AU2015350120B2 - Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof - Google Patents

Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof Download PDF

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AU2015350120B2
AU2015350120B2 AU2015350120A AU2015350120A AU2015350120B2 AU 2015350120 B2 AU2015350120 B2 AU 2015350120B2 AU 2015350120 A AU2015350120 A AU 2015350120A AU 2015350120 A AU2015350120 A AU 2015350120A AU 2015350120 B2 AU2015350120 B2 AU 2015350120B2
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nucleotides
rnai agent
nucleotide
double stranded
apoc3
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AU2015350120A1 (en
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James Butler
Kevin Fitzgerald
Gregory Hinkle
Satyanarayana Kuchimanchi
Abigail LIEBOW
Martin Maier
Muthiah Manoharan
Stuart Milstein
William Querbes
Stephanie Williams
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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Priority to AU2024200870A priority patent/AU2024200870A1/en
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

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AU2015350120A 2014-11-17 2015-11-17 Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof Active AU2015350120B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021212094A AU2021212094A1 (en) 2014-11-17 2021-08-06 Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof
AU2024200870A AU2024200870A1 (en) 2014-11-17 2024-02-12 Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462080941P 2014-11-17 2014-11-17
US62/080,941 2014-11-17
US201562136159P 2015-03-20 2015-03-20
US62/136,159 2015-03-20
PCT/US2015/061065 WO2016081444A1 (en) 2014-11-17 2015-11-17 Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof

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AU2021212094A Division AU2021212094A1 (en) 2014-11-17 2021-08-06 Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof

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AU2015350120B2 true AU2015350120B2 (en) 2021-05-27

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AU2021212094A Abandoned AU2021212094A1 (en) 2014-11-17 2021-08-06 Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof
AU2024200870A Pending AU2024200870A1 (en) 2014-11-17 2024-02-12 Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof

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AU2024200870A Pending AU2024200870A1 (en) 2014-11-17 2024-02-12 Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof

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US (7) US10407679B2 (enExample)
EP (1) EP3221451A1 (enExample)
JP (4) JP2017535552A (enExample)
CN (2) CN107250362B (enExample)
AU (3) AU2015350120B2 (enExample)
CA (1) CA2968114A1 (enExample)
HK (1) HK1244843A1 (enExample)
WO (1) WO2016081444A1 (enExample)

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