JP2018513212A5 - - Google Patents
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- JP2018513212A5 JP2018513212A5 JP2018503726A JP2018503726A JP2018513212A5 JP 2018513212 A5 JP2018513212 A5 JP 2018513212A5 JP 2018503726 A JP2018503726 A JP 2018503726A JP 2018503726 A JP2018503726 A JP 2018503726A JP 2018513212 A5 JP2018513212 A5 JP 2018513212A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 92
- 229920001184 polypeptide Polymers 0.000 claims description 82
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 82
- 239000000203 mixture Substances 0.000 claims description 66
- 235000001014 amino acid Nutrition 0.000 claims description 64
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 55
- 150000001413 amino acids Chemical class 0.000 claims description 44
- 238000006467 substitution reaction Methods 0.000 claims description 38
- 239000000126 substance Substances 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 34
- 239000007787 solid Substances 0.000 claims description 31
- 239000011347 resin Substances 0.000 claims description 16
- 229920005989 resin Polymers 0.000 claims description 16
- 239000011324 bead Substances 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 14
- 229920000936 Agarose Polymers 0.000 claims description 12
- 108010010803 Gelatin Proteins 0.000 claims description 12
- 230000027455 binding Effects 0.000 claims description 12
- 239000000356 contaminant Substances 0.000 claims description 12
- 229920000159 gelatin Polymers 0.000 claims description 12
- 239000008273 gelatin Substances 0.000 claims description 12
- 235000019322 gelatine Nutrition 0.000 claims description 12
- 235000011852 gelatine desserts Nutrition 0.000 claims description 12
- 239000011521 glass Substances 0.000 claims description 12
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 11
- 239000002245 particle Substances 0.000 claims description 11
- 239000002904 solvent Substances 0.000 claims description 8
- 230000009870 specific binding Effects 0.000 claims description 8
- 235000018417 cysteine Nutrition 0.000 claims description 5
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 5
- 108010052285 Membrane Proteins Proteins 0.000 claims description 4
- 102000018697 Membrane Proteins Human genes 0.000 claims description 4
- 238000012217 deletion Methods 0.000 claims description 4
- 230000037430 deletion Effects 0.000 claims description 4
- 108020001507 fusion proteins Proteins 0.000 claims description 4
- 102000037865 fusion proteins Human genes 0.000 claims description 4
- 238000001042 affinity chromatography Methods 0.000 claims description 2
- 238000004587 chromatography analysis Methods 0.000 claims description 2
- 239000013604 expression vector Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 3
- 230000008878 coupling Effects 0.000 claims 3
- 238000010168 coupling process Methods 0.000 claims 3
- 238000005859 coupling reaction Methods 0.000 claims 3
- BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 241000700605 Viruses Species 0.000 description 3
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 description 2
- 108010093488 His-His-His-His-His-His Proteins 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 2
- 108010090804 Streptavidin Proteins 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562143772P | 2015-04-06 | 2015-04-06 | |
| US62/143,772 | 2015-04-06 | ||
| PCT/US2016/025880 WO2016164308A1 (en) | 2015-04-06 | 2016-04-04 | De novo binding domain containing polypeptides and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018513212A JP2018513212A (ja) | 2018-05-24 |
| JP2018513212A5 true JP2018513212A5 (enExample) | 2019-05-09 |
| JP6873101B2 JP6873101B2 (ja) | 2021-05-19 |
Family
ID=57072017
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018503726A Active JP6873101B2 (ja) | 2015-04-06 | 2016-04-04 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2018503725A Active JP6871232B2 (ja) | 2015-04-06 | 2016-04-04 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2021068754A Active JP7244567B2 (ja) | 2015-04-06 | 2021-04-15 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2023007753A Withdrawn JP2023052563A (ja) | 2015-04-06 | 2023-01-23 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2024049923A Pending JP2024075751A (ja) | 2015-04-06 | 2024-03-26 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018503725A Active JP6871232B2 (ja) | 2015-04-06 | 2016-04-04 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2021068754A Active JP7244567B2 (ja) | 2015-04-06 | 2021-04-15 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2023007753A Withdrawn JP2023052563A (ja) | 2015-04-06 | 2023-01-23 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2024049923A Pending JP2024075751A (ja) | 2015-04-06 | 2024-03-26 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (9) | US10647775B2 (enExample) |
| EP (3) | EP3903804A1 (enExample) |
| JP (5) | JP6873101B2 (enExample) |
| KR (2) | KR102788389B1 (enExample) |
| CN (4) | CN120424177A (enExample) |
| AU (4) | AU2016246426B2 (enExample) |
| BR (1) | BR112017021308A2 (enExample) |
| CA (2) | CA2981616C (enExample) |
| CY (1) | CY1124453T1 (enExample) |
| DK (2) | DK3280432T3 (enExample) |
| EA (1) | EA201792226A1 (enExample) |
| ES (2) | ES2866202T3 (enExample) |
| HR (1) | HRP20210498T1 (enExample) |
| HU (1) | HUE054435T2 (enExample) |
| IL (2) | IL254907B (enExample) |
| LT (1) | LT3280432T (enExample) |
| MX (2) | MX387517B (enExample) |
| PH (1) | PH12017501834B1 (enExample) |
| PL (1) | PL3280432T3 (enExample) |
| PT (1) | PT3280432T (enExample) |
| RS (1) | RS61907B1 (enExample) |
| SG (2) | SG11201708257UA (enExample) |
| SI (1) | SI3280432T1 (enExample) |
| SM (1) | SMT202100285T1 (enExample) |
| WO (3) | WO2016164308A1 (enExample) |
| ZA (1) | ZA201706875B (enExample) |
Families Citing this family (54)
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| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| RS61907B1 (sr) | 2015-04-06 | 2021-06-30 | Subdomain Llc | Polipeptidi koji sadrže de novo vezujući domen i njihova primena |
| WO2018075586A1 (en) * | 2016-10-18 | 2018-04-26 | Memorial Sloan-Kettering Cancer Center | Antigen-binding proteins targeting melanoma differentiation antigens and uses thereof |
| CN110944651A (zh) | 2017-02-08 | 2020-03-31 | 蜻蜓疗法股份有限公司 | 用于自然杀伤细胞激活的多特异性结合蛋白及其治疗癌症的治疗性用途 |
| AU2018219348A1 (en) * | 2017-02-10 | 2019-08-29 | Dragonfly Therapeutics, Inc. | Proteins binding BCMA, NKG2D and CD16 |
| CN110913902A (zh) * | 2017-02-10 | 2020-03-24 | 蜻蜓疗法股份有限公司 | 结合psma、nkg2d和cd16的蛋白质 |
| ES2955074T3 (es) | 2017-02-20 | 2023-11-28 | Dragonfly Therapeutics Inc | Proteínas que se unen a HER2, NKG2D Y CD16 |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
| CA3026892A1 (en) * | 2017-05-10 | 2018-11-15 | Wellstat Immunotherapeutics, Llc | Enveloped virus resistant to complement inactivation for the treatment of cancer |
| CN107216395B (zh) * | 2017-07-03 | 2018-07-20 | 上海科医联创生物科技有限公司 | 一种tm4sf1特异性嵌合抗原受体及其应用 |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| CA3076611A1 (en) * | 2017-09-23 | 2019-03-28 | Memorial Sloan Kettering Cancer Center | A33 antibody compositions and methods of using the same in radioimmunotherapy |
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| TWI701259B (zh) | 2017-11-09 | 2020-08-11 | 大陸商上海懷越生物科技有限公司 | ４﹘１ｂｂ抗體及其製備方法和應用 |
| AU2018368431B2 (en) * | 2017-11-14 | 2024-03-21 | Arcellx, Inc. | Multifunctional immune cell therapies |
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| KR102832460B1 (ko) | 2018-02-20 | 2025-07-11 | 드래곤플라이 쎄라퓨틱스, 인크. | Cd33, nkg2d, 및 cd16에 결합하는 다중-특이적 결합 단백질, 및 이의 사용 방법 |
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| MX2021001527A (es) | 2018-08-08 | 2021-06-15 | Dragonfly Therapeutics Inc | Proteínas de unión a nkg2d, cd16 y a un antígeno asociado a tumor. |
| MA53293A (fr) | 2018-08-08 | 2021-11-17 | Dragonfly Therapeutics Inc | Protéines de liaison multi-spécifiques se liant à bcma, nkg2d et cd16, et méthodes d'utilisation |
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| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
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| CN114380907B (zh) * | 2020-10-16 | 2024-06-18 | 中国科学院上海药物研究所 | 靶向cmtm6的纳米抗体及其制备方法和应用 |
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