JP2018131450A5 - - Google Patents

Info

Publication number

JP2018131450A5

JP2018131450A5 JP2018083792A JP2018083792A JP2018131450A5 JP 2018131450 A5 JP2018131450 A5 JP 2018131450A5 JP 2018083792 A JP2018083792 A JP 2018083792A JP 2018083792 A JP2018083792 A JP 2018083792A JP 2018131450 A5 JP2018131450 A5 JP 2018131450A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

sulfonylurea

methyl

composition according

metformin

Prior art date

2018-04-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 37
• 229940100389 Sulfonylurea Drugs 0.000 claims 27
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 25
• YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 claims 23
• XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 16
• 229960003105 metformin Drugs 0.000 claims 16
• 229940090124 dipeptidyl peptidase 4 (dpp-4) inhibitors for blood glucose lowering Drugs 0.000 claims 12
• 239000003814 drug Substances 0.000 claims 12
• 102000004877 Insulin Human genes 0.000 claims 11
• 108090001061 Insulin Proteins 0.000 claims 11
• 229940125396 insulin Drugs 0.000 claims 11
• 229940079593 drug Drugs 0.000 claims 10
• -1 4-methyl-quinazolin-2-yl Chemical group 0.000 claims 9
• HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 claims 8
• 229940123464 Thiazolidinedione Drugs 0.000 claims 7
• 206010012601 diabetes mellitus Diseases 0.000 claims 7
• DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 6
• 230000002641 glycemic effect Effects 0.000 claims 6
• ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 claims 5
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 5
• 230000002058 anti-hyperglycaemic effect Effects 0.000 claims 5
• 239000008103 glucose Substances 0.000 claims 5
• 208000030159 metabolic disease Diseases 0.000 claims 5
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
• 230000002265 prevention Effects 0.000 claims 5
• 102100024295 Maltase-glucoamylase Human genes 0.000 claims 4
• 108010028144 alpha-Glucosidases Proteins 0.000 claims 4
• 239000003472 antidiabetic agent Substances 0.000 claims 4
• 239000008280 blood Substances 0.000 claims 4
• 210000004369 blood Anatomy 0.000 claims 4
• 238000002648 combination therapy Methods 0.000 claims 4
• 229960005095 pioglitazone Drugs 0.000 claims 4
• 102100025101 GATA-type zinc finger protein 1 Human genes 0.000 claims 3
• 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 3
• LTXREWYXXSTFRX-QGZVFWFLSA-N Linagliptin Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=C(C)N=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](N)C1 LTXREWYXXSTFRX-QGZVFWFLSA-N 0.000 claims 2
• 230000003914 insulin secretion Effects 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• 238000002560 therapeutic procedure Methods 0.000 claims 2
• 150000001467 thiazolidinediones Chemical class 0.000 claims 2
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
• 208000013016 Hypoglycemia Diseases 0.000 claims 1
• 206010062237 Renal impairment Diseases 0.000 claims 1
• 230000006978 adaptation Effects 0.000 claims 1
• 229940127003 anti-diabetic drug Drugs 0.000 claims 1
• 230000003178 anti-diabetic effect Effects 0.000 claims 1
• 229940125708 antidiabetic agent Drugs 0.000 claims 1
• 210000000941 bile Anatomy 0.000 claims 1
• 208000016097 disease of metabolism Diseases 0.000 claims 1
• 230000009977 dual effect Effects 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 229960004580 glibenclamide Drugs 0.000 claims 1
• WIGIZIANZCJQQY-RUCARUNLSA-N glimepiride Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)N[C@@H]2CC[C@@H](C)CC2)C=C1 WIGIZIANZCJQQY-RUCARUNLSA-N 0.000 claims 1
• 229960004346 glimepiride Drugs 0.000 claims 1
• 229960001381 glipizide Drugs 0.000 claims 1
• ZJJXGWJIGJFDTL-UHFFFAOYSA-N glipizide Chemical compound C1=NC(C)=CN=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZJJXGWJIGJFDTL-UHFFFAOYSA-N 0.000 claims 1
• ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 claims 1
• 230000002218 hypoglycaemic effect Effects 0.000 claims 1
• 239000004026 insulin derivative Substances 0.000 claims 1
• 210000003734 kidney Anatomy 0.000 claims 1
• 239000002207 metabolite Substances 0.000 claims 1
• 229940111334 metformin / pioglitazone Drugs 0.000 claims 1
• 229940127017 oral antidiabetic Drugs 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 238000011295 triple combination therapy Methods 0.000 claims 1
• 230000004584 weight gain Effects 0.000 claims 1
• 235000019786 weight gain Nutrition 0.000 claims 1
• 229940075420 xanthine Drugs 0.000 claims 1