JP2017538682A5 - - Google Patents
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- JP2017538682A5 JP2017538682A5 JP2017525949A JP2017525949A JP2017538682A5 JP 2017538682 A5 JP2017538682 A5 JP 2017538682A5 JP 2017525949 A JP2017525949 A JP 2017525949A JP 2017525949 A JP2017525949 A JP 2017525949A JP 2017538682 A5 JP2017538682 A5 JP 2017538682A5
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- Japan
- Prior art keywords
- hydrogen
- optionally substituted
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- chain
- alkyl
- Prior art date
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- 125000004429 atoms Chemical group 0.000 claims 35
- 239000001257 hydrogen Substances 0.000 claims 35
- 229910052739 hydrogen Inorganic materials 0.000 claims 35
- 150000003839 salts Chemical class 0.000 claims 32
- 239000011780 sodium chloride Substances 0.000 claims 32
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 31
- RWRDLPDLKQPQOW-UHFFFAOYSA-N pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 30
- 125000000217 alkyl group Chemical group 0.000 claims 29
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 18
- 125000005843 halogen group Chemical group 0.000 claims 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 17
- -1 amino, hydroxy Chemical group 0.000 claims 16
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 13
- 229910052799 carbon Inorganic materials 0.000 claims 13
- HONIICLYMWZJFZ-UHFFFAOYSA-N Azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 12
- OGYGFUAIIOPWQD-UHFFFAOYSA-N Thiazolidine Chemical compound C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 claims 11
- YNAVUWVOSKDBBP-UHFFFAOYSA-N morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 11
- 229940113083 morpholine Drugs 0.000 claims 11
- GLUUGHFHXGJENI-UHFFFAOYSA-N piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 11
- NQRYJNQNLNOLGT-UHFFFAOYSA-N piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 11
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 239000001301 oxygen Substances 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 10
- 239000011709 vitamin E Substances 0.000 claims 9
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 7
- 229960002685 biotin Drugs 0.000 claims 7
- 235000020958 biotin Nutrition 0.000 claims 7
- 239000011616 biotin Substances 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- MTAODLNXWYIKSO-UHFFFAOYSA-N 2-fluoropyridine Chemical compound FC1=CC=CC=N1 MTAODLNXWYIKSO-UHFFFAOYSA-N 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000004970 halomethyl group Chemical group 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 230000000875 corresponding Effects 0.000 claims 3
- 150000002431 hydrogen Chemical group 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 208000002154 Non-Small-Cell Lung Carcinoma Diseases 0.000 claims 2
- 108009000071 Non-small cell lung cancer Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 229940046009 Vitamin E Drugs 0.000 claims 2
- 229930003427 Vitamin E Natural products 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 201000009910 diseases by infectious agent Diseases 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 125000003831 tetrazolyl group Chemical group 0.000 claims 2
- 235000019165 vitamin E Nutrition 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 102100007290 CD274 Human genes 0.000 claims 1
- 101710012053 CD274 Proteins 0.000 claims 1
- 102100019451 CD80 Human genes 0.000 claims 1
- 101700080477 CD80 Proteins 0.000 claims 1
- 210000000981 Epithelium Anatomy 0.000 claims 1
- 206010017758 Gastric cancer Diseases 0.000 claims 1
- 208000005252 Hepatitis A Diseases 0.000 claims 1
- 208000002672 Hepatitis B Diseases 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 206010073071 Hepatocellular carcinoma Diseases 0.000 claims 1
- 208000006572 Human Influenza Diseases 0.000 claims 1
- 206010022000 Influenza Diseases 0.000 claims 1
- 206010025650 Malignant melanoma Diseases 0.000 claims 1
- 206010027476 Metastasis Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000006265 Renal Cell Carcinoma Diseases 0.000 claims 1
- 206010040070 Septic shock Diseases 0.000 claims 1
- 241000580858 Simian-Human immunodeficiency virus Species 0.000 claims 1
- 102100006355 TLR7 Human genes 0.000 claims 1
- 101700075266 TLR7 Proteins 0.000 claims 1
- 102100006354 TLR8 Human genes 0.000 claims 1
- 101700071772 TLR8 Proteins 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 239000003899 bactericide agent Substances 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 201000009030 carcinoma Diseases 0.000 claims 1
- 201000011231 colorectal cancer Diseases 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 230000002708 enhancing Effects 0.000 claims 1
- 230000002496 gastric Effects 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 201000008443 lung non-squamous non-small cell carcinoma Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462079944P | 2014-11-14 | 2014-11-14 | |
| US62/079,944 | 2014-11-14 | ||
| US201562111388P | 2015-02-03 | 2015-02-03 | |
| US62/111,388 | 2015-02-03 | ||
| US201562204689P | 2015-08-13 | 2015-08-13 | |
| US62/204,689 | 2015-08-13 | ||
| PCT/US2015/060265 WO2016077518A1 (en) | 2014-11-14 | 2015-11-12 | Macrocyclic peptides useful as immunomodulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017538682A JP2017538682A (ja) | 2017-12-28 |
| JP2017538682A5 true JP2017538682A5 (US07794700-20100914-C00152.png) | 2018-11-15 |
| JP6804442B2 JP6804442B2 (ja) | 2020-12-23 |
Family
ID=54704111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525949A Active JP6804442B2 (ja) | 2014-11-14 | 2015-11-12 | 免疫修飾因子として有用な大環状ペプチド |
Country Status (34)
Families Citing this family (95)
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