JP2018135346A5 - - Google Patents
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- JP2018135346A5 JP2018135346A5 JP2018072110A JP2018072110A JP2018135346A5 JP 2018135346 A5 JP2018135346 A5 JP 2018135346A5 JP 2018072110 A JP2018072110 A JP 2018072110A JP 2018072110 A JP2018072110 A JP 2018072110A JP 2018135346 A5 JP2018135346 A5 JP 2018135346A5
- Authority
- JP
- Japan
- Prior art keywords
- agonist
- pharmaceutically acceptable
- pharmaceutical composition
- glp
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 12
- 229940123232 Glucagon receptor agonist Drugs 0.000 claims 11
- 239000000556 agonist Substances 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 229940124597 therapeutic agent Drugs 0.000 claims 7
- 208000032928 Dyslipidaemia Diseases 0.000 claims 5
- 229940089838 Glucagon-like peptide 1 receptor agonist Drugs 0.000 claims 5
- 206010060378 Hyperinsulinaemia Diseases 0.000 claims 5
- 208000013016 Hypoglycemia Diseases 0.000 claims 5
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 5
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 5
- 208000008589 Obesity Diseases 0.000 claims 5
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 5
- 208000010706 fatty liver disease Diseases 0.000 claims 5
- 230000003451 hyperinsulinaemic effect Effects 0.000 claims 5
- 201000008980 hyperinsulinism Diseases 0.000 claims 5
- 230000002218 hypoglycaemic effect Effects 0.000 claims 5
- GNZCSGYHILBXLL-UHFFFAOYSA-N n-tert-butyl-6,7-dichloro-3-methylsulfonylquinoxalin-2-amine Chemical group ClC1=C(Cl)C=C2N=C(S(C)(=O)=O)C(NC(C)(C)C)=NC2=C1 GNZCSGYHILBXLL-UHFFFAOYSA-N 0.000 claims 5
- 230000000422 nocturnal effect Effects 0.000 claims 5
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 5
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 5
- 235000020824 obesity Nutrition 0.000 claims 5
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 5
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 2
- 102000051325 Glucagon Human genes 0.000 claims 2
- 108060003199 Glucagon Proteins 0.000 claims 2
- 108010063919 Glucagon Receptors Proteins 0.000 claims 2
- 102100040890 Glucagon receptor Human genes 0.000 claims 2
- -1 [2- (2-amino-ethoxy) -ethoxy] -acetyl Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 2
- 229960004666 glucagon Drugs 0.000 claims 2
- 150000003140 primary amides Chemical group 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 claims 1
- 102100032882 Glucagon-like peptide 1 receptor Human genes 0.000 claims 1
- 229940127519 Insulin Receptor Agonists Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940044601 receptor agonist Drugs 0.000 claims 1
- 239000000018 receptor agonist Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562246199P | 2015-10-26 | 2015-10-26 | |
| US62/246,199 | 2015-10-26 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017531687A Division JP6321299B2 (ja) | 2015-10-26 | 2016-10-14 | グルカゴン受容体アゴニスト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018135346A JP2018135346A (ja) | 2018-08-30 |
| JP2018135346A5 true JP2018135346A5 (https=) | 2019-11-21 |
| JP7211712B2 JP7211712B2 (ja) | 2023-01-24 |
Family
ID=57200152
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017531685A Active JP6354017B2 (ja) | 2015-10-26 | 2016-10-14 | グルカゴン受容体アゴニスト |
| JP2017531687A Active JP6321299B2 (ja) | 2015-10-26 | 2016-10-14 | グルカゴン受容体アゴニスト |
| JP2018072110A Active JP7211712B2 (ja) | 2015-10-26 | 2018-04-04 | グルカゴン受容体アゴニスト |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017531685A Active JP6354017B2 (ja) | 2015-10-26 | 2016-10-14 | グルカゴン受容体アゴニスト |
| JP2017531687A Active JP6321299B2 (ja) | 2015-10-26 | 2016-10-14 | グルカゴン受容体アゴニスト |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US9884093B2 (https=) |
| EP (2) | EP3368060B1 (https=) |
| JP (3) | JP6354017B2 (https=) |
| KR (1) | KR20180053747A (https=) |
| CN (2) | CN108348583B (https=) |
| AR (2) | AR106318A1 (https=) |
| AU (2) | AU2016344433B2 (https=) |
| BR (1) | BR112018006920A2 (https=) |
| CA (2) | CA3003242C (https=) |
| DK (1) | DK3368060T3 (https=) |
| EA (2) | EA038330B1 (https=) |
| ES (2) | ES2809548T3 (https=) |
| HR (1) | HRP20201353T1 (https=) |
| HU (1) | HUE050859T2 (https=) |
| IL (1) | IL258092A (https=) |
| LT (1) | LT3368060T (https=) |
| MX (2) | MX377610B (https=) |
| NZ (1) | NZ740644A (https=) |
| PL (2) | PL3368060T3 (https=) |
| PT (2) | PT3368060T (https=) |
| RS (1) | RS60567B1 (https=) |
| SI (1) | SI3368060T1 (https=) |
| TW (1) | TWI622596B (https=) |
| WO (2) | WO2017074714A1 (https=) |
| ZA (2) | ZA201801756B (https=) |
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| CN110831969B (zh) | 2017-06-20 | 2024-06-21 | 安进公司 | 使用抑胃肽受体（gipr）结合蛋白与glp-1激动剂的组合治疗或改善代谢障碍的方法 |
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| AU2018314773A1 (en) * | 2017-08-09 | 2020-03-26 | Sanofi | GLP-1/glucagon receptor agonists in the treatment of fatty liver disease and steatohepatitis |
| MY200364A (en) | 2017-09-22 | 2023-12-21 | Regeneron Pharma | Glucagon-like peptide 1 receptor agonists and uses thereof |
| TWI912614B (zh) * | 2017-12-21 | 2026-01-21 | 美商美國禮來大藥廠 | 腸促胰島素(incretin)類似物及其用途 |
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| EP3826662B9 (en) * | 2018-07-23 | 2025-02-19 | Eli Lilly and Company | Method of using a gip/glp1 co-agonist for diabetes |
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| HRP20230929T1 (hr) * | 2018-10-26 | 2023-11-24 | Novo Nordisk A/S | Stabilni pripravci semaglutida i njihova upotreba |
| CN111171134B (zh) * | 2018-11-12 | 2023-08-15 | 天津药物研究院有限公司 | 胰高血糖素衍生肽及其用途 |
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| DK3936142T3 (da) * | 2019-06-28 | 2024-03-25 | Hanmi Pharmaceutical Co Ltd | Tredobbelt agonist med aktivitet med hensyn til alle glucagon-, GLP-1- og GLP-receptorer til behandling af leversygdom |
| CN110684082B (zh) * | 2019-10-08 | 2021-12-10 | 江苏诺泰澳赛诺生物制药股份有限公司 | Gip和glp-1双激动多肽化合物及药学上可接受的盐与用途 |
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| IL308392A (en) | 2021-05-13 | 2024-01-01 | Carmot Therapeutics Inc | G protein-coupled receptor modulators |
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| CN120187750A (zh) | 2022-09-21 | 2025-06-20 | 瑞泽恩制药公司 | 治疗肥胖、糖尿病和肝功能障碍的方法 |
| WO2024209050A1 (en) | 2023-04-05 | 2024-10-10 | Antag Therapeutics Aps | Gip activity modulators and orthostatic intolerance |
| EP4724471A1 (en) | 2023-06-09 | 2026-04-15 | Sun Pharmaceutical Industries Limited | Glp-1/gip dual, glp-1/gcg dual and glp-1/gip/gcg triple receptor agonists |
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| JO3575B1 (ar) | 2015-01-09 | 2020-07-05 | Lilly Co Eli | مركبات مساعد مشترك من gip وglp-1 |
| US10336802B2 (en) | 2015-04-16 | 2019-07-02 | Zealand Pharma A/S | Acylated glucagon analogue |
| WO2016198604A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as dual glp-1 /glucagon receptor agonists |
| EA201890058A1 (ru) | 2015-06-30 | 2018-07-31 | Ханми Фарм. Ко., Лтд. | Производное глюкагона и композиция, содержащая длительно действующий конъюгат этого производного |
| AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
| TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
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