CA2894511C - Methods for high throughput receptor:ligand identification - Google Patents

Methods for high throughput receptor:ligand identification Download PDF

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Publication number
CA2894511C
CA2894511C CA2894511A CA2894511A CA2894511C CA 2894511 C CA2894511 C CA 2894511C CA 2894511 A CA2894511 A CA 2894511A CA 2894511 A CA2894511 A CA 2894511A CA 2894511 C CA2894511 C CA 2894511C
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protein
cell
cells
polypeptide
mutant
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French (fr)
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CA2894511A1 (en
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Steven C. Almo
Ronald D. Seidel, Iii
Brandan S. Hillerich
Sarah C. Garrett-Thomson
James D. Love
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Albert Einstein College of Medicine
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/06Methods of screening libraries by measuring effects on living organisms, tissues or cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326Magnetic particles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/149Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
CA2894511A 2012-12-11 2013-12-05 Methods for high throughput receptor:ligand identification Active CA2894511C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261735791P 2012-12-11 2012-12-11
US61/735,791 2012-12-11
US201361833588P 2013-06-11 2013-06-11
US61/833,588 2013-06-11
PCT/US2013/073275 WO2014093118A1 (en) 2012-12-11 2013-12-05 Methods for high throughput receptor:ligand identification

Publications (2)

Publication Number Publication Date
CA2894511A1 CA2894511A1 (en) 2014-06-19
CA2894511C true CA2894511C (en) 2021-12-07

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CA2894511A Active CA2894511C (en) 2012-12-11 2013-12-05 Methods for high throughput receptor:ligand identification

Country Status (11)

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US (2) US10048271B2 (enExample)
EP (2) EP2931949B1 (enExample)
JP (2) JP2016500255A (enExample)
KR (1) KR102208505B1 (enExample)
CN (2) CN105121715B (enExample)
AU (2) AU2013359907B2 (enExample)
BR (1) BR112015013557B1 (enExample)
CA (1) CA2894511C (enExample)
IL (2) IL239096B (enExample)
SG (2) SG11201504558TA (enExample)
WO (1) WO2014093118A1 (enExample)

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Also Published As

Publication number Publication date
CN105121715B (zh) 2018-10-26
US11226339B2 (en) 2022-01-18
US20160011204A1 (en) 2016-01-14
EP2931949A4 (en) 2016-07-27
HK1218144A1 (zh) 2017-02-03
SG10201808463RA (en) 2018-11-29
IL262785A (en) 2018-12-31
AU2018201812A1 (en) 2018-04-05
CA2894511A1 (en) 2014-06-19
JP2016500255A (ja) 2016-01-12
AU2013359907A1 (en) 2015-06-18
EP3640375A3 (en) 2020-07-29
KR102208505B1 (ko) 2021-01-27
AU2018201812B2 (en) 2020-09-10
IL239096B (en) 2019-03-31
EP2931949B1 (en) 2019-09-18
JP7128792B2 (ja) 2022-08-31
EP3640375A2 (en) 2020-04-22
KR20150094674A (ko) 2015-08-19
JP2020043860A (ja) 2020-03-26
IL239096A0 (en) 2015-07-30
EP2931949A1 (en) 2015-10-21
BR112015013557A2 (pt) 2020-01-14
BR112015013557B1 (pt) 2021-12-14
IL262785B (en) 2020-04-30
SG11201504558TA (en) 2015-07-30
CN109324190A (zh) 2019-02-12
WO2014093118A1 (en) 2014-06-19
CN105121715A (zh) 2015-12-02
US10048271B2 (en) 2018-08-14
US20200011875A1 (en) 2020-01-09
AU2013359907B2 (en) 2018-01-18

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