JP2017534282A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017534282A5 JP2017534282A5 JP2017523394A JP2017523394A JP2017534282A5 JP 2017534282 A5 JP2017534282 A5 JP 2017534282A5 JP 2017523394 A JP2017523394 A JP 2017523394A JP 2017523394 A JP2017523394 A JP 2017523394A JP 2017534282 A5 JP2017534282 A5 JP 2017534282A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion polypeptide
- ifnα2b
- seq
- amino acid
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 29
- 108090000765 processed proteins & peptides Proteins 0.000 claims 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims 29
- 230000004927 fusion Effects 0.000 claims 25
- 102220473689 Ras-related protein Rab-5A_Y89A_mutation Human genes 0.000 claims 12
- 102220535515 tRNA wybutosine-synthesizing protein 5_Y85A_mutation Human genes 0.000 claims 12
- 102220548502 Macrophage-capping protein_Q61S_mutation Human genes 0.000 claims 10
- 102220522737 Mitogen-activated protein kinase kinase kinase 6_H57Y_mutation Human genes 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 102220496408 Bone marrow stromal antigen 2_N65A_mutation Human genes 0.000 claims 8
- 102220496875 DNA dC->dU-editing enzyme APOBEC-3C_L80A_mutation Human genes 0.000 claims 8
- 102220509128 Sphingosine 1-phosphate receptor 1_R120A_mutation Human genes 0.000 claims 8
- -1 HLA-SR Proteins 0.000 claims 7
- 238000006467 substitution reaction Methods 0.000 claims 5
- 102220554170 APC membrane recruitment protein 1_L30A_mutation Human genes 0.000 claims 4
- 102220498199 Negative regulator of P-body association_R33A_mutation Human genes 0.000 claims 4
- 102220552408 Platelet-activating factor acetylhydrolase_L116A_mutation Human genes 0.000 claims 4
- 230000002238 attenuated effect Effects 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- 102220482092 Nuclear cap-binding protein subunit 2_D114A_mutation Human genes 0.000 claims 3
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 claims 3
- 102220497198 WD repeat domain phosphoinositide-interacting protein 4_D113A_mutation Human genes 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 2
- 102220554192 APC membrane recruitment protein 1_H34A_mutation Human genes 0.000 claims 2
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims 2
- 108010045374 CD36 Antigens Proteins 0.000 claims 2
- 108010065524 CD52 Antigen Proteins 0.000 claims 2
- 102220516986 Double homeobox protein 4_R23A_mutation Human genes 0.000 claims 2
- 102100021056 Ferroptosis suppressor protein 1 Human genes 0.000 claims 2
- 101710204931 Ferroptosis suppressor protein 1 Proteins 0.000 claims 2
- 102220474004 Gamma-secretase subunit PEN-2_L26A_mutation Human genes 0.000 claims 2
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 2
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 claims 2
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims 2
- 102220608646 Methyl-CpG-binding domain protein 1_R22K_mutation Human genes 0.000 claims 2
- 102220564303 Natural killer cells antigen CD94_Q40A_mutation Human genes 0.000 claims 2
- 102220564245 Natural killer cells antigen CD94_S25A_mutation Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102220552456 Platelet-activating factor acetylhydrolase_K31A_mutation Human genes 0.000 claims 2
- 102220599460 Protein NPAT_F27A_mutation Human genes 0.000 claims 2
- 102220599466 Protein NPAT_L15A_mutation Human genes 0.000 claims 2
- 102200002501 c.98G>A Human genes 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 102200044937 rs121913396 Human genes 0.000 claims 2
- 102220316641 rs146101365 Human genes 0.000 claims 2
- 102220157938 rs886063483 Human genes 0.000 claims 2
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 1
- 101001005269 Arabidopsis thaliana Ceramide synthase 1 LOH3 Proteins 0.000 claims 1
- 101001005312 Arabidopsis thaliana Ceramide synthase LOH1 Proteins 0.000 claims 1
- 102100026292 Asialoglycoprotein receptor 1 Human genes 0.000 claims 1
- 102100026293 Asialoglycoprotein receptor 2 Human genes 0.000 claims 1
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 1
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 102100037086 Bone marrow stromal antigen 2 Human genes 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- 102000049320 CD36 Human genes 0.000 claims 1
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- 102100025221 CD70 antigen Human genes 0.000 claims 1
- 102100035793 CD83 antigen Human genes 0.000 claims 1
- 102100028801 Calsyntenin-1 Human genes 0.000 claims 1
- 102100025137 Early activation antigen CD69 Human genes 0.000 claims 1
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 1
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 1
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims 1
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims 1
- 101710088083 Glomulin Proteins 0.000 claims 1
- 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000785944 Homo sapiens Asialoglycoprotein receptor 1 Proteins 0.000 claims 1
- 101000785948 Homo sapiens Asialoglycoprotein receptor 2 Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101000740785 Homo sapiens Bone marrow stromal antigen 2 Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 1
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims 1
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims 1
- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 1
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 1
- 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 claims 1
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims 1
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims 1
- 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 1
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 1
- 102100022297 Integrin alpha-X Human genes 0.000 claims 1
- 108010041012 Integrin alpha4 Proteins 0.000 claims 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 1
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 1
- 102100040018 Interferon alpha-2 Human genes 0.000 claims 1
- 108010079944 Interferon-alpha2b Proteins 0.000 claims 1
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 claims 1
- 102000002698 KIR Receptors Human genes 0.000 claims 1
- 108010043610 KIR Receptors Proteins 0.000 claims 1
- 102000010631 Kininogens Human genes 0.000 claims 1
- 108010077861 Kininogens Proteins 0.000 claims 1
- 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 claims 1
- 108010091175 Matriptase Proteins 0.000 claims 1
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 1
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 102100031574 Platelet glycoprotein 4 Human genes 0.000 claims 1
- 108010051742 Platelet-Derived Growth Factor beta Receptor Proteins 0.000 claims 1
- 102000018967 Platelet-Derived Growth Factor beta Receptor Human genes 0.000 claims 1
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims 1
- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 claims 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 claims 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 claims 1
- 102000014128 RANK Ligand Human genes 0.000 claims 1
- 108010025832 RANK Ligand Proteins 0.000 claims 1
- 101000600776 Rattus norvegicus Podoplanin Proteins 0.000 claims 1
- 102100038081 Signal transducer CD24 Human genes 0.000 claims 1
- 101000668858 Spinacia oleracea 30S ribosomal protein S1, chloroplastic Proteins 0.000 claims 1
- 101000898746 Streptomyces clavuligerus Clavaminate synthase 1 Proteins 0.000 claims 1
- 102100037942 Suppressor of tumorigenicity 14 protein Human genes 0.000 claims 1
- 102100035721 Syndecan-1 Human genes 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 1
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims 1
- 108010033576 Transferrin Receptors Proteins 0.000 claims 1
- 108091008605 VEGF receptors Proteins 0.000 claims 1
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims 1
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 108040006858 interleukin-6 receptor activity proteins Proteins 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000004248 saffron Substances 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020046259A JP6957666B2 (ja) | 2014-10-29 | 2020-03-17 | インターフェロンα２Ｂバリアント |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2014904326 | 2014-10-29 | ||
| AU2014904326A AU2014904326A0 (en) | 2014-10-29 | Interferon alpha 2b variants | |
| PCT/AU2015/050654 WO2016065409A1 (en) | 2014-10-29 | 2015-10-23 | INTERFERON α2B VARIANTS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020046259A Division JP6957666B2 (ja) | 2014-10-29 | 2020-03-17 | インターフェロンα２Ｂバリアント |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017534282A JP2017534282A (ja) | 2017-11-24 |
| JP2017534282A5 true JP2017534282A5 (cg-RX-API-DMAC7.html) | 2018-11-15 |
| JP6730271B2 JP6730271B2 (ja) | 2020-07-29 |
Family
ID=55851917
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017523394A Active JP6730271B2 (ja) | 2014-10-29 | 2015-10-23 | インターフェロンα２Ｂバリアント |
| JP2020046259A Active JP6957666B2 (ja) | 2014-10-29 | 2020-03-17 | インターフェロンα２Ｂバリアント |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020046259A Active JP6957666B2 (ja) | 2014-10-29 | 2020-03-17 | インターフェロンα２Ｂバリアント |
Country Status (18)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES3033729T3 (en) | 2011-10-28 | 2025-08-07 | Teva Pharmaceuticals Australia Pty Ltd | Polypeptide constructs and uses thereof |
| PT3677591T (pt) | 2013-04-29 | 2023-02-17 | Teva Pharmaceuticals Australia Pty Ltd | Anticorpos anti-cd38 e fusões a interferão alfa-2b atenuado |
| US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
| MX375441B (es) * | 2013-07-18 | 2025-03-06 | Vib Vzw | Fusocinas que implican citocinas con una afinidad de union al receptor considerablemente menor. |
| UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
| PE20170908A1 (es) * | 2014-10-29 | 2017-07-12 | Teva Pharmaceuticals Australia Pty Ltd | VARIANTES DE INTERFERON a2b |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| EP3402509A4 (en) * | 2016-01-14 | 2019-07-10 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | TUMOR SPECIFIC IFNA SECRETION BY CAR T CELLS FOR RESTORING SOLID TUMOR MICRO ENVIRONMENT |
| CA3013554A1 (en) * | 2016-02-05 | 2017-08-10 | Orionis Biosciences Nv | Targeted therapeutic agents and uses thereof |
| JP7241677B2 (ja) | 2016-07-19 | 2023-03-17 | テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド | 抗ｃｄ４７併用療法 |
| WO2018014068A1 (en) * | 2016-07-19 | 2018-01-25 | Teva Pharmaceuticals Australia Pty Ltd | Attenuated type i ifn cd47 combination therapy |
| US10906985B2 (en) | 2017-02-06 | 2021-02-02 | Orionis Biosciences, Inc. | Targeted engineered interferon and uses thereof |
| WO2019148089A1 (en) * | 2018-01-26 | 2019-08-01 | Orionis Biosciences Inc. | Xcr1 binding agents and uses thereof |
| CA3095310A1 (en) * | 2018-03-28 | 2019-10-03 | Orionis Biosciences, Inc. | Bi-functional proteins and construction thereof |
| US12162947B2 (en) | 2018-09-04 | 2024-12-10 | Nanjing Umab-Biopharma Co., Ltd. | Fusion protein and its applicaton in preparing medicine for treating tumor and/or viral infection |
| AU2019336426A1 (en) * | 2018-09-04 | 2021-04-29 | Nanjing Umab-Biopharma Co., Ltd. | Fusion protein and its application in preparing medicine for treating tumor and/or viral infection |
| IL293450A (en) | 2019-12-03 | 2022-07-01 | Evotec Int Gmbh | Interferon-associated antigen binding proteins and uses thereof |
| AR117715A1 (es) | 2019-12-17 | 2021-08-25 | Univ Nacional Del Litoral Unl | Interferón hiperglicosilado con inmunogenicidad reducida |
| US11767353B2 (en) * | 2020-06-05 | 2023-09-26 | Theraly Fibrosis, Inc. | Trail compositions with reduced immunogenicity |
| US20250002553A1 (en) * | 2021-08-12 | 2025-01-02 | Shanghai Jmt-Bio Technology Co., Ltd. | A GPC3-targeting antibody-interferon a fusion protein and a use thereof |
| JP2025516856A (ja) * | 2022-05-18 | 2025-05-30 | 武田薬品工業株式会社 | 抗ｃｄ３８融合タンパク質製剤 |
| WO2023227949A1 (en) | 2022-05-27 | 2023-11-30 | Takeda Pharmaceutical Company Limited | Dosing of cd38-binding fusion protein |
| WO2024069240A2 (en) | 2022-09-29 | 2024-04-04 | Takeda Pharmaceutical Company Limited | Cd38-binding fusion protein combination therapy |
| AR132623A1 (es) | 2023-05-08 | 2025-07-16 | Hoffmann La Roche | PROTEÍNAS DE FUSIÓN DE INTERFERÓN a DIRIGIDAS Y MÉTODOS DE USO |
Family Cites Families (122)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2148299B (en) | 1983-09-01 | 1988-01-06 | Hybritech Inc | Antibody compositions of therapeutic agents having an extended serum half-life |
| US4908431A (en) | 1986-01-22 | 1990-03-13 | Temple University-Of The Commonwealth System Of Higher Education | Monoclonal antibodies to human kininogen and methods of preparing same |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| JP3040121B2 (ja) | 1988-01-12 | 2000-05-08 | ジェネンテク，インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
| US5846534A (en) | 1988-02-12 | 1998-12-08 | British Technology Group Limited | Antibodies to the antigen campath-1 |
| AU4128089A (en) | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
| FI903489A0 (fi) | 1988-11-11 | 1990-07-10 | Medical Res Council | Ligander med en enda sektion, receptorer innehaollande naemnda ligander, foerfaranden foer deras framstaellning samt anvaendning av liganderna och receptorerna. |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5976531A (en) | 1990-04-19 | 1999-11-02 | The Dow Chemical Company | Composite antibodies of human subgroup IV light chain capable of binding to tag-72 |
| GB9022543D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
| US5650150A (en) | 1990-11-09 | 1997-07-22 | Gillies; Stephen D. | Recombinant antibody cytokine fusion proteins |
| ES2204890T3 (es) | 1991-03-06 | 2004-05-01 | Merck Patent Gmbh | Anticuerpos monoclonales humanizados. |
| HU218140B (hu) | 1991-04-25 | 2000-06-28 | Chugai Seiyaku Kabushiki Kaisha | Humán interleukin-6-receptorral szembeni átalakított humán antitest |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US6042828A (en) | 1992-09-07 | 2000-03-28 | Kyowa Hakko Kogyo Co., Ltd. | Humanized antibodies to ganglioside GM2 |
| WO1994009817A1 (en) | 1992-11-04 | 1994-05-11 | City Of Hope | Novel antibody construct |
| US5441734A (en) | 1993-02-25 | 1995-08-15 | Schering Corporation | Metal-interferon-alpha crystals |
| US5840299A (en) | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
| AU2071695A (en) | 1994-03-17 | 1995-10-03 | Merck Patent Gmbh | Anti-EGFR single-chain FVS and anti-EGFR antibodies |
| EP0706799B1 (en) | 1994-09-16 | 2001-11-14 | MERCK PATENT GmbH | Immunoconjugates II |
| US20020164788A1 (en) | 1994-12-02 | 2002-11-07 | The Wellcome Foundation Limited | Humanized antibodies to CD38 |
| ATE483733T1 (de) | 1995-06-14 | 2010-10-15 | Univ California | Hochaffine humane antikörper gegen tumorantigene |
| DK1143006T3 (da) | 1995-08-18 | 2008-07-14 | Morphosys Ip Gmbh | Vektorer/DNA-sekvenser fra humane kombinatoriske antistofbiblioteker |
| US5723125A (en) | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
| AU719513B2 (en) | 1996-05-04 | 2000-05-11 | Astrazeneca Ab | Monoclonal antibody to CEA, conjugates comprising said antibody, and their therapeutic use in an adept system |
| US6417337B1 (en) | 1996-10-31 | 2002-07-09 | The Dow Chemical Company | High affinity humanized anti-CEA monoclonal antibodies |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US6872568B1 (en) | 1997-03-17 | 2005-03-29 | Human Genome Sciences, Inc. | Death domain containing receptor 5 antibodies |
| GB9709421D0 (en) | 1997-05-10 | 1997-07-02 | Zeneca Ltd | Chemical compounds |
| US6608183B1 (en) * | 1997-07-14 | 2003-08-19 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
| AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
| ES2434961T5 (es) | 1998-04-20 | 2018-01-18 | Roche Glycart Ag | Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo |
| CZ300762B6 (cs) | 1998-10-16 | 2009-08-05 | Biogen Idec Ma Inc. | Fúzní proteiny interferonu-beta-1a a jejich použití |
| EP2264177B1 (en) | 1998-12-09 | 2015-09-30 | Phyton Holdings, LLC | Glycoproteins having human-type glycosylation |
| US7223397B1 (en) | 1999-01-07 | 2007-05-29 | Research Development Foundation | Potentiation of anti-CD38-Immunotoxin cytotoxicity |
| BR0008759B1 (pt) | 1999-01-14 | 2014-03-11 | Bolder Biotechnology Inc | Métodos para a produção de proteinas contendo resíduos de cisteina livre |
| PL209786B1 (pl) | 1999-01-15 | 2011-10-31 | Genentech Inc | Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna |
| US7355015B1 (en) | 1999-03-12 | 2008-04-08 | Georgetown University School Of Medicine | Matriptase, a serine protease and its applications |
| US6946129B1 (en) | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
| HUP0204475A2 (en) | 2000-02-11 | 2003-04-28 | Merck Patent Gmbh | Enhancing the circulating half-life of antibody-based fusion proteins |
| US7063845B2 (en) | 2000-04-28 | 2006-06-20 | Gemini Science, Inc. | Human anti-CD40 antibodies |
| US7521047B2 (en) | 2000-05-12 | 2009-04-21 | Gpc Biotech Ag | Human polypeptides causing or leading to the killing of cells including lymphoid tumor cells |
| EP1292334A4 (en) | 2000-06-22 | 2003-11-19 | Idec Pharma Corp | BISPECIFIC FUSION PROTEIN AND METHOD FOR USE TO ENHANCE THE KILLING OF TARGET CELLS BY EFFECTOR CELLS |
| EP1522590B1 (en) | 2000-06-28 | 2009-08-26 | Glycofi, Inc. | Methods for producing modified glycoproteins |
| EP1174440A1 (en) | 2000-07-19 | 2002-01-23 | U-BISys B.V. | A selectively-expressed epitope on the human CD38 molecule detected by a phage display library-derived human scFv antibody fragment |
| EP1355919B1 (en) | 2000-12-12 | 2010-11-24 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
| ES2344592T3 (es) | 2001-01-05 | 2010-09-01 | Pfizer Inc. | Anticuerpos frente al receptor del factor de crecimiento similar a la insulina i. |
| FR2823764B1 (fr) | 2001-04-24 | 2003-12-12 | Genodyssee | Nouveaux polynucleotides et polypeptides du gene ifn alpha-17 |
| US20020193569A1 (en) | 2001-06-04 | 2002-12-19 | Idec Pharmaceuticals Corporation | Bispecific fusion protein and method of use for enhancing effector cell killing of target cells |
| ATE433996T1 (de) | 2001-07-03 | 2009-07-15 | Genentech Inc | Humane dr4-antikörper und deren anwendungen |
| IL166244A0 (en) | 2001-07-12 | 2006-01-15 | Jefferson Foote | Super humanized antibodies |
| AR035119A1 (es) | 2001-08-16 | 2004-04-14 | Lilly Co Eli | Anticuerpos humanos antagonistas anti-htnfsf13b |
| AR039067A1 (es) | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
| KR100829283B1 (ko) | 2002-01-09 | 2008-05-13 | 메다렉스, 인코포레이티드 | Ｃｄ３０에 대한 인간 모노클로날 항체 |
| US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| ATE477276T1 (de) | 2002-03-01 | 2010-08-15 | Immunomedics Inc | Internalisierung von anti cd74 monoklonalen antikörpern und deren verwendungen |
| US7332580B2 (en) | 2002-04-05 | 2008-02-19 | The Regents Of The University Of California | Bispecific single chain Fv antibody molecules and methods of use thereof |
| US7332585B2 (en) | 2002-04-05 | 2008-02-19 | The Regents Of The California University | Bispecific single chain Fv antibody molecules and methods of use thereof |
| US7202346B2 (en) | 2002-07-03 | 2007-04-10 | Immunogen Inc. | Antibodies to non-shed Muc1 and Muc16, and uses thereof |
| EP1539950A1 (en) | 2002-09-09 | 2005-06-15 | Nautilus Biotech | Rational directed protein evolution using two-dimensional rational mutagenesis scanning |
| EP1539960B1 (en) | 2002-09-09 | 2010-04-28 | Hanall Pharmaceutical Co., Ltd. | Protease-resistant modified interferon alpha polypeptides |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| MXPA05008704A (es) | 2003-02-18 | 2005-10-05 | Merck Patent Gmbh | Proteinas de fusion de muteinas de interferon alfa con propiedades mejoradas. |
| US7709610B2 (en) | 2003-05-08 | 2010-05-04 | Facet Biotech Corporation | Therapeutic use of anti-CS1 antibodies |
| EP1684869B1 (en) | 2003-11-04 | 2011-07-20 | Novartis Vaccines and Diagnostics, Inc. | Methods of therapy for b cell-related cancers |
| CN101072789B (zh) * | 2004-01-08 | 2013-05-15 | 生物种属学股份公司 | 肽的o-连接的糖基化 |
| US8263746B2 (en) | 2004-02-06 | 2012-09-11 | Morphosys Ag | Anti-CD38 human antibodies and uses thereof |
| JP2008504013A (ja) | 2004-02-06 | 2008-02-14 | モルフォシス・アクチェンゲゼルシャフト | 抗ｃｄ３８ヒト抗体及びその用途 |
| US8034352B2 (en) | 2005-04-06 | 2011-10-11 | Ibc Pharmaceuticals, Inc. | Tetrameric cytokines with improved biological activity |
| WO2005086875A2 (en) | 2004-03-11 | 2005-09-22 | City Of Hope | A humanized anti-cea t84.66 antibody and uses thereof |
| US7670595B2 (en) | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| SI2287195T1 (sl) | 2004-07-01 | 2019-08-30 | Novo Nordisk A/S | Pan-kir2dl nk-receptor protitelesa in njihova uporaba pri diagnostiki in terapiji |
| US7491390B2 (en) | 2004-10-15 | 2009-02-17 | Seattle Genetics, Inc. | Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders |
| NZ586780A (en) | 2005-03-23 | 2012-02-24 | Genmab As | Antibodies against CD38 for treatment of multiple myeloma |
| EP2799451A1 (en) | 2005-05-24 | 2014-11-05 | MorphoSys AG | Generation and profiling of fully human HuCAL GOLD®-derived therapeutic antibodies specific for human CD38 |
| EP1899368A2 (en) | 2005-05-26 | 2008-03-19 | Schering Corporation | Interferon-igg fusion |
| EP2476428B1 (en) | 2005-06-29 | 2013-08-21 | Yeda Research and Development Co. Ltd. | Recombinant interferon alpha 2 (IFN alpha 2) mutants |
| CA2854576A1 (en) | 2005-07-18 | 2007-01-25 | Haichun Huang | Human anti-b7rp1 neutralizing antibodies |
| CA2623236A1 (en) | 2005-09-26 | 2007-04-05 | Medarex, Inc. | Human monoclonal antibodies to cd70 |
| US20070190068A1 (en) | 2005-10-10 | 2007-08-16 | Richard Hart | uPAR-binding molecule-drug conjugates and uses thereof |
| KR20150139636A (ko) | 2005-10-12 | 2015-12-11 | 모르포시스 아게 | 인간 ｃｄ38에 특이적인 완전 인간 ｈｕｃａｌ ｇｏｌｄ-유도 치료 항체들의 생성 및 프로파일링 |
| US8039593B2 (en) | 2005-10-31 | 2011-10-18 | Duke University | Antibodies and immunotoxins that target human glycoprotein NMB |
| GB0525214D0 (en) | 2005-12-12 | 2006-01-18 | Bioinvent Int Ab | Biological materials and uses thereof |
| CN101045156B (zh) | 2006-03-29 | 2012-05-02 | 刘宏利 | 特异靶向性药物及其用途 |
| EP1878747A1 (en) | 2006-07-11 | 2008-01-16 | greenovation Biotech GmbH | Glyco-engineered antibodies |
| FR2905375A1 (fr) | 2006-08-29 | 2008-03-07 | Biomethodes Sa | Variants ameliores de l'interferon alpha humain |
| US8394374B2 (en) | 2006-09-18 | 2013-03-12 | Xencor, Inc. | Optimized antibodies that target HM1.24 |
| EP3753576A1 (en) | 2006-09-26 | 2020-12-23 | Genmab A/S | Combination treatment of cd38-expressing tumors |
| EP1914242A1 (en) | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| DE102007001370A1 (de) | 2007-01-09 | 2008-07-10 | Curevac Gmbh | RNA-kodierte Antikörper |
| WO2008124086A2 (en) | 2007-04-05 | 2008-10-16 | President And Fellows Of Harvard College | Chimeric activators: quantitatively designed protein therapeutics and uses thereof |
| CL2008001334A1 (es) | 2007-05-08 | 2008-09-22 | Genentech Inc | Anticuerpo anti-muc16 disenado con cisteina; conjugado que lo comprende; metodo de produccion; formulacion farmaceutica que lo comprende; y su uso para tratar el cancer. |
| US20110045007A1 (en) | 2007-05-31 | 2011-02-24 | Genmab A/S | Fusion or linked proteins with extended half life |
| US8248984B2 (en) | 2007-06-20 | 2012-08-21 | I Squared Llc | System and method for interfacing devices |
| WO2009017823A2 (en) | 2007-08-01 | 2009-02-05 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health Of Human Services, National Institutes Of Health | A fold-back diabody diphtheria toxin immunotoxin and methods of use |
| JP2010534710A (ja) * | 2007-08-01 | 2010-11-11 | グラクソ グループ リミテッド | 新規抗体 |
| US20090076249A1 (en) | 2007-09-19 | 2009-03-19 | Michel De Weers | Antibodies against CD38 for treatment of multiple myeloma |
| ES2536772T3 (es) | 2007-09-21 | 2015-05-28 | The Regents Of The University Of California | El interferón dirigido demuestra potentes actividades apoptóticas y antitumorales |
| WO2009073975A1 (en) * | 2007-12-10 | 2009-06-18 | National Research Council Of Canada | Production of recombinant interferon proteins |
| US8092804B2 (en) | 2007-12-21 | 2012-01-10 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4Rα)-173 |
| US9221914B2 (en) | 2007-12-26 | 2015-12-29 | Biotest Ag | Agents targeting CD138 and uses thereof |
| EP2313435A4 (en) | 2008-07-01 | 2012-08-08 | Aveo Pharmaceuticals Inc | FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) BINDING PROTEINS |
| WO2010105290A1 (en) | 2009-03-16 | 2010-09-23 | Cephalon Australia Pty Ltd | Humanised antibodies with anti-tumour activity |
| RS59769B1 (sr) | 2010-06-09 | 2020-02-28 | Genmab As | Antitela protiv humanog cd38 |
| US8909257B2 (en) | 2010-06-19 | 2014-12-09 | Qualcomm Incorporated | Positioning protocol conveyance |
| KR101912957B1 (ko) | 2010-09-27 | 2018-10-29 | 모르포시스 아게 | 다발성 골수종 및 nhl 치료를 위한 항-cd38 항체 및 레날리도마이드 또는 보르테조밉 |
| MX2013007392A (es) | 2010-12-22 | 2013-11-01 | Cephalon Australia Pty Ltd | Anticuerpo modificado con vida media mejorada. |
| JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| JP2014531210A (ja) * | 2011-09-30 | 2014-11-27 | テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド | ＴＬ１ａに対する抗体およびその使用 |
| ES3033729T3 (en) * | 2011-10-28 | 2025-08-07 | Teva Pharmaceuticals Australia Pty Ltd | Polypeptide constructs and uses thereof |
| ES2694180T3 (es) | 2012-01-20 | 2018-12-18 | Vib Vzw | Citocinas de haz alfa-helicoidal mutantes dirigidas |
| IN2014DN08236A (cg-RX-API-DMAC7.html) | 2012-03-03 | 2015-05-15 | Immungene Inc | |
| WO2014028502A1 (en) * | 2012-08-13 | 2014-02-20 | ImmunGene Inc. | Engineered antibody-interferon fusion molecules for treatment of autoimmune diseases |
| US20150353485A1 (en) | 2013-01-25 | 2015-12-10 | Bayer Materialscience Ag | Security element having volume hologram and printed feature |
| PT3677591T (pt) | 2013-04-29 | 2023-02-17 | Teva Pharmaceuticals Australia Pty Ltd | Anticorpos anti-cd38 e fusões a interferão alfa-2b atenuado |
| US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
| UA119352C2 (uk) * | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
| PE20170908A1 (es) | 2014-10-29 | 2017-07-12 | Teva Pharmaceuticals Australia Pty Ltd | VARIANTES DE INTERFERON a2b |
| JP7241677B2 (ja) * | 2016-07-19 | 2023-03-17 | テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド | 抗ｃｄ４７併用療法 |
-
2015
- 2015-10-23 PE PE2017000753A patent/PE20170908A1/es unknown
- 2015-10-23 IL IL251822A patent/IL251822B2/en unknown
- 2015-10-23 EP EP15854166.4A patent/EP3212216A4/en active Pending
- 2015-10-23 AU AU2015337858A patent/AU2015337858B2/en active Active
- 2015-10-23 US US14/921,420 patent/US10544199B2/en active Active
- 2015-10-23 WO PCT/AU2015/050654 patent/WO2016065409A1/en not_active Ceased
- 2015-10-23 JP JP2017523394A patent/JP6730271B2/ja active Active
- 2015-10-23 CN CN201580064412.4A patent/CN107106656B/zh active Active
- 2015-10-23 SG SG11201703251TA patent/SG11201703251TA/en unknown
- 2015-10-23 UA UAA201705168A patent/UA125637C2/uk unknown
- 2015-10-23 CA CA2965414A patent/CA2965414C/en active Active
- 2015-10-23 EA EA201790934A patent/EA037749B1/ru unknown
- 2015-10-23 MX MX2017005481A patent/MX393988B/es unknown
- 2015-10-23 KR KR1020177014309A patent/KR102639037B1/ko active Active
-
2017
- 2017-04-25 ZA ZA2017/02891A patent/ZA201702891B/en unknown
- 2017-04-26 PH PH12017500785A patent/PH12017500785A1/en unknown
- 2017-04-28 CO CONC2017/0004318A patent/CO2017004318A2/es unknown
- 2017-04-28 CL CL2017001070A patent/CL2017001070A1/es unknown
-
2019
- 2019-12-11 US US16/710,574 patent/US11319356B2/en active Active
-
2020
- 2020-03-17 JP JP2020046259A patent/JP6957666B2/ja active Active
-
2022
- 2022-03-31 US US17/709,510 patent/US20220220184A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017534282A5 (cg-RX-API-DMAC7.html) | ||
| JP7781243B2 (ja) | ガイダンス及びナビゲーションコントロール蛋白質並びにその生産及び使用方法 | |
| Nishimoto et al. | Allogeneic CD20‐targeted γδ T cells exhibit innate and adaptive antitumor activities in preclinical B‐cell lymphoma models | |
| CN108884140B (zh) | 修饰的嵌合受体及相关组合物和方法 | |
| JP2019521169A5 (cg-RX-API-DMAC7.html) | ||
| TWI828625B (zh) | 引導及導航控制蛋白質以及彼之製造及使用方法 | |
| AU2018222749B2 (en) | Combination therapies for treatment of BCMA-related cancers and autoimmune disorders | |
| CN114761037A (zh) | 结合bcma和cd19的嵌合抗原受体及其用途 | |
| ES2968737T3 (es) | Proceso para producir células T manipuladas genéticamente | |
| NZ756727A (en) | Polypeptide constructs and uses thereof | |
| CN113365660A (zh) | 对受体酪氨酸激酶样孤儿受体1(ror1)具特异性的抗体及嵌合抗原受体 | |
| CN109790213B (zh) | 用于鉴定lilrb阻断抗体的方法 | |
| BR112021007626A2 (pt) | Receptores antigênicos quiméricos específicos pa-ra receptor acoplado à proteína g receptor de classe c, grupo 5, membro d (gprc5d) | |
| CN113474450A (zh) | 产生工程化细胞的方法以及所述工程化细胞的组合物 | |
| KR20200069358A (ko) | 키메라 항원 수용체 발현 세포의 제조 방법 | |
| WO2019227003A1 (en) | Combination therapy with chimeric antigen receptor (car) therapies | |
| JP2019536437A (ja) | Ｈｐｖ特異的結合分子 | |
| Reindl et al. | Immunotherapy with NK cells: recent developments in gene modification open up new avenues | |
| CN115916833B (zh) | 靶向b7h3的抗原结合多肽及其应用 | |
| EP3095792A1 (en) | T cell receptor with specificity for myeloperoxidase peptide and uses thereof | |
| WO2017064084A1 (en) | Novel chimeric antigen receptors | |
| Prinz et al. | An anti-CD19/CTLA-4 switch improves efficacy and selectivity of CAR T cells targeting CD80/86-upregulated DLBCL | |
| CN118176212A (zh) | 嵌合抗原受体（car）信号传导分子的组合物及其用途 | |
| WO2021231661A2 (en) | Process for producing donor-batched cells expressing a recombinant receptor | |
| CN113286815A (zh) | 间皮素特异性t细胞受体及其在免疫治疗中的应用 |