FR3025199B1 - Derives de n-aryl-2-amino-4-aryl-pyrimidines polyethers macrocycliques - Google Patents

Derives de n-aryl-2-amino-4-aryl-pyrimidines polyethers macrocycliques

Info

Publication number
FR3025199B1
FR3025199B1 FR1458203A FR1458203A FR3025199B1 FR 3025199 B1 FR3025199 B1 FR 3025199B1 FR 1458203 A FR1458203 A FR 1458203A FR 1458203 A FR1458203 A FR 1458203A FR 3025199 B1 FR3025199 B1 FR 3025199B1
Authority
FR
France
Prior art keywords
aryl
polyethyl
macrocyclic
amino
pyrimidine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1458203A
Other languages
English (en)
French (fr)
Other versions
FR3025199A1 (fr
Inventor
El Bachir Kaloun
Serge Grisoni
Bruno Gomes
Philippe Schmitt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1458203A priority Critical patent/FR3025199B1/fr
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to JP2017511998A priority patent/JP2017532299A/ja
Priority to BR112017003881A priority patent/BR112017003881A2/pt
Priority to US15/508,218 priority patent/US20170281622A1/en
Priority to PL15757283T priority patent/PL3189060T3/pl
Priority to RU2017108932A priority patent/RU2017108932A/ru
Priority to MX2017002627A priority patent/MX2017002627A/es
Priority to TR2018/13294T priority patent/TR201813294T4/tr
Priority to ES15757283.5T priority patent/ES2686828T3/es
Priority to CN201580054324.6A priority patent/CN106795173B/zh
Priority to DK15757283.5T priority patent/DK3189060T3/en
Priority to HUE15757283A priority patent/HUE040648T2/hu
Priority to PCT/EP2015/070066 priority patent/WO2016034634A1/fr
Priority to EP15757283.5A priority patent/EP3189060B1/fr
Publication of FR3025199A1 publication Critical patent/FR3025199A1/fr
Application granted granted Critical
Publication of FR3025199B1 publication Critical patent/FR3025199B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FR1458203A 2014-09-02 2014-09-02 Derives de n-aryl-2-amino-4-aryl-pyrimidines polyethers macrocycliques Expired - Fee Related FR3025199B1 (fr)

Priority Applications (14)

Application Number Priority Date Filing Date Title
FR1458203A FR3025199B1 (fr) 2014-09-02 2014-09-02 Derives de n-aryl-2-amino-4-aryl-pyrimidines polyethers macrocycliques
DK15757283.5T DK3189060T3 (en) 2014-09-02 2015-09-02 DERIVATIVES OF MACROCYCLIC N-ARYL-2-AMINO-4-ARYL-PYRIMIDINE POLYETHERS AS FTL3 AND JAK INHIBITORS
US15/508,218 US20170281622A1 (en) 2014-09-02 2015-09-02 Derivatives of macrocyclic n-aryl-2-amino-4-aryl-pyrimidine polyethers as inhibitors of ftl3 and jak
PL15757283T PL3189060T3 (pl) 2014-09-02 2015-09-02 Pochodne N-arylo-2-amino-4-arylo-pirymidynowe polieterów makrocyklicznych jako inhibitory FTL3 i JAK
RU2017108932A RU2017108932A (ru) 2014-09-02 2015-09-02 Производные макроциклических полиэфиров n-арил-2-амино-4-арил-пиримидина в качестве ингибиторов ftl3 и jak
MX2017002627A MX2017002627A (es) 2014-09-02 2015-09-02 Derivados de polieteres macrociclicos de n-aril-2-amino-4-aril-pir imidina como inhibidores de ftl3 y jak.
TR2018/13294T TR201813294T4 (tr) 2014-09-02 2015-09-02 N-aril-2-amino-4-aril-pirimidin makrosi̇kli̇k poli̇eter türevleri̇ ve bunlarin flt3 ve jak i̇nhi̇bi̇törleri̇ olarak kullanimlari.
ES15757283.5T ES2686828T3 (es) 2014-09-02 2015-09-02 Derivados de poliéteres macrocíclicos de N-aril-2-amino-4-aril-pirimidinas como inhibidores de la FLT3 y JAK
JP2017511998A JP2017532299A (ja) 2014-09-02 2015-09-02 Ｆｔｌ３およびｊａｋの阻害剤としての大環状ｎ−アリール−２−アミノ−４−アリール−ピリミジンポリエーテルの誘導体
BR112017003881A BR112017003881A2 (pt) 2014-09-02 2015-09-02 derivados do n-aril-2-amino-4-aril-pirimidinas poliéteres macrocíclicos como inibidores da ftl3 e jak
HUE15757283A HUE040648T2 (hu) 2014-09-02 2015-09-02 Makrociklusos N-aril-2-amino-4-aril-pirimidin poliéter származékok mint FTL3 és JAK inhibitorok
PCT/EP2015/070066 WO2016034634A1 (fr) 2014-09-02 2015-09-02 Derives de n-aryl-2-amino-4-aryl-pyrimidines polyethers macrocycliques comme inhibiteurs de la ftl3 and jak
EP15757283.5A EP3189060B1 (fr) 2014-09-02 2015-09-02 Derives de n-aryl-2-amino-4-aryl-pyrimidines polyethers macrocycliques comme inhibiteurs de la ftl3 and jak
CN201580054324.6A CN106795173B (zh) 2014-09-02 2015-09-02 作为ftl3和jak抑制剂的大环n-芳基-2-氨基-4-芳基-嘧啶聚醚的衍生物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1458203A FR3025199B1 (fr) 2014-09-02 2014-09-02 Derives de n-aryl-2-amino-4-aryl-pyrimidines polyethers macrocycliques

Publications (2)

Publication Number Publication Date
FR3025199A1 FR3025199A1 (fr) 2016-03-04
FR3025199B1 true FR3025199B1 (fr) 2016-09-23

Family

ID=51842564

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1458203A Expired - Fee Related FR3025199B1 (fr) 2014-09-02 2014-09-02 Derives de n-aryl-2-amino-4-aryl-pyrimidines polyethers macrocycliques

Country Status (14)

Country Link
US (1) US20170281622A1 (enExample)
EP (1) EP3189060B1 (enExample)
JP (1) JP2017532299A (enExample)
CN (1) CN106795173B (enExample)
BR (1) BR112017003881A2 (enExample)
DK (1) DK3189060T3 (enExample)
ES (1) ES2686828T3 (enExample)
FR (1) FR3025199B1 (enExample)
HU (1) HUE040648T2 (enExample)
MX (1) MX2017002627A (enExample)
PL (1) PL3189060T3 (enExample)
RU (1) RU2017108932A (enExample)
TR (1) TR201813294T4 (enExample)
WO (1) WO2016034634A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230150940A1 (en) * 2020-04-18 2023-05-18 Inipharm, Inc. Hsd17b13 inhibitors and uses thereof
CN113735879B (zh) * 2020-05-27 2022-05-17 百极弘烨（广东）医药科技有限公司 一种大环jak抑制剂及其应用
CN113735856A (zh) * 2020-05-29 2021-12-03 百极弘烨(南通)医药科技有限公司 大环jak抑制剂及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8143255B2 (en) * 2005-11-16 2012-03-27 S*Bio Pte Ltd. Heteroalkyl linked pyrimidine derivatives
WO2008060248A1 (en) * 2006-11-15 2008-05-22 S*Bio Pte Ltd. Indole sustituted pyrimidines and use thereof in the treatment of cancer
GB0805477D0 (en) * 2008-03-26 2008-04-30 Univ Nottingham Pyrimidines triazines and their use as pharmaceutical agents

Also Published As

Publication number Publication date
EP3189060B1 (fr) 2018-06-20
JP2017532299A (ja) 2017-11-02
CN106795173A (zh) 2017-05-31
ES2686828T3 (es) 2018-10-22
WO2016034634A1 (fr) 2016-03-10
US20170281622A1 (en) 2017-10-05
RU2017108932A3 (enExample) 2019-01-23
PL3189060T3 (pl) 2019-03-29
BR112017003881A2 (pt) 2017-12-26
TR201813294T4 (tr) 2018-11-21
EP3189060A1 (fr) 2017-07-12
DK3189060T3 (en) 2018-10-01
RU2017108932A (ru) 2018-10-03
FR3025199A1 (fr) 2016-03-04
CN106795173B (zh) 2019-05-31
MX2017002627A (es) 2017-09-19
HUE040648T2 (hu) 2019-03-28

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