JP2018503401A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018503401A5 JP2018503401A5 JP2017556795A JP2017556795A JP2018503401A5 JP 2018503401 A5 JP2018503401 A5 JP 2018503401A5 JP 2017556795 A JP2017556795 A JP 2017556795A JP 2017556795 A JP2017556795 A JP 2017556795A JP 2018503401 A5 JP2018503401 A5 JP 2018503401A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- amino acid
- constant region
- chain constant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 41
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 39
- 102000003390 tumor necrosis factor Human genes 0.000 claims description 39
- 102000005962 receptors Human genes 0.000 claims description 38
- 108020003175 receptors Proteins 0.000 claims description 38
- 239000000427 antigen Substances 0.000 claims description 33
- 102000036639 antigens Human genes 0.000 claims description 33
- 108091007433 antigens Proteins 0.000 claims description 33
- 239000012634 fragment Substances 0.000 claims description 23
- 108091033319 polynucleotide Proteins 0.000 claims description 23
- 102000040430 polynucleotide Human genes 0.000 claims description 23
- 239000002157 polynucleotide Substances 0.000 claims description 23
- 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 claims description 13
- 206010028980 Neoplasm Diseases 0.000 claims description 13
- 102100040112 Tumor necrosis factor receptor superfamily member 10B Human genes 0.000 claims description 13
- 230000006907 apoptotic process Effects 0.000 claims description 13
- 201000011510 cancer Diseases 0.000 claims description 13
- 229920001184 polypeptide Polymers 0.000 claims description 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 12
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 11
- 101000610605 Homo sapiens Tumor necrosis factor receptor superfamily member 10A Proteins 0.000 claims description 11
- 102100040113 Tumor necrosis factor receptor superfamily member 10A Human genes 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 230000001939 inductive effect Effects 0.000 claims description 9
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 8
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 8
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
- 101000840258 Homo sapiens Immunoglobulin J chain Proteins 0.000 claims description 7
- 101000610602 Homo sapiens Tumor necrosis factor receptor superfamily member 10C Proteins 0.000 claims description 7
- 101000610609 Homo sapiens Tumor necrosis factor receptor superfamily member 10D Proteins 0.000 claims description 7
- 102100029571 Immunoglobulin J chain Human genes 0.000 claims description 7
- 102100040115 Tumor necrosis factor receptor superfamily member 10C Human genes 0.000 claims description 7
- 102100040110 Tumor necrosis factor receptor superfamily member 10D Human genes 0.000 claims description 7
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 claims description 7
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 claims description 7
- 239000013598 vector Substances 0.000 claims description 7
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 6
- 238000006467 substitution reaction Methods 0.000 claims description 6
- 230000001404 mediated effect Effects 0.000 claims description 5
- 101150013553 CD40 gene Proteins 0.000 claims description 4
- 101001055311 Equus asinus Immunoglobulin heavy constant alpha Proteins 0.000 claims description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 4
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 4
- 150000007523 nucleic acids Chemical group 0.000 claims description 4
- 101000648505 Homo sapiens Tumor necrosis factor receptor superfamily member 12A Proteins 0.000 claims description 3
- 101000679907 Homo sapiens Tumor necrosis factor receptor superfamily member 27 Proteins 0.000 claims description 3
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims description 3
- 101000920026 Homo sapiens Tumor necrosis factor receptor superfamily member EDAR Proteins 0.000 claims description 3
- 108060003951 Immunoglobulin Proteins 0.000 claims description 3
- 108010035042 Osteoprotegerin Proteins 0.000 claims description 3
- 102000008108 Osteoprotegerin Human genes 0.000 claims description 3
- 108010014401 TWEAK Receptor Proteins 0.000 claims description 3
- 102000016946 TWEAK Receptor Human genes 0.000 claims description 3
- 102100032236 Tumor necrosis factor receptor superfamily member 11B Human genes 0.000 claims description 3
- 102100028786 Tumor necrosis factor receptor superfamily member 12A Human genes 0.000 claims description 3
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims description 3
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims description 3
- 102100022202 Tumor necrosis factor receptor superfamily member 27 Human genes 0.000 claims description 3
- 102100040403 Tumor necrosis factor receptor superfamily member 6 Human genes 0.000 claims description 3
- 102100030810 Tumor necrosis factor receptor superfamily member EDAR Human genes 0.000 claims description 3
- 230000001640 apoptogenic effect Effects 0.000 claims description 3
- 102000018358 immunoglobulin Human genes 0.000 claims description 3
- 101000648507 Homo sapiens Tumor necrosis factor receptor superfamily member 14 Proteins 0.000 claims description 2
- 101000679903 Homo sapiens Tumor necrosis factor receptor superfamily member 25 Proteins 0.000 claims description 2
- 101000597785 Homo sapiens Tumor necrosis factor receptor superfamily member 6B Proteins 0.000 claims description 2
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 2
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims description 2
- 102400001107 Secretory component Human genes 0.000 claims description 2
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims description 2
- 102100022203 Tumor necrosis factor receptor superfamily member 25 Human genes 0.000 claims description 2
- 102100035284 Tumor necrosis factor receptor superfamily member 6B Human genes 0.000 claims description 2
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims description 2
- 230000011664 signaling Effects 0.000 claims 5
- 230000019552 anatomical structure morphogenesis Effects 0.000 claims 3
- 230000035755 proliferation Effects 0.000 claims 3
- 230000019491 signal transduction Effects 0.000 claims 3
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 1
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 1
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000795167 Homo sapiens Tumor necrosis factor receptor superfamily member 13B Proteins 0.000 claims 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
- 102100029675 Tumor necrosis factor receptor superfamily member 13B Human genes 0.000 claims 1
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 22
- 210000003494 hepatocyte Anatomy 0.000 description 3
- 241001024304 Mino Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562105323P | 2015-01-20 | 2015-01-20 | |
| US62/105,323 | 2015-01-20 | ||
| PCT/US2016/014153 WO2016118641A1 (en) | 2015-01-20 | 2016-01-20 | Tumor necrosis factor (tnf) superfamily receptor binding molecules and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020158581A Division JP2021006044A (ja) | 2015-01-20 | 2020-09-23 | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018503401A JP2018503401A (ja) | 2018-02-08 |
| JP2018503401A5 true JP2018503401A5 (cg-RX-API-DMAC7.html) | 2019-02-28 |
| JP7179464B2 JP7179464B2 (ja) | 2022-11-29 |
Family
ID=56417700
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556795A Active JP7179464B2 (ja) | 2015-01-20 | 2016-01-20 | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
| JP2020158581A Pending JP2021006044A (ja) | 2015-01-20 | 2020-09-23 | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
| JP2022142258A Active JP7499813B2 (ja) | 2015-01-20 | 2022-09-07 | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
| JP2024090474A Withdrawn JP2024113039A (ja) | 2015-01-20 | 2024-06-04 | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020158581A Pending JP2021006044A (ja) | 2015-01-20 | 2020-09-23 | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
| JP2022142258A Active JP7499813B2 (ja) | 2015-01-20 | 2022-09-07 | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
| JP2024090474A Withdrawn JP2024113039A (ja) | 2015-01-20 | 2024-06-04 | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US10689449B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3247728B1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP7179464B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102435324B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN107207601A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2016209324B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2972990A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK3247728T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2806500T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE051013T2 (cg-RX-API-DMAC7.html) |
| IL (3) | IL308212A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ732922A (cg-RX-API-DMAC7.html) |
| PL (1) | PL3247728T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT3247728T (cg-RX-API-DMAC7.html) |
| SG (2) | SG10202001779UA (cg-RX-API-DMAC7.html) |
| SI (1) | SI3247728T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016118641A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3041862B1 (en) | 2013-09-05 | 2020-05-06 | IGM Biosciences, Inc. | Constant chain modified bispecific, penta- and hexavalent ig-m antibodies |
| CN105992772A (zh) | 2014-02-10 | 2016-10-05 | Igm生命科学股份有限公司 | IgA多特异性结合分子 |
| AU2015240595B2 (en) | 2014-04-03 | 2020-02-27 | Igm Biosciences, Inc. | Modified J-chain |
| IL308212A (en) | 2015-01-20 | 2024-01-01 | Igm Biosciences Inc | Tumor necrosis factor-α receptor binding molecules and their uses |
| CA2978324A1 (en) | 2015-03-04 | 2016-09-09 | Igm Biosciences, Inc. | Cd20 binding molecules and uses thereof |
| CA2980751A1 (en) | 2015-03-25 | 2016-09-29 | Stephen F. Carroll | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| HK1245675A1 (zh) | 2015-04-17 | 2018-08-31 | Igm Biosciences, Inc. | 多价人免疫缺陷病毒抗原结合分子及其用途 |
| SI3355913T1 (sl) | 2015-09-30 | 2025-01-31 | Igm Biosciences, Inc. | Vezalne molekule z modificirano j-verigo |
| ES2819870T3 (es) | 2015-09-30 | 2021-04-19 | Igm Biosciences Inc | Moléculas de unión con cadena J modificada |
| PT3455257T (pt) | 2016-05-09 | 2021-12-06 | Igm Biosciences Inc | Anticorpos anti-pd-l1 |
| CA3030659A1 (en) * | 2016-07-20 | 2018-01-25 | Igm Biosciences, Inc. | Multimeric gitr binding molecules and uses thereof |
| MA45941A (fr) * | 2016-08-12 | 2019-06-19 | Janssen Biotech Inc | Anticorps de membres de la superfamille anti-tnfr modifiés par fc ayant une activité agoniste améliorée et leurs procédés d'utilisation |
| EP3360898A1 (en) * | 2017-02-14 | 2018-08-15 | Boehringer Ingelheim International GmbH | Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer |
| AU2018247931B2 (en) * | 2017-04-06 | 2022-03-03 | Universität Stuttgart | Tumor necrosis factor receptor (TNFR) binding protein complex with improved binding and bioactivity |
| WO2018187702A2 (en) | 2017-04-07 | 2018-10-11 | Igm Biosciences A/S | Modified human igm constant regions for modulation of complement-dependent cytolysis effector function |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| EP3737692A4 (en) | 2018-01-09 | 2021-09-29 | Elstar Therapeutics, Inc. | CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES |
| CN108251443A (zh) * | 2018-01-23 | 2018-07-06 | 深圳市人民医院 | 一种tnfrsf10c重组质粒、制备方法及其应用 |
| WO2019157772A1 (zh) * | 2018-02-13 | 2019-08-22 | 和元生物技术（上海）股份有限公司 | 抗trailr2抗体-毒素-偶联物及其在抗肿瘤治疗中的药物用途 |
| EP3759229A4 (en) * | 2018-02-26 | 2021-12-29 | IGM Biosciences Inc. | Use of a multimeric anti-dr5 binding molecule in combination with a chemotherapeutic agent for treating cancer |
| CA3091144A1 (en) | 2018-03-01 | 2019-09-06 | Igm Biosciences, Inc. | Igm fc and j-chain mutations that affect igm serum half-life |
| EP3765517A1 (en) | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| EP3818083A2 (en) | 2018-07-03 | 2021-05-12 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| SG11202103720XA (en) * | 2018-10-23 | 2021-05-28 | Igm Biosciences Inc | MULTIVALENT IgM- AND IgA-Fc-BASED BINDING MOLECULES |
| CN119661722A (zh) | 2019-02-21 | 2025-03-21 | 马伦戈治疗公司 | 结合t细胞相关癌细胞的多功能分子及其用途 |
| SG11202108955QA (en) | 2019-02-21 | 2021-09-29 | Marengo Therapeutics Inc | Antibody molecules that bind to nkp30 and uses thereof |
| ES3031566T3 (en) | 2019-06-24 | 2025-07-09 | Univ Stuttgart | Tnfr2 agonists with improved stability |
| EP3907240A4 (en) * | 2019-08-02 | 2023-02-22 | Jiangsu Simcere Pharmaceutical Co., Ltd. | Anti-tnfr2 antibody and use thereof |
| WO2021030688A1 (en) | 2019-08-15 | 2021-02-18 | Igm Biosciences, Inc. | Immunostimulatory multimeric binding molecules |
| GB2609554B (en) | 2020-01-03 | 2025-08-20 | Marengo Therapeutics Inc | Anti-TCR antibody molecules and uses thereof |
| CN115443140A (zh) * | 2020-04-02 | 2022-12-06 | 苏州恒康生命科学有限公司 | 人ror-1抗体和抗ror-1-car-t细胞 |
| JP2023522962A (ja) | 2020-04-22 | 2023-06-01 | アイジーエム バイオサイエンシズ インコーポレイテッド | Ｐｄ－１アゴニスト多量体結合分子 |
| KR20230010221A (ko) * | 2020-05-12 | 2023-01-18 | 아이쥐엠 바이오사이언스 인코포레이티드 | 암 치료를 위한 암 요법과 병용된 다량체 항-dr5 결합 분자의 용도 |
| WO2022036495A1 (en) | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
| JP7203870B2 (ja) | 2021-01-18 | 2023-01-13 | イビデン株式会社 | 組電池用熱伝達抑制シート及び組電池 |
| WO2022212191A1 (en) * | 2021-04-01 | 2022-10-06 | Modernatx, Inc. | Mucosal expression of antibody structures and isotypes by mrna |
| EP4320147A4 (en) | 2021-04-08 | 2025-06-18 | Marengo Therapeutics, Inc. | TCR-BINDING MULTIFUNCTIONAL MOLECULES AND USES THEREOF |
Family Cites Families (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE69133566T2 (de) | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Bildung von xenogenen Antikörpern |
| GB9015908D0 (en) | 1990-07-19 | 1990-09-05 | Celltech Ltd | Multivalent immunoglobulin |
| US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| WO1993023550A2 (en) | 1992-05-18 | 1993-11-25 | Genentech, Inc. | Activation of oligomerizing receptors by using fused receptor ligands |
| DK0614984T4 (da) | 1993-03-05 | 2010-12-20 | Bayer Healthcare Llc | Humane monoklonale anti-TNF-alfa-antistoffer |
| CA2139385C (en) | 1994-02-04 | 2001-12-25 | Gottfried Alber | Products containing g-csf and tnf binding protein |
| AU697387C (en) | 1994-09-16 | 2006-03-02 | Austin Research Institute Cancer and Anti-inflammatory Syndicate No 1 | Polypeptides with Fc binding ability |
| US8791237B2 (en) | 1994-11-08 | 2014-07-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of non-hodgkins lymphoma |
| CA2211443A1 (en) | 1995-01-26 | 1996-08-01 | Biogen, Inc. | Lymphotoxin-.alpha./.beta. complexes and anti-lymphotoxin-beta receptor antibodies as anti-tumor agents |
| IL116784A (en) | 1996-01-16 | 2000-01-31 | Hadasit Med Res Service | Device for examining viscoelasticity of a living or artificial tissue |
| US8212004B2 (en) | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
| US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
| US20060269558A1 (en) | 1998-04-27 | 2006-11-30 | Murphy Gerald P | Nr-CAM gene, nucleic acids and nucleic acid products for therapeutic and diagnostic uses for tumors |
| EP1642972B1 (en) | 1999-01-07 | 2009-12-30 | ZymoGenetics, Inc. | Therapeutic uses of BR43X2 soluble receptors |
| JP2003512020A (ja) | 1999-03-04 | 2003-04-02 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | 腫瘍壊死因子レセプター６αおよび腫瘍壊死因子レセプター６β |
| AU3623700A (en) | 1999-03-11 | 2000-09-28 | Reinhard Ebner | Apoptosis inducing molecule ii and methods of use |
| DE19963859A1 (de) | 1999-12-30 | 2001-07-12 | Apotech Res & Dev Ltd | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
| US7262005B1 (en) | 2000-02-04 | 2007-08-28 | Aurora Biosciences Corporation | Methods of protein destabilization and uses thereof |
| MXPA02010011A (es) | 2000-04-11 | 2003-04-25 | Genentech Inc | Anticuerpos multivalentes y usos para los mismos. |
| TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
| EP1360290A2 (en) | 2000-06-23 | 2003-11-12 | Maxygen, Inc. | Co-stimulatory molecules |
| JP2004502450A (ja) | 2000-07-10 | 2004-01-29 | ノバルティス アクチエンゲゼルシャフト | ターゲッティング遺伝子送達のための二官能性分子およびそれと複合化されたベクター |
| WO2002102303A2 (en) | 2001-05-01 | 2002-12-27 | Medimmune, Inc. | Crystals and structure of synagis fab |
| AU2002256895B2 (en) | 2001-05-18 | 2008-09-18 | Kirin Beer Kabushiki Kaisha | Anti-TRAIL-R antibodies |
| WO2002097046A2 (en) | 2001-05-25 | 2002-12-05 | Amgen, Inc. | B7 related protein-2 molecules and uses thereof |
| US20050214210A1 (en) * | 2001-05-25 | 2005-09-29 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
| US7199227B2 (en) | 2001-06-14 | 2007-04-03 | Bristol-Myers Squibb Company | Polynucleotides encoding human histone deacetylase HDAC9c |
| NZ532881A (en) | 2001-12-20 | 2008-04-30 | Human Genome Sciences Inc | Antibodies that immunospecifically bind to trail receptors |
| PT1523496E (pt) | 2002-07-18 | 2011-09-29 | Merus B V | Produção de misturas de anticorpos de forma recombinante |
| GB0220205D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Neisseria toxin |
| ATE481092T1 (de) | 2002-11-27 | 2010-10-15 | Irm Llc | Verfahren und zusammensetzungen zur apoptoseinduktion in krebszellen |
| US20060269562A1 (en) | 2003-01-07 | 2006-11-30 | Christine Bain | Polypeptides f' of the hepatitis c virus, t epitopeo, and the diagnostic and therapeutic applications thereof |
| TW200510532A (en) | 2003-07-15 | 2005-03-16 | Chugai Pharmaceutical Co Ltd | IgM production by transformed cell and method of quantifying the same |
| DE602004009199T2 (de) | 2003-08-01 | 2008-06-19 | Enhan Technology Holdings International Co., Ltd. | Wirkungen von sporoderm-gebrochenen germinationsaktivierten ganoderma-sporen auf die behandlung von rückenmarksverletzungen und die proliferation und/oder differenzierung von neuralen stammzellen in verletztem rückenmark |
| CN100427505C (zh) | 2004-08-19 | 2008-10-22 | 中国医学科学院基础医学研究所 | 抗人肿瘤坏死因子相关凋亡诱导配体的受体dr5单克隆抗体（ad5-10）及其制法与用途 |
| CA2586285A1 (en) | 2004-11-05 | 2006-05-18 | Palingen, Inc. | Antibody induced cell membrane wounding |
| US20090311280A1 (en) | 2004-12-09 | 2009-12-17 | La Jolla Institute For Allergy And Immunology | Novel tnf receptor regulatory domain |
| JP2008528512A (ja) | 2005-01-21 | 2008-07-31 | エピトピックス，リミティド ライアビリティ カンパニー | エルシニアｓｐｐ．ポリペプチド及び使用方法 |
| US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
| US20060269556A1 (en) | 2005-04-18 | 2006-11-30 | Karl Nocka | Mast cell activation using siglec 6 antibodies |
| PA8672101A1 (es) | 2005-04-29 | 2006-12-07 | Centocor Inc | Anticuerpos anti-il-6, composiciones, métodos y usos |
| US8088908B2 (en) | 2005-05-10 | 2012-01-03 | City Of Hope | Humanized anti-prostate stem cell antigen monoclonal antibody |
| US20060269569A1 (en) | 2005-05-16 | 2006-11-30 | Liu Yuen | Universal antioncotic and pain relieving ointment |
| US20060269567A1 (en) | 2005-05-16 | 2006-11-30 | Liu Yuen | Universal detoxifying composition |
| WO2006127798A2 (en) | 2005-05-24 | 2006-11-30 | The United States Of America As Represented By The Secretary Of The Navy | Anti-adhesin based passive immunoprophylactic |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| PE20071101A1 (es) | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
| AR056142A1 (es) | 2005-10-21 | 2007-09-19 | Amgen Inc | Metodos para generar el anticuerpo igg monovalente |
| TWI461436B (zh) | 2005-11-25 | 2014-11-21 | Kyowa Hakko Kirin Co Ltd | 人類ｃｄ１３４（ｏｘ４０）之人類單株抗體及其製造及使用方法 |
| EP1981912A2 (en) | 2006-01-13 | 2008-10-22 | Irm, Llc | Antibodies against thymic stromal lymphopoietin receptor for treating allergic diseases |
| CN101074261A (zh) | 2006-04-30 | 2007-11-21 | 北京同为时代生物技术有限公司 | Trail受体1和/或trail受体2特异性抗体及其应用 |
| AU2007252295B2 (en) | 2006-05-19 | 2013-07-25 | Central Adelaide Local Health Network Incorporated | Selective modulation of receptor signalling |
| CN105837690A (zh) | 2006-06-12 | 2016-08-10 | 新兴产品开发西雅图有限公司 | 具有效应功能的单链多价结合蛋白 |
| KR100847010B1 (ko) | 2006-07-05 | 2008-07-17 | 아주대학교산학협력단 | 세포사멸 수용체 5 (ｄｒ5)에 특이적으로 결합하는 항체 및이를 포함하는 암 예방 또는 치료용 조성물 |
| EP1894940A1 (en) | 2006-08-28 | 2008-03-05 | Apogenix GmbH | TNF superfamily fusion proteins |
| CA2662701C (en) | 2006-09-08 | 2015-12-08 | Abbott Laboratories | Interleukin-13 binding proteins |
| GB0620894D0 (en) | 2006-10-20 | 2006-11-29 | Univ Southampton | Human immune therapies using a CD27 agonist alone or in combination with other immune modulators |
| DK3284825T3 (da) | 2006-11-02 | 2021-05-25 | Biomolecular Holdings Llc | Fremgangsmåder til at fremstille hybride polypeptider med bevægelige dele |
| EP2195342A1 (en) | 2007-09-07 | 2010-06-16 | Ablynx N.V. | Binding molecules with multiple binding sites, compositions comprising the same and uses thereof |
| US7960145B2 (en) | 2007-11-08 | 2011-06-14 | Cytimmune Sciences, Inc. | Compositions and methods for generating antibodies |
| EP2254592B1 (en) | 2008-02-28 | 2019-06-05 | Dako Denmark A/S | Mhc multimers in borrelia diagnostics and disease |
| EP2322220B1 (en) | 2008-08-01 | 2014-01-01 | Axis, Inc. | Therapeutic agent or preventive agent for osteoarthritis |
| US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| WO2011090762A1 (en) | 2009-12-29 | 2011-07-28 | Emergent Product Development Seattle, Llc | Heterodimer binding proteins and uses thereof |
| WO2011116387A1 (en) | 2010-03-19 | 2011-09-22 | Tetragenetics, Inc. | Production of aglycosylated monoclonal antibodies in ciliates |
| JP2013523153A (ja) | 2010-04-07 | 2013-06-17 | アッヴィ・インコーポレイテッド | ＴＮＦ−α結合タンパク質 |
| DK2614082T3 (en) | 2010-09-09 | 2018-11-26 | Pfizer | 4-1BB BINDING MOLECULES |
| RS54846B1 (sr) | 2010-10-29 | 2016-10-31 | Daiichi Sankyo Co Ltd | Novo anti-dr5 antitelo |
| EP2655415A4 (en) | 2010-12-22 | 2016-03-09 | Abbvie Inc | THREE VARIABLE DOMAIN LINK PROTEINS AND USES THEREOF |
| DK2699601T3 (en) | 2011-04-21 | 2018-04-23 | Bristol Myers Squibb Co | ANTIBODY POLYPEPTIDES ANTAGONIZING CD40 |
| GB201115280D0 (en) | 2011-09-05 | 2011-10-19 | Alligator Bioscience Ab | Antibodies, uses and methods |
| GB201116092D0 (en) | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
| US9382319B2 (en) * | 2011-09-26 | 2016-07-05 | Jn Biosciences Llc | Hybrid constant regions |
| WO2013049254A1 (en) * | 2011-09-26 | 2013-04-04 | Jn Biosciences Llc | Hybrid constant regions |
| SG11201401796SA (en) | 2011-10-24 | 2014-10-30 | Abbvie Inc | Bispecific immunobinders directed against tnf and il-17 |
| IN2014MN01781A (cg-RX-API-DMAC7.html) | 2012-02-08 | 2015-07-03 | Igm Biosciences Inc | |
| EP2684896A1 (en) | 2012-07-09 | 2014-01-15 | International-Drug-Development-Biotech | Anti-DR5 family antibodies, bispecific or multivalent anti-DR5 family antibodies and methods of use thereof |
| PT2879719T (pt) * | 2012-08-01 | 2018-10-08 | Ohio State Innovation Foundation | Administração intratecal do vírus adeno-associado 9 recombinante |
| EP2880057A4 (en) * | 2012-08-02 | 2016-03-23 | Jn Biosciences Llc | MULTIMERIZED FUSION ANTIBODIES OR PROTEINS THROUGH THE MUTATION OF A CYSTEINE AND A PIECE OF TAIL |
| CN104245736B (zh) | 2012-10-26 | 2016-12-21 | 和元生物技术（上海）股份有限公司 | 抗人死亡受体5胞外区的人源化单克隆抗体 |
| US9487773B2 (en) | 2013-03-01 | 2016-11-08 | Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa | Cell-based methods for coupling protein interactions and binding molecule selection |
| UA118028C2 (uk) | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування |
| JP6618463B2 (ja) | 2013-05-07 | 2019-12-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 三量体型抗原結合分子 |
| US20150038682A1 (en) | 2013-08-02 | 2015-02-05 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via homomultimerizing peptide |
| EP3041862B1 (en) | 2013-09-05 | 2020-05-06 | IGM Biosciences, Inc. | Constant chain modified bispecific, penta- and hexavalent ig-m antibodies |
| WO2015037000A1 (en) | 2013-09-11 | 2015-03-19 | Compugen Ltd | Vstm5 polypeptides and uses thereof as a drug for treatment of cancer, infectious diseases and immune related diseases |
| KR102056963B1 (ko) | 2013-12-30 | 2019-12-17 | 에피맙 바이오테라퓨틱스 인코포레이티드 | Fabs-인-탠덤 면역글로불린 및 이의 용도 |
| SG11201605691VA (en) | 2014-01-16 | 2016-08-30 | Mario Umberto Francesco Mondelli | Neutralizing human monoclonal antibodies against hepatitis b virus surface antigen |
| CN105992772A (zh) | 2014-02-10 | 2016-10-05 | Igm生命科学股份有限公司 | IgA多特异性结合分子 |
| CN107172880B (zh) | 2014-03-24 | 2021-09-28 | 癌症研究技术有限公司 | 含有修饰IgG2结构域的引起激动或拮抗特性的修饰抗体及其用途 |
| AU2015240595B2 (en) | 2014-04-03 | 2020-02-27 | Igm Biosciences, Inc. | Modified J-chain |
| AU2015330087A1 (en) | 2014-10-08 | 2017-04-06 | F. Hoffmann-La Roche Ag | Combination therapy of bispecific antibodies specific for FAP and DR5 and chemotherapeutic agents |
| IL308212A (en) | 2015-01-20 | 2024-01-01 | Igm Biosciences Inc | Tumor necrosis factor-α receptor binding molecules and their uses |
| SG11201706024YA (en) | 2015-01-26 | 2017-08-30 | Macrogenics Inc | Multivalent molecules comprising dr5-binding domains |
| CA2978324A1 (en) | 2015-03-04 | 2016-09-09 | Igm Biosciences, Inc. | Cd20 binding molecules and uses thereof |
| CA2980751A1 (en) | 2015-03-25 | 2016-09-29 | Stephen F. Carroll | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| HK1245675A1 (zh) | 2015-04-17 | 2018-08-31 | Igm Biosciences, Inc. | 多价人免疫缺陷病毒抗原结合分子及其用途 |
| BR112017028316A2 (en) | 2015-06-30 | 2018-09-04 | Sanford-Burnham Medical Research Institute | btla fusion protein agonists and uses thereof |
| WO2015151081A2 (en) | 2015-07-12 | 2015-10-08 | Suzhou M-Conj Biotech Co., Ltd | Bridge linkers for conjugation of a cell-binding molecule |
| ES2819870T3 (es) | 2015-09-30 | 2021-04-19 | Igm Biosciences Inc | Moléculas de unión con cadena J modificada |
| SI3355913T1 (sl) | 2015-09-30 | 2025-01-31 | Igm Biosciences, Inc. | Vezalne molekule z modificirano j-verigo |
| PT3455257T (pt) | 2016-05-09 | 2021-12-06 | Igm Biosciences Inc | Anticorpos anti-pd-l1 |
| CA3030659A1 (en) | 2016-07-20 | 2018-01-25 | Igm Biosciences, Inc. | Multimeric gitr binding molecules and uses thereof |
| MX2019000796A (es) | 2016-07-20 | 2019-06-03 | Igm Biosciences Inc | Moleculas multimericas de union a ox40 y usos de las mismas. |
| AU2017299610B2 (en) | 2016-07-20 | 2022-09-29 | Igm Biosciences, Inc. | Multimeric CD40 binding molecules and uses thereof |
| CA3030634A1 (en) | 2016-07-20 | 2018-01-25 | Igm Biosciences, Inc. | Multimeric cd137/4-1bb binding molecules and uses thereof |
| AU2017332452B2 (en) | 2016-09-23 | 2021-01-07 | Merus N.V. | Binding molecules that modulate a biological activity expressed by a cell |
| WO2018187702A2 (en) | 2017-04-07 | 2018-10-11 | Igm Biosciences A/S | Modified human igm constant regions for modulation of complement-dependent cytolysis effector function |
| EP3759229A4 (en) | 2018-02-26 | 2021-12-29 | IGM Biosciences Inc. | Use of a multimeric anti-dr5 binding molecule in combination with a chemotherapeutic agent for treating cancer |
| CA3091144A1 (en) | 2018-03-01 | 2019-09-06 | Igm Biosciences, Inc. | Igm fc and j-chain mutations that affect igm serum half-life |
| SG11202103720XA (en) | 2018-10-23 | 2021-05-28 | Igm Biosciences Inc | MULTIVALENT IgM- AND IgA-Fc-BASED BINDING MOLECULES |
| US20220106398A1 (en) | 2019-02-08 | 2022-04-07 | Igm Biosciences, Inc. | Anti-gitr antigen-binding domains and uses thereof |
| WO2021030688A1 (en) | 2019-08-15 | 2021-02-18 | Igm Biosciences, Inc. | Immunostimulatory multimeric binding molecules |
| CN114341179B (zh) | 2019-08-17 | 2025-01-28 | Igm生物科学股份有限公司 | 多聚体双特异性抗cd123结合分子及其用途 |
| WO2021041250A1 (en) | 2019-08-23 | 2021-03-04 | Igm Biosciences, Inc. | Igm glycovariants |
| CA3151237A1 (en) | 2019-09-19 | 2021-03-25 | Ramesh Baliga | Multimeric antibodies with enhanced selectivity for cells with high target density |
| CN114945384A (zh) | 2020-01-06 | 2022-08-26 | Igm生物科学股份有限公司 | 高度唾液酸化的多聚体结合分子 |
| JP2023522962A (ja) | 2020-04-22 | 2023-06-01 | アイジーエム バイオサイエンシズ インコーポレイテッド | Ｐｄ－１アゴニスト多量体結合分子 |
| KR20230010221A (ko) | 2020-05-12 | 2023-01-18 | 아이쥐엠 바이오사이언스 인코포레이티드 | 암 치료를 위한 암 요법과 병용된 다량체 항-dr5 결합 분자의 용도 |
| WO2022026475A2 (en) | 2020-07-27 | 2022-02-03 | Igm Biosciences, Inc. | Multimeric coronavirus binding molecules and uses thereof |
| US20240002526A1 (en) | 2020-11-17 | 2024-01-04 | Igm Biosciences, Inc. | Uses of effector cell engaging molecules with moieties of differing potencies |
| WO2022177870A1 (en) | 2021-02-17 | 2022-08-25 | The Board Of Regents Of The University Of Texas System | Multimeric sars-cov-2 binding molecules and uses thereof |
| MX2023009615A (es) | 2021-02-17 | 2023-08-24 | Igm Biosciences Inc | Moleculas de union anti-cd123 y usos de estas. |
-
2016
- 2016-01-20 IL IL308212A patent/IL308212A/en unknown
- 2016-01-20 ES ES16740686T patent/ES2806500T3/es active Active
- 2016-01-20 PT PT167406867T patent/PT3247728T/pt unknown
- 2016-01-20 PL PL16740686T patent/PL3247728T3/pl unknown
- 2016-01-20 SI SI201630842T patent/SI3247728T1/sl unknown
- 2016-01-20 EP EP16740686.7A patent/EP3247728B1/en active Active
- 2016-01-20 CA CA2972990A patent/CA2972990A1/en active Pending
- 2016-01-20 SG SG10202001779UA patent/SG10202001779UA/en unknown
- 2016-01-20 KR KR1020177022773A patent/KR102435324B1/ko active Active
- 2016-01-20 NZ NZ732922A patent/NZ732922A/en unknown
- 2016-01-20 EP EP20168740.7A patent/EP3750918A1/en active Pending
- 2016-01-20 IL IL284430A patent/IL284430B2/en unknown
- 2016-01-20 US US15/544,873 patent/US10689449B2/en active Active
- 2016-01-20 SG SG11201705116SA patent/SG11201705116SA/en unknown
- 2016-01-20 JP JP2017556795A patent/JP7179464B2/ja active Active
- 2016-01-20 CN CN201680006321.XA patent/CN107207601A/zh active Pending
- 2016-01-20 DK DK16740686.7T patent/DK3247728T3/da active
- 2016-01-20 WO PCT/US2016/014153 patent/WO2016118641A1/en not_active Ceased
- 2016-01-20 AU AU2016209324A patent/AU2016209324B2/en active Active
- 2016-01-20 HU HUE16740686A patent/HUE051013T2/hu unknown
-
2017
- 2017-06-21 IL IL253054A patent/IL253054B/en unknown
- 2017-06-30 US US15/638,748 patent/US9938347B2/en active Active
-
2020
- 2020-02-24 AU AU2020201323A patent/AU2020201323B2/en active Active
- 2020-04-28 US US16/861,102 patent/US11578131B2/en active Active
- 2020-09-23 JP JP2020158581A patent/JP2021006044A/ja active Pending
-
2022
- 2022-09-07 JP JP2022142258A patent/JP7499813B2/ja active Active
- 2022-11-14 US US18/055,340 patent/US20230203173A1/en not_active Abandoned
-
2024
- 2024-06-04 JP JP2024090474A patent/JP2024113039A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018503401A5 (cg-RX-API-DMAC7.html) | ||
| JP7499813B2 (ja) | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 | |
| JP2019530640A5 (cg-RX-API-DMAC7.html) | ||
| JP2019528683A5 (cg-RX-API-DMAC7.html) | ||
| JP2022177090A5 (cg-RX-API-DMAC7.html) | ||
| JP2007530588A5 (cg-RX-API-DMAC7.html) | ||
| CA2969888A1 (en) | Agonistic tnf receptor binding agents | |
| TWI874613B (zh) | 微型導引和導航控制(miniGNC)類抗體蛋白及其製造和使用方法 | |
| JP2019513370A5 (cg-RX-API-DMAC7.html) | ||
| CA3022636A1 (en) | Cd40l-fc fusion polypeptides and methods of use thereof | |
| EP2938637A2 (en) | Multivalent binding protein compositions | |
| EP2483310A1 (en) | Bispecific death receptor agonistic antibodies | |
| US20210380691A1 (en) | Multifunctional molecules that bind to t cells and uses thereof to treat autoimmune disorders | |
| CA3079363A1 (en) | Multispecific antigen binding proteins | |
| AU2019416503A1 (en) | Antibody fusion protein, preparation method therefor and application thereof | |
| RU2016132370A (ru) | ХИМЕРНЫЙ БЕЛОК, СОСТАВЛЕННЫЙ ИЗ ДОМЕНА АНТАГОНИСТА NGF И ДОМЕНА АНТАГОНИСТА TNFα | |
| CA3205985A1 (en) | Antibodies to tnfr2 and uses thereof | |
| RU2019104896A (ru) | Антитела к глюкокортикоид-индуцированному рецептору фактора некроза опухоли (gitr) и способы их использования | |
| CN115052888A (zh) | FcγRIIB亲和力增强的抗体Fc区 | |
| TW202306984A (zh) | 抗ｃｄ１３７抗體及使用方法 | |
| KR20210046725A (ko) | 신규 암 면역요법 항체 조성물 | |
| WO2024114676A1 (zh) | Cldn18.2/4-1bb结合蛋白及其医药用途 | |
| CN119894930A (zh) | 一种双特异性抗体及其应用 | |
| JPWO2021050656A5 (cg-RX-API-DMAC7.html) | ||
| JPWO2022235662A5 (cg-RX-API-DMAC7.html) |