JP2018512047A5 - - Google Patents
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- Publication number
- JP2018512047A5 JP2018512047A5 JP2017557481A JP2017557481A JP2018512047A5 JP 2018512047 A5 JP2018512047 A5 JP 2018512047A5 JP 2017557481 A JP2017557481 A JP 2017557481A JP 2017557481 A JP2017557481 A JP 2017557481A JP 2018512047 A5 JP2018512047 A5 JP 2018512047A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- cells
- tcr
- modified
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 21
- 210000000822 natural killer cell Anatomy 0.000 claims 15
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 238000009172 cell transfer therapy Methods 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000002163 immunogen Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 210000005260 human cell Anatomy 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1501175.2A GB201501175D0 (en) | 2015-01-23 | 2015-01-23 | A universal T-cell for personalised medicine |
| GB1501175.2 | 2015-01-23 | ||
| PCT/EP2016/051344 WO2016116601A1 (en) | 2015-01-23 | 2016-01-22 | Universal killer t-cell |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512047A JP2018512047A (ja) | 2018-05-10 |
| JP2018512047A5 true JP2018512047A5 (enExample) | 2019-03-07 |
| JP6899333B2 JP6899333B2 (ja) | 2021-07-07 |
Family
ID=52673865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557481A Active JP6899333B2 (ja) | 2015-01-23 | 2016-01-22 | 汎用キラーｔ細胞 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11155786B2 (enExample) |
| EP (2) | EP4095239A1 (enExample) |
| JP (1) | JP6899333B2 (enExample) |
| KR (1) | KR102479118B1 (enExample) |
| CN (1) | CN107250351A (enExample) |
| AU (2) | AU2016208475B2 (enExample) |
| CA (1) | CA2973924C (enExample) |
| DK (1) | DK3247791T3 (enExample) |
| EA (1) | EA201791381A1 (enExample) |
| ES (1) | ES2922231T3 (enExample) |
| GB (1) | GB201501175D0 (enExample) |
| IL (1) | IL253464B (enExample) |
| MX (1) | MX390756B (enExample) |
| PL (1) | PL3247791T3 (enExample) |
| PT (1) | PT3247791T (enExample) |
| SG (1) | SG11201705693XA (enExample) |
| WO (1) | WO2016116601A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201501175D0 (en) * | 2015-01-23 | 2015-03-11 | Univ Oslo Hf | A universal T-cell for personalised medicine |
| KR20180029201A (ko) | 2015-05-18 | 2018-03-20 | 티씨알2 테라퓨틱스 인크. | 융합 단백질을 이용하는 tcr 리프로그래밍을 위한 조성물 및 방법 |
| WO2017192440A1 (en) * | 2016-05-02 | 2017-11-09 | Cerus Corporation | Compositions and methods for improved nk cell therapies |
| WO2018026953A1 (en) | 2016-08-02 | 2018-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| IL302917A (en) | 2016-10-07 | 2023-07-01 | Tcr2 Therapeutics Inc | Compositions and methods for t-cell receptors reprogramming using fusion proteins |
| JP7291396B2 (ja) | 2016-11-22 | 2023-06-15 | ティーシーアール２ セラピューティクス インク． | 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法 |
| WO2018104473A1 (en) | 2016-12-07 | 2018-06-14 | Oslo Universitetssykehus Hf | Compositions and methods for cell therapy |
| EP3565565A4 (en) * | 2017-01-04 | 2020-12-09 | Nova Southeastern University | NATURAL KILLER CELLS (NK) EXPRESSING AN ANTIGEN-SPECIFIC FUNCTIONAL T-LYMPHOCYTE RECEPTOR COMPLEX (TCR), THEIR PRODUCTION METHODS AND THEIR THERAPEUTIC USE METHODS |
| GB201803178D0 (en) | 2018-02-27 | 2018-04-11 | Univ Oslo Hf | Specific binding molecules for htert |
| JP7429222B2 (ja) * | 2018-08-31 | 2024-02-07 | アンヴェクティ エスアー | Ｃａｒの機能を評価する方法 |
| WO2020191358A1 (en) * | 2019-03-20 | 2020-09-24 | Bluebird Bio, Inc. | Adoptive cell therapy |
| JP6977969B2 (ja) * | 2019-03-22 | 2021-12-08 | 株式会社ガイアバイオメディシン | 免疫細胞提供システム |
| EP3750547A1 (en) | 2019-06-13 | 2020-12-16 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Modified nk-92 cells, and therapeutic and diagnostic uses thereof |
| US12084685B2 (en) | 2019-07-29 | 2024-09-10 | Massaachusetts Institute Of Technology | Synthetic hydrogels for organogenesis |
| CN111662871A (zh) * | 2020-06-11 | 2020-09-15 | 福建医科大学孟超肝胆医院(福州市传染病医院) | 一种核酸适体功能化nk细胞及其制备与应用 |
| IL301543A (en) | 2020-09-24 | 2023-05-01 | Medigene Immunotherapies Gmbh | Prame specific t cell receptors and uses thereof |
| TW202233831A (zh) * | 2020-11-03 | 2022-09-01 | 中國大陸商杭州啟函生物科技有限公司 | 增強免疫療法的系統和方法 |
| GB202017873D0 (en) | 2020-11-12 | 2020-12-30 | Olso Unversitetssykehus Hf | Method of determining DLBCL prognosis |
| WO2022250312A1 (ko) * | 2021-05-27 | 2022-12-01 | (주)에스엠티바이오 | 신경내분비종양의 치료용 자연살해세포 |
| EP4404956A1 (en) | 2021-09-21 | 2024-07-31 | Oslo Universitetssykehus HF | Binding proteins for terminal deoxynucleotidyl transferase (tdt) |
| TW202325844A (zh) * | 2021-11-03 | 2023-07-01 | 中國大陸商杭州啟函生物科技有限公司 | 增強免疫療法的系統和方法 |
| JP2025524005A (ja) * | 2022-07-22 | 2025-07-25 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 養子免疫療法のための亢進された機能を有するｃｄ３発現ナチュラルキラー細胞 |
| WO2024261045A1 (en) | 2023-06-20 | 2024-12-26 | Zelluna Immunotherapy As | Methods of enhancing or modifying nk cells |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5124251A (en) | 1990-01-31 | 1992-06-23 | Becton, Dickinson And Company | CD3 ζ co-associated complex on CD16- NK cells |
| EP1007630B1 (en) | 1997-04-30 | 2006-04-19 | Hans Klingemann | Natural killer cell lines and methods of use |
| IL127142A0 (en) | 1998-11-19 | 1999-09-22 | Yeda Res & Dev | Immune cells having predefined biological specificity |
| AU2002351239A1 (en) | 2001-12-04 | 2003-06-17 | Dana-Farber Cancer Institute, Inc. | Antibody to latent membrane proteins and uses thereof |
| US7618817B2 (en) * | 2004-07-10 | 2009-11-17 | Fox Chase Cancer Center | Genetically modified human natural killer cell lines |
| WO2006050270A2 (en) * | 2004-11-02 | 2006-05-11 | The Government Of The United States Of America As Represented By The Secretary Department Of Health & Human Services | Compositions and methods for treating hyperproliferative disorders |
| US8518697B2 (en) | 2006-04-04 | 2013-08-27 | Washington University | Single chain trimers and uses therefor |
| CN101631138A (zh) | 2008-07-18 | 2010-01-20 | 深圳富泰宏精密工业有限公司 | 个人信息代理系统及方法 |
| WO2010088160A1 (en) * | 2009-01-28 | 2010-08-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors and related materials and methods of use |
| US10247731B2 (en) * | 2012-02-22 | 2019-04-02 | Verik Bio, Inc. | System for immunotherapy targeting tumor propagation and progression |
| EP2893003B1 (en) | 2012-09-04 | 2021-03-31 | Inven2 AS | Selective and controlled expansion of educated nk cells |
| SG11201505858VA (en) | 2013-01-28 | 2015-09-29 | St Jude Childrens Res Hospital | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| JP2016511636A (ja) | 2013-02-04 | 2016-04-21 | ロジャー ウィリアムズ メディカル センターＲｏｇｅｒ Ｗｉｌｌｉａｍｓ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ | 消化管間質腫瘍（ｇｉｓｔ）を治療する方法及び組成物 |
| JP6425301B2 (ja) * | 2014-05-29 | 2018-11-21 | 国立大学法人富山大学 | Ｔｃｒの細胞傷害活性誘導能を評価するためのｎｋ細胞株、およびその作製方法 |
| KR20170018450A (ko) | 2014-06-18 | 2017-02-17 | 케모테라포이티쉐스 포르슝스인스티투트 게오르크-스파이어-하우스 | 세포 치료제로서의 car-발현 nk-92 세포 |
| US20170274014A1 (en) * | 2014-07-21 | 2017-09-28 | Jennifer Brogdon | Combinations of low, immune enhancing, doses of mtor inhibitors and cars |
| GB201501175D0 (en) * | 2015-01-23 | 2015-03-11 | Univ Oslo Hf | A universal T-cell for personalised medicine |
-
2015
- 2015-01-23 GB GBGB1501175.2A patent/GB201501175D0/en not_active Ceased
-
2016
- 2016-01-22 WO PCT/EP2016/051344 patent/WO2016116601A1/en not_active Ceased
- 2016-01-22 CA CA2973924A patent/CA2973924C/en active Active
- 2016-01-22 SG SG11201705693XA patent/SG11201705693XA/en unknown
- 2016-01-22 PL PL16701339.0T patent/PL3247791T3/pl unknown
- 2016-01-22 DK DK16701339.0T patent/DK3247791T3/da active
- 2016-01-22 CN CN201680006587.4A patent/CN107250351A/zh active Pending
- 2016-01-22 PT PT167013390T patent/PT3247791T/pt unknown
- 2016-01-22 EA EA201791381A patent/EA201791381A1/ru unknown
- 2016-01-22 MX MX2017009459A patent/MX390756B/es unknown
- 2016-01-22 ES ES16701339T patent/ES2922231T3/es active Active
- 2016-01-22 EP EP22170488.5A patent/EP4095239A1/en active Pending
- 2016-01-22 JP JP2017557481A patent/JP6899333B2/ja active Active
- 2016-01-22 US US15/545,021 patent/US11155786B2/en active Active
- 2016-01-22 KR KR1020177023284A patent/KR102479118B1/ko active Active
- 2016-01-22 EP EP16701339.0A patent/EP3247791B1/en active Active
- 2016-01-22 AU AU2016208475A patent/AU2016208475B2/en active Active
-
2017
- 2017-07-13 IL IL253464A patent/IL253464B/en unknown
-
2021
- 2021-09-23 US US17/483,484 patent/US20220127574A1/en not_active Abandoned
-
2022
- 2022-01-11 AU AU2022200126A patent/AU2022200126A1/en not_active Abandoned
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