JP2017535552A - アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法 - Google Patents

アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法 Download PDF

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JP2017535552A
JP2017535552A JP2017526493A JP2017526493A JP2017535552A JP 2017535552 A JP2017535552 A JP 2017535552A JP 2017526493 A JP2017526493 A JP 2017526493A JP 2017526493 A JP2017526493 A JP 2017526493A JP 2017535552 A JP2017535552 A JP 2017535552A
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double
rnai agent
nucleotides
stranded rnai
nucleotide
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JP2017535552A5 (enExample
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ケビン・フィッツジェラルド
ウィリアム・クアーベス
ジェイムズ・バトラー
ステファニー・ウィリアムズ
アビゲイル・リーボウ
グレゴリー・ヒンクル
マルティン・マイアー
スチュアート・ミルスタイン
サティアナラヤーナ・クチマンチ
ムティア・マノハラン
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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JP2017526493A 2014-11-17 2015-11-17 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法 Pending JP2017535552A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462080941P 2014-11-17 2014-11-17
US62/080,941 2014-11-17
US201562136159P 2015-03-20 2015-03-20
US62/136,159 2015-03-20
PCT/US2015/061065 WO2016081444A1 (en) 2014-11-17 2015-11-17 Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof

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JP2020083294A Division JP2020141685A (ja) 2014-11-17 2020-05-11 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法

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JP2017535552A5 JP2017535552A5 (enExample) 2018-12-27

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JP2017526493A Pending JP2017535552A (ja) 2014-11-17 2015-11-17 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法
JP2020083294A Pending JP2020141685A (ja) 2014-11-17 2020-05-11 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法
JP2023077186A Active JP7516613B2 (ja) 2014-11-17 2023-05-09 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法
JP2024107357A Active JP7778857B2 (ja) 2014-11-17 2024-07-03 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法
JP2025197843A Pending JP2026048670A (ja) 2014-11-17 2025-11-19 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法

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JP2023077186A Active JP7516613B2 (ja) 2014-11-17 2023-05-09 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法
JP2024107357A Active JP7778857B2 (ja) 2014-11-17 2024-07-03 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法
JP2025197843A Pending JP2026048670A (ja) 2014-11-17 2025-11-19 アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法

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EP (1) EP3221451A1 (enExample)
JP (5) JP2017535552A (enExample)
CN (2) CN107250362B (enExample)
AU (3) AU2015350120B2 (enExample)
CA (1) CA2968114A1 (enExample)
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Cited By (7)

* Cited by examiner, † Cited by third party
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JP2021503929A (ja) * 2017-12-01 2021-02-15 スーチョウ リボ ライフ サイエンス カンパニー、リミテッドＳｕｚｈｏｕ Ｒｉｂｏ Ｌｉｆｅ Ｓｃｉｅｎｃｅ Ｃｏ．， Ｌｔｄ． 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用
JP2021509402A (ja) * 2017-12-29 2021-03-25 スーチョウ リボ ライフ サイエンス カンパニー、リミテッドＳｕｚｈｏｕ Ｒｉｂｏ Ｌｉｆｅ Ｓｃｉｅｎｃｅ Ｃｏ．， Ｌｔｄ． 複合体及びその調製方法と使用
JP2022501059A (ja) * 2018-09-30 2022-01-06 スーチョウ リボ ライフ サイエンス カンパニー、リミテッドSuzhou Ribo Life Science Co., Ltd. ｓｉＲＮＡ複合体及びその調製方法と使用
JP2022506503A (ja) * 2018-11-09 2022-01-17 アルニラム ファーマスーティカルズ インコーポレイテッド 修飾二重鎖オリゴヌクレオチド
JP2022515503A (ja) * 2018-12-28 2022-02-18 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用
JP2022543136A (ja) * 2019-08-05 2022-10-07 アローヘッド ファーマシューティカルズ インコーポレイテッド Ａｐｏｃ３関連疾患および障害の処置のための方法
JP2025520796A (ja) * 2022-06-27 2025-07-03 大睿生物 アポリポタンパク質Ｃ３発現を阻害するｓｉＲＮＡ

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MX342945B (es) 2009-07-06 2016-10-18 Ontorii Inc * Profármacos de ácido nucleico novedosos y métodos de uso de los mismos.
US9605019B2 (en) 2011-07-19 2017-03-28 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
HK1200191A1 (en) * 2011-11-18 2015-07-31 Alnylam Pharmaceuticals, Inc. Modified rnai agents
KR102592370B1 (ko) 2014-02-11 2023-10-25 알닐람 파마슈티칼스 인코포레이티드 케토헥소키나제(ＫＨＫ) ｉＲＮＡ 조성물 및 그의 사용 방법
CN107250362B (zh) 2014-11-17 2021-10-22 阿尔尼拉姆医药品有限公司 载脂蛋白C3(APOC3)iRNA组合物及其使用方法
EP3488241B1 (en) * 2016-07-21 2025-02-26 Cleveland Heartlab, Inc. Hdl-associated protein biomarker panel detection
WO2018104499A1 (en) * 2016-12-08 2018-06-14 Juntti Berggren Lisa Methods for treating and limiting development of obesity and fatty liver disorders
US11597927B2 (en) 2017-06-02 2023-03-07 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
WO2018223056A1 (en) * 2017-06-02 2018-12-06 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
CN120330183A (zh) * 2017-06-02 2025-07-18 波涛生命科学有限公司 寡核苷酸组合物及其使用方法
JOP20200054A1 (ar) * 2017-09-11 2020-03-10 Arrowhead Pharmaceuticals Inc عوامل RNAi وتركيبات لتثبيط تعبير صَميمُ البروتينِ الشَّحْمِيّ C-III (APOC3)
WO2019105404A1 (zh) * 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
WO2019105403A1 (zh) * 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
JP7273417B2 (ja) 2017-12-01 2023-05-15 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用
WO2019105418A1 (zh) * 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途
KR20250107294A (ko) * 2017-12-01 2025-07-11 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 핵산, 이를 포함하는 조성물과 컨쥬게이트, 및 그의 제조 방법과 용도
US11414661B2 (en) 2017-12-01 2022-08-16 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof
BR112020012088A2 (pt) * 2017-12-18 2020-11-17 Alnylam Pharmaceuticals, Inc. composições de irna do grupo de elevada mobilidade box-1 (hmgb1) e métodos de uso dos mesmos
BR112020020670A2 (pt) 2018-04-12 2021-03-02 Wave Life Sciences Ltd. composição de oligonucleotídeo, composição farmacêutica, método para alterar o splicing de uma transcrição alvo, método para tratar distrofia muscular, método para preparar um oligonucleotídeo ou uma composição de oligonucleotídeo do mesmo e oligonucleotídeo
TWI844541B (zh) 2018-05-11 2024-06-11 新加坡商波濤生命科學有限公司 寡核苷酸組成物及其使用方法
TWI851574B (zh) * 2018-05-14 2024-08-11 美商阿尼拉製藥公司 血管收縮素原（ＡＧＴ）ｉＲＮＡ組成物及其使用方法
MX2021001056A (es) * 2018-08-13 2021-04-12 Alnylam Pharmaceuticals Inc Composiciones de agente de acido ribonucleico bicatenario (arnbc) de virus de la hepatitis b (vhb) y metodos de uso de las mismas.
EP3842534A4 (en) * 2018-08-21 2022-07-06 Suzhou Ribo Life Science Co., Ltd. NUCLEIC ACID, PHARMACEUTICAL COMPOSITION AND CONJUGATE WITH NUCLEIC ACID AND THEIR USE
US20210332367A1 (en) * 2018-09-18 2021-10-28 Alnylam Pharmaceuticals, Inc. KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
CA3109553A1 (en) * 2018-09-19 2020-03-26 Arrowhead Pharmaceuticals, Inc. Rnai agents for inhibiting expression of 17beta-hsd type 13 (hsd17b13), compositions thereof, and methods of use
DK4285929T3 (da) 2018-12-20 2025-12-22 Humabs Biomed Sa Kombinationsterapi mod hbv
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