JP6716683B2 - 安定なナノ磁性粒子分散 - Google Patents
安定なナノ磁性粒子分散 Download PDFInfo
- Publication number
- JP6716683B2 JP6716683B2 JP2018509734A JP2018509734A JP6716683B2 JP 6716683 B2 JP6716683 B2 JP 6716683B2 JP 2018509734 A JP2018509734 A JP 2018509734A JP 2018509734 A JP2018509734 A JP 2018509734A JP 6716683 B2 JP6716683 B2 JP 6716683B2
- Authority
- JP
- Japan
- Prior art keywords
- particles
- targeted
- magnetic
- particle
- nanomagnetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/552—Glass or silica
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Inorganic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562156141P | 2015-05-01 | 2015-05-01 | |
| US62/156,141 | 2015-05-01 | ||
| PCT/US2016/030327 WO2016179053A1 (en) | 2015-05-01 | 2016-04-30 | Stable nanomagnetic particle dispersions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018514794A JP2018514794A (ja) | 2018-06-07 |
| JP2018514794A5 JP2018514794A5 (enExample) | 2019-04-04 |
| JP6716683B2 true JP6716683B2 (ja) | 2020-07-01 |
Family
ID=57205761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018509734A Active JP6716683B2 (ja) | 2015-05-01 | 2016-04-30 | 安定なナノ磁性粒子分散 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US10585088B2 (enExample) |
| EP (1) | EP3288912A4 (enExample) |
| JP (1) | JP6716683B2 (enExample) |
| CN (1) | CN107614458B (enExample) |
| IL (2) | IL255354B (enExample) |
| WO (1) | WO2016179053A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11291931B2 (en) | 2014-12-15 | 2022-04-05 | Akadeum Life Sciences, Inc. | Method and system for buoyant separation |
| EP3288912A4 (en) | 2015-05-01 | 2018-11-07 | Biolegend, Inc. | Stable nanomagnetic particle dispersions |
| US10633428B2 (en) * | 2015-08-20 | 2020-04-28 | Albumedix Ltd | Albumin variants and conjugates |
| WO2017190117A1 (en) | 2016-04-30 | 2017-11-02 | BioLegend, Inc. | Compositions and methods for performing magnetibuoyant separations |
| EP3555267B1 (en) * | 2016-12-16 | 2021-08-04 | Diagnologix, LLC | Buoyancy enabled separation method and system |
| JP7189314B2 (ja) | 2018-07-09 | 2022-12-13 | アカデューム ライフ サイエンセズ,インコーポレイテッド | 浮遊性粒子を処理するシステムおよび方法 |
| WO2020080833A1 (ko) * | 2018-10-17 | 2020-04-23 | 주식회사 이지다이아텍 | 생체물질 검출용 미세 입자 및 이를 이용한 생체물질 검출방법 |
| EP3693739A1 (de) * | 2019-02-06 | 2020-08-12 | Stefan Schreier | Verfahren und vorrichtung zur isolierung von gewünschten zellen aus einer probe nicht-magnetischer biologischer materialien |
| FR3100338B1 (fr) * | 2019-08-30 | 2022-09-02 | Centre Nat Rech Scient | Kit et méthode de capture d’une molécule |
| KR102272915B1 (ko) * | 2019-09-27 | 2021-07-06 | 주식회사 이지다이아텍 | 새로운 외상성 뇌손상 및 감염병 poct 진단시스템 |
| CN112641955B (zh) * | 2021-01-18 | 2022-04-19 | 四川大学 | 人间充质干细胞小囊泡作为靶向递药平台的应用 |
| US11819842B2 (en) | 2021-08-26 | 2023-11-21 | Akadeum Life Sciences, Inc. | Method and system for buoyant separation |
| CN113583865A (zh) * | 2021-10-08 | 2021-11-02 | 深圳市瑞沃德生命科技有限公司 | 分选柱的制备方法及分选柱 |
| CN114459877B (zh) * | 2021-12-17 | 2024-05-10 | 中国计量科学研究院 | 用于富集外泌体的dna四面体复合磁性纳米材料及制备 |
| WO2023191984A1 (en) | 2022-04-01 | 2023-10-05 | Akadeum Life Sciences, Inc. | Method and system for buoyant-particle-assisted cell therapy |
| US12370266B2 (en) * | 2022-09-13 | 2025-07-29 | Core Quantum, Inc. | Polymer composite nanomaterial encapsulation system |
| EP4646244A1 (en) | 2023-02-14 | 2025-11-12 | Akadeum Life Sciences, Inc. | Method and system for partially or fully automated buoyancy-assisted separation |
| EP4435045A1 (en) * | 2023-03-21 | 2024-09-25 | COSA Group GmbH | Labelled particles |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3933997A (en) | 1974-03-01 | 1976-01-20 | Corning Glass Works | Solid phase radioimmunoassay of digoxin |
| GB1582956A (en) | 1976-07-30 | 1981-01-21 | Ici Ltd | Composite magnetic particles |
| US4169804A (en) | 1976-08-19 | 1979-10-02 | Minnesota Mining And Manufacturing Company | Magnetically responsive composite microparticle |
| US4267234A (en) | 1978-03-17 | 1981-05-12 | California Institute Of Technology | Polyglutaraldehyde synthesis and protein bonding substrates |
| US4230685A (en) | 1979-02-28 | 1980-10-28 | Northwestern University | Method of magnetic separation of cells and the like, and microspheres for use therein |
| FR2480764B1 (fr) | 1980-04-18 | 1985-10-04 | Rhone Poulenc Spec Chim | Latex de polymeres magnetiques et procede de preparation |
| IL63220A (en) | 1981-07-01 | 1985-09-29 | Yeda Res & Dev | Process for production of polyacrolein microspheres |
| US4454234A (en) | 1981-12-30 | 1984-06-12 | Czerlinski George H | Coated magnetizable microparticles, reversible suspensions thereof, and processes relating thereto |
| US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
| NO155316C (no) | 1982-04-23 | 1987-03-11 | Sintef | Fremgangsmaate for fremstilling av magnetiske polymerpartikler. |
| US4695392A (en) | 1983-05-12 | 1987-09-22 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| US4554088A (en) | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| US5246829A (en) | 1984-10-04 | 1993-09-21 | Immunotech | Products for separation applicable to cells in the immunopurification field |
| FR2571498B1 (fr) | 1984-10-04 | 1988-04-08 | Immunotech Sa | Procede de separation de cellules utilisant des anticorps et des billes de faible densite |
| US4582622A (en) | 1984-10-12 | 1986-04-15 | Fujirebio Kabushiki Kaisha | Magnetic particulate for immobilization of biological protein and process of producing the same |
| US5597531A (en) | 1985-10-04 | 1997-01-28 | Immunivest Corporation | Resuspendable coated magnetic particles and stable magnetic particle suspensions |
| US5512332A (en) | 1985-10-04 | 1996-04-30 | Immunivest Corporation | Process of making resuspendable coated magnetic particles |
| US4795698A (en) | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
| US5069216A (en) * | 1986-07-03 | 1991-12-03 | Advanced Magnetics Inc. | Silanized biodegradable super paramagnetic metal oxides as contrast agents for imaging the gastrointestinal tract |
| US5091206A (en) | 1987-10-26 | 1992-02-25 | Baxter Diagnostics Inc. | Process for producing magnetically responsive polymer particles and application thereof |
| US4965007A (en) | 1988-05-10 | 1990-10-23 | Eastman Kodak Company | Encapsulated superparamagnetic particles |
| US5108933A (en) | 1988-09-16 | 1992-04-28 | Immunicon Corporation | Manipulation of colloids for facilitating magnetic separations |
| US5385707A (en) | 1988-12-28 | 1995-01-31 | Stefan Miltenyi | Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same |
| US5698271A (en) | 1989-08-22 | 1997-12-16 | Immunivest Corporation | Methods for the manufacture of magnetically responsive particles |
| JP2979414B2 (ja) | 1989-09-29 | 1999-11-15 | 富士レビオ株式会社 | 磁性粒子およびそれを用いた免疫測定法 |
| US5169754A (en) | 1990-10-31 | 1992-12-08 | Coulter Corporation | Biodegradable particle coatings having a protein covalently immobilized by means of a crosslinking agent and processes for making same |
| US5639620A (en) | 1990-10-31 | 1997-06-17 | Coulter Corporation | Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same |
| US5186827A (en) | 1991-03-25 | 1993-02-16 | Immunicon Corporation | Apparatus for magnetic separation featuring external magnetic means |
| US5610274A (en) | 1991-11-20 | 1997-03-11 | Cpg, Inc. | Production and use of magnetic porous inorganic materials |
| AU670108B2 (en) * | 1992-09-11 | 1996-07-04 | Becton Dickinson & Company | Improved antibodies to plasmodium falciparum |
| US5648124A (en) | 1993-07-09 | 1997-07-15 | Seradyn, Inc. | Process for preparing magnetically responsive microparticles |
| US5411730A (en) | 1993-07-20 | 1995-05-02 | Research Corporation Technologies, Inc. | Magnetic microparticles |
| DE19520398B4 (de) | 1995-06-08 | 2009-04-16 | Roche Diagnostics Gmbh | Magnetisches Pigment |
| DE19528029B4 (de) | 1995-07-31 | 2008-01-10 | Chemagen Biopolymer-Technologie Aktiengesellschaft | Magnetische Polymerpartikel auf der Basis von Polyvinylalkohol, Verfahren für ihre Herstellung und Verwendung |
| US20070036722A1 (en) | 1996-10-28 | 2007-02-15 | Pal Rongved | Separation processes |
| AU7685498A (en) * | 1997-05-14 | 1998-12-08 | Weixin Tang | Fully-coated, uniform-sized metallic particles |
| EP1073716B1 (en) | 1998-04-28 | 2004-04-28 | Amersham Health AS | Improvements in or relating to separation processes |
| JP2002535678A (ja) | 1999-01-27 | 2002-10-22 | バイエル コーポレイション | 粒子のカゼインコーティングを用いる免疫アッセイ |
| US7169618B2 (en) * | 2000-06-28 | 2007-01-30 | Skold Technology | Magnetic particles and methods of producing coated magnetic particles |
| EP1311820B1 (en) * | 2000-07-14 | 2015-02-11 | Janssen Diagnostics, LLC | Increased separation efficiency via controlled aggregation of magnetic nanoparticles |
| US20080194022A1 (en) | 2000-08-03 | 2008-08-14 | Clarke Michael F | Isolation and use of solid tumor stem cells |
| WO2004003142A2 (en) | 2002-06-28 | 2004-01-08 | Xcyte Therapies, Inc. | Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| WO2006137933A2 (en) | 2004-11-03 | 2006-12-28 | Leucadia Technologies, Inc. | Microbubbles for affinity separation |
| US20060216697A1 (en) * | 2005-03-24 | 2006-09-28 | General Electric Company | Method of separating unattached Raman-active tag from bioassay or other reaction mixture |
| EP1715344A1 (en) * | 2005-04-22 | 2006-10-25 | Universiteit Utrecht Holding B.V. | Immobilisation of antigenic carbohydrates to support detection of pathogenic micro-organisms |
| US7989065B2 (en) | 2005-05-20 | 2011-08-02 | Seradyn, Inc. | Magnetically-responsive microparticles with improved response times |
| CN1312046C (zh) * | 2005-07-07 | 2007-04-25 | 华中科技大学 | 一种超顺磁氧化铁复合纳米颗粒的制备方法 |
| US20070026435A1 (en) | 2005-07-28 | 2007-02-01 | Polysciences, Inc. | Hydroxysilane functionalized magnetic particles and nucleic acid separation method |
| CN101305087A (zh) * | 2005-09-15 | 2008-11-12 | 阿尔特弥斯康复公司 | 用于磁富集细胞和其他颗粒的装置和方法 |
| CN1951495B (zh) * | 2005-10-25 | 2010-12-01 | 朱宏 | 恶性肿瘤磁热疗用纳米靶向药物 |
| GB0616508D0 (en) | 2006-08-18 | 2006-09-27 | Iti Scotland Ltd | Analyte manipulation and detection |
| CA2662795A1 (en) | 2006-09-05 | 2008-03-13 | Columbus Nanoworks, Inc. | Magnetic particles and methods of making and using the same |
| WO2011053435A1 (en) | 2009-10-05 | 2011-05-05 | Scientific Nanomedicine, Inc. | Cell detection using targeted nanoparticles and magnetic properties thereof |
| GB0701641D0 (en) * | 2007-01-29 | 2007-03-07 | Iti Scotland Ltd | Analyte manipulation and detection |
| CN101013132A (zh) * | 2007-01-30 | 2007-08-08 | 上海师范大学 | 一种免疫荧光磁球及其制备方法和应用 |
| US20110045081A1 (en) * | 2007-10-12 | 2011-02-24 | Benedikt Steitz | Magnetic, paramagnetic and/or superparamagnetic nanoparticles |
| CN101441210B (zh) * | 2008-12-25 | 2013-08-28 | 上海交通大学 | 纳米磁性粒子层析试纸检测方法 |
| JP5960146B2 (ja) * | 2010-10-14 | 2016-08-02 | ジャンセン ダイアグノスティックス,エルエルシー | 多特異性捕捉試薬及び混合検出試薬を用いる膵臓患者の循環腫瘍細胞を検出する方法及びキット |
| CN102617810B (zh) * | 2012-02-27 | 2014-09-24 | 重庆医科大学 | 用两端带羧基的直链亲水聚合物包被纳米磁芯制备微纳米磁性材料的方法及其应用 |
| JP5844195B2 (ja) * | 2012-03-29 | 2016-01-13 | 三洋化成工業株式会社 | 磁性シリカ粒子並びにこれを用いた免疫測定法及び免疫測定用試薬 |
| US10060915B2 (en) | 2012-03-31 | 2018-08-28 | Nvigen, Inc. | Multifunctional nanoparticles for molecular and cellular separation, detection and quantification |
| US9797817B2 (en) | 2012-05-03 | 2017-10-24 | The Regents Of The University Of Michigan | Multi-mode separation for target detection |
| US9599610B2 (en) | 2012-12-19 | 2017-03-21 | Dnae Group Holdings Limited | Target capture system |
| JP2014156411A (ja) | 2013-02-14 | 2014-08-28 | Toda Kogyo Corp | 複合磁性微粒子粉末、分散体 |
| CN103323603A (zh) * | 2013-06-07 | 2013-09-25 | 博奥生物有限公司 | 一种在磁珠表面共价偶联蛋白质的方法 |
| US20150219636A1 (en) | 2014-01-28 | 2015-08-06 | Targeson, Inc. | Isolation of cells and biological substances using buoyant microbubbles |
| WO2016100290A1 (en) | 2014-12-15 | 2016-06-23 | Akadeum Life Sciences, LLC | Method and system for buoyant separation |
| EP3288912A4 (en) | 2015-05-01 | 2018-11-07 | Biolegend, Inc. | Stable nanomagnetic particle dispersions |
| WO2017190117A1 (en) | 2016-04-30 | 2017-11-02 | BioLegend, Inc. | Compositions and methods for performing magnetibuoyant separations |
-
2016
- 2016-04-30 EP EP16789869.1A patent/EP3288912A4/en active Pending
- 2016-04-30 WO PCT/US2016/030327 patent/WO2016179053A1/en not_active Ceased
- 2016-04-30 US US15/143,552 patent/US10585088B2/en active Active
- 2016-04-30 JP JP2018509734A patent/JP6716683B2/ja active Active
- 2016-04-30 CN CN201680031170.3A patent/CN107614458B/zh active Active
-
2017
- 2017-10-31 IL IL255354A patent/IL255354B/en active IP Right Grant
-
2019
- 2019-12-18 US US16/719,337 patent/US11630104B2/en active Active
-
2020
- 2020-09-03 IL IL277137A patent/IL277137B/en unknown
-
2023
- 2023-01-19 US US18/099,224 patent/US12461095B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10585088B2 (en) | 2020-03-10 |
| IL255354A0 (en) | 2017-12-31 |
| CN107614458B (zh) | 2021-05-11 |
| US20160320376A1 (en) | 2016-11-03 |
| US12461095B2 (en) | 2025-11-04 |
| US20230160884A1 (en) | 2023-05-25 |
| IL255354B (en) | 2020-09-30 |
| CN107614458A (zh) | 2018-01-19 |
| IL277137B (en) | 2021-08-31 |
| US20200200746A1 (en) | 2020-06-25 |
| EP3288912A4 (en) | 2018-11-07 |
| CA2984506A1 (en) | 2016-11-10 |
| US11630104B2 (en) | 2023-04-18 |
| WO2016179053A1 (en) | 2016-11-10 |
| IL277137A (en) | 2020-10-29 |
| EP3288912A1 (en) | 2018-03-07 |
| JP2018514794A (ja) | 2018-06-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12461095B2 (en) | Stable nanomagnetic particle dispersions | |
| US20230272344A1 (en) | Compositions and methods for performing magnetibuoyant separations | |
| US9739768B2 (en) | Methods and reagents for improved selection of biological materials | |
| JP6255035B2 (ja) | 分離方法、検出方法、シグナル測定方法、疾患の判定方法、疾患治療薬の薬効評価方法、キット及び液状組成物 | |
| US6620627B1 (en) | Increased separation efficiency via controlled aggregation of magnetic nanoparticles | |
| DK1311820T3 (en) | Increased separation efficiency via a controlled aggregation of magnetic nanoparticles | |
| JP2018514794A5 (enExample) | ||
| Rashid et al. | Surface modification and bioconjugation of anti-CD4 monoclonal antibody to magnetic nanoparticles as a highly efficient affinity adsorbent for positive selection of peripheral blood T CD4+ lymphocytes | |
| CA2984506C (en) | Stable nanomagnetic particle dispersions | |
| US20160282353A1 (en) | Systems and methods of detecting malignant cells | |
| JP5080434B2 (ja) | 生物学的試料から標的生体部分を単離する方法およびそのためのキット | |
| CN107532149A (zh) | 通过各成分基本上同时孵育和通用载体以分离细胞 | |
| Gauffin et al. | Improved Magnetic Beads for Large Scale Separation of Biomolecules |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20181112 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20181112 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20181114 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190221 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190221 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20191120 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20191227 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200228 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20200605 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20200610 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6716683 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |