JP2017533191A - ＡｃｔＲＩＩリガンドトラップを用いた心血管疾患の治療 - Google Patents

ＡｃｔＲＩＩリガンドトラップを用いた心血管疾患の治療 Download PDF

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JP2017533191A
JP2017533191A JP2017518975A JP2017518975A JP2017533191A JP 2017533191 A JP2017533191 A JP 2017533191A JP 2017518975 A JP2017518975 A JP 2017518975A JP 2017518975 A JP2017518975 A JP 2017518975A JP 2017533191 A JP2017533191 A JP 2017533191A
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JP2017533191A5 (OSRAM
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フルスカ キース
フルスカ キース
ファング イイフ
ファング イイフ
スミス ウイリアム
スミス ウイリアム
チェン ニアンハング
チェン ニアンハング
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Washington University in St Louis WUSTL
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Priority to JP2021110451A priority Critical patent/JP2021169464A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2017518975A 2014-10-09 2015-10-08 ＡｃｔＲＩＩリガンドトラップを用いた心血管疾患の治療 Pending JP2017533191A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021110451A JP2021169464A (ja) 2014-10-09 2021-07-02 ＡｃｔＲＩＩリガンドトラップを用いた心血管疾患の治療

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201462062021P 2014-10-09 2014-10-09
US62/062,021 2014-10-09
US201462078321P 2014-11-11 2014-11-11
US62/078,321 2014-11-11
US201562103515P 2015-01-14 2015-01-14
US62/103,515 2015-01-14
US201562167052P 2015-05-27 2015-05-27
US62/167,052 2015-05-27
US201562170015P 2015-06-02 2015-06-02
US62/170,015 2015-06-02
PCT/US2015/054674 WO2016069234A1 (en) 2014-10-09 2015-10-08 Treatment of cardiovascular disease using actrii ligand traps

Related Child Applications (1)

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JP2021110451A Division JP2021169464A (ja) 2014-10-09 2021-07-02 ＡｃｔＲＩＩリガンドトラップを用いた心血管疾患の治療

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JP2017533191A true JP2017533191A (ja) 2017-11-09
JP2017533191A5 JP2017533191A5 (OSRAM) 2018-11-29

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JP2017518975A Pending JP2017533191A (ja) 2014-10-09 2015-10-08 ＡｃｔＲＩＩリガンドトラップを用いた心血管疾患の治療
JP2021110451A Pending JP2021169464A (ja) 2014-10-09 2021-07-02 ＡｃｔＲＩＩリガンドトラップを用いた心血管疾患の治療

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Country Status (15)

Country Link
US (1) US11813308B2 (OSRAM)
EP (1) EP3204118B8 (OSRAM)
JP (2) JP2017533191A (OSRAM)
KR (1) KR20170088836A (OSRAM)
CN (1) CN107206255A (OSRAM)
AU (2) AU2015339786B2 (OSRAM)
CA (1) CA2964129A1 (OSRAM)
ES (1) ES2978963T3 (OSRAM)
HK (1) HK1244741A1 (OSRAM)
IL (1) IL251649B (OSRAM)
MA (1) MA41052A (OSRAM)
MX (1) MX392749B (OSRAM)
RU (1) RU2017115720A (OSRAM)
TW (2) TW202300170A (OSRAM)
WO (1) WO2016069234A1 (OSRAM)

Cited By (1)

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JP2023534143A (ja) * 2020-06-23 2023-08-08 アクセルロン ファーマ インコーポレイテッド 肺動脈性肺高血圧症（ｐａｈ）の処置のためのａｃｔｒｉｉタンパク質

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JP2018501307A (ja) 2014-12-03 2018-01-18 セルジーン コーポレイション アクチビン−ＡｃｔＲＩＩアンタゴニスト及び貧血を治療するための使用
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CN114630681A (zh) 2019-09-03 2022-06-14 诺华股份有限公司 包含actrii受体拮抗剂的肝疾病或障碍的治疗
EP4121088A4 (en) 2020-03-20 2024-07-03 Keros Therapeutics, Inc. Methods of using activin receptor type iib variants
CN111474369A (zh) * 2020-04-22 2020-07-31 河北医科大学 一种平滑肌蛋白SM22α作为检测心血管疾病标志物的应用
CN111870685B (zh) * 2020-07-16 2022-11-29 上海市同仁医院 运动相关多肽在制备防治缺血性心脏病药物中的应用
US12186370B1 (en) 2020-11-05 2025-01-07 Celgene Corporation ACTRIIB ligand trap compositions and uses thereof
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