JP2017537925A5 - - Google Patents
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- JP2017537925A5 JP2017537925A5 JP2017529746A JP2017529746A JP2017537925A5 JP 2017537925 A5 JP2017537925 A5 JP 2017537925A5 JP 2017529746 A JP2017529746 A JP 2017529746A JP 2017529746 A JP2017529746 A JP 2017529746A JP 2017537925 A5 JP2017537925 A5 JP 2017537925A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 260
- 238000012986 modification Methods 0.000 claims description 225
- 230000004048 modification Effects 0.000 claims description 210
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 133
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 80
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 77
- 229920001184 polypeptide Polymers 0.000 claims description 76
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- 108091007433 antigens Proteins 0.000 claims description 30
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- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 14
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 14
- 230000003834 intracellular effect Effects 0.000 claims description 12
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- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 8
- 208000017604 Hodgkin disease Diseases 0.000 claims description 8
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- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 8
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims description 8
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 claims description 7
- 102000004127 Cytokines Human genes 0.000 claims description 6
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- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 6
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 102100036008 CD48 antigen Human genes 0.000 claims description 2
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- 101000716130 Homo sapiens CD48 antigen Proteins 0.000 claims description 2
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims description 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims description 2
- 101000648507 Homo sapiens Tumor necrosis factor receptor superfamily member 14 Proteins 0.000 claims description 2
- 108090000177 Interleukin-11 Proteins 0.000 claims description 2
- 108010065805 Interleukin-12 Proteins 0.000 claims description 2
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- 108050003558 Interleukin-17 Proteins 0.000 claims description 2
- 108010002350 Interleukin-2 Proteins 0.000 claims description 2
- 108010002386 Interleukin-3 Proteins 0.000 claims description 2
- 108090001005 Interleukin-6 Proteins 0.000 claims description 2
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- 102000017578 LAG3 Human genes 0.000 claims description 2
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- 108010042215 OX40 Ligand Proteins 0.000 claims description 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims description 2
- 102100026890 Tumor necrosis factor ligand superfamily member 4 Human genes 0.000 claims description 2
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 claims description 2
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 108010074108 interleukin-21 Proteins 0.000 claims description 2
- 210000004698 lymphocyte Anatomy 0.000 claims description 2
- 210000003738 lymphoid progenitor cell Anatomy 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
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- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462088309P | 2014-12-05 | 2014-12-05 | |
| US62/088,309 | 2014-12-05 | ||
| PCT/US2015/064112 WO2016090320A1 (en) | 2014-12-05 | 2015-12-04 | Chimeric antigen receptors targeting b-cell maturation antigen and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020075434A Division JP2020114254A (ja) | 2014-12-05 | 2020-04-21 | Ｂ細胞成熟抗原を標的化するキメラ抗原受容体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537925A JP2017537925A (ja) | 2017-12-21 |
| JP2017537925A5 true JP2017537925A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2019-01-17 |
| JP6997620B2 JP6997620B2 (ja) | 2022-02-04 |
Family
ID=56092569
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529746A Active JP6997620B2 (ja) | 2014-12-05 | 2015-12-04 | Ｂ細胞成熟抗原を標的化するキメラ抗原受容体およびその使用 |
| JP2020075434A Withdrawn JP2020114254A (ja) | 2014-12-05 | 2020-04-21 | Ｂ細胞成熟抗原を標的化するキメラ抗原受容体およびその使用 |
| JP2022077378A Pending JP2022105192A (ja) | 2014-12-05 | 2022-05-10 | Ｂ細胞成熟抗原を標的化するキメラ抗原受容体およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020075434A Withdrawn JP2020114254A (ja) | 2014-12-05 | 2020-04-21 | Ｂ細胞成熟抗原を標的化するキメラ抗原受容体およびその使用 |
| JP2022077378A Pending JP2022105192A (ja) | 2014-12-05 | 2022-05-10 | Ｂ細胞成熟抗原を標的化するキメラ抗原受容体およびその使用 |
Country Status (21)
Families Citing this family (150)
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| US9428567B2 (en) | 2010-12-22 | 2016-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Antagonists of interleukin-2 receptor |
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| EP2954330A4 (en) | 2013-02-08 | 2016-08-31 | Inst Myeloma & Bone Cancer Res | IMPROVED DIAGNOSTIC, PROGNOSTIC AND MONITORING METHODS FOR MULTIPLE MYELOMA, CHRONIC LYMPHOCYTIC LEUKEMIA AND NON-HODGKIN LYMPHOMA B-CELL LYMPHOMA |
| WO2015164815A1 (en) | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
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| WO2016090148A1 (en) | 2014-12-03 | 2016-06-09 | IsoPlexis Corporation | Analysis and screening of cell secretion profiles |
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| WO2016166630A1 (en) | 2015-04-13 | 2016-10-20 | Pfizer Inc. | Chimeric antigen receptors targeting b-cell maturation antigen |
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