JP2010527919A5 - - Google Patents
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- JP2010527919A5 JP2010527919A5 JP2010507463A JP2010507463A JP2010527919A5 JP 2010527919 A5 JP2010527919 A5 JP 2010527919A5 JP 2010507463 A JP2010507463 A JP 2010507463A JP 2010507463 A JP2010507463 A JP 2010507463A JP 2010527919 A5 JP2010527919 A5 JP 2010527919A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- protein complex
- soluble
- polypeptide
- soluble fusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000037865 fusion proteins Human genes 0.000 claims 77
- 108020001507 fusion proteins Proteins 0.000 claims 77
- 102000003812 Interleukin-15 Human genes 0.000 claims 55
- 108090000172 Interleukin-15 Proteins 0.000 claims 55
- 108090000765 processed proteins & peptides Proteins 0.000 claims 34
- 229920001184 polypeptide Polymers 0.000 claims 30
- 102000004196 processed proteins & peptides Human genes 0.000 claims 30
- 210000004027 cell Anatomy 0.000 claims 22
- 108091008874 T cell receptors Proteins 0.000 claims 20
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 20
- 150000001413 amino acids Chemical class 0.000 claims 16
- 238000006467 substitution reaction Methods 0.000 claims 16
- 239000012634 fragment Substances 0.000 claims 15
- 239000000427 antigen Substances 0.000 claims 14
- 102000036639 antigens Human genes 0.000 claims 13
- 108091007433 antigens Proteins 0.000 claims 13
- 239000002609 medium Substances 0.000 claims 11
- 230000027455 binding Effects 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102000005962 receptors Human genes 0.000 claims 7
- 108020003175 receptors Proteins 0.000 claims 7
- 101001055157 Homo sapiens Interleukin-15 Proteins 0.000 claims 6
- 102000056003 human IL15 Human genes 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 239000003446 ligand Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000000556 agonist Substances 0.000 claims 4
- 239000005557 antagonist Substances 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 230000000975 bioactive effect Effects 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- 102100026008 Breakpoint cluster region protein Human genes 0.000 claims 1
- 108010067225 Cell Adhesion Molecules Proteins 0.000 claims 1
- 102000000844 Cell Surface Receptors Human genes 0.000 claims 1
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 1
- 102000009410 Chemokine receptor Human genes 0.000 claims 1
- 108050000299 Chemokine receptor Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 102000009058 Death Domain Receptors Human genes 0.000 claims 1
- 108010049207 Death Domain Receptors Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 102000009465 Growth Factor Receptors Human genes 0.000 claims 1
- 108010009202 Growth Factor Receptors Proteins 0.000 claims 1
- 101000933320 Homo sapiens Breakpoint cluster region protein Proteins 0.000 claims 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 1
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 1
- 108010053727 Interleukin-15 Receptor alpha Subunit Proteins 0.000 claims 1
- 108010017535 Interleukin-15 Receptors Proteins 0.000 claims 1
- 102000004556 Interleukin-15 Receptors Human genes 0.000 claims 1
- 102000000588 Interleukin-2 Human genes 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 102000002689 Toll-like receptor Human genes 0.000 claims 1
- 108020000411 Toll-like receptor Proteins 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 102000008395 cell adhesion mediator activity proteins Human genes 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 108091008034 costimulatory receptors Proteins 0.000 claims 1
- 108010057085 cytokine receptors Proteins 0.000 claims 1
- 230000034994 death Effects 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 239000000833 heterodimer Substances 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 102000008616 interleukin-15 receptor activity proteins Human genes 0.000 claims 1
- 108040002039 interleukin-15 receptor activity proteins Proteins 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 230000005298 paramagnetic effect Effects 0.000 claims 1
- 230000014621 translational initiation Effects 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92890007P | 2007-05-11 | 2007-05-11 | |
| US60/928,900 | 2007-05-11 | ||
| PCT/US2008/005918 WO2008143794A1 (en) | 2007-05-11 | 2008-05-09 | Fusion molecules and il-15 variants |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014009393A Division JP5841623B2 (ja) | 2007-05-11 | 2014-01-22 | 融合分子及びｉｌ−１５変異体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010527919A JP2010527919A (ja) | 2010-08-19 |
| JP2010527919A5 true JP2010527919A5 (enExample) | 2011-06-23 |
| JP5501222B2 JP5501222B2 (ja) | 2014-05-21 |
Family
ID=40122019
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010507463A Active JP5501222B2 (ja) | 2007-05-11 | 2008-05-09 | 融合分子及びｉｌ−１５変異体 |
| JP2014009393A Active JP5841623B2 (ja) | 2007-05-11 | 2014-01-22 | 融合分子及びｉｌ−１５変異体 |
| JP2015222615A Active JP6152156B2 (ja) | 2007-05-11 | 2015-11-13 | 融合分子及びｉｌ−１５変異体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014009393A Active JP5841623B2 (ja) | 2007-05-11 | 2014-01-22 | 融合分子及びｉｌ−１５変異体 |
| JP2015222615A Active JP6152156B2 (ja) | 2007-05-11 | 2015-11-13 | 融合分子及びｉｌ−１５変異体 |
Country Status (10)
| Country | Link |
|---|---|
| US (11) | US8492118B2 (enExample) |
| EP (4) | EP2388266B1 (enExample) |
| JP (3) | JP5501222B2 (enExample) |
| CN (3) | CN104109200B (enExample) |
| AU (1) | AU2008253720B2 (enExample) |
| CA (2) | CA3028038C (enExample) |
| DK (3) | DK2388266T3 (enExample) |
| ES (3) | ES2470772T3 (enExample) |
| PT (3) | PT2388266E (enExample) |
| WO (1) | WO2008143794A1 (enExample) |
Families Citing this family (149)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ563263A (en) | 2005-05-17 | 2010-04-30 | Univ Connecticut | Composition and methods for immunomodulation in an organism |
| HUE037464T2 (hu) | 2005-12-02 | 2018-08-28 | Icahn School Med Mount Sinai | Nem-natív felületi fehérjéket prezentáló kiméra Newcastle disease vírusok és alkalmazásuk |
| CA2636111C (en) | 2006-01-13 | 2018-04-03 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Codon optimized il-15 and il-15r-alpha genes for expression in mammalian cells |
| DK2388266T3 (da) | 2007-05-11 | 2014-05-26 | Altor Bioscience Corp | Fusionsmolekyler og IL-15-varianter |
| EP2724727A1 (en) * | 2007-06-27 | 2014-04-30 | The United States of America, as Represented by The Secretary, Department of Health and Human Services | Complexes of IL-15 and IL-15R alpha and uses thereof |
| US9102734B2 (en) * | 2009-03-10 | 2015-08-11 | Baylor Research Institute | Fusion proteins comprising antibody and HPV E6 and E7 antigens |
| WO2010104761A2 (en) | 2009-03-10 | 2010-09-16 | Baylor Research Institute | Anti-cd40 antibodies and uses thereof |
| EP2258719A1 (en) * | 2009-05-19 | 2010-12-08 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Multiple target T cell receptor |
| AU2010282280B2 (en) | 2009-08-14 | 2016-06-09 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of IL-15 to increase thymic output and to treat lymphopenia |
| US8592364B2 (en) * | 2010-02-11 | 2013-11-26 | Ecole Polytechnique Federale de Lausanne (“EPFL”) | CCR7 ligand delivery and co-delivery in immunotherapy |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| CN108129554A (zh) | 2010-08-10 | 2018-06-08 | 洛桑聚合联合学院 | 红细胞结合性治疗剂 |
| WO2018112219A1 (en) * | 2016-12-14 | 2018-06-21 | Nant Holdings Ip, Llc | Superkine |
| US11053299B2 (en) | 2010-09-21 | 2021-07-06 | Immunity Bio, Inc. | Superkine |
| CN105017429B (zh) | 2010-09-21 | 2021-04-06 | 阿尔托生物科学有限公司 | 多聚体il-15可溶性融合分子与其制造与使用方法 |
| JP2014502258A (ja) * | 2010-10-22 | 2014-01-30 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | 免疫反応を抑制するためにプログラムされた制御性ｔ細胞の発見 |
| EP2537933A1 (en) | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
| HK1202051A1 (en) | 2012-02-15 | 2015-09-18 | 洛桑聚合联合学院 | Erythrocyte-binding therapeutics |
| WO2014023315A1 (en) | 2012-08-10 | 2014-02-13 | Aarhus Universitet | Multimerization through beta-strand swapping in ccp domains |
| US10548957B2 (en) | 2012-09-28 | 2020-02-04 | Dana-Farber Cancer Institute, Inc. | Targeted expansion of Qa-1-peptide-specific regulatory CD8 T cells to ameliorate arthritis |
| CA2888896A1 (en) * | 2012-10-24 | 2014-05-01 | Admune Therapeutics Llc | Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes |
| WO2014158811A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Newcastle disease viruses and uses thereof |
| JP2016518361A (ja) | 2013-04-19 | 2016-06-23 | シーチューヌ ファルマＣｙｔｕｎｅ Ｐｈａｒｍａ | 血管漏出症候群の発生を抑制するサイトカイン治療 |
| WO2015007520A1 (en) * | 2013-07-19 | 2015-01-22 | Vib Vzw | Targeting of cytokine antagonists |
| DK3444271T3 (da) | 2013-08-08 | 2022-01-10 | Cytune Pharma | Il-15- og il-15r-alfa-sushi-domænebaserede modulokiner |
| US10286058B2 (en) | 2014-01-13 | 2019-05-14 | Baylor Research Institute | Vaccines against HPV and HPV-related diseases |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| ES2874884T3 (es) | 2014-02-21 | 2021-11-05 | Ecole Polytechnique Fed De Lausanne Epfl Epfl Tto | Compuestos terapéuticos dirigidos a la glucosa |
| JP6857498B2 (ja) | 2014-02-27 | 2021-04-14 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 癌を処置するための併用方法 |
| EP2915569A1 (en) | 2014-03-03 | 2015-09-09 | Cytune Pharma | IL-15/IL-15Ralpha based conjugates purification method |
| US10464982B2 (en) | 2014-04-23 | 2019-11-05 | Emory University | Compositions of GM-CSF and interleukin fusions for immune modulation and uses related thereto |
| WO2016004060A2 (en) | 2014-06-30 | 2016-01-07 | Altor Bioscience Corporation | Il-15-based molecules and methods of use thereof |
| EP3174974B1 (en) | 2014-07-29 | 2020-05-20 | Novartis AG | Il-15 and il-15ralpha heterodimer dose escalation regimens for treating conditions |
| US20170269076A1 (en) | 2014-08-27 | 2017-09-21 | Dana-Farber Cancer Institute, Inc. | Intracellular osteopontin regulates the lineage commitment of lymphoid subsets |
| KR20170068553A (ko) * | 2014-10-14 | 2017-06-19 | 아르모 바이오사이언시스 인코포레이티드 | 인터류킨-15 조성물 및 이의 용도 |
| RS60996B1 (sr) * | 2014-12-19 | 2020-11-30 | Jiangsu hengrui medicine co ltd | Interleukin 15 proteinski kompleks i njegova upotreba |
| EP3064507A1 (en) * | 2015-03-06 | 2016-09-07 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Fusion proteins comprising a binding protein and an interleukin-15 polypeptide having a reduced affinity for IL15ra and therapeutic uses thereof |
| WO2017046200A1 (en) * | 2015-09-16 | 2017-03-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Specific interleukin-15 (il-15) antagonist polypeptide and uses thereof for the treatment of inflammatory and auto-immune diseases |
| EP3352779A4 (en) * | 2015-09-25 | 2020-02-19 | Altor BioScience Corporation | INTERLEUKIN-15-SUPERAGONIST FOR SIGNIFICANT REINFORCEMENT OF TRANSPLANT AGAINST TUMOR ACTIVITY |
| WO2017059900A1 (en) * | 2015-10-07 | 2017-04-13 | Biontech Cell & Gene Therapies Gmbh | Antigen receptors and uses thereof |
| EP3430055B1 (en) * | 2016-03-17 | 2020-10-28 | Oslo Universitetssykehus HF | Fusion proteins targeting tumour associated macrophages for treating cancer |
| EP3433281A1 (en) * | 2016-03-21 | 2019-01-30 | Elstar Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
| WO2017177063A1 (en) * | 2016-04-06 | 2017-10-12 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of heterodimeric il-15 in adoptive cell transfer |
| WO2017201352A1 (en) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Mrna combination therapy for the treatment of cancer |
| AU2017271593B2 (en) * | 2016-05-27 | 2021-04-22 | Altor Bioscience Corporation | Construction and characterization of multimeric IL-15-based molecules with CD3 binding domains |
| EP3468581A1 (en) | 2016-06-13 | 2019-04-17 | Torque Therapeutics, Inc. | Methods and compositions for promoting immune cell function |
| WO2018013855A2 (en) | 2016-07-14 | 2018-01-18 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Il-15/il-15 receptor alpha treatment regimens and use with therapeutic vaccines |
| KR102562519B1 (ko) | 2016-10-14 | 2023-08-02 | 젠코어 인코포레이티드 | IL-15/IL-15Rα FC-융합 단백질 및 PD-1 항체 단편을 포함하는 이중특이성 이종이량체 융합 단백질 |
| WO2018075989A1 (en) * | 2016-10-21 | 2018-04-26 | Altor Bioscience Corporation | Multimeric il-15-based molecules |
| CN108250301A (zh) * | 2016-12-29 | 2018-07-06 | 天津天锐生物科技有限公司 | 一种多靶点嵌合抗原受体 |
| CN108250302A (zh) * | 2016-12-29 | 2018-07-06 | 天津天锐生物科技有限公司 | 一种多功能蛋白质 |
| US20200237874A1 (en) | 2017-01-20 | 2020-07-30 | Novartis Ag | Combination therapy for the treatment of cancer |
| CN110177568A (zh) | 2017-01-20 | 2019-08-27 | 诺华股份有限公司 | 用于治疗癌症的组合疗法 |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| CA3055318C (en) | 2017-03-06 | 2025-11-25 | Altor Bioscience Corporation | IL-15-BASED FUSION PROTEINS SPECIFIC TO IL-12 AND IL-18 |
| WO2018166589A1 (en) * | 2017-03-15 | 2018-09-20 | Biontech Cell & Gene Therapies Gmbh | Antigen receptors and uses thereof |
| AR111651A1 (es) | 2017-04-28 | 2019-08-07 | Novartis Ag | Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación |
| JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| WO2018229706A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Combination therapy for the treatment of cancer |
| EP3638296A1 (en) | 2017-06-16 | 2020-04-22 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| WO2018236890A1 (en) | 2017-06-20 | 2018-12-27 | Nantkwest, Inc. | Nk-92 cells and il-15 agonist combination therapy |
| US20200172628A1 (en) | 2017-06-22 | 2020-06-04 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| WO2018235056A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | Il-1beta binding antibodies for use in treating cancer |
| AU2018287519B2 (en) | 2017-06-22 | 2021-07-22 | Novartis Ag | IL-1beta binding antibodies for use in treating cancer |
| PE20200717A1 (es) | 2017-06-22 | 2020-07-21 | Novartis Ag | Moleculas de anticuerpo que se unen a cd73 y usos de las mismas |
| AU2018292618A1 (en) | 2017-06-27 | 2019-12-19 | Novartis Ag | Dosage regimens for anti-TIM-3 antibodies and uses thereof |
| EP3645122A1 (en) | 2017-06-30 | 2020-05-06 | Xencor, Inc. | Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and antigen binding domains |
| KR20200090742A (ko) | 2017-08-28 | 2020-07-29 | 알토 바이오사이언스 엘엘씨 | Il-7 및 il-21에의 il-15 기반 융합 |
| US11524033B2 (en) | 2017-09-05 | 2022-12-13 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
| US10610585B2 (en) | 2017-09-26 | 2020-04-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for treating and preventing HIV |
| MX2020004756A (es) | 2017-11-16 | 2020-08-20 | Novartis Ag | Terapias de combinacion. |
| MX2020005651A (es) | 2017-11-30 | 2020-10-28 | Novartis Ag | Receptor de antigeno quimerico dirigido a bcma y usos del mismo. |
| WO2019126240A1 (en) * | 2017-12-19 | 2019-06-27 | Blaze Bioscience, Inc. | Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof |
| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| EP3746104A1 (en) | 2018-02-02 | 2020-12-09 | Novartis AG | Combination of sting agonist and il-15/il15-ra for the treatment of cancer |
| EP3752203A1 (en) | 2018-02-13 | 2020-12-23 | Novartis AG | Chimeric antigen receptor therapy in combination with il-15r and il15 |
| MA52426A (fr) * | 2018-02-26 | 2021-06-02 | Synthorx Inc | Conjugués d'il-15 et leurs utilisations |
| EP3759129A1 (en) | 2018-02-28 | 2021-01-06 | Pfizer Inc | Il-15 variants and uses thereof |
| AU2019226387A1 (en) * | 2018-03-01 | 2020-08-20 | Glycotope Gmbh | Fusion protein constructs comprising an anti-MUC1 antibody and IL-15 |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| US20210147547A1 (en) | 2018-04-13 | 2021-05-20 | Novartis Ag | Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof |
| KR20210003170A (ko) | 2018-04-18 | 2021-01-11 | 젠코어 인코포레이티드 | IL-15/IL-15Rα 이종이량체 Fc 융합 단백질 및 이의 용도 |
| AU2019256539A1 (en) | 2018-04-18 | 2020-11-26 | Xencor, Inc. | PD-1 targeted heterodimeric fusion proteins containing IL-15/IL-15Ra Fc-fusion proteins and PD-1 antigen binding domains and uses thereof |
| CA3097741A1 (en) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains |
| WO2019204646A1 (en) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Lag-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and lag-3 antigen binding domains |
| US12383617B2 (en) | 2018-05-09 | 2025-08-12 | The University Of Chicago | Compositions and methods concerning immune tolerance |
| AR126019A1 (es) | 2018-05-30 | 2023-09-06 | Novartis Ag | Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación |
| WO2019232244A2 (en) | 2018-05-31 | 2019-12-05 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| UY38251A (es) | 2018-06-01 | 2019-12-31 | Novartis Ag | Moléculas de unión contra bcma y usos de las mismas |
| CN112955465A (zh) | 2018-07-03 | 2021-06-11 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| WO2020021465A1 (en) | 2018-07-25 | 2020-01-30 | Advanced Accelerator Applications (Italy) S.R.L. | Method of treatment of neuroendocrine tumors |
| WO2020037215A1 (en) | 2018-08-17 | 2020-02-20 | Icahn School Of Medicine At Mount Sinai | Recombinant newcastle disease viruses and uses thereof for the prevention of rsv disease or human metapneumovirus disease |
| PE20211055A1 (es) | 2018-10-12 | 2021-06-07 | Xencor Inc | Proteinas de fusion il-15 / il-15 ralpha f c dirigidas a pd-1 y usos en terapias de combinacion de las mismas |
| MX2021005485A (es) * | 2018-11-09 | 2021-06-18 | Nektar Therapeutics | Agonista del receptor de interleuquina-15 de accion prolongada con otro agente farmacologicamente activo. |
| US11618776B2 (en) | 2018-12-20 | 2023-04-04 | Xencor, Inc. | Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15RA and NKG2D antigen binding domains |
| WO2020128972A1 (en) | 2018-12-20 | 2020-06-25 | Novartis Ag | Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
| WO2020128637A1 (en) | 2018-12-21 | 2020-06-25 | Novartis Ag | Use of il-1 binding antibodies in the treatment of a msi-h cancer |
| AU2019409139A1 (en) | 2018-12-21 | 2021-06-03 | Novartis Ag | Use of IL-1β binding antibodies |
| EP3897613A1 (en) | 2018-12-21 | 2021-10-27 | Novartis AG | Use of il-1beta binding antibodies |
| US20200369762A1 (en) | 2018-12-21 | 2020-11-26 | Novartis Ag | Use of il-1beta binding antibodies |
| ES3032659T3 (en) | 2019-02-15 | 2025-07-23 | Novartis Ag | 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| AU2020222346B2 (en) | 2019-02-15 | 2021-12-09 | Novartis Ag | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| CA3130754A1 (en) | 2019-02-21 | 2020-08-27 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| CN114127111B (zh) | 2019-02-21 | 2024-09-10 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| MX2021014189A (es) | 2019-05-20 | 2022-01-06 | Cytune Pharma | Regimenes de dosificacion de agonistas de la il-2/il-15r?y para el tratamiento del cancer o enfermedades infecciosas. |
| CN113646328B (zh) * | 2019-08-19 | 2024-03-26 | 南通壹宸生物医药科技有限公司 | 一种免疫细胞因子及其制备与用途 |
| US20220332780A1 (en) | 2019-09-10 | 2022-10-20 | Obsidian Therapeutics, Inc. | Ca2-il15 fusion proteins for tunable regulation |
| WO2021053559A1 (en) | 2019-09-18 | 2021-03-25 | Novartis Ag | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
| RU2753282C2 (ru) * | 2019-09-19 | 2021-08-12 | Закрытое Акционерное Общество "Биокад" | ИММУНОЦИТОКИН, ВКЛЮЧАЮЩИЙ ГЕТЕРОДИМЕРНЫЙ БЕЛКОВЫЙ КОМПЛЕКС НА ОСНОВЕ IL-15/IL-15Rα, И ЕГО ПРИМЕНЕНИЕ |
| TW202128757A (zh) | 2019-10-11 | 2021-08-01 | 美商建南德克公司 | 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白 |
| WO2021079188A1 (en) | 2019-10-21 | 2021-04-29 | Novartis Ag | Combination therapies with venetoclax and tim-3 inhibitors |
| EP4048285A1 (en) | 2019-10-21 | 2022-08-31 | Novartis AG | Tim-3 inhibitors and uses thereof |
| CN111690069B (zh) * | 2019-11-13 | 2022-04-19 | 中国科学技术大学 | 一种IL-15/SuIL-15Rα-mFc-γ4复合体蛋白及其构造方法、应用 |
| US20210188933A1 (en) * | 2019-12-18 | 2021-06-24 | Nantcell, Inc | Methods of treating pancytopenia |
| BR112022011902A2 (pt) | 2019-12-20 | 2022-09-06 | Novartis Ag | Terapias de combinação |
| CN116234829A (zh) | 2020-01-03 | 2023-06-06 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| WO2021144657A1 (en) | 2020-01-17 | 2021-07-22 | Novartis Ag | Combination comprising a tim-3 inhibitor and a hypomethylating agent for use in treating myelodysplastic syndrome or chronic myelomonocytic leukemia |
| JP2022522566A (ja) * | 2020-02-05 | 2022-04-20 | ノバルティス アーゲー | ＣＨＯ細胞で発現されたｈｅｔ ＩＬ－１５ |
| BR112022020973A2 (pt) | 2020-04-22 | 2022-12-06 | Novartis Ag | Composições farmacêuticas e produtos farmacêuticos de interleucina-15 humana heterodimérica (hetil-15) |
| CN115916199A (zh) | 2020-06-23 | 2023-04-04 | 诺华股份有限公司 | 包含3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物的给药方案 |
| CN114057889B (zh) * | 2020-07-30 | 2023-11-10 | 深圳市北科生物科技有限公司 | 二硫键稳定的IL15-IL15Rα复合物及其应用 |
| US20230280356A1 (en) | 2020-08-03 | 2023-09-07 | Nantcell, Inc. | Drug-specific pharmacokinetic assay for il-15 superagonist |
| CN116134027B (zh) | 2020-08-03 | 2025-01-24 | 诺华股份有限公司 | 杂芳基取代的3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途 |
| EP4204020A1 (en) | 2020-08-31 | 2023-07-05 | Advanced Accelerator Applications International S.A. | Method of treating psma-expressing cancers |
| EP4204021A1 (en) | 2020-08-31 | 2023-07-05 | Advanced Accelerator Applications International S.A. | Method of treating psma-expressing cancers |
| KR20230096047A (ko) | 2020-10-26 | 2023-06-29 | 싸이튠 파마 | 비흑색종 피부암 치료용 IL-2/IL-15Rβγ 작용제 |
| AU2021367887A1 (en) | 2020-10-26 | 2023-06-01 | Cytune Pharma | IL-2/IL-15Rβү AGONIST FOR TREATING SQUAMOUS CELL CARCINOMA |
| EP4240491A1 (en) | 2020-11-06 | 2023-09-13 | Novartis AG | Cd19 binding molecules and uses thereof |
| KR20230118887A (ko) | 2020-12-03 | 2023-08-14 | 센츄리 쎄라퓨틱스 인코포레이티드 | 유전자 조작 세포 및 이의 용도 |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| CA3203531A1 (en) | 2020-12-30 | 2022-07-07 | Simon Olivares | Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途 |
| AR125874A1 (es) | 2021-05-18 | 2023-08-23 | Novartis Ag | Terapias de combinación |
| CN116655771A (zh) * | 2021-05-28 | 2023-08-29 | 苏州复融生物技术有限公司 | 一种新型白介素15突变体多肽的开发及其应用 |
| WO2022268991A1 (en) | 2021-06-23 | 2022-12-29 | Cytune Pharma | Interleukin 15 variants |
| EP4376870A4 (en) * | 2021-07-28 | 2025-07-23 | Anwita Biosciences Inc | INTERLEUKIN-2 MUTEINS, FUSION PROTEINS, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC APPLICATIONS |
| WO2023017191A1 (en) | 2021-08-13 | 2023-02-16 | Cytune Pharma | Il-2/il-15rbetagamma agonist combination with antibody-drug conjugates for treating cancer |
| WO2023086772A1 (en) | 2021-11-12 | 2023-05-19 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and nkg2d |
| US12297247B2 (en) | 2022-01-22 | 2025-05-13 | Nantcell, Inc. | Fusion molecules of CTLA4 and IL-15 |
| WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
| WO2024102636A1 (en) | 2022-11-07 | 2024-05-16 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and mica/b |
| WO2024215989A1 (en) | 2023-04-14 | 2024-10-17 | Sotio Biotech Inc. | ENGINEERED IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-2/IL-15 RECEPTOR βγ AGONISTS |
| WO2024215987A1 (en) | 2023-04-14 | 2024-10-17 | Sotio Biotech Inc. | IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-15/IL-15Rα CONJUGATES |
| GB202315149D0 (en) | 2023-10-03 | 2023-11-15 | Celleron Therapeutics Ltd | Combination therapy |
| WO2025085672A1 (en) | 2023-10-17 | 2025-04-24 | Xencor, Inc. | Bispecific antibodies that bind to nkp46 and mica/b |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS551222U (enExample) | 1978-06-15 | 1980-01-07 | ||
| JPS5841623U (ja) | 1981-09-17 | 1983-03-18 | 日産デイ−ゼル工業株式会社 | リアエンジンバスにおけるエンジンル−ムの冷却及び房内熱風排出装置 |
| JPS6152156U (enExample) | 1984-09-12 | 1986-04-08 | ||
| JPS6251570U (enExample) | 1985-09-18 | 1987-03-31 | ||
| JPS648039U (enExample) | 1987-06-29 | 1989-01-17 | ||
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| US5314995A (en) | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
| US5288931A (en) | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
| WO1994004689A1 (en) | 1992-08-14 | 1994-03-03 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Recombinant toxin with increased half-life |
| US5747654A (en) | 1993-06-14 | 1998-05-05 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant disulfide-stabilized polypeptide fragments having binding specificity |
| AU680909B2 (en) * | 1994-04-06 | 1997-08-14 | Immunex Corporation | Interleukin-15 |
| DE69425906T2 (de) | 1994-04-06 | 2001-03-29 | Immunex Corp., Seattle | Interleukin-15 |
| US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| US5795966A (en) * | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
| US7008624B1 (en) * | 1995-02-22 | 2006-03-07 | Immunex Corporation | Antagonists of interleukin-15 |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| US5534592A (en) | 1995-09-22 | 1996-07-09 | The Goodyear Tire & Rubber Company | High performance blend for tire treads |
| CA2249195A1 (en) | 1996-03-18 | 1997-09-25 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
| JP2001502521A (ja) | 1996-04-26 | 2001-02-27 | ベス イスラエル デアコネス メディカル センター | インターロイキン―１５の拮抗剤 |
| DK1273304T4 (da) | 1997-02-21 | 2009-08-31 | Amgen Inc | Anvendelse af interleukin-15 |
| GB9912350D0 (en) | 1999-05-26 | 1999-07-28 | European Molecular Biology Lab Embl | Modified cytokine |
| JP2003533488A (ja) * | 2000-05-12 | 2003-11-11 | ベス・イスラエル・ディーコニス・メディカル・センター・インコーポレーテッド | 免疫抑制を達成するための組成物および方法 |
| AU7524601A (en) | 2000-06-05 | 2001-12-17 | Sunol Molecular Corp | T cell receptor fusions and conjugates and methods of use thereof |
| ES2322936T3 (es) | 2000-09-14 | 2009-07-02 | Beth Israel Deaconess Medical Center, Inc. | Modulacion de las respuestas de las celulas t mediadas por il-2 y por il-15. |
| US20030180888A1 (en) * | 2000-11-03 | 2003-09-25 | Millennium Pharmaceuticals, Inc. | CD2000 and CD2001 molecules, and uses thereof |
| FI117667B (fi) | 2001-07-05 | 2007-01-15 | Univ Zuerich | Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä |
| EP1532175B1 (en) | 2002-03-22 | 2012-10-17 | Aprogen, Inc. | Humanized antibody and process for preparing the same |
| US20040156826A1 (en) | 2002-09-27 | 2004-08-12 | Fernando Dangond | Treatment of patients with multiple sclerosis based on gene expression changes in central nervous system tissues |
| EA015897B1 (ru) | 2003-02-26 | 2011-12-30 | Генмаб А/С | Применение человеческого моноклонального антитела к ил-15 в составе композиции и лекарственного препарата (варианты), композиция и лекарственный препарат, его включающие |
| DE10324708A1 (de) | 2003-05-30 | 2004-12-16 | Ltn Servotechnik Gmbh | Schleifringelement und Verfahren zu dessen Herstellung |
| CN1233822C (zh) | 2003-09-05 | 2005-12-28 | 中国科学技术大学 | 白细胞介素－15基因修饰的自然杀伤细胞株及其制备方法 |
| KR101131297B1 (ko) | 2003-11-10 | 2012-03-30 | 알토 바이오사이언스 코포레이션 | 가용성 티씨알 분자 및 이용 방법 |
| EP1718670B1 (en) | 2004-02-27 | 2011-07-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Il-15 binding site for il 15-ralpha and specific il-15 mutants having agonist/antagonist activity |
| EP1586585A1 (de) | 2004-04-14 | 2005-10-19 | F. Hoffmann-La Roche Ag | Expressionssystem zur Herstellung von IL-15/Fc-Fusionsproteinen und ihre Verwendung |
| CN100334112C (zh) | 2004-10-15 | 2007-08-29 | 上海海欣生物技术有限公司 | 人白细胞介素15与Fc融合蛋白 |
| PT1814580T (pt) | 2004-11-24 | 2016-11-11 | Hutchinson Fred Cancer Res | Métodos de utilização de il-21 para imunoterapia adotiva e identificação de antigénios tumorais |
| EP1830875A2 (en) * | 2004-12-13 | 2007-09-12 | Cytos Biotechnology AG | Il-15 antigen arrays and uses thereof |
| NZ563263A (en) | 2005-05-17 | 2010-04-30 | Univ Connecticut | Composition and methods for immunomodulation in an organism |
| KR20070000252A (ko) | 2005-06-27 | 2007-01-02 | 삼성에스디아이 주식회사 | 연료 전지용 전극 및 이를 포함하는 연료 전지 시스템 |
| EP1777294A1 (en) | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins |
| ES2352561T3 (es) | 2006-06-30 | 2011-02-21 | Conaris Research Institute Ag | Dímeros de sgp 130fc mejorados. |
| US7965180B2 (en) | 2006-09-28 | 2011-06-21 | Semiconductor Energy Laboratory Co., Ltd. | Wireless sensor device |
| EP2537416B1 (en) | 2007-03-30 | 2014-11-12 | Memorial Sloan-Kettering Cancer Center | Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes |
| DK2388266T3 (da) | 2007-05-11 | 2014-05-26 | Altor Bioscience Corp | Fusionsmolekyler og IL-15-varianter |
| AU2013273643C1 (en) | 2007-05-11 | 2016-08-11 | Altor Bioscience Corporation | Fusion molecules and il-15 variants |
| US8252897B2 (en) | 2007-06-21 | 2012-08-28 | Angelica Therapeutics, Inc. | Modified toxins |
| EP2724727A1 (en) | 2007-06-27 | 2014-04-30 | The United States of America, as Represented by The Secretary, Department of Health and Human Services | Complexes of IL-15 and IL-15R alpha and uses thereof |
| WO2009117117A1 (en) * | 2008-03-19 | 2009-09-24 | Altor Bioscience Corporation | T cell receptor fusions and conjugates and methods of use there of |
| US11053299B2 (en) | 2010-09-21 | 2021-07-06 | Immunity Bio, Inc. | Superkine |
| CN105017429B (zh) | 2010-09-21 | 2021-04-06 | 阿尔托生物科学有限公司 | 多聚体il-15可溶性融合分子与其制造与使用方法 |
| EP2537933A1 (en) | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
| US20130302274A1 (en) | 2011-11-25 | 2013-11-14 | Roche Glycart Ag | Combination therapy |
| US9682143B2 (en) | 2012-08-14 | 2017-06-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
| WO2014028776A1 (en) | 2012-08-15 | 2014-02-20 | Zyngenia, Inc. | Monovalent and multivalent multispecific complexes and uses thereof |
| CA2888896A1 (en) | 2012-10-24 | 2014-05-01 | Admune Therapeutics Llc | Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes |
| US8977012B2 (en) | 2012-10-31 | 2015-03-10 | Google Inc. | Image denoising system and method |
| SI3094351T1 (sl) | 2014-01-15 | 2022-05-31 | Kadmon Corporation, Llc | Imunomodulatorna sredstva |
| WO2016004060A2 (en) | 2014-06-30 | 2016-01-07 | Altor Bioscience Corporation | Il-15-based molecules and methods of use thereof |
| CN104672325A (zh) | 2015-03-11 | 2015-06-03 | 福建农林大学 | 一种用新鲜螺旋藻制备藻蓝蛋白的方法 |
| EP3352779A4 (en) | 2015-09-25 | 2020-02-19 | Altor BioScience Corporation | INTERLEUKIN-15-SUPERAGONIST FOR SIGNIFICANT REINFORCEMENT OF TRANSPLANT AGAINST TUMOR ACTIVITY |
| AU2017271593B2 (en) | 2016-05-27 | 2021-04-22 | Altor Bioscience Corporation | Construction and characterization of multimeric IL-15-based molecules with CD3 binding domains |
| WO2018075989A1 (en) | 2016-10-21 | 2018-04-26 | Altor Bioscience Corporation | Multimeric il-15-based molecules |
| CA3055318C (en) * | 2017-03-06 | 2025-11-25 | Altor Bioscience Corporation | IL-15-BASED FUSION PROTEINS SPECIFIC TO IL-12 AND IL-18 |
| KR20200090742A (ko) * | 2017-08-28 | 2020-07-29 | 알토 바이오사이언스 엘엘씨 | Il-7 및 il-21에의 il-15 기반 융합 |
| US11168138B2 (en) | 2018-03-26 | 2021-11-09 | Altor Bioscience, Llc | Anti-PDL1, IL-15 and TGF-beta receptor combination molecules |
-
2008
- 2008-05-09 DK DK11178091.2T patent/DK2388266T3/da active
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