JP2017532299A5 - - Google Patents
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- Publication number
- JP2017532299A5 JP2017532299A5 JP2017511998A JP2017511998A JP2017532299A5 JP 2017532299 A5 JP2017532299 A5 JP 2017532299A5 JP 2017511998 A JP2017511998 A JP 2017511998A JP 2017511998 A JP2017511998 A JP 2017511998A JP 2017532299 A5 JP2017532299 A5 JP 2017532299A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- alkyl
- halogen atom
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 32
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 31
- 125000005843 halogen group Chemical group 0.000 claims 26
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 17
- 125000000623 heterocyclic group Chemical group 0.000 claims 14
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical group ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- DTXOCJGLLMAFBX-UHFFFAOYSA-N oxo-[[1-[2-[[4-(oxoazaniumylmethylidene)pyridin-1-yl]methoxy]ethoxymethyl]pyridin-4-ylidene]methyl]azanium;dichloride Chemical compound [Cl-].[Cl-].C1=CC(=C[NH+]=O)C=CN1COCCOCN1C=CC(=C[NH+]=O)C=C1 DTXOCJGLLMAFBX-UHFFFAOYSA-N 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000005309 thioalkoxy group Chemical group 0.000 claims 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- OSDBJMYIUDLIRI-UHFFFAOYSA-N oxo-[[1-[[4-[[4-(oxoazaniumylmethylidene)pyridin-1-yl]methoxy]cyclohexyl]oxymethyl]pyridin-4-ylidene]methyl]azanium;dichloride Chemical compound [Cl-].[Cl-].C1=CC(=C[NH+]=O)C=CN1COC1CCC(OCN2C=CC(=C[NH+]=O)C=C2)CC1 OSDBJMYIUDLIRI-UHFFFAOYSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 238000003477 Sonogashira cross-coupling reaction Methods 0.000 claims 1
- 125000002355 alkine group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000001620 monocyclic carbocycle group Chemical group 0.000 claims 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 238000007363 ring formation reaction Methods 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1458203 | 2014-09-02 | ||
| FR1458203A FR3025199B1 (fr) | 2014-09-02 | 2014-09-02 | Derives de n-aryl-2-amino-4-aryl-pyrimidines polyethers macrocycliques |
| PCT/EP2015/070066 WO2016034634A1 (fr) | 2014-09-02 | 2015-09-02 | Derives de n-aryl-2-amino-4-aryl-pyrimidines polyethers macrocycliques comme inhibiteurs de la ftl3 and jak |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017532299A JP2017532299A (ja) | 2017-11-02 |
| JP2017532299A5 true JP2017532299A5 (enExample) | 2018-10-18 |
Family
ID=51842564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017511998A Pending JP2017532299A (ja) | 2014-09-02 | 2015-09-02 | Ｆｔｌ３およびｊａｋの阻害剤としての大環状ｎ−アリール−２−アミノ−４−アリール−ピリミジンポリエーテルの誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20170281622A1 (enExample) |
| EP (1) | EP3189060B1 (enExample) |
| JP (1) | JP2017532299A (enExample) |
| CN (1) | CN106795173B (enExample) |
| BR (1) | BR112017003881A2 (enExample) |
| DK (1) | DK3189060T3 (enExample) |
| ES (1) | ES2686828T3 (enExample) |
| FR (1) | FR3025199B1 (enExample) |
| HU (1) | HUE040648T2 (enExample) |
| MX (1) | MX2017002627A (enExample) |
| PL (1) | PL3189060T3 (enExample) |
| RU (1) | RU2017108932A (enExample) |
| TR (1) | TR201813294T4 (enExample) |
| WO (1) | WO2016034634A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230150940A1 (en) * | 2020-04-18 | 2023-05-18 | Inipharm, Inc. | Hsd17b13 inhibitors and uses thereof |
| CN113735879B (zh) * | 2020-05-27 | 2022-05-17 | 百极弘烨（广东）医药科技有限公司 | 一种大环jak抑制剂及其应用 |
| CN113735856A (zh) * | 2020-05-29 | 2021-12-03 | 百极弘烨(南通)医药科技有限公司 | 大环jak抑制剂及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8143255B2 (en) * | 2005-11-16 | 2012-03-27 | S*Bio Pte Ltd. | Heteroalkyl linked pyrimidine derivatives |
| WO2008060248A1 (en) * | 2006-11-15 | 2008-05-22 | S*Bio Pte Ltd. | Indole sustituted pyrimidines and use thereof in the treatment of cancer |
| GB0805477D0 (en) * | 2008-03-26 | 2008-04-30 | Univ Nottingham | Pyrimidines triazines and their use as pharmaceutical agents |
-
2014
- 2014-09-02 FR FR1458203A patent/FR3025199B1/fr not_active Expired - Fee Related
-
2015
- 2015-09-02 HU HUE15757283A patent/HUE040648T2/hu unknown
- 2015-09-02 TR TR2018/13294T patent/TR201813294T4/tr unknown
- 2015-09-02 RU RU2017108932A patent/RU2017108932A/ru not_active Application Discontinuation
- 2015-09-02 CN CN201580054324.6A patent/CN106795173B/zh not_active Expired - Fee Related
- 2015-09-02 JP JP2017511998A patent/JP2017532299A/ja active Pending
- 2015-09-02 ES ES15757283.5T patent/ES2686828T3/es active Active
- 2015-09-02 DK DK15757283.5T patent/DK3189060T3/en active
- 2015-09-02 WO PCT/EP2015/070066 patent/WO2016034634A1/fr not_active Ceased
- 2015-09-02 PL PL15757283T patent/PL3189060T3/pl unknown
- 2015-09-02 US US15/508,218 patent/US20170281622A1/en not_active Abandoned
- 2015-09-02 MX MX2017002627A patent/MX2017002627A/es unknown
- 2015-09-02 EP EP15757283.5A patent/EP3189060B1/fr not_active Not-in-force
- 2015-09-02 BR BR112017003881A patent/BR112017003881A2/pt not_active IP Right Cessation
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