JP2018046872A5 - - Google Patents
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- JP2018046872A5 JP2018046872A5 JP2018000123A JP2018000123A JP2018046872A5 JP 2018046872 A5 JP2018046872 A5 JP 2018046872A5 JP 2018000123 A JP2018000123 A JP 2018000123A JP 2018000123 A JP2018000123 A JP 2018000123A JP 2018046872 A5 JP2018046872 A5 JP 2018046872A5
- Authority
- JP
- Japan
- Prior art keywords
- binding protein
- antigen
- domain
- protein according
- antigen binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36990910P | 2010-08-02 | 2010-08-02 | |
| US61/369,909 | 2010-08-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016009916A Division JP2016054746A (ja) | 2010-08-02 | 2016-01-21 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018212094A Division JP6759303B2 (ja) | 2010-08-02 | 2018-11-12 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018046872A JP2018046872A (ja) | 2018-03-29 |
| JP2018046872A5 true JP2018046872A5 (enExample) | 2018-12-20 |
| JP7078400B2 JP7078400B2 (ja) | 2022-05-31 |
Family
ID=44543797
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523258A Active JP6146913B2 (ja) | 2010-08-02 | 2011-08-02 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
| JP2016009916A Withdrawn JP2016054746A (ja) | 2010-08-02 | 2016-01-21 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
| JP2018000123A Active JP7078400B2 (ja) | 2010-08-02 | 2018-01-04 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
| JP2018212094A Active JP6759303B2 (ja) | 2010-08-02 | 2018-11-12 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
| JP2020023076A Active JP7110257B2 (ja) | 2010-08-02 | 2020-02-14 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
| JP2021084769A Pending JP2021119792A (ja) | 2010-08-02 | 2021-05-19 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523258A Active JP6146913B2 (ja) | 2010-08-02 | 2011-08-02 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
| JP2016009916A Withdrawn JP2016054746A (ja) | 2010-08-02 | 2016-01-21 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018212094A Active JP6759303B2 (ja) | 2010-08-02 | 2018-11-12 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
| JP2020023076A Active JP7110257B2 (ja) | 2010-08-02 | 2020-02-14 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
| JP2021084769A Pending JP2021119792A (ja) | 2010-08-02 | 2021-05-19 | Ｖｌドメインを含む結合タンパク質を作製するマウス |
Country Status (27)
| Country | Link |
|---|---|
| US (8) | US9516868B2 (enExample) |
| EP (3) | EP3960865A1 (enExample) |
| JP (6) | JP6146913B2 (enExample) |
| KR (4) | KR102008655B1 (enExample) |
| CN (4) | CN103154255B (enExample) |
| AU (1) | AU2011285919C1 (enExample) |
| BR (1) | BR112013002695B1 (enExample) |
| CA (2) | CA2807282A1 (enExample) |
| CY (1) | CY1118562T1 (enExample) |
| DK (1) | DK2601298T3 (enExample) |
| ES (1) | ES2612459T3 (enExample) |
| HK (1) | HK1217511A1 (enExample) |
| HR (1) | HRP20170322T1 (enExample) |
| HU (1) | HUE031903T2 (enExample) |
| IL (4) | IL315833A (enExample) |
| LT (1) | LT2601298T (enExample) |
| MX (5) | MX363084B (enExample) |
| MY (1) | MY172618A (enExample) |
| NZ (2) | NZ707327A (enExample) |
| PL (1) | PL2601298T3 (enExample) |
| PT (1) | PT2601298T (enExample) |
| RS (1) | RS55495B1 (enExample) |
| RU (2) | RU2750219C2 (enExample) |
| SG (3) | SG10201912639SA (enExample) |
| SI (1) | SI2601298T1 (enExample) |
| SM (2) | SMT201700023T1 (enExample) |
| WO (1) | WO2012018764A1 (enExample) |
Families Citing this family (89)
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| EP2669298A3 (en) * | 2008-05-23 | 2014-02-26 | Ablexis, LLC | Single variable immunoglobulin domain comprising VL-DH-JL |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| CN102638971B (zh) | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US10143186B2 (en) | 2010-02-08 | 2018-12-04 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| DK2597945T3 (da) | 2010-07-26 | 2020-09-21 | Trianni Inc | Transgene dyr og fremgangsmåder til anvendelse deraf |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| EP3960865A1 (en) | 2010-08-02 | 2022-03-02 | Regeneron Pharmaceuticals, Inc. | Mice that make binding proteins comprising vl domains |
| HRP20192255T1 (hr) | 2011-08-05 | 2020-03-06 | Regeneron Pharmaceuticals, Inc. | Humanizirani miševi s univerzalnim lakim lancem |
| JP2014531452A (ja) | 2011-09-19 | 2014-11-27 | カイマブ・リミテッド | 動物、レパートリーおよび方法 |
| BR112014006390A2 (pt) | 2011-09-19 | 2017-03-28 | Kymab Ltd | anticorpos, domínios variáveis e cadeias feitos especialmente para uso humano |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| HRP20220253T1 (hr) | 2011-10-17 | 2022-04-29 | Regeneron Pharmaceuticals, Inc. | Miševi s ograničenim teškim lancem imunoglobulina |
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| ME03477B (me) | 2011-12-20 | 2020-01-20 | Regeneron Pharma | Miševi sa humanizovanim lakim lancem |
| SG10201913428QA (en) * | 2012-02-01 | 2020-03-30 | Regeneron Pharma | Humanized rodents that express heavy chains containing vl domains |
| EP2825653A4 (en) | 2012-03-14 | 2016-01-20 | Innovative Targeting Solutions Inc | PRODUCTION OF TARGETED SEQUENCE DIVERSITY IN FUSION PROTEINS |
| CA2867231C (en) * | 2012-03-14 | 2021-10-19 | Innovative Targeting Solutions Inc. | Generating targeted sequence diversity in proteins |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| KR102484480B1 (ko) | 2012-06-12 | 2023-01-04 | 리제너론 파마슈티칼스 인코포레이티드 | 제한된 면역글로불린 중쇄 유전자좌를 가지는 인간화된 비-인간 동물 |
| US20150203591A1 (en) | 2012-08-02 | 2015-07-23 | Regeneron Pharmaceuticals, Inc. | Mutivalent antigen-binding proteins |
| LT2840892T (lt) * | 2013-02-20 | 2018-07-25 | Regeneron Pharmaceuticals, Inc. | Nežmogaus tipo gyvūnai su modifikuotomis imunoglobulino sunkiųjų grandinių sekomis |
| LT3501272T (lt) * | 2013-03-13 | 2023-03-27 | Regeneron Pharmaceuticals, Inc. | Pelės, vykdančios imunoglobulino lengvosios grandinės riboto rinkinio raišką |
| AU2014233385C1 (en) | 2013-03-15 | 2019-09-19 | Regeneron Pharmaceuticals, Inc. | Biologically active molecules, conjugates thereof, and therapeutic uses |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| KR102252925B1 (ko) | 2013-08-26 | 2021-05-18 | 리제너론 파마슈티칼스 인코포레이티드 | 마크롤라이드 디아스테레오머를 포함하는 약제학적 조성물, 이의 합성 방법 및 치료학적 용도 |
| ES2993142T3 (en) | 2013-10-01 | 2024-12-23 | Kymab Ltd | Animal models and therapeutic molecules |
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| CN109475109B (zh) | 2016-05-20 | 2021-10-29 | 瑞泽恩制药公司 | 用于使用多个引导rna来破坏免疫耐受性的方法 |
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| US11021540B2 (en) | 2017-09-07 | 2021-06-01 | Augusta University Research Institute, Inc. | Antibodies to programmed cell death protein 1 |
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| HUE070158T2 (hu) | 2018-03-24 | 2025-05-28 | Regeneron Pharma | Genetikailag módosított egerek vagy patkányok peptid-mhc komplexek elleni terápiás antitestek létrehozásra, ezek elõállítására szolgáló módszerek, valamint alkalmazásuk |
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| JP2020146299A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146307A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146306A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146314A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146315A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
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| JP2020146305A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146316A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146301A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146304A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146297A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146300A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
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