JP2018135346A5 - - Google Patents

Info

Publication number

JP2018135346A5

JP2018135346A5 JP2018072110A JP2018072110A JP2018135346A5 JP 2018135346 A5 JP2018135346 A5 JP 2018135346A5 JP 2018072110 A JP2018072110 A JP 2018072110A JP 2018072110 A JP2018072110 A JP 2018072110A JP 2018135346 A5 JP2018135346 A5 JP 2018135346A5

Authority

JP

Japan

Prior art keywords

agonist

pharmaceutically acceptable

pharmaceutical composition

glp

seq

Prior art date

2018-04-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 13
• 150000003839 salts Chemical class 0.000 claims 12
• 229940123232 Glucagon receptor agonist Drugs 0.000 claims 11
• 239000000556 agonist Substances 0.000 claims 8
• 239000003814 drug Substances 0.000 claims 7
• 229940124597 therapeutic agent Drugs 0.000 claims 7
• 208000032928 Dyslipidaemia Diseases 0.000 claims 5
• 229940089838 Glucagon-like peptide 1 receptor agonist Drugs 0.000 claims 5
• 206010060378 Hyperinsulinaemia Diseases 0.000 claims 5
• 208000013016 Hypoglycemia Diseases 0.000 claims 5
• 208000017170 Lipid metabolism disease Diseases 0.000 claims 5
• 208000001145 Metabolic Syndrome Diseases 0.000 claims 5
• 208000008589 Obesity Diseases 0.000 claims 5
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 5
• 208000010706 fatty liver disease Diseases 0.000 claims 5
• 230000003451 hyperinsulinaemic effect Effects 0.000 claims 5
• 201000008980 hyperinsulinism Diseases 0.000 claims 5
• 230000002218 hypoglycaemic effect Effects 0.000 claims 5
• GNZCSGYHILBXLL-UHFFFAOYSA-N n-tert-butyl-6,7-dichloro-3-methylsulfonylquinoxalin-2-amine Chemical group ClC1=C(Cl)C=C2N=C(S(C)(=O)=O)C(NC(C)(C)C)=NC2=C1 GNZCSGYHILBXLL-UHFFFAOYSA-N 0.000 claims 5
• 230000000422 nocturnal effect Effects 0.000 claims 5
• 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 5
• 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 5
• 235000020824 obesity Nutrition 0.000 claims 5
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 5
• 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 2
• 102000051325 Glucagon Human genes 0.000 claims 2
• 108060003199 Glucagon Proteins 0.000 claims 2
• 108010063919 Glucagon Receptors Proteins 0.000 claims 2
• 102100040890 Glucagon receptor Human genes 0.000 claims 2
• -1 [2- (2-amino-ethoxy) -ethoxy] -acetyl Chemical group 0.000 claims 2
• 125000003277 amino group Chemical group 0.000 claims 2
• 210000004899 c-terminal region Anatomy 0.000 claims 2
• MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 2
• 229960004666 glucagon Drugs 0.000 claims 2
• 150000003140 primary amides Chemical group 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 claims 1
• 102100032882 Glucagon-like peptide 1 receptor Human genes 0.000 claims 1
• 229940127519 Insulin Receptor Agonists Drugs 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 229940044601 receptor agonist Drugs 0.000 claims 1
• 239000000018 receptor agonist Substances 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 230000004580 weight loss Effects 0.000 claims 1