EA201791381A1 - Универсальная клетка т-киллер - Google Patents
Универсальная клетка т-киллерInfo
- Publication number
- EA201791381A1 EA201791381A1 EA201791381A EA201791381A EA201791381A1 EA 201791381 A1 EA201791381 A1 EA 201791381A1 EA 201791381 A EA201791381 A EA 201791381A EA 201791381 A EA201791381 A EA 201791381A EA 201791381 A1 EA201791381 A1 EA 201791381A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cells
- modified
- universal
- immunogenic
- tcr
- Prior art date
Links
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 title 1
- 210000000822 natural killer cell Anatomy 0.000 abstract 6
- 210000004027 cell Anatomy 0.000 abstract 5
- 230000002163 immunogen Effects 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/32—T-cell receptors [TCR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4225—Growth factors
- A61K40/4229—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4244—Enzymes
- A61K40/4246—Telomerase or [telomerase reverse transcriptase [TERT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4271—Melanoma antigens
- A61K40/4272—Melan-A/MART
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by targeting or presenting multiple antigens
- A61K2239/28—Expressing multiple CARs, TCRs or antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1501175.2A GB201501175D0 (en) | 2015-01-23 | 2015-01-23 | A universal T-cell for personalised medicine |
| PCT/EP2016/051344 WO2016116601A1 (en) | 2015-01-23 | 2016-01-22 | Universal killer t-cell |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201791381A1 true EA201791381A1 (ru) | 2018-02-28 |
Family
ID=52673865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201791381A EA201791381A1 (ru) | 2015-01-23 | 2016-01-22 | Универсальная клетка т-киллер |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11155786B2 (enExample) |
| EP (3) | EP4095239A1 (enExample) |
| JP (1) | JP6899333B2 (enExample) |
| KR (1) | KR102479118B1 (enExample) |
| CN (1) | CN107250351A (enExample) |
| AU (2) | AU2016208475B2 (enExample) |
| CA (1) | CA2973924C (enExample) |
| DK (1) | DK3247791T3 (enExample) |
| EA (1) | EA201791381A1 (enExample) |
| ES (1) | ES2922231T3 (enExample) |
| GB (1) | GB201501175D0 (enExample) |
| IL (1) | IL253464B (enExample) |
| MX (1) | MX390756B (enExample) |
| PL (1) | PL3247791T3 (enExample) |
| PT (1) | PT3247791T (enExample) |
| SG (1) | SG11201705693XA (enExample) |
| WO (1) | WO2016116601A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201501175D0 (en) * | 2015-01-23 | 2015-03-11 | Univ Oslo Hf | A universal T-cell for personalised medicine |
| EP3770168A1 (en) | 2015-05-18 | 2021-01-27 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| EP3452580B1 (en) * | 2016-05-02 | 2023-08-16 | Cerus Corporation | Compositions and methods for improved nk cell therapies |
| WO2018026953A1 (en) | 2016-08-02 | 2018-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| BR112019007100A2 (pt) | 2016-10-07 | 2019-06-25 | Tcr2 Therapeutics Inc | composições e métodos para reprogramação de receptores de célula t com o uso de proteínas de fusão |
| CN110177803A (zh) | 2016-11-22 | 2019-08-27 | T细胞受体治疗公司 | 用于使用融合蛋白进行tcr重新编程的组合物和方法 |
| WO2018104473A1 (en) | 2016-12-07 | 2018-06-14 | Oslo Universitetssykehus Hf | Compositions and methods for cell therapy |
| WO2018129199A1 (en) * | 2017-01-04 | 2018-07-12 | Nova Southeastern University | Natural killer (nk) cells expressing an antigen-specific functional t cell receptor (tcr) complex, methods for production thereof, and methods for therapeutic use thereof |
| GB201803178D0 (en) | 2018-02-27 | 2018-04-11 | Univ Oslo Hf | Specific binding molecules for htert |
| EP3844499A1 (en) * | 2018-08-31 | 2021-07-07 | Invectys Sa | Method to assess car functionality |
| EP3941490A4 (en) * | 2019-03-20 | 2023-01-04 | 2seventy bio, Inc. | ADOPTIVE CELLULAR THERAPY |
| JP6977969B2 (ja) * | 2019-03-22 | 2021-12-08 | 株式会社ガイアバイオメディシン | 免疫細胞提供システム |
| EP3750547A1 (en) | 2019-06-13 | 2020-12-16 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Modified nk-92 cells, and therapeutic and diagnostic uses thereof |
| CN115052965A (zh) | 2019-07-29 | 2022-09-13 | 麻省理工学院 | 用于器官发生的合成水凝胶 |
| CN111662871A (zh) * | 2020-06-11 | 2020-09-15 | 福建医科大学孟超肝胆医院(福州市传染病医院) | 一种核酸适体功能化nk细胞及其制备与应用 |
| IL301543A (en) | 2020-09-24 | 2023-05-01 | Medigene Immunotherapies Gmbh | Prame specific t cell receptors and uses thereof |
| JP2023547695A (ja) * | 2020-11-03 | 2023-11-13 | ハンチョウ キハン バイオテック カンパニー リミテッド | 増強された免疫療法のためのシステムおよび方法 |
| GB202017873D0 (en) | 2020-11-12 | 2020-12-30 | Olso Unversitetssykehus Hf | Method of determining DLBCL prognosis |
| KR20220160479A (ko) * | 2021-05-27 | 2022-12-06 | (주)에스엠티바이오 | 신경내분비종양의 치료용 자연살해세포 |
| WO2023047089A1 (en) | 2021-09-21 | 2023-03-30 | Oslo Universitetssykehus Hf | Binding proteins for terminal deoxynucleotidyl transferase (tdt) |
| WO2023078287A1 (en) * | 2021-11-03 | 2023-05-11 | Hangzhou Qihan Biotechnology Co., Ltd. | Systems and methods for enhanced immunotherapies |
| WO2024020537A2 (en) * | 2022-07-22 | 2024-01-25 | Board Of Regents, The University Of Texas System | Cd3-expressing natural killer cells with enhanced function for adoptive immunotherapy |
| WO2024261045A1 (en) | 2023-06-20 | 2024-12-26 | Zelluna Immunotherapy As | Methods of enhancing or modifying nk cells |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5124251A (en) | 1990-01-31 | 1992-06-23 | Becton, Dickinson And Company | CD3 ζ co-associated complex on CD16- NK cells |
| DE69834257T2 (de) | 1997-04-30 | 2007-01-04 | Klingemann, Hans | Natürliche killerzelllinien und verfahren zu ihrer verwendung |
| IL127142A0 (en) | 1998-11-19 | 1999-09-22 | Yeda Res & Dev | Immune cells having predefined biological specificity |
| US7786269B2 (en) | 2001-12-04 | 2010-08-31 | Dana-Farber Cancer Institute, Inc. | Antibody to latent membrane proteins and uses thereof |
| ES2678094T3 (es) * | 2004-07-10 | 2018-08-08 | Fox Chase Cancer Center | Líneas de células asesinas naturales genéticamente modificadas |
| JP5525689B2 (ja) * | 2004-11-02 | 2014-06-18 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンティッド バイ ザ セクレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 過剰増殖性障害を処置するための組成物および方法 |
| US8518697B2 (en) | 2006-04-04 | 2013-08-27 | Washington University | Single chain trimers and uses therefor |
| CN101631138A (zh) | 2008-07-18 | 2010-01-20 | 深圳富泰宏精密工业有限公司 | 个人信息代理系统及方法 |
| US8785601B2 (en) * | 2009-01-28 | 2014-07-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors and related materials and methods of use |
| EP2817620B1 (en) * | 2012-02-22 | 2016-06-01 | Verik Bio, Inc. | A system for immunotherapy targeting tumor propagation and progression |
| US11471486B2 (en) | 2012-09-04 | 2022-10-18 | Inven2 As | Selective and controlled expansion of educated NK cells |
| SG11201505858VA (en) | 2013-01-28 | 2015-09-29 | St Jude Childrens Res Hospital | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| CN105378078B (zh) | 2013-02-04 | 2019-03-01 | 罗杰威廉姆斯医疗中心 | 用于治疗胃肠道间质瘤(gist)的方法和组合物 |
| JP6425301B2 (ja) * | 2014-05-29 | 2018-11-21 | 国立大学法人富山大学 | Ｔｃｒの細胞傷害活性誘導能を評価するためのｎｋ細胞株、およびその作製方法 |
| US10550197B2 (en) | 2014-06-18 | 2020-02-04 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | CAR-expressing NK-92 cells as cell therapeutic agents |
| US20170274014A1 (en) * | 2014-07-21 | 2017-09-28 | Jennifer Brogdon | Combinations of low, immune enhancing, doses of mtor inhibitors and cars |
| GB201501175D0 (en) * | 2015-01-23 | 2015-03-11 | Univ Oslo Hf | A universal T-cell for personalised medicine |
-
2015
- 2015-01-23 GB GBGB1501175.2A patent/GB201501175D0/en not_active Ceased
-
2016
- 2016-01-22 JP JP2017557481A patent/JP6899333B2/ja active Active
- 2016-01-22 EA EA201791381A patent/EA201791381A1/ru unknown
- 2016-01-22 WO PCT/EP2016/051344 patent/WO2016116601A1/en not_active Ceased
- 2016-01-22 US US15/545,021 patent/US11155786B2/en active Active
- 2016-01-22 KR KR1020177023284A patent/KR102479118B1/ko active Active
- 2016-01-22 AU AU2016208475A patent/AU2016208475B2/en active Active
- 2016-01-22 ES ES16701339T patent/ES2922231T3/es active Active
- 2016-01-22 CN CN201680006587.4A patent/CN107250351A/zh active Pending
- 2016-01-22 SG SG11201705693XA patent/SG11201705693XA/en unknown
- 2016-01-22 PL PL16701339.0T patent/PL3247791T3/pl unknown
- 2016-01-22 EP EP22170488.5A patent/EP4095239A1/en not_active Withdrawn
- 2016-01-22 EP EP25201972.4A patent/EP4681735A3/en active Pending
- 2016-01-22 DK DK16701339.0T patent/DK3247791T3/da active
- 2016-01-22 PT PT167013390T patent/PT3247791T/pt unknown
- 2016-01-22 CA CA2973924A patent/CA2973924C/en active Active
- 2016-01-22 EP EP16701339.0A patent/EP3247791B1/en active Active
- 2016-01-22 MX MX2017009459A patent/MX390756B/es unknown
-
2017
- 2017-07-13 IL IL253464A patent/IL253464B/en unknown
-
2021
- 2021-09-23 US US17/483,484 patent/US20220127574A1/en not_active Abandoned
-
2022
- 2022-01-11 AU AU2022200126A patent/AU2022200126A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20180010097A1 (en) | 2018-01-11 |
| AU2016208475A1 (en) | 2017-08-03 |
| US20220127574A1 (en) | 2022-04-28 |
| SG11201705693XA (en) | 2017-08-30 |
| EP4681735A2 (en) | 2026-01-21 |
| PL3247791T3 (pl) | 2022-09-05 |
| KR102479118B1 (ko) | 2022-12-16 |
| JP2018512047A (ja) | 2018-05-10 |
| CA2973924C (en) | 2024-06-04 |
| JP6899333B2 (ja) | 2021-07-07 |
| EP4681735A3 (en) | 2026-03-25 |
| EP3247791A1 (en) | 2017-11-29 |
| IL253464A0 (en) | 2017-09-28 |
| EP4095239A1 (en) | 2022-11-30 |
| AU2016208475B2 (en) | 2021-10-14 |
| MX390756B (es) | 2025-03-04 |
| CA2973924A1 (en) | 2016-07-28 |
| NZ733855A (en) | 2023-10-27 |
| KR20170121178A (ko) | 2017-11-01 |
| MX2017009459A (es) | 2018-04-11 |
| AU2022200126A1 (en) | 2022-02-10 |
| BR112017015631A2 (pt) | 2018-03-13 |
| IL253464B (en) | 2022-04-01 |
| PT3247791T (pt) | 2022-07-20 |
| ES2922231T3 (es) | 2022-09-12 |
| US11155786B2 (en) | 2021-10-26 |
| GB201501175D0 (en) | 2015-03-11 |
| EP3247791B1 (en) | 2022-05-04 |
| DK3247791T3 (da) | 2022-07-11 |
| WO2016116601A1 (en) | 2016-07-28 |
| CN107250351A (zh) | 2017-10-13 |
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