JP2017532299A - Ｆｔｌ３およびｊａｋの阻害剤としての大環状ｎ−アリール−２−アミノ−４−アリール−ピリミジンポリエーテルの誘導体 - Google Patents
Ｆｔｌ３およびｊａｋの阻害剤としての大環状ｎ−アリール−２−アミノ−４−アリール−ピリミジンポリエーテルの誘導体 Download PDFInfo
- Publication number
- JP2017532299A JP2017532299A JP2017511998A JP2017511998A JP2017532299A JP 2017532299 A JP2017532299 A JP 2017532299A JP 2017511998 A JP2017511998 A JP 2017511998A JP 2017511998 A JP2017511998 A JP 2017511998A JP 2017532299 A JP2017532299 A JP 2017532299A
- Authority
- JP
- Japan
- Prior art keywords
- group
- arom
- compound
- alkyl
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- RVJUVDJHKCXVBV-UHFFFAOYSA-N Brc(ccc(Nc1nccc-2n1)c1)c1OCCOCCOc1cccc-2c1 Chemical compound Brc(ccc(Nc1nccc-2n1)c1)c1OCCOCCOc1cccc-2c1 RVJUVDJHKCXVBV-UHFFFAOYSA-N 0.000 description 1
- XBXYNFHTJOKYOT-UHFFFAOYSA-N C(COc1cccc(-c2ccnc(N3)n2)c1)OCCSc1cccc3c1 Chemical compound C(COc1cccc(-c2ccnc(N3)n2)c1)OCCSc1cccc3c1 XBXYNFHTJOKYOT-UHFFFAOYSA-N 0.000 description 1
- QBMMITATXZJWDG-BQYQJAHWSA-N CN(C)/C=C/C(c1cc(OC)ccc1)=O Chemical compound CN(C)/C=C/C(c1cc(OC)ccc1)=O QBMMITATXZJWDG-BQYQJAHWSA-N 0.000 description 1
- VTQHQGLPPJXBSU-UHFFFAOYSA-N Oc1cc(-c2ccnc(Nc3cc(SCCOCCBr)ccc3)n2)ccc1 Chemical compound Oc1cc(-c2ccnc(Nc3cc(SCCOCCBr)ccc3)n2)ccc1 VTQHQGLPPJXBSU-UHFFFAOYSA-N 0.000 description 1
- FBHTXOQEDBGING-UHFFFAOYSA-N Oc1cc(-c2nc(Cl)ncc2)ccc1 Chemical compound Oc1cc(-c2nc(Cl)ncc2)ccc1 FBHTXOQEDBGING-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1458203 | 2014-09-02 | ||
| FR1458203A FR3025199B1 (fr) | 2014-09-02 | 2014-09-02 | Derives de n-aryl-2-amino-4-aryl-pyrimidines polyethers macrocycliques |
| PCT/EP2015/070066 WO2016034634A1 (fr) | 2014-09-02 | 2015-09-02 | Derives de n-aryl-2-amino-4-aryl-pyrimidines polyethers macrocycliques comme inhibiteurs de la ftl3 and jak |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017532299A true JP2017532299A (ja) | 2017-11-02 |
| JP2017532299A5 JP2017532299A5 (enExample) | 2018-10-18 |
Family
ID=51842564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017511998A Pending JP2017532299A (ja) | 2014-09-02 | 2015-09-02 | Ｆｔｌ３およびｊａｋの阻害剤としての大環状ｎ−アリール−２−アミノ−４−アリール−ピリミジンポリエーテルの誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20170281622A1 (enExample) |
| EP (1) | EP3189060B1 (enExample) |
| JP (1) | JP2017532299A (enExample) |
| CN (1) | CN106795173B (enExample) |
| BR (1) | BR112017003881A2 (enExample) |
| DK (1) | DK3189060T3 (enExample) |
| ES (1) | ES2686828T3 (enExample) |
| FR (1) | FR3025199B1 (enExample) |
| HU (1) | HUE040648T2 (enExample) |
| MX (1) | MX2017002627A (enExample) |
| PL (1) | PL3189060T3 (enExample) |
| RU (1) | RU2017108932A (enExample) |
| TR (1) | TR201813294T4 (enExample) |
| WO (1) | WO2016034634A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023528394A (ja) * | 2020-05-27 | 2023-07-04 | バイオポーラー ホンイェ（グアンドン）ファーマシューティカル カンパニー リミテッド | 大環状ｊａｋ阻害剤およびその適用 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230150940A1 (en) * | 2020-04-18 | 2023-05-18 | Inipharm, Inc. | Hsd17b13 inhibitors and uses thereof |
| CN113735856A (zh) * | 2020-05-29 | 2021-12-03 | 百极弘烨(南通)医药科技有限公司 | 大环jak抑制剂及其应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008060248A1 (en) * | 2006-11-15 | 2008-05-22 | S*Bio Pte Ltd. | Indole sustituted pyrimidines and use thereof in the treatment of cancer |
| JP2009515954A (ja) * | 2005-11-16 | 2009-04-16 | エス＊バイオ プライベート リミティッド | 酸素結合−ピリミジン誘導体 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0805477D0 (en) * | 2008-03-26 | 2008-04-30 | Univ Nottingham | Pyrimidines triazines and their use as pharmaceutical agents |
-
2014
- 2014-09-02 FR FR1458203A patent/FR3025199B1/fr not_active Expired - Fee Related
-
2015
- 2015-09-02 HU HUE15757283A patent/HUE040648T2/hu unknown
- 2015-09-02 TR TR2018/13294T patent/TR201813294T4/tr unknown
- 2015-09-02 RU RU2017108932A patent/RU2017108932A/ru not_active Application Discontinuation
- 2015-09-02 CN CN201580054324.6A patent/CN106795173B/zh not_active Expired - Fee Related
- 2015-09-02 JP JP2017511998A patent/JP2017532299A/ja active Pending
- 2015-09-02 ES ES15757283.5T patent/ES2686828T3/es active Active
- 2015-09-02 DK DK15757283.5T patent/DK3189060T3/en active
- 2015-09-02 WO PCT/EP2015/070066 patent/WO2016034634A1/fr not_active Ceased
- 2015-09-02 PL PL15757283T patent/PL3189060T3/pl unknown
- 2015-09-02 US US15/508,218 patent/US20170281622A1/en not_active Abandoned
- 2015-09-02 MX MX2017002627A patent/MX2017002627A/es unknown
- 2015-09-02 EP EP15757283.5A patent/EP3189060B1/fr not_active Not-in-force
- 2015-09-02 BR BR112017003881A patent/BR112017003881A2/pt not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009515954A (ja) * | 2005-11-16 | 2009-04-16 | エス＊バイオ プライベート リミティッド | 酸素結合−ピリミジン誘導体 |
| JP2009517344A (ja) * | 2005-11-16 | 2009-04-30 | エス＊バイオ プライベート リミティッド | ヘテロアルキル結合ピリミジン誘導体 |
| WO2008060248A1 (en) * | 2006-11-15 | 2008-05-22 | S*Bio Pte Ltd. | Indole sustituted pyrimidines and use thereof in the treatment of cancer |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023528394A (ja) * | 2020-05-27 | 2023-07-04 | バイオポーラー ホンイェ（グアンドン）ファーマシューティカル カンパニー リミテッド | 大環状ｊａｋ阻害剤およびその適用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3189060B1 (fr) | 2018-06-20 |
| CN106795173A (zh) | 2017-05-31 |
| ES2686828T3 (es) | 2018-10-22 |
| WO2016034634A1 (fr) | 2016-03-10 |
| US20170281622A1 (en) | 2017-10-05 |
| RU2017108932A3 (enExample) | 2019-01-23 |
| PL3189060T3 (pl) | 2019-03-29 |
| BR112017003881A2 (pt) | 2017-12-26 |
| TR201813294T4 (tr) | 2018-11-21 |
| EP3189060A1 (fr) | 2017-07-12 |
| DK3189060T3 (en) | 2018-10-01 |
| RU2017108932A (ru) | 2018-10-03 |
| FR3025199A1 (fr) | 2016-03-04 |
| CN106795173B (zh) | 2019-05-31 |
| FR3025199B1 (fr) | 2016-09-23 |
| MX2017002627A (es) | 2017-09-19 |
| HUE040648T2 (hu) | 2019-03-28 |
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