nickel Inorganic materials 0.000 claims description 2
- 235000004252 protein component Nutrition 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- 229910000077 silane Inorganic materials 0.000 claims description 2
- 229910052725 zinc Inorganic materials 0.000 claims description 2
- 239000006249 magnetic particle Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 230000009257 reactivity Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 230000014509 gene expression Effects 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562156141P | 2015-05-01 | 2015-05-01 | |
| US62/156,141 | 2015-05-01 | ||
| PCT/US2016/030327 WO2016179053A1 (en) | 2015-05-01 | 2016-04-30 | Stable nanomagnetic particle dispersions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018514794A JP2018514794A (ja) | 2018-06-07 |
| JP2018514794A5 true JP2018514794A5 (enExample) | 2019-04-04 |
| JP6716683B2 JP6716683B2 (ja) | 2020-07-01 |
Family
ID=57205761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018509734A Active JP6716683B2 (ja) | 2015-05-01 | 2016-04-30 | 安定なナノ磁性粒子分散 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US10585088B2 (enExample) |
| EP (1) | EP3288912A4 (enExample) |
| JP (1) | JP6716683B2 (enExample) |
| CN (1) | CN107614458B (enExample) |
| IL (2) | IL255354B (enExample) |
| WO (1) | WO2016179053A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11291931B2 (en) | 2014-12-15 | 2022-04-05 | Akadeum Life Sciences, Inc. | Method and system for buoyant separation |
| US10585088B2 (en) | 2015-05-01 | 2020-03-10 | BioLegend, Inc. | Stable nanomagnetic particle dispersions |
| CA2989966C (en) * | 2015-08-20 | 2024-04-30 | Albumedix A/S | Albumin variants and conjugates |
| US20190127697A1 (en) * | 2016-04-30 | 2019-05-02 | BioLegend, Inc. | Compositions and methods for performing magnetibuoyant separations |
| WO2018112262A2 (en) | 2016-12-16 | 2018-06-21 | Diagnologix, Llc | Buoyancy enabled separation method and system |
| WO2020014273A1 (en) | 2018-07-09 | 2020-01-16 | Akadeum Life Sciences, Inc. | System and method for buoyant particle processing |
| EP3851854A4 (en) | 2018-10-17 | 2022-06-29 | Ezdiatech Inc. | Biomaterial-detecting microparticle and biomaterial detection method using same |
| EP3693739A1 (de) * | 2019-02-06 | 2020-08-12 | Stefan Schreier | Verfahren und vorrichtung zur isolierung von gewünschten zellen aus einer probe nicht-magnetischer biologischer materialien |
| FR3100338B1 (fr) * | 2019-08-30 | 2022-09-02 | Centre Nat Rech Scient | Kit et méthode de capture d’une molécule |
| KR102272916B1 (ko) * | 2019-09-27 | 2021-07-06 | 주식회사 이지다이아텍 | 새로운 암 poct 진단시스템 |
| CN112641955B (zh) * | 2021-01-18 | 2022-04-19 | 四川大学 | 人间充质干细胞小囊泡作为靶向递药平台的应用 |
| US11819842B2 (en) | 2021-08-26 | 2023-11-21 | Akadeum Life Sciences, Inc. | Method and system for buoyant separation |
| CN113583865A (zh) * | 2021-10-08 | 2021-11-02 | 深圳市瑞沃德生命科技有限公司 | 分选柱的制备方法及分选柱 |
| CN114459877B (zh) * | 2021-12-17 | 2024-05-10 | 中国计量科学研究院 | 用于富集外泌体的dna四面体复合磁性纳米材料及制备 |
| EP4504367A1 (en) | 2022-04-01 | 2025-02-12 | Akadeum Life Sciences, Inc. | Method and system for buoyant-particle-assisted cell therapy |
| US12370266B2 (en) * | 2022-09-13 | 2025-07-29 | Core Quantum, Inc. | Polymer composite nanomaterial encapsulation system |
| US12099050B2 (en) | 2023-02-14 | 2024-09-24 | Akadeum Life Sciences, Inc. | Method and system for partially or fully automated buoyancy-assisted separation |
| EP4435045A1 (en) * | 2023-03-21 | 2024-09-25 | COSA Group GmbH | Labelled particles |
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| US10585088B2 (en) | 2015-05-01 | 2020-03-10 | BioLegend, Inc. | Stable nanomagnetic particle dispersions |
| US20190127697A1 (en) | 2016-04-30 | 2019-05-02 | BioLegend, Inc. | Compositions and methods for performing magnetibuoyant separations |
-
2016
- 2016-04-30 US US15/143,552 patent/US10585088B2/en active Active
- 2016-04-30 WO PCT/US2016/030327 patent/WO2016179053A1/en not_active Ceased
- 2016-04-30 EP EP16789869.1A patent/EP3288912A4/en active Pending
- 2016-04-30 CN CN201680031170.3A patent/CN107614458B/zh active Active
- 2016-04-30 JP JP2018509734A patent/JP6716683B2/ja active Active
-
2017
- 2017-10-31 IL IL255354A patent/IL255354B/en active IP Right Grant
-
2019
- 2019-12-18 US US16/719,337 patent/US11630104B2/en active Active
-
2020
- 2020-09-03 IL IL277137A patent/IL277137B/en unknown
-
2023
- 2023-01-19 US US18/099,224 patent/US12461095B2/en active Active
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