JP2018502598A5 - - Google Patents

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Publication number

JP2018502598A5

JP2018502598A5 JP2017551379A JP2017551379A JP2018502598A5 JP 2018502598 A5 JP2018502598 A5 JP 2018502598A5 JP 2017551379 A JP2017551379 A JP 2017551379A JP 2017551379 A JP2017551379 A JP 2017551379A JP 2018502598 A5 JP2018502598 A5 JP 2018502598A5

Authority

JP

Japan

Prior art keywords

seq

antibody

variable region

chain variable

heavy chain

Prior art date

2015-12-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 18
• 125000003275 alpha amino acid group Chemical group 0.000 claims 16
• 208000014674 injury Diseases 0.000 claims 7
• 101100496569 Homo sapiens C6 gene Proteins 0.000 claims 6
• 208000027418 Wounds and injury Diseases 0.000 claims 6
• 230000006378 damage Effects 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
• 208000035475 disorder Diseases 0.000 claims 5
• 210000005036 nerve Anatomy 0.000 claims 4
• 230000000694 effects Effects 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 108010034753 Complement Membrane Attack Complex Proteins 0.000 claims 2
• 210000003169 central nervous system Anatomy 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 230000001404 mediated effect Effects 0.000 claims 2
• 208000015122 neurodegenerative disease Diseases 0.000 claims 2
• 210000001428 peripheral nervous system Anatomy 0.000 claims 2
• 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 2
• 206010018910 Haemolysis Diseases 0.000 claims 1
• 208000032984 Intraoperative Complications Diseases 0.000 claims 1
• 230000021917 activation of membrane attack complex Effects 0.000 claims 1
• 238000003556 assay Methods 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 230000004154 complement system Effects 0.000 claims 1
• 230000007850 degeneration Effects 0.000 claims 1
• 230000003210 demyelinating effect Effects 0.000 claims 1
• 230000008588 hemolysis Effects 0.000 claims 1
• 208000027866 inflammatory disease Diseases 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
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• 239000002773 nucleotide Substances 0.000 claims 1
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