JP2018046872A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018046872A5 JP2018046872A5 JP2018000123A JP2018000123A JP2018046872A5 JP 2018046872 A5 JP2018046872 A5 JP 2018046872A5 JP 2018000123 A JP2018000123 A JP 2018000123A JP 2018000123 A JP2018000123 A JP 2018000123A JP 2018046872 A5 JP2018046872 A5 JP 2018046872A5
- Authority
- JP
- Japan
- Prior art keywords
- binding protein
- antigen
- domain
- protein according
- antigen binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36990910P | 2010-08-02 | 2010-08-02 | |
| US61/369,909 | 2010-08-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016009916A Division JP2016054746A (ja) | 2010-08-02 | 2016-01-21 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018212094A Division JP6759303B2 (ja) | 2010-08-02 | 2018-11-12 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018046872A JP2018046872A (ja) | 2018-03-29 |
| JP2018046872A5 true JP2018046872A5 (enExample) | 2018-12-20 |
| JP7078400B2 JP7078400B2 (ja) | 2022-05-31 |
Family
ID=44543797
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523258A Active JP6146913B2 (ja) | 2010-08-02 | 2011-08-02 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
| JP2016009916A Withdrawn JP2016054746A (ja) | 2010-08-02 | 2016-01-21 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
| JP2018000123A Active JP7078400B2 (ja) | 2010-08-02 | 2018-01-04 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
| JP2018212094A Active JP6759303B2 (ja) | 2010-08-02 | 2018-11-12 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
| JP2020023076A Active JP7110257B2 (ja) | 2010-08-02 | 2020-02-14 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
| JP2021084769A Pending JP2021119792A (ja) | 2010-08-02 | 2021-05-19 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523258A Active JP6146913B2 (ja) | 2010-08-02 | 2011-08-02 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
| JP2016009916A Withdrawn JP2016054746A (ja) | 2010-08-02 | 2016-01-21 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018212094A Active JP6759303B2 (ja) | 2010-08-02 | 2018-11-12 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
| JP2020023076A Active JP7110257B2 (ja) | 2010-08-02 | 2020-02-14 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
| JP2021084769A Pending JP2021119792A (ja) | 2010-08-02 | 2021-05-19 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
Country Status (27)
| Country | Link |
|---|---|
| US (8) | US9516868B2 (enExample) |
| EP (3) | EP2601298B1 (enExample) |
| JP (6) | JP6146913B2 (enExample) |
| KR (4) | KR102306967B1 (enExample) |
| CN (4) | CN103154255B (enExample) |
| AU (1) | AU2011285919C1 (enExample) |
| BR (1) | BR112013002695B1 (enExample) |
| CA (2) | CA3250882A1 (enExample) |
| CY (1) | CY1118562T1 (enExample) |
| DK (1) | DK2601298T3 (enExample) |
| ES (1) | ES2612459T3 (enExample) |
| HK (1) | HK1217511A1 (enExample) |
| HR (1) | HRP20170322T1 (enExample) |
| HU (1) | HUE031903T2 (enExample) |
| IL (4) | IL315833A (enExample) |
| LT (1) | LT2601298T (enExample) |
| MX (5) | MX2018014787A (enExample) |
| MY (1) | MY172618A (enExample) |
| NZ (2) | NZ707327A (enExample) |
| PL (1) | PL2601298T3 (enExample) |
| PT (1) | PT2601298T (enExample) |
| RS (1) | RS55495B1 (enExample) |
| RU (2) | RU2750219C2 (enExample) |
| SG (3) | SG10201912639SA (enExample) |
| SI (1) | SI2601298T1 (enExample) |
| SM (2) | SMT201700023T1 (enExample) |
| WO (1) | WO2012018764A1 (enExample) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2436044T3 (es) * | 2008-05-23 | 2013-12-26 | Ablexis, Llc | Procedimiento de generación de anticuerpos de dominio VL individual en animales transgénicos |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| CN102638971B (zh) | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| HRP20151188T4 (hr) | 2010-02-08 | 2021-10-01 | Regeneron Pharmaceuticals, Inc. | Miš sa zajedničkim lakim lancem |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| RU2580017C2 (ru) | 2010-07-26 | 2016-04-10 | Трианни, Инк. | Трансгенные животные и способы применения |
| KR102306967B1 (ko) | 2010-08-02 | 2021-10-01 | 리제너론 파아마슈티컬스, 인크. | Ｖｌ 도메인을 포함하는 결합 단백질을 생성하는 마우스 |
| PT3865581T (pt) | 2011-08-05 | 2024-10-04 | Regeneron Pharma | Murganhos da cadeia leve universal humanizada |
| AU2012311286B2 (en) | 2011-09-19 | 2018-07-26 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| EP3741862A1 (en) | 2011-09-19 | 2020-11-25 | Kymab Limited | Animals, repertoires & methods for the production of human antibodies |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| KR20140082824A (ko) | 2011-10-17 | 2014-07-02 | 리제너론 파아마슈티컬스, 인크. | 제한된 면역글로불린 중쇄 마우스 |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| PT3527070T (pt) | 2011-12-20 | 2025-12-19 | Regeneron Pharma | Murganhos de cadeia leve humanizada |
| NZ810648A (en) * | 2012-02-01 | 2025-11-28 | Regeneron Pharma | Humanized rodents that express heavy chains containing vl domains |
| EP2839009B1 (en) * | 2012-03-14 | 2019-08-21 | Innovative Targeting Solutions Inc. | Generating targeted sequence diversity in proteins |
| WO2013134881A1 (en) | 2012-03-14 | 2013-09-19 | Innovative Targeting Solutions Inc. | Generating targeted sequence diversity in fusion proteins |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| EP3912464A1 (en) | 2012-06-12 | 2021-11-24 | Regeneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
| US20150203591A1 (en) | 2012-08-02 | 2015-07-23 | Regeneron Pharmaceuticals, Inc. | Mutivalent antigen-binding proteins |
| MY185881A (en) | 2013-02-20 | 2021-06-14 | Regeneron Pharma | Non-human animals with modified immunoglobulin heavy chain sequences |
| EP4218409B1 (en) * | 2013-03-13 | 2025-02-12 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| EP3964237B1 (en) | 2013-03-15 | 2026-02-18 | Regeneron Pharmaceuticals, Inc. | Biologically active molecules, conjugates thereof, and therapeutic uses |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| KR102252925B1 (ko) | 2013-08-26 | 2021-05-18 | 리제너론 파마슈티칼스 인코포레이티드 | 마크롤라이드 디아스테레오머를 포함하는 약제학적 조성물, 이의 합성 방법 및 치료학적 용도 |
| CA2925723A1 (en) | 2013-10-01 | 2015-04-09 | Kymab Limited | Animal models and therapeutic molecules |
| FR3011249A1 (enExample) * | 2013-10-01 | 2015-04-03 | Kymab Ltd | |
| CN106255410B (zh) | 2014-03-21 | 2020-01-10 | 瑞泽恩制药公司 | 产生单结构域结合蛋白的非人动物 |
| CN106164092A (zh) | 2014-03-21 | 2016-11-23 | 瑞泽恩制药公司 | 表现不同结合特征的vl抗原结合蛋白 |
| US11111314B2 (en) | 2015-03-19 | 2021-09-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| KR20240142591A (ko) | 2015-03-27 | 2024-09-30 | 리제너론 파아마슈티컬스, 인크. | 메이탄시노이드 유도체, 이의 컨주게이트, 및 사용 방법 |
| UA126272C2 (uk) * | 2015-06-05 | 2022-09-14 | Дженентек, Інк. | Антитіло проти тау-білка та спосіб його застосування |
| WO2017095939A1 (en) | 2015-12-03 | 2017-06-08 | Trianni, Inc. | Enhanced immunoglobulin diversity |
| MY198605A (en) | 2016-01-25 | 2023-09-08 | Regeneron Pharma | Maytansinoid derivatives conjugates thereof, and methods of use |
| AU2017213633B2 (en) | 2016-02-04 | 2023-08-03 | Trianni, Inc. | Enhanced production of immunoglobulins |
| US20170332610A1 (en) | 2016-05-20 | 2017-11-23 | Regeneron Pharmaceuticals, Inc. | Methods for breaking immunological tolerance using multiple guide rnas |
| KR102483193B1 (ko) | 2016-06-03 | 2023-01-04 | 리제너론 파마슈티칼스 인코포레이티드 | 외인성 말단 데옥시뉴클레오타이드 전달효소를 발현하는 비인간 동물 |
| KR20250114431A (ko) | 2016-11-08 | 2025-07-29 | 리제너론 파마슈티칼스 인코포레이티드 | 스테로이드 및 이의 단백질-접합체 |
| KR20240035636A (ko) | 2016-12-07 | 2024-03-15 | 제넨테크, 인크. | 항-타우 항체 및 이의 이용 방법 |
| AR110321A1 (es) | 2016-12-07 | 2019-03-20 | Genentech Inc | Anticuerpos antitau y métodos de uso |
| US12016313B2 (en) * | 2017-01-19 | 2024-06-25 | Omniab Operations, Inc. | Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci |
| KR20200007905A (ko) | 2017-05-18 | 2020-01-22 | 리제너론 파마슈티칼스 인코포레이티드 | 사이클로덱스트린 단백질 약물 접합체 |
| CN118909118A (zh) | 2017-09-07 | 2024-11-08 | 奥古斯塔大学研究所公司 | 程序性细胞死亡蛋白1抗体 |
| IL313068A (en) | 2017-11-07 | 2024-07-01 | Regeneron Pharma | Hydrophilic linkers for antibody drug conjugates |
| IL275757B2 (en) | 2018-01-08 | 2025-08-01 | Regeneron Pharma | Steroids and antibody-conjugates thereof |
| SG11202008799PA (en) | 2018-03-24 | 2020-10-29 | Regeneron Pharma | Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
| WO2019190990A1 (en) | 2018-03-26 | 2019-10-03 | Regeneron Pharmaceuticals, Inc. | Humanized rodents for testing therapeutic agents |
| MX2020011546A (es) | 2018-05-09 | 2021-01-29 | Regeneron Pharma | Anticuerpos anti-msr1 y metodos de uso de los mismos. |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| JP2020146302A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146314A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146306A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146318A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146301A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146315A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146307A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146308A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146316A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146299A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146313A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146309A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146297A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146300A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146305A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146303A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146310A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146317A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146312A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146304A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146298A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2023521885A (ja) | 2020-04-16 | 2023-05-25 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ディールス－アルダーコンジュゲーション方法 |
| US12605459B2 (en) | 2020-07-13 | 2026-04-21 | Regeneron Pharmaceuticals, Inc. | Protein-drug conjugates comprising camptothecin analogs and methods of use thereof |
| KR20230066386A (ko) | 2020-09-11 | 2023-05-15 | 리제너론 파마슈티칼스 인코포레이티드 | 항원 특이적 항체의 확인 및 제조 |
| MX2023002974A (es) | 2020-09-14 | 2023-05-25 | Regeneron Pharma | Conjugados de anticuerpo-farmaco que comprenden peptidomimeticos glp1 y usos de los mismos. |
| AU2021400584A1 (en) | 2020-12-16 | 2023-06-29 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| US20240317849A1 (en) | 2020-12-23 | 2024-09-26 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| CN118829449A (zh) | 2022-01-12 | 2024-10-22 | 瑞泽恩制药公司 | 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 |
| JP2025504020A (ja) | 2022-01-28 | 2025-02-06 | ジョージアミューン・インコーポレイテッド | Ｐｄ－１アゴニストであるプログラム細胞死タンパク質１に対する抗体 |
| CN120752059A (zh) | 2022-12-21 | 2025-10-03 | 瑞泽恩制药公司 | 用于adc缀合的拓扑异构酶i抑制剂的前药及其使用方法 |
| US20250171516A1 (en) | 2023-11-03 | 2025-05-29 | Regeneron Pharmaceuticals, Inc. | Peptide acids as a glp1r agonist and antibody-drug conjugates thereof |
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
| US20260123608A1 (en) | 2024-08-06 | 2026-05-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof |
| WO2026096736A1 (en) | 2024-10-31 | 2026-05-07 | Regeneron Pharmaceuticals, Inc. | Rodents expressing humanized polymeric immunoglobulin receptor |
Family Cites Families (135)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4977081A (en) | 1987-05-04 | 1990-12-11 | Adi Diagnostics, Inc. | Stable rabbit-mouse hybridomas and secretion products thereof |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5075181A (en) | 1989-05-05 | 1991-12-24 | Kennametal Inc. | High hardness/high compressive stress multilayer coated tool |
| WO1991000906A1 (en) | 1989-07-12 | 1991-01-24 | Genetics Institute, Inc. | Chimeric and transgenic animals capable of producing human antibodies |
| US6657103B1 (en) | 1990-01-12 | 2003-12-02 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| ES2284161T3 (es) | 1990-01-12 | 2007-11-01 | Amgen Fremont Inc. | Generacion de anticuerpos xenogenicos. |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| CA2066433A1 (en) | 1990-07-10 | 1992-01-11 | Haruo Matsuda | Chicken-specific immunoglobulin g-producing hybridoma |
| US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| JP2835787B2 (ja) | 1991-03-22 | 1998-12-14 | キヤノン株式会社 | 強誘電性液晶素子 |
| CA2078539C (en) * | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
| US5150584A (en) | 1991-09-26 | 1992-09-29 | General Motors Corporation | Method and apparatus for detecting low refrigerant charge |
| ES2301158T3 (es) | 1992-07-24 | 2008-06-16 | Amgen Fremont Inc. | Produccion de anticuerpos xenogenicos. |
| EP0583980A1 (en) | 1992-08-20 | 1994-02-23 | Eli Lilly And Company | Method for generating monoclonal antibodies from rabbits |
| US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
| PT1621554E (pt) | 1992-08-21 | 2009-07-13 | Univ Bruxelles | Imunoglobtainas desprovidas de cadeias leves |
| US6765087B1 (en) | 1992-08-21 | 2004-07-20 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| CA2149025A1 (en) | 1992-12-01 | 1994-06-09 | Man Sung Co | Humanized antibodies reactive with l-selectin |
| DE4309308C1 (de) | 1993-03-23 | 1994-04-14 | Siemens Nixdorf Inf Syst | Belüftungssystem für Schränke mit stark wärmeerzeugenden elektronischen Funktionseinheiten |
| IL109168A0 (en) * | 1993-04-01 | 1994-06-24 | Univ Columbia | A retroviral vector capable of transducing the aldehyde dehydrogenase-1 gene and making cells resistant to the chemotherapeutic agent cyclophosphamide and its derivatives and analogs |
| AU6819494A (en) | 1993-04-26 | 1994-11-21 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| US6632976B1 (en) | 1995-08-29 | 2003-10-14 | Kirin Beer Kabushiki Kaisha | Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene |
| WO1997016537A1 (en) | 1995-10-30 | 1997-05-09 | Spectral Diagnostics, Inc. | Stable chicken b-cell line and method of use thereof |
| EP0907726A4 (en) | 1996-06-26 | 2001-11-07 | Baylor College Medicine | CHROMOSOMAL REORDERING BY INSERTING TWO RECOMBINATION SUBSTRATES |
| ATE549918T1 (de) | 1996-12-03 | 2012-04-15 | Amgen Fremont Inc | Menschliche antikörper, die ausdrücklich menschliches tnf alpha binden |
| CN1203922A (zh) | 1997-03-21 | 1999-01-06 | 三共株式会社 | 人源化抗人fas抗体 |
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| JP2003501016A (ja) | 1999-05-27 | 2003-01-14 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | Ａｄａｍのポリヌクレオチドおよびポリペプチド |
| GB0001448D0 (en) | 2000-01-21 | 2000-03-08 | Novartis Ag | Organic compounds |
| EP1311530A4 (en) * | 2000-08-03 | 2004-10-06 | Wim-Van Schooten | PRODUCTION OF HUMANIZED ANTIBODIES IN TRANSGENIC ANIMALS |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| TWI255272B (en) | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| US7034134B2 (en) | 2001-04-26 | 2006-04-25 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29 |
| EP1970448A1 (en) | 2001-05-11 | 2008-09-17 | Kirin Pharma Kabushiki Kaisha | Human artificial chromosome containting human antibody lambda light chain and non-human animal containting the human artificial chromosome capable of genetic transmission |
| GB0115256D0 (en) | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
| AU2002319402B2 (en) | 2001-06-28 | 2008-09-11 | Domantis Limited | Dual-specific ligand and its use |
| FR2827302B1 (fr) * | 2001-07-13 | 2003-10-10 | Genoway | Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations |
| US20060199204A1 (en) | 2001-10-05 | 2006-09-07 | U.S. Epa | Genetic testing for male factor infertility |
| US20030108925A1 (en) | 2001-10-05 | 2003-06-12 | U.S. Epa | Genetic testing for male factor infertility |
| EP3698626A1 (en) | 2001-11-30 | 2020-08-26 | Amgen Fremont Inc. | Transgenic animals bearing human ig lambda light chain genes |
| DE60226641D1 (de) | 2001-12-03 | 2008-06-26 | Amgen Fremont Inc | Antikörperkategorisierung auf der grundlage von bindungseigenschaften |
| WO2003081993A2 (en) | 2002-03-22 | 2003-10-09 | Origen Therapeutics | Transgenic aves producing human polyclonal antibodies |
| US20030182675A1 (en) | 2002-03-22 | 2003-09-25 | Origen Therapeutics | Functional disruption of avian immunoglobulin genes |
| EP1600459A3 (en) | 2002-06-28 | 2005-12-07 | Domantis Limited | Ligand |
| FI117110B (fi) | 2002-07-05 | 2006-06-15 | Outokumpu Oy | Anodin syöttö sulatusreaktoriin |
| EP2314629B2 (en) | 2002-07-18 | 2022-11-16 | Merus N.V. | Recombinant production of mixtures of antibodies |
| US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
| GB0228210D0 (en) * | 2002-12-03 | 2003-01-08 | Babraham Inst | Single chain antibodies |
| GB0230201D0 (en) | 2002-12-27 | 2003-02-05 | Domantis Ltd | Retargeting |
| GB0230203D0 (en) * | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
| JP2006523090A (ja) | 2002-12-27 | 2006-10-12 | ドマンティス リミテッド | リガンドに、そしてリガンド受容体に特異的な二重特異性単一ドメイン抗体 |
| GB2398784B (en) | 2003-02-26 | 2005-07-27 | Babraham Inst | Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal |
| WO2004106375A1 (en) * | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
| US20100069614A1 (en) * | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| US7205148B2 (en) | 2003-06-11 | 2007-04-17 | Regeneron Pharmaceuticals, Inc. | Genome mutation by intron insertion into an embryonic stem cell genome |
| CN103205436B (zh) | 2003-07-15 | 2016-05-25 | 人类多克隆治疗公司 | 人源化免疫球蛋白基因座 |
| US20050153392A1 (en) | 2003-08-11 | 2005-07-14 | Roland Buelow | Transgenesis with humanized immunoglobulin loci |
| RU2251699C1 (ru) | 2003-09-25 | 2005-05-10 | Киселев Всеволод Иванович | Способ ранней и доклинической диагностики цервикального рака |
| WO2005038001A2 (en) | 2003-10-14 | 2005-04-28 | Therapeutic Human Polyclonals, Inc. | Improved transgenesis by sperm-mediated gene transfer |
| FR2861255B1 (fr) | 2003-10-24 | 2006-02-17 | Centre Nat Rech Scient | Mammifere non-humain transgenique pour la region constante de la chaine lourde des immunoglobulines humaines de classe a et ses applications. |
| HUE028552T2 (en) | 2004-02-20 | 2016-12-28 | Woodwelding Ag | An implant for implantation into bone tissue and a method for preparing it |
| EP1978032A3 (en) * | 2004-07-22 | 2009-02-18 | Erasmus University Medical Center Rotterdam | Binding molecules |
| WO2006044962A1 (en) | 2004-10-19 | 2006-04-27 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
| CN101084317A (zh) | 2004-10-22 | 2007-12-05 | 人类多克隆治疗公司 | 对内源免疫球蛋白表达的抑制 |
| SG169348A1 (en) | 2006-01-25 | 2011-03-30 | Univ Erasmus Medical Ct | Generation of heavy-chain only antibodies in transgenic animals |
| GB0618345D0 (en) * | 2006-09-18 | 2006-10-25 | Univ Erasmus | Binding molecules |
| JP5514539B2 (ja) | 2006-03-31 | 2014-06-04 | メダレックス・リミテッド・ライアビリティ・カンパニー | ヒト抗体の調製に用いるためのキメラ抗体を発現するトランスジェニック動物 |
| NZ587107A (en) | 2006-06-02 | 2012-05-25 | Regeneron Pharma | High affinity antibodies to human il-6 receptor |
| ES2378407T3 (es) | 2006-09-01 | 2012-04-12 | Therapeutic Human Polyclonals, Inc. | Aumento de la expresión de inmunoglobulina humana o humanizada en animales transgénicos no humanos |
| LT2769992T (lt) * | 2006-10-02 | 2021-04-12 | Regeneron Pharmaceuticals, Inc. | Didelio afiniškumo žmogaus antikūnai, atpažįstantys žmogaus il-4 receptorių |
| RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
| CA2688834C (en) | 2007-06-01 | 2020-01-07 | Ronald Buelow | Compositions and methods for inhibiting endogenous immunoglobulin genes and producing transgenic human idiotype antibodies |
| WO2009013620A2 (en) | 2007-06-11 | 2009-01-29 | Erasmus University Medical Center Rotterdam | Homologous recombination |
| ITMI20071522A1 (it) | 2007-07-27 | 2009-01-28 | Areta Internat S R L | Vaccino idiotipico |
| US20090155275A1 (en) * | 2007-07-31 | 2009-06-18 | Medimmune, Llc | Multispecific epitope binding proteins and uses thereof |
| WO2009097006A2 (en) | 2007-08-10 | 2009-08-06 | Medarex, Inc. | Hco32 and hco27 and related examples |
| CN101970491A (zh) | 2007-08-30 | 2011-02-09 | 沃尔特及伊莱萨霍尔医学研究院 | 树突状细胞标记物及其用途 |
| EP3415529B1 (en) | 2007-09-26 | 2020-11-04 | Chugai Seiyaku Kabushiki Kaisha | Modified antibody constant region |
| EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| EP2271758B1 (en) | 2008-04-14 | 2018-09-12 | Innovative Targeting Solutions Inc. | Sequence diversity generation in immunoglobulins |
| ES2436044T3 (es) * | 2008-05-23 | 2013-12-26 | Ablexis, Llc | Procedimiento de generación de anticuerpos de dominio VL individual en animales transgénicos |
| US20100122358A1 (en) | 2008-06-06 | 2010-05-13 | Crescendo Biologics Limited | H-Chain-only antibodies |
| RU2731084C2 (ru) | 2008-06-27 | 2020-08-28 | Мерюс Н.В. | Продуцирующие антитела млекопитающие, не являющиеся человеком |
| WO2010039900A2 (en) | 2008-09-30 | 2010-04-08 | Aliva Biopharmaceuticals, Inc. | Non-human mammals for the production of chimeric antibodies |
| CA2747534C (en) | 2008-12-18 | 2020-08-18 | Erasmus University Medical Center Rotterdam | Non-human transgenic animals expressing humanised antibodies and use therof |
| US9085795B2 (en) | 2009-02-04 | 2015-07-21 | Molecular Innovations, Inc. | Methods for screening candidate agents for modulating prorenin and renin, assays for detecting prorenin and antibodies |
| GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| AU2010233993A1 (en) * | 2009-04-07 | 2011-09-08 | Roche Glycart Ag | Bispecific anti-ErbB-1/anti-c-Met antibodies |
| LT2975051T (lt) | 2009-06-26 | 2021-07-12 | Regeneron Pharmaceuticals, Inc. | Lengvai išskiriami bispecifiniai antikūnai su natyvios formos imunoglobulinu |
| CN102638971B (zh) | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| RU2425880C2 (ru) | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| CN101620635A (zh) * | 2009-08-07 | 2010-01-06 | 中兴通讯股份有限公司 | 页面数据获取方法及服务器、页面更新方法及服务器 |
| DK2509409T3 (en) | 2009-12-10 | 2016-11-14 | Regeneron Pharma | MICE, WHICH PRODUCES HEAVY CHAIN ANTIBODIES |
| US20120021409A1 (en) | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US20130185821A1 (en) | 2010-02-08 | 2013-07-18 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| HRP20151188T4 (hr) | 2010-02-08 | 2021-10-01 | Regeneron Pharmaceuticals, Inc. | Miš sa zajedničkim lakim lancem |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| CN103228130B (zh) | 2010-06-17 | 2016-03-16 | 科马布有限公司 | 动物模型及治疗分子 |
| SI2480675T1 (sl) | 2010-06-22 | 2016-08-31 | Regeneron Pharmaceuticals, Inc. | Miši, ki izražajo lahko verigo s spremenljivo regijo humanega lambda in konstantno mišjo regijo |
| KR102306967B1 (ko) | 2010-08-02 | 2021-10-01 | 리제너론 파아마슈티컬스, 인크. | Ｖｌ 도메인을 포함하는 결합 단백질을 생성하는 마우스 |
| WO2012063048A1 (en) | 2010-11-08 | 2012-05-18 | Kymab Limited | Cells & vertebrates for enhanced somatic hypermutation and class switch recombination |
| LT2738259T (lt) | 2011-02-25 | 2020-03-10 | Regeneron Pharmaceuticals, Inc. | Adam6 pelės |
| AR085403A1 (es) | 2011-02-28 | 2013-09-25 | Hoffmann La Roche | Proteinas monovalentes que se unen a antigenos |
| EP2681239B8 (en) | 2011-02-28 | 2015-09-09 | F. Hoffmann-La Roche AG | Antigen binding proteins |
| US20120310284A1 (en) | 2011-06-03 | 2012-12-06 | Royal Oak Industries | Polyaxial pedicle screw |
| PT3865581T (pt) | 2011-08-05 | 2024-10-04 | Regeneron Pharma | Murganhos da cadeia leve universal humanizada |
| EP3741862A1 (en) | 2011-09-19 | 2020-11-25 | Kymab Limited | Animals, repertoires & methods for the production of human antibodies |
| AU2012311286B2 (en) | 2011-09-19 | 2018-07-26 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| KR20140082824A (ko) | 2011-10-17 | 2014-07-02 | 리제너론 파아마슈티컬스, 인크. | 제한된 면역글로불린 중쇄 마우스 |
| GB2496375A (en) | 2011-10-28 | 2013-05-15 | Kymab Ltd | A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
| PT3527070T (pt) | 2011-12-20 | 2025-12-19 | Regeneron Pharma | Murganhos de cadeia leve humanizada |
| NZ810648A (en) | 2012-02-01 | 2025-11-28 | Regeneron Pharma | Humanized rodents that express heavy chains containing vl domains |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| TWI682941B (zh) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | 含嵌合恆定區之抗體 |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| DK2986729T3 (en) | 2013-04-16 | 2018-10-29 | Regeneron Pharma | TARGETED MODIFICATION OF ROOT THROUGH |
| CN106164092A (zh) | 2014-03-21 | 2016-11-23 | 瑞泽恩制药公司 | 表现不同结合特征的vl抗原结合蛋白 |
| CN106255410B (zh) | 2014-03-21 | 2020-01-10 | 瑞泽恩制药公司 | 产生单结构域结合蛋白的非人动物 |
| US11111314B2 (en) | 2015-03-19 | 2021-09-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
-
2011
- 2011-08-02 KR KR1020207027965A patent/KR102306967B1/ko active Active
- 2011-08-02 KR KR1020197022706A patent/KR102163138B1/ko active Active
- 2011-08-02 KR KR1020137004960A patent/KR102008655B1/ko active Active
- 2011-08-02 SG SG10201912639SA patent/SG10201912639SA/en unknown
- 2011-08-02 SM SM20170023T patent/SMT201700023T1/it unknown
- 2011-08-02 NZ NZ707327A patent/NZ707327A/en unknown
- 2011-08-02 EP EP11741730.3A patent/EP2601298B1/en active Active
- 2011-08-02 CA CA3250882A patent/CA3250882A1/en active Pending
- 2011-08-02 NZ NZ606824A patent/NZ606824A/en unknown
- 2011-08-02 ES ES11741730.3T patent/ES2612459T3/es active Active
- 2011-08-02 MX MX2018014787A patent/MX2018014787A/es unknown
- 2011-08-02 LT LTEP11741730.3T patent/LT2601298T/lt unknown
- 2011-08-02 JP JP2013523258A patent/JP6146913B2/ja active Active
- 2011-08-02 RS RS20161086A patent/RS55495B1/sr unknown
- 2011-08-02 SG SG2013007893A patent/SG187673A1/en unknown
- 2011-08-02 US US13/195,951 patent/US9516868B2/en active Active
- 2011-08-02 MX MX2016014021A patent/MX350591B/es unknown
- 2011-08-02 CN CN201180045609.5A patent/CN103154255B/zh active Active
- 2011-08-02 BR BR112013002695-2A patent/BR112013002695B1/pt active IP Right Grant
- 2011-08-02 CA CA2807282A patent/CA2807282A1/en active Pending
- 2011-08-02 RU RU2017106292A patent/RU2750219C2/ru active
- 2011-08-02 IL IL315833A patent/IL315833A/en unknown
- 2011-08-02 WO PCT/US2011/046196 patent/WO2012018764A1/en not_active Ceased
- 2011-08-02 PT PT117417303T patent/PT2601298T/pt unknown
- 2011-08-02 AU AU2011285919A patent/AU2011285919C1/en active Active
- 2011-08-02 MY MYPI2013000340A patent/MY172618A/en unknown
- 2011-08-02 CN CN202410984383.4A patent/CN118791596A/zh active Pending
- 2011-08-02 RU RU2013109068A patent/RU2612903C2/ru active
- 2011-08-02 MX MX2013001360A patent/MX345251B/es active IP Right Grant
- 2011-08-02 HR HRP20170322TT patent/HRP20170322T1/hr unknown
- 2011-08-02 SI SI201131072A patent/SI2601298T1/sl unknown
- 2011-08-02 IL IL271804A patent/IL271804B2/en unknown
- 2011-08-02 SG SG10201504971QA patent/SG10201504971QA/en unknown
- 2011-08-02 EP EP15173007.4A patent/EP2947151A1/en not_active Ceased
- 2011-08-02 EP EP21174332.3A patent/EP3960865A1/en active Pending
- 2011-08-02 HU HUE11741730A patent/HUE031903T2/en unknown
- 2011-08-02 KR KR1020217030387A patent/KR102434557B1/ko active Active
- 2011-08-02 CN CN201610124564.5A patent/CN105753979B/zh active Active
- 2011-08-02 PL PL11741730T patent/PL2601298T3/pl unknown
- 2011-08-02 MX MX2017006698A patent/MX363084B/es unknown
- 2011-08-02 DK DK11741730.3T patent/DK2601298T3/en active
- 2011-08-02 CN CN202110412459.2A patent/CN113150121B9/zh active Active
-
2013
- 2013-01-31 IL IL224523A patent/IL224523B/en active IP Right Grant
- 2013-02-01 MX MX2023001793A patent/MX2023001793A/es unknown
- 2013-12-19 US US14/135,510 patent/US9686970B2/en active Active
- 2013-12-19 US US14/135,518 patent/US20140130194A1/en not_active Abandoned
-
2016
- 2016-01-21 JP JP2016009916A patent/JP2016054746A/ja not_active Withdrawn
- 2016-05-10 HK HK16105319.5A patent/HK1217511A1/en unknown
-
2017
- 2017-01-04 CY CY20171100009T patent/CY1118562T1/el unknown
- 2017-01-16 SM SM201700023T patent/SMT201700023B/it unknown
- 2017-04-25 US US15/497,043 patent/US20170226231A1/en not_active Abandoned
- 2017-04-25 US US15/497,075 patent/US10954310B2/en active Active
-
2018
- 2018-01-04 JP JP2018000123A patent/JP7078400B2/ja active Active
- 2018-03-25 IL IL258338A patent/IL258338B/en active IP Right Grant
- 2018-11-12 JP JP2018212094A patent/JP6759303B2/ja active Active
-
2020
- 2020-02-14 JP JP2020023076A patent/JP7110257B2/ja active Active
-
2021
- 2021-02-05 US US17/168,708 patent/US20210163628A1/en active Pending
- 2021-05-19 JP JP2021084769A patent/JP2021119792A/ja active Pending
- 2021-12-14 US US17/550,839 patent/US12486335B2/en active Active
-
2025
- 2025-10-23 US US19/367,570 patent/US20260071006A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020039360A5 (enExample) | ||
| JP2020508655A5 (enExample) | ||
| JP2020514277A5 (enExample) | ||
| JP2023052214A5 (enExample) | ||
| JP2020510646A5 (enExample) | ||
| IL277355B1 (en) | Humanized rodents for testing therapeutic agents | |
| SI2699264T1 (en) | Antibodies and other molecules that bind b7-h1 and pd-1 | |
| RU2019129511A (ru) | Белки, связывающие gd2, nkg2d и cd16 | |
| JP2021530251A5 (enExample) | ||
| EP4286415A3 (en) | Humanized antigen-binding domains against cd19 and methods of use | |
| JP2017052784A5 (enExample) | ||
| TR201901929T4 (tr) | TGFBeta'ya antikorlar. | |
| RU2011148913A (ru) | Иммуноглобулин с двумя вариабельными доменами и его применение | |
| JP2020508997A5 (enExample) | ||
| JP2018522888A5 (enExample) | ||
| JP2020507577A5 (enExample) | ||
| JP2020513759A5 (enExample) | ||
| RU2019121086A (ru) | Иммунотерапия с применением антител, связывающих лиганд 1 белка программируемой смерти клеток (PD-L1) | |
| JP2017504578A5 (enExample) | ||
| RU2018137110A (ru) | Антитела против psma и их применение | |
| RU2021111382A (ru) | Мультивалентные и мультиспецифические гибридные белки, связывающиеся с dr5 | |
| RU2019128204A (ru) | Белки, связывающиеся с psma, nkg2d и cd16 | |
| JP2019505477A5 (enExample) | ||
| JP2017129381A5 (enExample) | ||
| RU2019121106A (ru) | Иммунотерапия с применением антител, связывающих белок 1 программируемой смерти клеток (pd-1) |