JP2017533191A5 - - Google Patents

Info

Publication number

JP2017533191A5

JP2017533191A5 JP2017518975A JP2017518975A JP2017533191A5 JP 2017533191 A5 JP2017533191 A5 JP 2017533191A5 JP 2017518975 A JP2017518975 A JP 2017518975A JP 2017518975 A JP2017518975 A JP 2017518975A JP 2017533191 A5 JP2017533191 A5 JP 2017533191A5

Authority

JP

Japan

Prior art keywords

level

levels

reference population

seq

compared

Prior art date

2015-10-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• -1 phospho Chemical class 0.000 claims description 257
• 102000005606 Activins Human genes 0.000 claims description 105
• 108010059616 Activins Proteins 0.000 claims description 105
• 102000015775 Core Binding Factor Alpha 1 Subunit Human genes 0.000 claims description 105
• 108010024682 Core Binding Factor Alpha 1 Subunit Proteins 0.000 claims description 105
• 102100030074 Dickkopf-related protein 1 Human genes 0.000 claims description 105
• 101710099518 Dickkopf-related protein 1 Proteins 0.000 claims description 105
• 102000002624 Sp7 Transcription Factor Human genes 0.000 claims description 105
• 108010043267 Sp7 Transcription Factor Proteins 0.000 claims description 105
• 239000000488 activin Substances 0.000 claims description 105
• 238000000034 method Methods 0.000 claims description 103
• 108010081823 Myocardin Proteins 0.000 claims description 101
• 102100030217 Myocardin Human genes 0.000 claims description 101
• 102000004169 proteins and genes Human genes 0.000 claims description 94
• 108090000623 proteins and genes Proteins 0.000 claims description 94
• 238000005259 measurement Methods 0.000 claims description 80
• 101150096411 AXIN2 gene Proteins 0.000 claims description 67
• 102100035683 Axin-2 Human genes 0.000 claims description 67
• 101100108660 Escherichia coli (strain K12) alpA gene Proteins 0.000 claims description 65
• 101100003994 Mus musculus Atrnl1 gene Proteins 0.000 claims description 65
• 101100324525 Rattus norvegicus Asrgl1 gene Proteins 0.000 claims description 65
• 101150024193 alp1 gene Proteins 0.000 claims description 65
• 239000003112 inhibitor Substances 0.000 claims description 58
• 230000011664 signaling Effects 0.000 claims description 58
• 208000024172 Cardiovascular disease Diseases 0.000 claims description 53
• 210000002700 urine Anatomy 0.000 claims description 46
• 230000002485 urinary effect Effects 0.000 claims description 43
• 230000003247 decreasing effect Effects 0.000 claims description 24
• 102000018918 Activin Receptors Human genes 0.000 claims description 21
• 108010052946 Activin Receptors Proteins 0.000 claims description 21
• 208000005475 Vascular calcification Diseases 0.000 claims description 18
• 208000020832 chronic kidney disease Diseases 0.000 claims description 18
• 208000007177 Left Ventricular Hypertrophy Diseases 0.000 claims description 16
• 208000004434 Calcinosis Diseases 0.000 claims description 12
• 230000002308 calcification Effects 0.000 claims description 12
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 8
• 208000006386 Bone Resorption Diseases 0.000 claims description 7
• 230000024279 bone resorption Effects 0.000 claims description 7
• 201000010099 disease Diseases 0.000 claims description 7
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
• 208000017169 kidney disease Diseases 0.000 claims description 7
• 201000001320 Atherosclerosis Diseases 0.000 claims description 6
• 238000002965 ELISA Methods 0.000 claims description 6
• 210000000988 bone and bone Anatomy 0.000 claims description 5
• 108020004999 messenger RNA Proteins 0.000 claims description 5
• 102000002260 Alkaline Phosphatase Human genes 0.000 claims description 4
• 108020004774 Alkaline Phosphatase Proteins 0.000 claims description 4
• 101150008656 COL1A1 gene Proteins 0.000 claims description 4
• 101150101626 TAGLN gene Proteins 0.000 claims description 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 4
• 238000002347 injection Methods 0.000 claims description 4
• 239000007924 injection Substances 0.000 claims description 4
• 229920001184 polypeptide Polymers 0.000 claims description 4
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
• 210000001519 tissue Anatomy 0.000 claims description 4
• 206010059245 Angiopathy Diseases 0.000 claims description 3
• 206010010356 Congenital anomaly Diseases 0.000 claims description 3
• 208000031226 Hyperlipidaemia Diseases 0.000 claims description 3
• 206010020772 Hypertension Diseases 0.000 claims description 3
• 206010061218 Inflammation Diseases 0.000 claims description 3
• 208000001132 Osteoporosis Diseases 0.000 claims description 3
• 208000034189 Sclerosis Diseases 0.000 claims description 3
• 238000002266 amputation Methods 0.000 claims description 3
• 206010002906 aortic stenosis Diseases 0.000 claims description 3
• 208000028208 end stage renal disease Diseases 0.000 claims description 3
• 201000000523 end stage renal failure Diseases 0.000 claims description 3
• 230000004054 inflammatory process Effects 0.000 claims description 3
• 229910052500 inorganic mineral Inorganic materials 0.000 claims description 3
• 208000019423 liver disease Diseases 0.000 claims description 3
• 239000011707 mineral Substances 0.000 claims description 3
• 210000004115 mitral valve Anatomy 0.000 claims description 3
• 208000007232 portal hypertension Diseases 0.000 claims description 3
• 210000003240 portal vein Anatomy 0.000 claims description 3
• 208000004124 rheumatic heart disease Diseases 0.000 claims description 3
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 3
• 208000019553 vascular disease Diseases 0.000 claims description 3
• 108010085238 Actins Proteins 0.000 claims description 2
• 102000007469 Actins Human genes 0.000 claims description 2
• 102000008186 Collagen Human genes 0.000 claims description 2
• 108010035532 Collagen Proteins 0.000 claims description 2
• 241000237858 Gastropoda Species 0.000 claims description 2
• 102100025368 Runt-related transcription factor 2 Human genes 0.000 claims description 2
• 101710102802 Runt-related transcription factor 2 Proteins 0.000 claims description 2
• 108090000333 Transgelin Proteins 0.000 claims description 2
• 102100031013 Transgelin Human genes 0.000 claims description 2
• 210000000709 aorta Anatomy 0.000 claims description 2
• 210000001185 bone marrow Anatomy 0.000 claims description 2
• 229920001436 collagen Polymers 0.000 claims description 2
• 108020001507 fusion proteins Proteins 0.000 claims description 2
• 102000037865 fusion proteins Human genes 0.000 claims description 2
• 210000004185 liver Anatomy 0.000 claims description 2
• 238000003757 reverse transcription PCR Methods 0.000 claims description 2
• 210000002966 serum Anatomy 0.000 claims description 2
• 210000002460 smooth muscle Anatomy 0.000 claims description 2
• 210000000952 spleen Anatomy 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 21
• 230000002159 abnormal effect Effects 0.000 claims 2
• 230000003176 fibrotic effect Effects 0.000 claims 2
• 230000004060 metabolic process Effects 0.000 claims 2
• 206010016654 Fibrosis Diseases 0.000 description 1
• 230000004761 fibrosis Effects 0.000 description 1
• 230000006371 metabolic abnormality Effects 0.000 description 1