JP2018186837A5 - - Google Patents
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- JP2018186837A5 JP2018186837A5 JP2018166687A JP2018166687A JP2018186837A5 JP 2018186837 A5 JP2018186837 A5 JP 2018186837A5 JP 2018166687 A JP2018166687 A JP 2018166687A JP 2018166687 A JP2018166687 A JP 2018166687A JP 2018186837 A5 JP2018186837 A5 JP 2018186837A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- leucine
- histidine
- isoleucine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 96
- 235000001014 amino acid Nutrition 0.000 claims 78
- 229940024606 amino acid Drugs 0.000 claims 73
- 150000001413 amino acids Chemical class 0.000 claims 72
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 63
- 235000005772 leucine Nutrition 0.000 claims 63
- 229960003136 leucine Drugs 0.000 claims 63
- 125000003275 alpha amino acid group Chemical group 0.000 claims 61
- 108010078123 amadoriase Proteins 0.000 claims 57
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 56
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 53
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 53
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 53
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 53
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 53
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 53
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 53
- 235000018417 cysteine Nutrition 0.000 claims 53
- 229960002433 cysteine Drugs 0.000 claims 53
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 53
- 235000014705 isoleucine Nutrition 0.000 claims 53
- 229960000310 isoleucine Drugs 0.000 claims 53
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 53
- 235000006109 methionine Nutrition 0.000 claims 53
- 229930182817 methionine Natural products 0.000 claims 53
- 229960004452 methionine Drugs 0.000 claims 53
- 235000013930 proline Nutrition 0.000 claims 53
- 229960002429 proline Drugs 0.000 claims 53
- 229960004799 tryptophan Drugs 0.000 claims 53
- 235000014393 valine Nutrition 0.000 claims 53
- 229960004295 valine Drugs 0.000 claims 53
- 239000004474 valine Substances 0.000 claims 53
- 239000004471 Glycine Substances 0.000 claims 52
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 52
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 52
- 229960002449 glycine Drugs 0.000 claims 52
- 235000002374 tyrosine Nutrition 0.000 claims 52
- 229960004441 tyrosine Drugs 0.000 claims 52
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 52
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 51
- 235000008729 phenylalanine Nutrition 0.000 claims 51
- 229960005190 phenylalanine Drugs 0.000 claims 51
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 51
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 49
- 235000014304 histidine Nutrition 0.000 claims 48
- 229960002885 histidine Drugs 0.000 claims 48
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Chemical group OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 48
- 239000004472 Lysine Chemical group 0.000 claims 47
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Chemical group NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 47
- 235000018977 lysine Nutrition 0.000 claims 47
- 229960003646 lysine Drugs 0.000 claims 47
- 239000004475 Arginine Substances 0.000 claims 44
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 44
- 235000009697 arginine Nutrition 0.000 claims 44
- 229960003121 arginine Drugs 0.000 claims 44
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 44
- 235000004400 serine Nutrition 0.000 claims 44
- 229960001153 serine Drugs 0.000 claims 44
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 43
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 43
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 43
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical group NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 43
- 235000009582 asparagine Nutrition 0.000 claims 43
- 229960001230 asparagine Drugs 0.000 claims 43
- 235000004554 glutamine Nutrition 0.000 claims 43
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 43
- 229960002743 glutamine Drugs 0.000 claims 43
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 42
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical group OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 42
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 42
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 42
- 239000004473 Threonine Substances 0.000 claims 42
- 235000008521 threonine Nutrition 0.000 claims 42
- 229960002898 threonine Drugs 0.000 claims 42
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 40
- 235000004279 alanine Nutrition 0.000 claims 34
- 229960003767 alanine Drugs 0.000 claims 34
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical group C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 33
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 25
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 25
- 235000013922 glutamic acid Nutrition 0.000 claims 25
- 229960002989 glutamic acid Drugs 0.000 claims 25
- 239000004220 glutamic acid Substances 0.000 claims 25
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 24
- 235000003704 aspartic acid Nutrition 0.000 claims 24
- 229960005261 aspartic acid Drugs 0.000 claims 24
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 24
- 230000000694 effects Effects 0.000 claims 15
- -1 α-fructosyl Chemical group 0.000 claims 13
- 230000009257 reactivity Effects 0.000 claims 10
- 238000006467 substitution reaction Methods 0.000 claims 9
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 8
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 7
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 4
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 3
- 241001337994 Cryptococcus <scale insect> Species 0.000 claims 2
- 241000235035 Debaryomyces Species 0.000 claims 2
- 241000228138 Emericella Species 0.000 claims 2
- 241000223609 Microascus Species 0.000 claims 2
- 241000228143 Penicillium Species 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 241000235648 Pichia Species 0.000 claims 2
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 2
- 241000868613 Achaetomium sp. Species 0.000 claims 1
- 241000589158 Agrobacterium Species 0.000 claims 1
- 241000171738 Arthrinium Species 0.000 claims 1
- 241000186063 Arthrobacter Species 0.000 claims 1
- 241000228257 Aspergillus sp. Species 0.000 claims 1
- 241000221955 Chaetomium Species 0.000 claims 1
- 241001327444 Coniochaeta Species 0.000 claims 1
- 241001340163 Coniochaetidium Species 0.000 claims 1
- 241000186216 Corynebacterium Species 0.000 claims 1
- 241000223208 Curvularia Species 0.000 claims 1
- 241001149959 Fusarium sp. Species 0.000 claims 1
- 241001149562 Gelasinospora Species 0.000 claims 1
- 241000228456 Leptosphaeria Species 0.000 claims 1
- 241000124176 Neocosmospora Species 0.000 claims 1
- 241000190509 Ophiobolus Species 0.000 claims 1
- 241000228168 Penicillium sp. Species 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 241000555275 Phaeosphaeria Species 0.000 claims 1
- 241001136503 Pleospora Species 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 241000812330 Pyrenochaeta Species 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 241001494489 Thielavia Species 0.000 claims 1
- 241000266300 Ulocladium Species 0.000 claims 1
- BNQVUHQWZGTIBX-IUCAKERBSA-N Val-His Chemical compound CC(C)[C@H]([NH3+])C(=O)N[C@H](C([O-])=O)CC1=CN=CN1 BNQVUHQWZGTIBX-IUCAKERBSA-N 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 235000019833 protease Nutrition 0.000 claims 1
- 235000019419 proteases Nutrition 0.000 claims 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012102771 | 2012-04-27 | ||
| JP2012102771 | 2012-04-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512732A Division JP6401056B2 (ja) | 2012-04-27 | 2013-04-26 | フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018186837A JP2018186837A (ja) | 2018-11-29 |
| JP2018186837A5 true JP2018186837A5 (https=) | 2019-06-27 |
| JP6726243B2 JP6726243B2 (ja) | 2020-07-22 |
Family
ID=49483330
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512732A Active JP6401056B2 (ja) | 2012-04-27 | 2013-04-26 | フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ |
| JP2018166687A Active JP6726243B2 (ja) | 2012-04-27 | 2018-09-06 | フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512732A Active JP6401056B2 (ja) | 2012-04-27 | 2013-04-26 | フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10767211B2 (https=) |
| EP (2) | EP3508577A3 (https=) |
| JP (2) | JP6401056B2 (https=) |
| WO (1) | WO2013162035A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013162035A1 (ja) * | 2012-04-27 | 2013-10-31 | キッコーマン株式会社 | フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ |
| JP6363327B2 (ja) * | 2013-03-25 | 2018-07-25 | キッコーマン株式会社 | 改変アマドリアーゼ |
| WO2015005258A1 (ja) * | 2013-07-09 | 2015-01-15 | 協和メデックス株式会社 | 糖化ヘキサペプチドオキシダーゼとその利用 |
| US10619183B2 (en) * | 2013-08-09 | 2020-04-14 | Kikkoman Corporation | Modified amadoriase and method for producing the same, agent for improving surfactant resistance of amadoriase and composition for measuring HbA1c using the same |
| EP3061829B1 (en) * | 2013-10-25 | 2021-09-22 | Kikkoman Corporation | METHOD FOR MEASUREMENT OF HbA1c USING AMADORIASE THAT REACTS WITH GLYCATED PEPTIDE |
| JP6542671B2 (ja) | 2013-10-25 | 2019-07-10 | キッコーマン株式会社 | ヘモグロビンＡ１ｃの測定方法および測定キット |
| CN107148475A (zh) * | 2014-10-24 | 2017-09-08 | 龟甲万株式会社 | 脱氢酶活性提高的阿马多里酶 |
| US11198852B2 (en) * | 2014-11-07 | 2021-12-14 | Kikkoman Corporation | Amadoriase having enhanced anionic surfactant tolerance |
| JP6764219B2 (ja) * | 2014-12-26 | 2020-09-30 | キッコーマン株式会社 | グッド緩衝液に対して安定なアマドリアーゼ |
| US10934530B2 (en) | 2015-04-03 | 2021-03-02 | Kikkoman Corporation | Amadoriase having improved specific activity |
| JP7471772B2 (ja) | 2016-04-22 | 2024-04-22 | キッコーマン株式会社 | ＨｂＡ１ｃデヒドロゲナーゼ |
| WO2018012607A1 (ja) | 2016-07-13 | 2018-01-18 | キッコーマン株式会社 | 反応促進剤 |
| JP7020413B2 (ja) | 2016-07-29 | 2022-02-16 | ミナリスメディカル株式会社 | 糖化ヘモグロビンの測定方法 |
| WO2019045052A1 (ja) | 2017-08-31 | 2019-03-07 | キッコーマン株式会社 | 糖化ヘモグロビンオキシダーゼ改変体及び測定方法 |
| JP6818718B2 (ja) * | 2018-06-28 | 2021-01-20 | キッコーマン株式会社 | 改変アマドリアーゼ |
| CN112143825B (zh) * | 2020-09-28 | 2021-08-03 | 华南农业大学 | 一种区分检测花生黑腐病菌和花生基腐病菌的双重pcr检测引物及应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61280297A (ja) | 1985-06-04 | 1986-12-10 | Noda Sangyo Kagaku Kenkyusho | アマドリ化合物の定量法及びその定量用試薬 |
| GB9116315D0 (en) | 1991-07-29 | 1991-09-11 | Genzyme Ltd | Assay |
| WO1997013872A1 (en) | 1995-10-12 | 1997-04-17 | Kyoto Daiichi Kagaku Co., Ltd. | Method and assaying amodori compounds |
| US6767701B1 (en) * | 1998-10-26 | 2004-07-27 | Novozymes A/S | Methods of constructing and screening a DNA library of interest in filamentous fungal cells |
| JP3949854B2 (ja) | 1999-10-01 | 2007-07-25 | キッコーマン株式会社 | 糖化蛋白質の測定方法 |
| JP4231668B2 (ja) | 2001-09-04 | 2009-03-04 | キッコーマン株式会社 | 新規なフルクトシルペプチドオキシダーゼ |
| DE60330376D1 (de) | 2002-10-23 | 2010-01-14 | Daiichi Pure Chemicals Co Ltd | Defructosylierungsverfahren |
| JP4227820B2 (ja) | 2003-03-12 | 2009-02-18 | 旭化成ファーマ株式会社 | 新規な酵素 |
| JP4248900B2 (ja) | 2003-03-14 | 2009-04-02 | イチビキ株式会社 | 新規なフルクトシルアミンオキシダーゼをコードする遺伝子及びそれを用いての該フルクトシルアミンオキシダーゼの製造方法 |
| DE602004030328D1 (de) | 2003-05-21 | 2011-01-13 | Asahi Kasei Pharma Corp | Verfahren zur messung von glykoliertem hämoglobin a1c, dafür zu verwendendes enzym und verfahren zur herstellung davon |
| JP2005110657A (ja) | 2003-09-18 | 2005-04-28 | Kikkoman Corp | α−糖化ジペプチドの製造法及びα−糖化ジペプチドの測定法 |
| US7951553B2 (en) | 2003-11-19 | 2011-05-31 | Sekisui Medical Co., Ltd. | Method of assaying glycated protein |
| JP5074386B2 (ja) | 2006-04-25 | 2012-11-14 | キッコーマン株式会社 | 熱安定性に優れた真核型アマドリアーゼ、その遺伝子及び組換え体ｄｎａ、並びに熱安定性に優れた真核型アマドリアーゼの製造法 |
| EP2054787B1 (en) | 2006-08-07 | 2009-12-23 | STMicroelectronics S.r.l. | Control device for power factor correction device in switching mode power supplies |
| JP5442432B2 (ja) | 2007-03-05 | 2014-03-12 | キッコーマン株式会社 | 糖化ヘキサペプチドの測定方法 |
| JP5243878B2 (ja) | 2008-08-04 | 2013-07-24 | 東洋紡株式会社 | フルクトシルバリルヒスチジン測定用酵素、およびその利用法 |
| JP5350762B2 (ja) | 2008-08-04 | 2013-11-27 | 東洋紡株式会社 | フルクトシルアミノ酸オキシダーゼ、およびその利用法 |
| US8304249B2 (en) | 2008-10-09 | 2012-11-06 | Kyowa Medex Co., Ltd. | Fructosyl peptide oxidase |
| CN102171338B (zh) | 2008-10-10 | 2014-08-13 | 东洋纺织株式会社 | 具有果糖基缬氨酰基组氨酸氧化酶活性的蛋白质及其修饰产物以及其应用 |
| JP5476021B2 (ja) * | 2008-10-17 | 2014-04-23 | 東洋紡株式会社 | フルクトシルアミノ酸オキシダーゼ改変体およびその利用 |
| EP2281900A1 (en) | 2009-08-03 | 2011-02-09 | Roche Diagnostics GmbH | Fructosyl peptidyl oxidase and sensor for assaying a glycated protein |
| EP2287295A1 (en) * | 2009-08-03 | 2011-02-23 | Roche Diagnostics GmbH | Mutant Fructosyl amino acid oxidase |
| JP5927771B2 (ja) | 2010-04-09 | 2016-06-01 | 東洋紡株式会社 | ヘモグロビンＡ１ｃの測定方法 |
| WO2012018094A1 (ja) | 2010-08-06 | 2012-02-09 | キッコーマン株式会社 | 基質特異性が改変されたアマドリアーゼ |
| WO2013162035A1 (ja) * | 2012-04-27 | 2013-10-31 | キッコーマン株式会社 | フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ |
-
2013
- 2013-04-26 WO PCT/JP2013/062508 patent/WO2013162035A1/ja not_active Ceased
- 2013-04-26 EP EP19154807.2A patent/EP3508577A3/en active Pending
- 2013-04-26 JP JP2014512732A patent/JP6401056B2/ja active Active
- 2013-04-26 US US14/396,855 patent/US10767211B2/en active Active
- 2013-04-26 EP EP13781492.7A patent/EP2843050B1/en active Active
-
2018
- 2018-09-06 JP JP2018166687A patent/JP6726243B2/ja active Active
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