|
DE2947526A1
(de)
|
1978-11-29 |
1980-06-12 |
Ono Pharmaceutical Co |
Prostacyclin-analoge
|
|
US4668814A
(en)
|
1984-03-08 |
1987-05-26 |
The Upjohn Company |
Interphenylene carbacyclin derivatives
|
|
JPS61289034A
(ja)
|
1985-06-17 |
1986-12-19 |
Teijin Ltd |
イソカルバサイクリン類脂肪乳剤
|
|
US4837342A
(en)
|
1986-02-28 |
1989-06-06 |
Sagami Chemical Research Center |
Prostacyclin analogue, and blood circulation improving agent and anti-ulcer composition containing it as active ingredient
|
|
GB8814438D0
(en)
|
1988-06-17 |
1988-07-20 |
Wellcome Found |
Compounds for use in medicine
|
|
GB9011588D0
(en)
|
1990-05-24 |
1990-07-11 |
Wellcome Found |
Prostaglandin analogues for use in medicine
|
|
US6165500A
(en)
|
1990-08-24 |
2000-12-26 |
Idea Ag |
Preparation for the application of agents in mini-droplets
|
|
CA2056039A1
(en)
|
1991-01-22 |
1992-07-23 |
Philip L. Fuchs |
Carbacyclin analogs
|
|
US5190972A
(en)
|
1992-01-27 |
1993-03-02 |
The University Of Melbourne |
Method of combatting cyclosporine organ toxicity with prostaglandin analogs
|
|
CA2091152C
(en)
|
1993-03-05 |
2005-05-03 |
Kirsten Westesen |
Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof
|
|
US5576016A
(en)
|
1993-05-18 |
1996-11-19 |
Pharmos Corporation |
Solid fat nanoemulsions as drug delivery vehicles
|
|
US6638621B2
(en)
|
2000-08-16 |
2003-10-28 |
Lyotropic Therapeutics, Inc. |
Coated particles, methods of making and using
|
|
US6441245B1
(en)
|
1997-10-24 |
2002-08-27 |
United Therapeutics Corporation |
Process for stereoselective synthesis of prostacyclin derivatives
|
|
ES2214753T3
(es)
|
1997-11-14 |
2004-09-16 |
United Therapeutics Corporation |
Uso de 9-desoxi-2',9-alfa-metano-3-oxa-4,5,6-trinor-3,7-(1',3'-interfenilen)-13,14-dihidro-prostaglandina f1 para tratar la enfermedad vascular periferica.
|
|
NZ505163A
(en)
|
1997-12-26 |
2002-11-26 |
Yamanouchi Pharma Co Ltd |
Sustained release medicinal compositions comprising an ionic compound with an opposite charge to the ionic active substance
|
|
JP2002521423A
(ja)
|
1998-07-31 |
2002-07-16 |
コリア インスティチュート オブ サイエンス アンド テクノロージ |
遺伝子又は薬物運搬体としての脂質エマルジョン及び固形脂質微粒子
|
|
US6265495B1
(en)
*
|
1998-09-22 |
2001-07-24 |
Nippon Shokubai Co., Ltd. |
Method for production of esterified product
|
|
US6521212B1
(en)
|
1999-03-18 |
2003-02-18 |
United Therapeutics Corporation |
Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation
|
|
KR20020012169A
(ko)
|
1999-03-31 |
2002-02-15 |
유나이티드 쎄러퓨틱스 코포레이션 |
프로스타글란딘 화합물, 조성물 및 말초혈관질병 및폐고혈압증의 치료방법
|
|
US6242482B1
(en)
|
2000-06-05 |
2001-06-05 |
United Therapeutics Corporation |
Prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of congestive heart failure
|
|
US6306435B1
(en)
|
2000-06-26 |
2001-10-23 |
Yung Shin Pharmaceutical Industrial Co. Ltd. |
Oral pharmaceutical preparation embedded in an oily matrix and methods of making the same
|
|
US6991809B2
(en)
|
2001-06-23 |
2006-01-31 |
Lyotropic Therapeutics, Inc. |
Particles with improved solubilization capacity
|
|
US20030108512A1
(en)
|
2001-12-10 |
2003-06-12 |
Robert Shorr |
Modified prostaglandin compounds and analogs thereof, compositions containing the same useful for the treatment of cancer
|
|
US6803386B2
(en)
|
2002-01-16 |
2004-10-12 |
United Therapeutics Corporation |
Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer
|
|
WO2004012680A2
(en)
|
2002-08-06 |
2004-02-12 |
Lyotropic Therapeutics, Inc. |
Lipid-drug complexes in reversed liquid and liquid crystalline phases
|
|
CN1791386A
(zh)
|
2003-05-19 |
2006-06-21 |
巴克斯特国际公司 |
抗癫痫和抗痴呆药物以及免疫抑制剂的小－颗粒药物制剂
|
|
DE60308828T2
(de)
|
2003-05-20 |
2007-05-24 |
Ethypharm |
Orale pharmazeutische Zusammensetzung mit verzögerter Freisetzung
|
|
ES2622471T5
(es)
|
2003-05-22 |
2020-07-23 |
United Therapeutics Corp |
Compuestos y procedimientos para la administración de análogos de prostaciclina
|
|
CN1917866B
(zh)
|
2003-12-16 |
2010-12-15 |
联合治疗公司 |
曲前列环素或它的衍生物，或其药学上可接受的盐在制备治疗和预防缺血性损害的药物中的用途
|
|
WO2005058329A1
(en)
|
2003-12-16 |
2005-06-30 |
United Therapeutics Corporation |
Use of treprostinil to improve kidney functions
|
|
CN101287457B
(zh)
|
2004-04-12 |
2011-11-16 |
联合治疗公司 |
Treprostinil用于治疗神经性糖尿病的足部溃疡的用途
|
|
GB0416328D0
(en)
|
2004-07-21 |
2004-08-25 |
Univ Cardiff |
Use of dry powder compositions for pulmonary delivery
|
|
CA2574958A1
(en)
|
2004-07-26 |
2006-02-09 |
Cotherix, Inc. |
Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
|
|
JP4893999B2
(ja)
|
2004-10-22 |
2012-03-07 |
小野薬品工業株式会社 |
吸入用医薬組成物
|
|
US20070178166A1
(en)
|
2005-12-15 |
2007-08-02 |
Acusphere, Inc. |
Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration
|
|
ES2707548T3
(es)
|
2006-05-15 |
2019-04-04 |
United Therapeutics Corp |
Administración de treprostinil utilizando un inhalador de dosis medida
|
|
WO2008049000A2
(en)
|
2006-10-18 |
2008-04-24 |
United Therapeutics Corporation |
Combination therapy for pulmonary arterial hypertension
|
|
US20080280986A1
(en)
|
2007-02-09 |
2008-11-13 |
United Therapeutics Corporation |
Treprostinil treatment for interstitial lung disease and asthma
|
|
JP2010523595A
(ja)
|
2007-04-04 |
2010-07-15 |
マサチューセッツ インスティテュート オブ テクノロジー |
ポリ（アミノ酸）ターゲッティング部分
|
|
CN101827612A
(zh)
|
2007-09-07 |
2010-09-08 |
联合治疗公司 |
针对革兰氏阴性细菌具有选择性杀菌活性的缓冲液及其使用方法
|
|
CN103274926B
(zh)
|
2007-12-17 |
2016-08-10 |
联合治疗公司 |
一种制备Remodulin中的活性成分曲前列素的改良方法
|
|
CA2723540C
(en)
|
2008-05-08 |
2016-01-05 |
United Therapeutics Corporation |
Treprostinil monohydrate
|
|
WO2009152160A1
(en)
|
2008-06-10 |
2009-12-17 |
Gilead Sciences, Inc. |
Inhaled carbaprostacyclin and prostacyclin prodrugs for the treatment of pulmonary arterial hypertension
|
|
WO2009158010A1
(en)
|
2008-06-27 |
2009-12-30 |
Concert Pharmaceuticals, Inc. |
Prostacyclin analogs
|
|
WO2010039531A1
(en)
|
2008-09-23 |
2010-04-08 |
Resolvyx Pharmaceuticals, Inc. |
Therapeutic compounds
|
|
WO2010036798A1
(en)
|
2008-09-25 |
2010-04-01 |
Aradigm Corporation |
Deep lung pulmonary delivery of treprostinil
|
|
JP2012516187A
(ja)
|
2009-02-20 |
2012-07-19 |
マイクロ ラブズ リミテッド |
貯蔵安定性プロスタグランジン製品
|
|
KR101544246B1
(ko)
|
2009-05-07 |
2015-08-12 |
유나이티드 세러퓨틱스 코오포레이션 |
프로스타시클린 유사체의 고체 제제
|
|
WO2011005505A2
(en)
|
2009-06-22 |
2011-01-13 |
Johnson Matthey Public Limited Company |
Method for the purification of prostaglandins
|
|
WO2011003058A1
(en)
|
2009-07-03 |
2011-01-06 |
Concert Pharmaceuticals, Inc. |
Prostacyclin derivatives
|
|
US20120184622A1
(en)
|
2009-08-07 |
2012-07-19 |
Scipharm Sarl |
Composition for the treatment of cystic fibrosis
|
|
KR20120129864A
(ko)
|
2009-08-21 |
2012-11-28 |
타겟티드 딜리버리 테크놀러지스 리미티드 |
소포성 제형
|
|
CN101669904B
(zh)
|
2009-09-29 |
2011-06-22 |
北京中海康医药科技发展有限公司 |
一种依前列醇脂质纳米粒及制备方法
|
|
US20130030359A1
(en)
|
2010-01-22 |
2013-01-31 |
Ascendis Pharma A/S |
Dipeptide-based prodrug linkers for aromatic amine-containing drugs
|
|
WO2011089216A1
(en)
|
2010-01-22 |
2011-07-28 |
Ascendis Pharma As |
Dipeptide-based prodrug linkers for aliphatic amine-containing drugs
|
|
KR101508047B1
(ko)
|
2010-03-15 |
2015-04-06 |
유나이티드 세러퓨틱스 코오포레이션 |
폐고혈압의 치료
|
|
ES2658139T3
(es)
|
2010-06-03 |
2018-03-08 |
United Therapeutics Corporation |
Producción de treprostinil
|
|
EP2582235A4
(en)
|
2010-06-15 |
2014-04-30 |
United Therapeutics Corp |
ORAL TREATMENT OF DIGITAL ISCHEMIC LESIONS
|
|
US20120010159A1
(en)
|
2010-07-09 |
2012-01-12 |
United Therapeutics Corporation |
Combination therapies with cox-2 inhibitors and treprostinil
|
|
CA2710726C
(en)
|
2010-07-22 |
2016-02-23 |
Alphora Research Inc. |
Synthesis of treprostinil and intermediates useful therein
|
|
WO2012107364A1
(en)
|
2011-02-07 |
2012-08-16 |
Scipharm Sàrl |
Novel composition for the treatment of cystic fibrosis
|
|
JP5780775B2
(ja)
|
2011-02-18 |
2015-09-16 |
株式会社Ｌｔｔバイオファーマ |
プロスタグランジンｉ２誘導体を含有するナノ粒子
|
|
CN103476762B
(zh)
|
2011-03-02 |
2015-04-22 |
联合治疗公司 |
用于生产曲前列环素的中间体的合成
|
|
EP2687204B1
(en)
|
2011-03-14 |
2020-10-14 |
National University Corporation Hokkaido University |
Vector for pulmonary delivery, inducing agent, and uses
|
|
EP2741779A1
(en)
|
2011-08-12 |
2014-06-18 |
Ascendis Pharma A/S |
High-loading water-soluble carrier-linked prodrugs
|
|
AU2012296951B2
(en)
|
2011-08-12 |
2016-09-15 |
Ascendis Pharma A/S |
Protein carrier-linked prodrugs
|
|
US20140243254A1
(en)
|
2011-08-12 |
2014-08-28 |
Ascendis Pharma A/S |
Polymeric Hyperbranched Carrier-Linked Prodrugs
|
|
IN2014CN00989A
(show.php)
|
2011-08-12 |
2015-04-10 |
Ascendis Pharma As |
|
|
US9872864B2
(en)
|
2011-08-12 |
2018-01-23 |
Ascendis Pharma A/S |
Sustained release composition of prostacyclin
|
|
CA2843506C
(en)
|
2011-08-12 |
2020-05-12 |
Ascendis Pharma A/S |
Carrier-linked prodrugs having reversible carboxylic ester linkages
|
|
US8524939B2
(en)
|
2011-08-24 |
2013-09-03 |
Chirogate International Inc. |
Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
|
|
US9387214B2
(en)
|
2012-01-13 |
2016-07-12 |
United Therapeutics Corporation |
Method of identifying therapies for pulmonary hypertension
|
|
LT2674413T
(lt)
|
2012-06-15 |
2017-09-25 |
Scipharm Sąrl |
Treprostinilo ir jo darinių gavimo būdas
|
|
IN2015DN00934A
(show.php)
|
2012-08-01 |
2015-06-12 |
United Therapeutics Corp |
|
|
IN2015DN00976A
(show.php)
|
2012-08-01 |
2015-06-12 |
United Therapeutics Corp |
|
|
EP2925303A4
(en)
|
2012-11-30 |
2016-04-27 |
Insmed Inc |
PROSTACYLINE COMPOSITIONS AND METHOD FOR USE THEREOF
|
|
EP3878452B1
(en)
|
2013-01-09 |
2023-09-20 |
United Therapeutics Corporation |
Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
|
|
WO2014110491A1
(en)
*
|
2013-01-11 |
2014-07-17 |
Theratrophix Llc |
Prodrugs of treprostinil
|
|
US9505737B2
(en)
|
2013-01-11 |
2016-11-29 |
Corsair Pharma, Inc. |
Treprostinil derivative compounds and methods of using same
|
|
CA3125504C
(en)
|
2013-03-14 |
2023-10-24 |
United Therapeutics Corporation |
Solid forms of treprostinil
|
|
CN105189434A
(zh)
|
2013-03-15 |
2015-12-23 |
联合治疗公司 |
曲前列环素的盐
|
|
CA2908244C
(en)
|
2013-03-25 |
2021-04-20 |
United Therapeutics Corporation |
Process of making prostacyclin compounds with linker thiol and pegylated forms
|
|
EP2991639A4
(en)
|
2013-04-30 |
2016-11-30 |
United Therapeutics Corp |
PHARMACEUTICAL FORMULATIONS WITH CONTROLLED RELEASE
|
|
WO2014203278A2
(en)
|
2013-06-19 |
2014-12-24 |
Msn Laboratories Private Limited |
NOVEL PROCESS FOR THE PREPARATION OF (1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-HEXAHYDRO-2-HYDROXY-1-[(3S)-3-HYDROXYOCTYL]-1H-BENZ[f]INDEN-5-YL]OXY]ACETIC ACID
|
|
CA2926793C
(en)
|
2013-10-11 |
2022-11-22 |
Lawrence S. ZISMAN |
Spray-dry formulations for treating pulmonary arterial hypertension
|
|
EP3808731A1
(en)
|
2013-10-25 |
2021-04-21 |
Insmed Incorporated |
Prostacyclin compounds
|
|
WO2015138423A1
(en)
|
2014-03-11 |
2015-09-17 |
Insmed Incorporated |
Prostacylin compositions and methods for using the same
|
|
CN106573066A
(zh)
|
2014-06-13 |
2017-04-19 |
联合治疗学有限公司 |
曲前列环素制剂
|
|
CA2964804C
(en)
|
2014-10-20 |
2019-04-02 |
United Therapeutics Corporation |
Synthesis of intermediate for producing prostacyclin derivatives
|
|
US10343979B2
(en)
|
2014-11-18 |
2019-07-09 |
Insmed Incorporated |
Methods of manufacturing treprostinil and treprostinil derivative prodrugs
|
|
WO2016176555A1
(en)
|
2015-04-29 |
2016-11-03 |
Insmed Incorporated |
Prostacyclin compounds, compositions and methods of use thereof
|
|
EP3452170A4
(en)
|
2016-05-05 |
2020-04-01 |
Liquidia Technologies, Inc. |
TREPROSTINIL IN POWDER FORM FOR TREATING PULMONAL HYPERTENSION
|
|
WO2017223400A1
(en)
|
2016-06-24 |
2017-12-28 |
Insmed Incorporated |
Prostacyclin compounds and compositions for treating sarcoidosis
|
|
US20180153847A1
(en)
|
2016-09-26 |
2018-06-07 |
United Therapeutics Corporation |
Treprostinil prodrugs
|
|
EP3673895A1
(en)
|
2018-12-28 |
2020-07-01 |
Université Libre de Bruxelles |
Dry powder inhalation formulation and its use for the therapeutic treatment of lungs
|
|
AU2020265576B2
(en)
|
2019-04-29 |
2025-09-18 |
Insmed Incorporated |
Dry powder compositions of treprostinil prodrugs and methods of use thereof
|