JP2018531016A5 - - Google Patents
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- Publication number
- JP2018531016A5 JP2018531016A5 JP2018519323A JP2018519323A JP2018531016A5 JP 2018531016 A5 JP2018531016 A5 JP 2018531016A5 JP 2018519323 A JP2018519323 A JP 2018519323A JP 2018519323 A JP2018519323 A JP 2018519323A JP 2018531016 A5 JP2018531016 A5 JP 2018531016A5
- Authority
- JP
- Japan
- Prior art keywords
- transduced
- cell
- nucleic acid
- acid sequence
- cxcr6
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001744 T-lymphocyte Anatomy 0.000 claims 30
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 16
- 150000007523 nucleic acids Chemical group 0.000 claims 16
- 102000009410 Chemokine receptor Human genes 0.000 claims 10
- 108050000299 Chemokine receptor Proteins 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 239000013598 vector Substances 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 102100039396 C-X-C motif chemokine 16 Human genes 0.000 claims 2
- 101000889133 Homo sapiens C-X-C motif chemokine 16 Proteins 0.000 claims 2
- 102000003812 Interleukin-15 Human genes 0.000 claims 2
- 108090000172 Interleukin-15 Proteins 0.000 claims 2
- 102000000588 Interleukin-2 Human genes 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 230000002018 overexpression Effects 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 claims 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000014509 gene expression Effects 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000011216 nasopharynx carcinoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 230000002463 transducing effect Effects 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021162481A JP2022008805A (ja) | 2015-10-16 | 2021-10-01 | 腫瘍標的療法のためのｃｘｃｒ６形質導入ｔ細胞 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15190179 | 2015-10-16 | ||
| EP15190179.0 | 2015-10-16 | ||
| PCT/EP2016/074644 WO2017064222A1 (en) | 2015-10-16 | 2016-10-14 | Cxcr6-transduced t cells for targeted tumor therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021162481A Division JP2022008805A (ja) | 2015-10-16 | 2021-10-01 | 腫瘍標的療法のためのｃｘｃｒ６形質導入ｔ細胞 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2018531016A JP2018531016A (ja) | 2018-10-25 |
| JP2018531016A6 JP2018531016A6 (ja) | 2018-12-13 |
| JP2018531016A5 true JP2018531016A5 (enExample) | 2019-11-28 |
| JP7018387B2 JP7018387B2 (ja) | 2022-02-10 |
Family
ID=54359823
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018519323A Active JP7018387B2 (ja) | 2015-10-16 | 2016-10-14 | 腫瘍標的療法のためのｃｘｃｒ６形質導入ｔ細胞 |
| JP2021162481A Pending JP2022008805A (ja) | 2015-10-16 | 2021-10-01 | 腫瘍標的療法のためのｃｘｃｒ６形質導入ｔ細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021162481A Pending JP2022008805A (ja) | 2015-10-16 | 2021-10-01 | 腫瘍標的療法のためのｃｘｃｒ６形質導入ｔ細胞 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11723922B2 (enExample) |
| EP (1) | EP3362569B1 (enExample) |
| JP (2) | JP7018387B2 (enExample) |
| AU (2) | AU2016336868B2 (enExample) |
| CA (1) | CA3001507C (enExample) |
| DK (1) | DK3362569T3 (enExample) |
| ES (1) | ES2895901T3 (enExample) |
| WO (1) | WO2017064222A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20200054677A1 (en) * | 2017-02-21 | 2020-02-20 | The University Of Adelaide | T cells expressing chemokine receptors for treating cancer |
| AU2018248672B2 (en) * | 2017-04-05 | 2021-09-30 | Korea Research Institute Of Bioscience And Biotechnology | NK cell-activating fusion protein, NK cell, and pharmaceutical composition including same |
| US20210002609A1 (en) * | 2017-12-05 | 2021-01-07 | Caribou Biosciences, Inc. | Modified lymphocytes |
| US20210130438A1 (en) * | 2019-10-28 | 2021-05-06 | The Broad Institute, Inc. | Pan-cancer t cell exhaustion genes |
| CN116333999A (zh) * | 2020-07-14 | 2023-06-27 | 广州泛恩生物科技有限公司 | 基于cxcl13阳性t细胞的用于杀伤肿瘤的tcr-t细胞及其制备方法和应用 |
| CN113736740A (zh) * | 2021-07-27 | 2021-12-03 | 天津市肿瘤医院（天津医科大学肿瘤医院） | 胰腺癌稳转细胞系及其构建方法和应用 |
| US20250152629A1 (en) * | 2022-02-15 | 2025-05-15 | Memorial Sloan-Kettering Cancer Center | Compositions including killer innate-like t cells and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6696244B2 (en) * | 1997-07-17 | 2004-02-24 | New York University | G-coupled receptors associated with retroviral entry into cells, and therapeutic uses thereof |
| DE19822115B4 (de) | 1998-05-08 | 2004-04-08 | Heinrich-Pette-Institut | Retrovirale Gentransfervektoren |
| US8003770B2 (en) | 2005-09-13 | 2011-08-23 | Mie University | T-cell receptor and nucleic acid encoding the receptor |
| EP2318434A1 (en) | 2008-07-31 | 2011-05-11 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Her2/neu specific t cell receptors |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| ES2696000T3 (es) | 2011-04-08 | 2019-01-11 | Us Health | Receptores de antígenos quiméricos anti-variante III de receptor de factor de crecimiento epidérmico y uso de los mismos para el tratamiento de cáncer |
| EP2768863B1 (en) | 2011-10-20 | 2017-09-27 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Anti-cd22 chimeric antigen receptors |
| AU2013235726B2 (en) | 2012-03-23 | 2017-04-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mesothelin chimeric antigen receptors |
| RU2650805C2 (ru) | 2012-04-11 | 2018-04-17 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Химерные антигенные рецепторы, нацеленные на антиген созревания в-клеток |
| US9657105B2 (en) | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
| TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症 |
| ES2905557T3 (es) | 2013-08-26 | 2022-04-11 | Hinrich Abken | Receptor de antígeno quimérico anti-CD30 y su uso |
-
2016
- 2016-10-14 EP EP16793764.8A patent/EP3362569B1/en active Active
- 2016-10-14 DK DK16793764.8T patent/DK3362569T3/da active
- 2016-10-14 AU AU2016336868A patent/AU2016336868B2/en active Active
- 2016-10-14 ES ES16793764T patent/ES2895901T3/es active Active
- 2016-10-14 JP JP2018519323A patent/JP7018387B2/ja active Active
- 2016-10-14 CA CA3001507A patent/CA3001507C/en active Active
- 2016-10-14 WO PCT/EP2016/074644 patent/WO2017064222A1/en not_active Ceased
- 2016-10-14 US US15/768,301 patent/US11723922B2/en active Active
-
2021
- 2021-10-01 JP JP2021162481A patent/JP2022008805A/ja active Pending
-
2022
- 2022-07-14 AU AU2022205240A patent/AU2022205240A1/en not_active Abandoned
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