ES2895901T3 - Células T transducidas con CXCR6 para terapia tumoral dirigida - Google Patents

Células T transducidas con CXCR6 para terapia tumoral dirigida Download PDF

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Publication number
ES2895901T3
ES2895901T3 ES16793764T ES16793764T ES2895901T3 ES 2895901 T3 ES2895901 T3 ES 2895901T3 ES 16793764 T ES16793764 T ES 16793764T ES 16793764 T ES16793764 T ES 16793764T ES 2895901 T3 ES2895901 T3 ES 2895901T3
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cell
cells
transduced
cxcr6
nucleic acid
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Spanish (es)
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Sebastian Kobold
Stefan Endres
Moritz Rapp
Simon Grassmann
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Ludwig Maximilians Universitaet Muenchen LMU
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Ludwig Maximilians Universitaet Muenchen LMU
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4202Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214Receptors for cytokines
    • A61K40/4219Receptors for chemokines
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70521CD28, CD152
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • C12N5/12Fused cells, e.g. hybridomas
    • C12N5/16Animal cells
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    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/13011Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
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  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Output Control And Ontrol Of Special Type Engine (AREA)
  • Developmental Biology & Embryology (AREA)
ES16793764T 2015-10-16 2016-10-14 Células T transducidas con CXCR6 para terapia tumoral dirigida Active ES2895901T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15190179 2015-10-16
PCT/EP2016/074644 WO2017064222A1 (en) 2015-10-16 2016-10-14 Cxcr6-transduced t cells for targeted tumor therapy

Publications (1)

Publication Number Publication Date
ES2895901T3 true ES2895901T3 (es) 2022-02-23

Family

ID=54359823

Family Applications (1)

Application Number Title Priority Date Filing Date
ES16793764T Active ES2895901T3 (es) 2015-10-16 2016-10-14 Células T transducidas con CXCR6 para terapia tumoral dirigida

Country Status (8)

Country Link
US (1) US11723922B2 (enExample)
EP (1) EP3362569B1 (enExample)
JP (2) JP7018387B2 (enExample)
AU (2) AU2016336868B2 (enExample)
CA (1) CA3001507C (enExample)
DK (1) DK3362569T3 (enExample)
ES (1) ES2895901T3 (enExample)
WO (1) WO2017064222A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018152572A1 (en) * 2017-02-21 2018-08-30 The University Of Adelaide T cells expressing chemokine receptors for treating cancer
BR112019020909A2 (pt) 2017-04-05 2020-05-12 Korea Research Institute Of Bioscience And Biotechnology Proteína de fusão ativadora de célula nk, célula nk e composição farmacêutica incluindo a mesma
US20210002609A1 (en) * 2017-12-05 2021-01-07 Caribou Biosciences, Inc. Modified lymphocytes
US20210130438A1 (en) * 2019-10-28 2021-05-06 The Broad Institute, Inc. Pan-cancer t cell exhaustion genes
CN116333984A (zh) * 2020-07-14 2023-06-27 广州泛恩生物科技有限公司 基于galnt2阳性t细胞的用于杀伤肿瘤的tcr-t细胞及其制备方法和应用
CN113736740A (zh) * 2021-07-27 2021-12-03 天津市肿瘤医院(天津医科大学肿瘤医院) 胰腺癌稳转细胞系及其构建方法和应用
WO2023158997A2 (en) * 2022-02-15 2023-08-24 Memorial Sloan-Kettering Cancer Center Compositions including killer innate-like t cells and uses therof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696244B2 (en) * 1997-07-17 2004-02-24 New York University G-coupled receptors associated with retroviral entry into cells, and therapeutic uses thereof
DE19822115B4 (de) 1998-05-08 2004-04-08 Heinrich-Pette-Institut Retrovirale Gentransfervektoren
CN101287831B (zh) 2005-09-13 2013-05-15 国立大学法人三重大学 T细胞受体和编码该受体的核酸
WO2010012829A1 (en) 2008-07-31 2010-02-04 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Her2/neu specific t cell receptors
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
TR201815488T4 (tr) 2011-04-08 2018-11-21 Health Anti-epidermal büyüme faktör reseptörü varyant III kimerik antijen reseptörleri ve kanser tedavisi için kullanımı.
IN2014CN02906A (enExample) 2011-10-20 2015-07-03 Us Health
CA2868121C (en) 2012-03-23 2021-06-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-mesothelin chimeric antigen receptors
ES3065694T3 (en) 2012-04-11 2026-05-07 Us Health Chimeric antigen receptors targeting b-cell maturation antigen
US9657105B2 (en) 2013-03-15 2017-05-23 City Of Hope CD123-specific chimeric antigen receptor redirected T cells and methods of their use
TWI654206B (zh) 2013-03-16 2019-03-21 諾華公司 使用人類化抗-cd19嵌合抗原受體治療癌症
JP6285553B2 (ja) 2013-08-26 2018-02-28 インノバイオファーム リミテッド 抗cd30キメラ抗原受容体およびその使用

Also Published As

Publication number Publication date
DK3362569T3 (da) 2021-10-18
AU2016336868A1 (en) 2018-03-15
JP7018387B2 (ja) 2022-02-10
CA3001507C (en) 2023-09-19
US11723922B2 (en) 2023-08-15
AU2022205240A1 (en) 2022-09-29
AU2016336868B2 (en) 2022-04-14
CA3001507A1 (en) 2017-04-20
EP3362569B1 (en) 2021-09-01
EP3362569A1 (en) 2018-08-22
WO2017064222A1 (en) 2017-04-20
JP2018531016A (ja) 2018-10-25
US20180256645A1 (en) 2018-09-13
JP2022008805A (ja) 2022-01-14

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