JP2016500255A5 - - Google Patents
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- JP2016500255A5 JP2016500255A5 JP2015545835A JP2015545835A JP2016500255A5 JP 2016500255 A5 JP2016500255 A5 JP 2016500255A5 JP 2015545835 A JP2015545835 A JP 2015545835A JP 2015545835 A JP2015545835 A JP 2015545835A JP 2016500255 A5 JP2016500255 A5 JP 2016500255A5
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- protein
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- 102000004169 proteins and genes Human genes 0.000 claims description 315
- 108090000623 proteins and genes Proteins 0.000 claims description 315
- 210000004027 cell Anatomy 0.000 claims description 267
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 163
- 108091006047 fluorescent proteins Proteins 0.000 claims description 109
- 102000034287 fluorescent proteins Human genes 0.000 claims description 109
- 239000003446 ligand Substances 0.000 claims description 60
- 238000000034 method Methods 0.000 claims description 50
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 50
- 238000004114 suspension culture Methods 0.000 claims description 49
- 229920001184 polypeptide Polymers 0.000 claims description 48
- 239000011325 microbead Substances 0.000 claims description 38
- 239000013598 vector Substances 0.000 claims description 21
- 230000001086 cytosolic effect Effects 0.000 claims description 16
- 239000002773 nucleotide Substances 0.000 claims description 16
- 125000003729 nucleotide group Chemical group 0.000 claims description 16
- 230000035772 mutation Effects 0.000 claims description 11
- 210000004962 mammalian cell Anatomy 0.000 claims description 10
- 125000000539 amino acid group Chemical group 0.000 claims description 9
- 102000039446 nucleic acids Human genes 0.000 claims description 9
- 108020004707 nucleic acids Proteins 0.000 claims description 9
- 150000007523 nucleic acids Chemical class 0.000 claims description 9
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims description 8
- 102000027257 transmembrane receptors Human genes 0.000 claims description 8
- 108091008578 transmembrane receptors Proteins 0.000 claims description 8
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims description 8
- 238000005406 washing Methods 0.000 claims description 8
- 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 claims description 7
- 108060003951 Immunoglobulin Proteins 0.000 claims description 7
- 102000018358 immunoglobulin Human genes 0.000 claims description 7
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims description 5
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims description 5
- 102000009465 Growth Factor Receptors Human genes 0.000 claims description 5
- 108010009202 Growth Factor Receptors Proteins 0.000 claims description 5
- 102000004310 Ion Channels Human genes 0.000 claims description 5
- 108090000862 Ion Channels Proteins 0.000 claims description 5
- 102000002356 Nectin Human genes 0.000 claims description 5
- 108060005251 Nectin Proteins 0.000 claims description 5
- 230000001747 exhibiting effect Effects 0.000 claims description 5
- 102000002467 interleukin receptors Human genes 0.000 claims description 5
- 108010093036 interleukin receptors Proteins 0.000 claims description 5
- 238000012163 sequencing technique Methods 0.000 claims description 5
- 102000019034 Chemokines Human genes 0.000 claims description 4
- 108010012236 Chemokines Proteins 0.000 claims description 4
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 241000238631 Hexapoda Species 0.000 claims description 4
- 102000015696 Interleukins Human genes 0.000 claims description 4
- 108010063738 Interleukins Proteins 0.000 claims description 4
- 102000002689 Toll-like receptor Human genes 0.000 claims description 4
- 108020000411 Toll-like receptor Proteins 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 2
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 7
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 3
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 2
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 2
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 2
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 2
- 108091008035 T cell costimulatory receptors Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 102100021396 Cell surface glycoprotein CD200 receptor 1 Human genes 0.000 claims 1
- 101000969553 Homo sapiens Cell surface glycoprotein CD200 receptor 1 Proteins 0.000 claims 1
- 101001019455 Homo sapiens ICOS ligand Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 102100034980 ICOS ligand Human genes 0.000 claims 1
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 1
- 102000003675 cytokine receptors Human genes 0.000 claims 1
- 108010057085 cytokine receptors Proteins 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000008611 intercellular interaction Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000002493 microarray Methods 0.000 description 55
- 239000007787 solid Substances 0.000 description 13
- 230000000875 corresponding effect Effects 0.000 description 5
- 102000018697 Membrane Proteins Human genes 0.000 description 3
- 108010052285 Membrane Proteins Proteins 0.000 description 3
- 108090000301 Membrane transport proteins Proteins 0.000 description 3
- 102000003939 Membrane transport proteins Human genes 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 210000005260 human cell Anatomy 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 238000001890 transfection Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- 230000010399 physical interaction Effects 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 1
- XZWYTXMRWQJBGX-VXBMVYAYSA-N FLAG peptide Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)CC1=CC=C(O)C=C1 XZWYTXMRWQJBGX-VXBMVYAYSA-N 0.000 description 1
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
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- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 239000005090 green fluorescent protein Substances 0.000 description 1
- 238000007885 magnetic separation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 108010054624 red fluorescent protein Proteins 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- 108091005957 yellow fluorescent proteins Proteins 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261735791P | 2012-12-11 | 2012-12-11 | |
| US61/735,791 | 2012-12-11 | ||
| US201361833588P | 2013-06-11 | 2013-06-11 | |
| US61/833,588 | 2013-06-11 | ||
| PCT/US2013/073275 WO2014093118A1 (en) | 2012-12-11 | 2013-12-05 | Methods for high throughput receptor:ligand identification |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019200491A Division JP7128792B2 (ja) | 2012-12-11 | 2019-11-05 | ハイスループットなレセプター：リガンド同定の方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016500255A JP2016500255A (ja) | 2016-01-12 |
| JP2016500255A5 true JP2016500255A5 (enExample) | 2017-01-19 |
Family
ID=50934838
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545835A Ceased JP2016500255A (ja) | 2012-12-11 | 2013-12-05 | ハイスループットなレセプター：リガンド同定の方法 |
| JP2019200491A Active JP7128792B2 (ja) | 2012-12-11 | 2019-11-05 | ハイスループットなレセプター：リガンド同定の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019200491A Active JP7128792B2 (ja) | 2012-12-11 | 2019-11-05 | ハイスループットなレセプター：リガンド同定の方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10048271B2 (enExample) |
| EP (2) | EP2931949B1 (enExample) |
| JP (2) | JP2016500255A (enExample) |
| KR (1) | KR102208505B1 (enExample) |
| CN (2) | CN105121715B (enExample) |
| AU (2) | AU2013359907B2 (enExample) |
| BR (1) | BR112015013557B1 (enExample) |
| CA (1) | CA2894511C (enExample) |
| IL (2) | IL239096B (enExample) |
| SG (2) | SG11201504558TA (enExample) |
| WO (1) | WO2014093118A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105121715B (zh) | 2012-12-11 | 2018-10-26 | 艾伯特叶史瓦大学爱因斯坦医学院 | 高通量受体:配体鉴定方法 |
| CA2954360C (en) * | 2014-07-07 | 2022-11-22 | Johan ELF | Phenotypic characterization and in situ genotyping of a library of genetically different cells |
| CN109475628A (zh) | 2016-05-18 | 2019-03-15 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
| CA3022331A1 (en) * | 2016-05-18 | 2017-11-23 | Albert Einstein College Of Medicine, Inc. | Variant pd-l1 polypeptides, t-cell modulatory multimeric polypeptides, and methods of use thereof |
| JP7019171B2 (ja) * | 2016-11-24 | 2022-02-15 | 国立研究開発法人物質・材料研究機構 | 細胞表面に存在する分子の結合による細胞間相互作用を計測する方法 |
| WO2018111941A1 (en) * | 2016-12-12 | 2018-06-21 | 13.8, Inc. | Compositions of high affinity reagents and methods of use thereof |
| AU2017379900B2 (en) | 2016-12-22 | 2024-12-05 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| WO2018129474A1 (en) | 2017-01-09 | 2018-07-12 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| EP3596118B1 (en) | 2017-03-15 | 2024-08-21 | Cue Biopharma, Inc. | Combination of multimeric fusion polypeptides and immune checkpoint inhibitor for treating hpv-associated cancer |
| WO2019051127A1 (en) | 2017-09-07 | 2019-03-14 | Cue Biopharma, Inc. | MULTIMER MODULATOR POLYPEPTIDE OF LYMPHOCYTE T HAVING CONJUGATION SITES AND METHODS OF USE THEREOF |
| WO2019139896A1 (en) | 2018-01-09 | 2019-07-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| EP4143221A1 (en) * | 2020-04-30 | 2023-03-08 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Pd-l1 variants with improved affinity towards pd-1 |
| EP4149534A4 (en) | 2020-05-12 | 2024-09-04 | Cue Biopharma, Inc. | MULTIMERIC POLYPEPTIDES MODULATING T CELLS AND METHODS OF USE THEREOF |
| WO2022056014A1 (en) | 2020-09-09 | 2022-03-17 | Cue Biopharma, Inc. | Mhc class ii t-cell modulatory multimeric polypeptides for treating type 1 diabetes mellitus (t1d) and methods of use thereof |
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| US20180221503A1 (en) | 2015-07-31 | 2018-08-09 | Tarveda Therapeutics, Inc. | Compositions and methods for immuno-oncology therapies |
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