JP2018009012A5 - - Google Patents
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- Publication number
- JP2018009012A5 JP2018009012A5 JP2017157335A JP2017157335A JP2018009012A5 JP 2018009012 A5 JP2018009012 A5 JP 2018009012A5 JP 2017157335 A JP2017157335 A JP 2017157335A JP 2017157335 A JP2017157335 A JP 2017157335A JP 2018009012 A5 JP2018009012 A5 JP 2018009012A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- divalent
- sulfonamide
- amide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 125000000565 sulfonamide group Chemical group 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361773773P | 2013-03-06 | 2013-03-06 | |
| US61/773,773 | 2013-03-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015561536A Division JP6196327B2 (ja) | 2013-03-06 | 2014-03-04 | 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019043934A Division JP6672500B2 (ja) | 2013-03-06 | 2019-03-11 | 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018009012A JP2018009012A (ja) | 2018-01-18 |
| JP2018009012A5 true JP2018009012A5 (enExample) | 2019-01-31 |
| JP6496786B2 JP6496786B2 (ja) | 2019-04-03 |
Family
ID=50382628
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015561536A Active JP6196327B2 (ja) | 2013-03-06 | 2014-03-04 | 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用 |
| JP2017157334A Active JP6602351B2 (ja) | 2013-03-06 | 2017-08-17 | 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用 |
| JP2017157335A Active JP6496786B2 (ja) | 2013-03-06 | 2017-08-17 | 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用 |
| JP2019043934A Active JP6672500B2 (ja) | 2013-03-06 | 2019-03-11 | 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015561536A Active JP6196327B2 (ja) | 2013-03-06 | 2014-03-04 | 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用 |
| JP2017157334A Active JP6602351B2 (ja) | 2013-03-06 | 2017-08-17 | 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019043934A Active JP6672500B2 (ja) | 2013-03-06 | 2019-03-11 | 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9850264B2 (enExample) |
| EP (2) | EP2964213B1 (enExample) |
| JP (4) | JP6196327B2 (enExample) |
| KR (2) | KR102227201B1 (enExample) |
| CN (2) | CN110279684B (enExample) |
| AR (1) | AR095034A1 (enExample) |
| AU (3) | AU2014225992B2 (enExample) |
| BR (2) | BR112015021371B1 (enExample) |
| CA (2) | CA3133264A1 (enExample) |
| CL (3) | CL2015002485A1 (enExample) |
| ES (2) | ES2835825T3 (enExample) |
| IL (3) | IL241012B (enExample) |
| MX (2) | MX364916B (enExample) |
| MY (1) | MY207109A (enExample) |
| PH (3) | PH12020500285B1 (enExample) |
| RU (2) | RU2768730C2 (enExample) |
| SG (2) | SG11201507113RA (enExample) |
| TW (1) | TWI616200B (enExample) |
| WO (1) | WO2014138037A1 (enExample) |
| ZA (1) | ZA201505134B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012329098B2 (en) * | 2011-10-26 | 2017-08-03 | Allergan, Inc. | Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators |
| SG11201406629VA (en) * | 2012-04-16 | 2014-11-27 | Allergan Inc | (2-ureidoacetamido)alkyl derivatives as formyl peptide receptor 2 modulators |
| TW201348219A (zh) | 2012-05-16 | 2013-12-01 | Actelion Pharmaceuticals Ltd | 作爲ａｌｘ受體激動劑之經１－（對－甲苯基）環丙基取代橋聯螺［２．４］庚烷衍生物 |
| MA37618B1 (fr) | 2012-05-16 | 2017-08-31 | Actelion Pharmaceuticals Ltd | Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx |
| CN107312039B (zh) | 2012-08-30 | 2019-06-25 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药的制备方法 |
| CN110279684B (zh) * | 2013-03-06 | 2023-02-28 | 阿勒根公司 | 用于治疗眼部炎性疾病的甲酰基肽受体2激动剂的用途 |
| JP6196328B2 (ja) | 2013-03-06 | 2017-09-13 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 皮膚疾患を治療するためのホルミルペプチド受容体２アゴニストの使用 |
| AR096686A1 (es) | 2013-06-25 | 2016-01-27 | Actelion Pharmaceuticals Ltd | Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx |
| US9428549B2 (en) * | 2013-07-16 | 2016-08-30 | Allegran, Inc. | Derivatives of N-urea substituted amino acids as formyl peptide receptor modulators |
| ES2639798T3 (es) | 2013-07-18 | 2017-10-30 | Idorsia Pharmaceuticals Ltd | Derivados de espiro[2.4]heptano con puente sustituidos con piperazina como agonistas del receptor ALX |
| AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
| US9663457B2 (en) | 2014-04-09 | 2017-05-30 | Allergan, Inc. | Carbamoyl hydrazine derivatives as formyl peptide modulators |
| ES2788700T3 (es) | 2014-05-21 | 2020-10-22 | Allergan Inc | Derivados de imidazol como moduladores del receptor de péptido formilado |
| WO2016149667A1 (en) | 2015-03-19 | 2016-09-22 | University Of Maryland , Baltimore | Runx2 transcription factor inhibitors and uses thereof |
| EP3303284B1 (en) | 2015-05-27 | 2020-04-08 | Kyorin Pharmaceutical Co., Ltd. | Urea derivative or pharmacologically acceptable salt thereof |
| JP7032323B6 (ja) * | 2016-03-28 | 2023-12-18 | アラーガン、インコーポレイテッド | Ｎ－ホルミルペプチド受容体モジュレーターとしてのフェニル尿素誘導体 |
| AU2017249047B2 (en) * | 2016-04-12 | 2021-08-05 | Allergan, Inc. | Phenyl urea derivatives as N-formyl peptide receptor modulators |
| CN109843283B (zh) | 2016-10-06 | 2022-08-30 | 第一三共株式会社 | 脲衍生物 |
| CN109134533B (zh) | 2017-06-27 | 2020-08-11 | 维眸生物科技（上海）有限公司 | 一种含磷化合物及其制备和应用 |
| CN107814773B (zh) * | 2017-11-13 | 2020-05-22 | 西安交通大学 | 含有喹唑啉酮的二芳基脲类化合物及其制备方法和应用 |
| RU2712229C2 (ru) * | 2018-05-17 | 2020-01-27 | Закрытое акционерное общество "Институт экспериментальной фармакологии" | Эфиры тригидроксигептаеновой кислоты в качестве агонистов fpr2 рецептора |
| KR102429281B1 (ko) * | 2020-05-25 | 2022-08-05 | (주)노바셀테크놀로지 | 신규 안구건조증 치료용 약학적 조성물 |
| IT202100004964A1 (it) * | 2021-03-03 | 2022-09-03 | Univ Degli Studi Di Bari Aldo Moro | Agonisti del recettore fpr2 (formyl peptide receptor 2) e loro uso nel trattamento del disturbo dello spettro autistico. |
| JP2022151437A (ja) * | 2021-03-26 | 2022-10-07 | 均 石井 | 網膜炎治療薬。 |
| WO2025233915A1 (en) * | 2024-05-10 | 2025-11-13 | Allgenesis Biotherapeutics Inc. | Use of an agonist of formyl peptide receptors 1 and 2 for treating ocular inflammatory diseases |
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| US4521210A (en) | 1982-12-27 | 1985-06-04 | Wong Vernon G | Eye implant for relieving glaucoma, and device and method for use therewith |
| JPS63232846A (ja) | 1987-03-20 | 1988-09-28 | Haruo Ogura | 新規な固定相担体 |
| AU667995B2 (en) * | 1993-02-15 | 1996-04-18 | Bayer Aktiengesellschaft | New pseudopeptides having an antiviral action |
| US6423689B1 (en) * | 1997-12-22 | 2002-07-23 | Warner-Lambert Company | Peptidyl calcium channel blockers |
| AU6909300A (en) * | 1999-08-20 | 2001-03-19 | Merck & Co., Inc. | Substituted ureas as cell adhesion inhibitors |
| EP1162194A1 (en) | 2000-06-06 | 2001-12-12 | Aventis Pharma Deutschland GmbH | Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use |
| DE10063008A1 (de) | 2000-12-16 | 2002-06-20 | Merck Patent Gmbh | Carbonsäureamidderivate |
| DE60328202D1 (de) * | 2002-09-05 | 2009-08-13 | Neurosearch As | Diarylharnstoffderivate und deren verwendung als chloridkanalblocker |
| AU2003277575A1 (en) * | 2002-11-07 | 2004-06-07 | Takeda Pharmaceutical Company Limited | Novel fprl1 ligands and use thereof |
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| WO2005058823A1 (ja) | 2003-12-17 | 2005-06-30 | Takeda Pharmaceutical Company Limited | ウレア誘導体、その製造法及び用途 |
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| US20100035932A1 (en) * | 2008-08-07 | 2010-02-11 | Schepetkin Igor A | Novel formyl peptide receptor like 1 agonists that induce macrophage tumor necrosis factor alpha and computational structure-activity relationship analysis of thereof |
| WO2010104307A2 (ko) * | 2009-03-07 | 2010-09-16 | 주식회사 메디젠텍 | 세포핵에서 세포질로의 ｇｓｋ３의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 gsk3 이동에 의해 발생되는 질환의 치료 또는 예방용 약학적 조성물 |
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| AU2012329098B2 (en) * | 2011-10-26 | 2017-08-03 | Allergan, Inc. | Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators |
| US8541577B2 (en) * | 2011-11-10 | 2013-09-24 | Allergan, Inc. | Aryl urea derivatives as N-formyl peptide receptors like-1 (FPRL-1) receptor modulators |
| US8492556B2 (en) * | 2011-11-10 | 2013-07-23 | Allergan, Inc. | 2,5-Dioxoimidazolidin-1-yl-3-phenylurea derivatives as formyl peptide receptor like-1 (FPRL-1) receptor modulators |
| AU2013221749A1 (en) | 2012-02-16 | 2014-09-11 | Allergan, Inc. | Imidazolidine-2,4-dione derivatives as N-formyl peptide receptor 2 modulators |
| SG11201406629VA (en) | 2012-04-16 | 2014-11-27 | Allergan Inc | (2-ureidoacetamido)alkyl derivatives as formyl peptide receptor 2 modulators |
| CN110279684B (zh) | 2013-03-06 | 2023-02-28 | 阿勒根公司 | 用于治疗眼部炎性疾病的甲酰基肽受体2激动剂的用途 |
-
2014
- 2014-03-04 CN CN201910497947.0A patent/CN110279684B/zh active Active
- 2014-03-04 SG SG11201507113RA patent/SG11201507113RA/en unknown
- 2014-03-04 EP EP14712888.8A patent/EP2964213B1/en active Active
- 2014-03-04 WO PCT/US2014/020245 patent/WO2014138037A1/en not_active Ceased
- 2014-03-04 KR KR1020157024036A patent/KR102227201B1/ko active Active
- 2014-03-04 ES ES14712888T patent/ES2835825T3/es active Active
- 2014-03-04 BR BR112015021371-5A patent/BR112015021371B1/pt active IP Right Grant
- 2014-03-04 ES ES20205401T patent/ES3036990T3/es active Active
- 2014-03-04 CA CA3133264A patent/CA3133264A1/en active Pending
- 2014-03-04 PH PH1/2020/500285A patent/PH12020500285B1/en unknown
- 2014-03-04 BR BR122017004254-8A patent/BR122017004254B1/pt active IP Right Grant
- 2014-03-04 CN CN201480012204.5A patent/CN105007909B/zh active Active
- 2014-03-04 EP EP20205401.1A patent/EP3795148B1/en active Active
- 2014-03-04 RU RU2018127997A patent/RU2768730C2/ru active
- 2014-03-04 AU AU2014225992A patent/AU2014225992B2/en active Active
- 2014-03-04 MX MX2015011593A patent/MX364916B/es active IP Right Grant
- 2014-03-04 RU RU2015136774A patent/RU2663911C2/ru active
- 2014-03-04 CA CA2898301A patent/CA2898301C/en active Active
- 2014-03-04 US US14/196,047 patent/US9850264B2/en active Active
- 2014-03-04 SG SG10201801471RA patent/SG10201801471RA/en unknown
- 2014-03-04 KR KR1020207023766A patent/KR102290134B1/ko active Active
- 2014-03-04 JP JP2015561536A patent/JP6196327B2/ja active Active
- 2014-03-04 MX MX2019005541A patent/MX393070B/es unknown
- 2014-03-04 MY MYPI2019001743A patent/MY207109A/en unknown
- 2014-03-06 TW TW103107761A patent/TWI616200B/zh active
- 2014-03-06 AR ARP140100732A patent/AR095034A1/es not_active Application Discontinuation
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2015
- 2015-07-16 ZA ZA2015/05134A patent/ZA201505134B/en unknown
- 2015-08-24 PH PH12015501858A patent/PH12015501858A1/en unknown
- 2015-09-01 IL IL241012A patent/IL241012B/en active IP Right Grant
- 2015-09-04 CL CL2015002485A patent/CL2015002485A1/es unknown
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2017
- 2017-07-21 US US15/656,766 patent/US10208071B2/en active Active
- 2017-08-17 JP JP2017157334A patent/JP6602351B2/ja active Active
- 2017-08-17 JP JP2017157335A patent/JP6496786B2/ja active Active
- 2017-10-06 CL CL2017002527A patent/CL2017002527A1/es unknown
- 2017-10-06 CL CL2017002526A patent/CL2017002526A1/es unknown
-
2018
- 2018-05-28 AU AU2018203719A patent/AU2018203719B2/en active Active
- 2018-11-27 IL IL263314A patent/IL263314B/en active IP Right Grant
-
2019
- 2019-01-22 US US16/254,438 patent/US10899780B2/en active Active
- 2019-03-11 JP JP2019043934A patent/JP6672500B2/ja active Active
- 2019-09-06 AU AU2019226215A patent/AU2019226215B2/en active Active
-
2020
- 2020-02-07 PH PH12020500286A patent/PH12020500286A1/en unknown
- 2020-03-11 IL IL273208A patent/IL273208A/en active IP Right Grant
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