JP2018100276A5 - - Google Patents
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- JP2018100276A5 JP2018100276A5 JP2018017168A JP2018017168A JP2018100276A5 JP 2018100276 A5 JP2018100276 A5 JP 2018100276A5 JP 2018017168 A JP2018017168 A JP 2018017168A JP 2018017168 A JP2018017168 A JP 2018017168A JP 2018100276 A5 JP2018100276 A5 JP 2018100276A5
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- 238000000034 method Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261681447P | 2012-08-09 | 2012-08-09 | |
| US61/681,447 | 2012-08-09 | ||
| US201261722727P | 2012-11-05 | 2012-11-05 | |
| US61/722,727 | 2012-11-05 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015526690A Division JP6347782B2 (ja) | 2012-08-09 | 2013-08-08 | ３−（４−（（４−（モルホリノメチル）ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオンを使用する癌の治療方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018100276A JP2018100276A (ja) | 2018-06-28 |
| JP2018100276A5 true JP2018100276A5 (enExample) | 2018-08-09 |
Family
ID=49004013
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015526690A Active JP6347782B2 (ja) | 2012-08-09 | 2013-08-08 | ３−（４−（（４−（モルホリノメチル）ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオンを使用する癌の治療方法 |
| JP2018017168A Withdrawn JP2018100276A (ja) | 2012-08-09 | 2018-02-02 | ３−（４−（（４−（モルホリノメチル）ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオンを使用する癌の治療方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015526690A Active JP6347782B2 (ja) | 2012-08-09 | 2013-08-08 | ３−（４−（（４−（モルホリノメチル）ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオンを使用する癌の治療方法 |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US20140045843A1 (enExample) |
| EP (2) | EP3949968A1 (enExample) |
| JP (2) | JP6347782B2 (enExample) |
| KR (3) | KR102266510B1 (enExample) |
| CN (4) | CN108245518B (enExample) |
| AU (1) | AU2013299627C1 (enExample) |
| BR (1) | BR112015002285B1 (enExample) |
| CA (1) | CA2881116C (enExample) |
| CY (1) | CY1124622T1 (enExample) |
| DK (1) | DK2882442T3 (enExample) |
| EA (1) | EA029485B1 (enExample) |
| ES (1) | ES2881220T3 (enExample) |
| HR (1) | HRP20211243T1 (enExample) |
| HU (1) | HUE056127T2 (enExample) |
| IL (3) | IL288506B2 (enExample) |
| IN (1) | IN2015DN00886A (enExample) |
| LT (1) | LT2882442T (enExample) |
| MX (1) | MX367869B (enExample) |
| NI (1) | NI201500012A (enExample) |
| NZ (1) | NZ628078A (enExample) |
| PH (1) | PH12015500212A1 (enExample) |
| PL (1) | PL2882442T3 (enExample) |
| PT (1) | PT2882442T (enExample) |
| RS (1) | RS62201B1 (enExample) |
| SG (3) | SG10201701057SA (enExample) |
| SI (1) | SI2882442T1 (enExample) |
| SM (1) | SMT202100457T1 (enExample) |
| TW (2) | TWI653977B (enExample) |
| UA (1) | UA116544C2 (enExample) |
| WO (1) | WO2014025960A1 (enExample) |
| ZA (1) | ZA201500564B (enExample) |
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| US20120134969A1 (en) | 2009-05-25 | 2012-05-31 | Hiroshi Handa | Pharmaceutical composition containing nuclear factor involved in proliferation and differentiation of central neuronal cells |
| US8491927B2 (en) * | 2009-12-02 | 2013-07-23 | Nimble Epitech, Llc | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
| SG183257A1 (en) | 2010-02-11 | 2012-09-27 | Celgene Corp | Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same |
| CN107501241B (zh) | 2011-03-28 | 2020-10-13 | 梅制药公司 | 化合物、含有其的药物组合物以及它们在治疗增生性疾病中的用途 |
| ES2872967T3 (es) | 2012-06-29 | 2021-11-03 | Celgene Corp | Métodos para determinar la eficacia de fármacos usando IKZF3 (AIOLOS) |
| US9587281B2 (en) | 2012-08-14 | 2017-03-07 | Celgene Corporation | Cereblon isoforms and their use as biomarkers for therapeutic treatment |
| CN104797256A (zh) | 2012-09-10 | 2015-07-22 | 细胞基因公司 | 用于治疗局部晚期乳腺癌的方法 |
| US9695145B2 (en) | 2013-01-22 | 2017-07-04 | Celgene Corporation | Processes for the preparation of isotopologues of 3-(4-((4- morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof |
| WO2015085172A2 (en) | 2013-12-06 | 2015-06-11 | Celgene Corporation | Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers |
| ES2843973T3 (es) | 2014-06-27 | 2021-07-21 | Celgene Corp | Composiciones y métodos para inducir cambios conformacionales en cereblon y otras ubiquitina ligasas E3 |
| JP2017538104A (ja) * | 2014-10-07 | 2017-12-21 | セルジーン コーポレイション | 癌治療に対する臨床的感応性を予測するためのバイオマーカーの使用 |
| AU2016326499A1 (en) * | 2015-09-25 | 2018-04-12 | Celgene Corporation | Methods for treating diffuse large B-cell lymphoma and the use of biomarkers as a predictor of responsiveness to drugs |
| US10830762B2 (en) | 2015-12-28 | 2020-11-10 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases |
| KR102002581B1 (ko) * | 2016-10-04 | 2019-07-22 | 주식회사 종근당 | 혈액암 치료를 위한 hdac 저해제 및 프로테아좀 억제제 또는 면역조절성 약물을 포함하는 약학적 조합물 |
| US20180238886A1 (en) * | 2017-01-31 | 2018-08-23 | Celgene Corporation | Methods for treating hematological cancer and the use of biomarkers as a predictor for responsiveness to treatment compounds |
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| EP3630118A4 (en) | 2017-05-23 | 2021-03-31 | MEI Pharma, Inc. | COMBINATION THERAPY |
| EP4201399A3 (en) * | 2017-06-30 | 2023-08-09 | Celgene Corporation | Compositions and methods of use of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl) -2,2-difluoroacetamide |
| JP7258009B2 (ja) * | 2017-07-10 | 2023-04-14 | セルジーン コーポレイション | 抗増殖化合物及びその使用方法 |
| MX2020001727A (es) | 2017-08-14 | 2020-03-20 | Mei Pharma Inc | Terapia de combinacion. |
| WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
| US11709164B2 (en) | 2017-10-26 | 2023-07-25 | National University Of Singapore | Approach for universal monitoring of minimal residual disease in acute myeloid leukemia |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| EP3737666A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | PROTEIN DEGRADATION AGENTS AND ASSOCIATED USES |
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| US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
| JP2021534116A (ja) * | 2018-08-14 | 2021-12-09 | エムイーアイ ファーマ，インク． | 再発性の濾胞性リンパ腫の処置 |
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| CN113573719A (zh) * | 2018-11-08 | 2021-10-29 | 朱诺治疗学股份有限公司 | 治疗和t细胞调节的方法和组合 |
| AU2019389174A1 (en) | 2018-11-30 | 2021-07-01 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| KR102980990B1 (ko) | 2019-04-05 | 2026-06-25 | 카이메라 쎄라퓨틱스 인코포레이티드 | Stat 분해제 및 이의 용도 |
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| EA039874B1 (ru) * | 2019-06-06 | 2022-03-22 | Общество С Ограниченной Ответственностью "Технология Лекарств" | Композиция помалидомида для лечения заболеваний, ассоциированных с фактором некроза опухоли (фно) |
| US12624044B2 (en) | 2019-06-10 | 2026-05-12 | Kymera Therapeutics, Inc. | SMARCA degraders and uses thereof |
| WO2020251972A1 (en) | 2019-06-10 | 2020-12-17 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
| PH12022500002A1 (en) | 2019-06-28 | 2023-04-03 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| US12558427B2 (en) | 2019-07-17 | 2026-02-24 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| CN114885602A (zh) * | 2019-10-21 | 2022-08-09 | 新基公司 | 包含(s)-2-(2,6-二氧代哌啶-3-基)-4-((2-氟-4-((3-吗啉代氮杂环丁烷-1-基)甲基)苄基)氨基)异吲哚啉-1,3-二酮的药物组合物及其使用方法 |
| EP4054623A1 (en) | 2019-11-07 | 2022-09-14 | Juno Therapeutics, Inc. | Combination of a t cell therapy and (s)-3-[4-(4-morpholin-4 ylmethyl-benzyloxy)-l-oxo-l,3-dihydro-isoindol-2-yl]- piperidine-2,6-dione |
| KR20220110243A (ko) * | 2019-12-02 | 2022-08-05 | 셀진 코포레이션 | 암의 치료를 위한 요법 |
| WO2021119159A1 (en) | 2019-12-10 | 2021-06-17 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| CA3161878A1 (en) | 2019-12-17 | 2021-06-24 | Matthew M. Weiss | Irak degraders and uses thereof |
| US11679109B2 (en) | 2019-12-23 | 2023-06-20 | Kymera Therapeutics, Inc. | SMARCA degraders and uses thereof |
| WO2021188948A1 (en) | 2020-03-19 | 2021-09-23 | Kymera Therapeutics, Inc. | Mdm2 degraders and uses thereof |
| EP4161521A4 (en) | 2020-06-03 | 2024-07-10 | Kymera Therapeutics, Inc. | DEUTERED IRAQ DEGRADERS AND USES THEREOF |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| CN115916191B (zh) * | 2020-06-25 | 2026-06-23 | 新基公司 | 用组合疗法治疗癌症的方法 |
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| WO2022174268A1 (en) | 2021-02-15 | 2022-08-18 | Kymera Therapeutics, Inc. | Irak4 degraders and uses thereof |
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| JP2024540080A (ja) | 2021-10-29 | 2024-10-31 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ４分解剤およびその合成 |
| EP4472967A4 (en) | 2022-01-31 | 2026-04-15 | Kymera Therapeutics Inc | Iraqi Degradation Agents and Their Uses |
| US20260014133A1 (en) * | 2022-07-15 | 2026-01-15 | St. Jude's Chidren's Research Hospital, Inc. | SUBSTITUTED 3-(l-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE/2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-l,3-DIONE ANALOGS AS MODULATORS OF CEREBLON PROTEIN |
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| KR20260088542A (ko) | 2023-10-06 | 2026-06-12 | 주노 쎄러퓨티크스 인코퍼레이티드 | Gprc5d-표적화 car을 발현하는 세포 요법을 사용한 조합 요법 및 관련 방법 및 용도 |
| TW202532072A (zh) | 2023-12-08 | 2025-08-16 | 美商西建公司 | 治療多發性骨髓瘤之療法 |
| WO2025195464A1 (zh) * | 2024-03-21 | 2025-09-25 | 上海惠康济民生物医药技术有限公司 | 取代的异吲哚啉类化合物、制备方法、药物组合物及应用 |
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2013
- 2013-08-08 UA UAA201501971A patent/UA116544C2/uk unknown
- 2013-08-08 TW TW102128576A patent/TWI653977B/zh active
- 2013-08-08 EP EP21177385.8A patent/EP3949968A1/en active Pending
- 2013-08-08 TW TW107117959A patent/TWI723266B/zh active
- 2013-08-08 EA EA201590345A patent/EA029485B1/ru not_active IP Right Cessation
- 2013-08-08 KR KR1020207023283A patent/KR102266510B1/ko active Active
- 2013-08-08 RS RS20210904A patent/RS62201B1/sr unknown
- 2013-08-08 AU AU2013299627A patent/AU2013299627C1/en active Active
- 2013-08-08 NZ NZ628078A patent/NZ628078A/en unknown
- 2013-08-08 IL IL288506A patent/IL288506B2/en unknown
- 2013-08-08 WO PCT/US2013/054055 patent/WO2014025960A1/en not_active Ceased
- 2013-08-08 HU HUE13751007A patent/HUE056127T2/hu unknown
- 2013-08-08 BR BR112015002285-5A patent/BR112015002285B1/pt active IP Right Grant
- 2013-08-08 KR KR1020217018115A patent/KR102414005B1/ko active Active
- 2013-08-08 ES ES13751007T patent/ES2881220T3/es active Active
- 2013-08-08 SG SG10201701057SA patent/SG10201701057SA/en unknown
- 2013-08-08 CA CA2881116A patent/CA2881116C/en active Active
- 2013-08-08 IN IN886DEN2015 patent/IN2015DN00886A/en unknown
- 2013-08-08 JP JP2015526690A patent/JP6347782B2/ja active Active
- 2013-08-08 CN CN201711401933.1A patent/CN108245518B/zh active Active
- 2013-08-08 CN CN202110938460.9A patent/CN114344307A/zh active Pending
- 2013-08-08 CN CN202110936758.6A patent/CN114366746A/zh active Pending
- 2013-08-08 SM SM20210457T patent/SMT202100457T1/it unknown
- 2013-08-08 PT PT137510079T patent/PT2882442T/pt unknown
- 2013-08-08 DK DK13751007.9T patent/DK2882442T3/da active
- 2013-08-08 CN CN201380052496.0A patent/CN104837491A/zh active Pending
- 2013-08-08 MX MX2015001775A patent/MX367869B/es active IP Right Grant
- 2013-08-08 SG SG10202108516PA patent/SG10202108516PA/en unknown
- 2013-08-08 HR HRP20211243TT patent/HRP20211243T1/hr unknown
- 2013-08-08 SG SG11201500998QA patent/SG11201500998QA/en unknown
- 2013-08-08 EP EP13751007.9A patent/EP2882442B1/en active Active
- 2013-08-08 US US13/962,776 patent/US20140045843A1/en not_active Abandoned
- 2013-08-08 PL PL13751007T patent/PL2882442T3/pl unknown
- 2013-08-08 KR KR1020157006019A patent/KR102146848B1/ko active Active
- 2013-08-08 LT LTEPPCT/US2013/054055T patent/LT2882442T/lt unknown
- 2013-08-08 SI SI201331908T patent/SI2882442T1/sl unknown
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2015
- 2015-01-26 ZA ZA2015/00564A patent/ZA201500564B/en unknown
- 2015-01-29 IL IL237013A patent/IL237013B/en active IP Right Grant
- 2015-01-30 PH PH12015500212A patent/PH12015500212A1/en unknown
- 2015-02-06 NI NI201500012A patent/NI201500012A/es unknown
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2016
- 2016-05-13 US US15/154,838 patent/US20160256468A1/en not_active Abandoned
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2018
- 2018-02-02 JP JP2018017168A patent/JP2018100276A/ja not_active Withdrawn
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2019
- 2019-08-01 US US16/529,233 patent/US20190388429A1/en not_active Abandoned
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2020
- 2020-07-27 IL IL276319A patent/IL276319B/en unknown
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2021
- 2021-07-16 CY CY20211100645T patent/CY1124622T1/el unknown
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2025
- 2025-02-06 US US19/047,418 patent/US20260007679A1/en active Pending
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