TR201813294T4 - N-aril-2-amino-4-aril-pirimidin makrosi̇kli̇k poli̇eter türevleri̇ ve bunlarin flt3 ve jak i̇nhi̇bi̇törleri̇ olarak kullanimlari. - Google Patents
N-aril-2-amino-4-aril-pirimidin makrosi̇kli̇k poli̇eter türevleri̇ ve bunlarin flt3 ve jak i̇nhi̇bi̇törleri̇ olarak kullanimlari. Download PDFInfo
- Publication number
- TR201813294T4 TR201813294T4 TR2018/13294T TR201813294T TR201813294T4 TR 201813294 T4 TR201813294 T4 TR 201813294T4 TR 2018/13294 T TR2018/13294 T TR 2018/13294T TR 201813294 T TR201813294 T TR 201813294T TR 201813294 T4 TR201813294 T4 TR 201813294T4
- Authority
- TR
- Turkey
- Prior art keywords
- aril
- pirimidine
- polyeter
- jac
- flt3
- Prior art date
Links
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 title 1
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1458203A FR3025199B1 (fr) | 2014-09-02 | 2014-09-02 | Derives de n-aryl-2-amino-4-aryl-pyrimidines polyethers macrocycliques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201813294T4 true TR201813294T4 (tr) | 2018-11-21 |
Family
ID=51842564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2018/13294T TR201813294T4 (tr) | 2014-09-02 | 2015-09-02 | N-aril-2-amino-4-aril-pirimidin makrosi̇kli̇k poli̇eter türevleri̇ ve bunlarin flt3 ve jak i̇nhi̇bi̇törleri̇ olarak kullanimlari. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20170281622A1 (enExample) |
| EP (1) | EP3189060B1 (enExample) |
| JP (1) | JP2017532299A (enExample) |
| CN (1) | CN106795173B (enExample) |
| BR (1) | BR112017003881A2 (enExample) |
| DK (1) | DK3189060T3 (enExample) |
| ES (1) | ES2686828T3 (enExample) |
| FR (1) | FR3025199B1 (enExample) |
| HU (1) | HUE040648T2 (enExample) |
| MX (1) | MX2017002627A (enExample) |
| PL (1) | PL3189060T3 (enExample) |
| RU (1) | RU2017108932A (enExample) |
| TR (1) | TR201813294T4 (enExample) |
| WO (1) | WO2016034634A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230150940A1 (en) * | 2020-04-18 | 2023-05-18 | Inipharm, Inc. | Hsd17b13 inhibitors and uses thereof |
| CN113735879B (zh) * | 2020-05-27 | 2022-05-17 | 百极弘烨（广东）医药科技有限公司 | 一种大环jak抑制剂及其应用 |
| CN113735856A (zh) * | 2020-05-29 | 2021-12-03 | 百极弘烨(南通)医药科技有限公司 | 大环jak抑制剂及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8143255B2 (en) * | 2005-11-16 | 2012-03-27 | S*Bio Pte Ltd. | Heteroalkyl linked pyrimidine derivatives |
| WO2008060248A1 (en) * | 2006-11-15 | 2008-05-22 | S*Bio Pte Ltd. | Indole sustituted pyrimidines and use thereof in the treatment of cancer |
| GB0805477D0 (en) * | 2008-03-26 | 2008-04-30 | Univ Nottingham | Pyrimidines triazines and their use as pharmaceutical agents |
-
2014
- 2014-09-02 FR FR1458203A patent/FR3025199B1/fr not_active Expired - Fee Related
-
2015
- 2015-09-02 HU HUE15757283A patent/HUE040648T2/hu unknown
- 2015-09-02 TR TR2018/13294T patent/TR201813294T4/tr unknown
- 2015-09-02 RU RU2017108932A patent/RU2017108932A/ru not_active Application Discontinuation
- 2015-09-02 CN CN201580054324.6A patent/CN106795173B/zh not_active Expired - Fee Related
- 2015-09-02 JP JP2017511998A patent/JP2017532299A/ja active Pending
- 2015-09-02 ES ES15757283.5T patent/ES2686828T3/es active Active
- 2015-09-02 DK DK15757283.5T patent/DK3189060T3/en active
- 2015-09-02 WO PCT/EP2015/070066 patent/WO2016034634A1/fr not_active Ceased
- 2015-09-02 PL PL15757283T patent/PL3189060T3/pl unknown
- 2015-09-02 US US15/508,218 patent/US20170281622A1/en not_active Abandoned
- 2015-09-02 MX MX2017002627A patent/MX2017002627A/es unknown
- 2015-09-02 EP EP15757283.5A patent/EP3189060B1/fr not_active Not-in-force
- 2015-09-02 BR BR112017003881A patent/BR112017003881A2/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP3189060B1 (fr) | 2018-06-20 |
| JP2017532299A (ja) | 2017-11-02 |
| CN106795173A (zh) | 2017-05-31 |
| ES2686828T3 (es) | 2018-10-22 |
| WO2016034634A1 (fr) | 2016-03-10 |
| US20170281622A1 (en) | 2017-10-05 |
| RU2017108932A3 (enExample) | 2019-01-23 |
| PL3189060T3 (pl) | 2019-03-29 |
| BR112017003881A2 (pt) | 2017-12-26 |
| EP3189060A1 (fr) | 2017-07-12 |
| DK3189060T3 (en) | 2018-10-01 |
| RU2017108932A (ru) | 2018-10-03 |
| FR3025199A1 (fr) | 2016-03-04 |
| CN106795173B (zh) | 2019-05-31 |
| FR3025199B1 (fr) | 2016-09-23 |
| MX2017002627A (es) | 2017-09-19 |
| HUE040648T2 (hu) | 2019-03-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA033544B1 (ru) | Производные пиридона в качестве ингибиторов киназы, реаранжированной во время трансфекции (ret) | |
| MD20170016A2 (ro) | Compuşi aminopirimidinici ca inhibitori JAK | |
| PH12016501972A1 (en) | Bicyclic-fused heteroaryl or aryl compounds and their use as irak4 inhibitors | |
| ZA201606320B (en) | Human plasma kallikrein inhibitors | |
| EA201791256A1 (ru) | Производные хиназолина, применяемые для лечения вич | |
| MX2015017201A (es) | Derivados de pirazolopiridina para uso en el tratamiento del cancer de vejiga. | |
| PH12016502378A1 (en) | Substituted dihydroisoquinolinone compounds | |
| EA201791304A1 (ru) | Производные изохинолина для лечения вич | |
| PH12018500061A1 (en) | Oxysterols and methods of use thereof | |
| EA201891063A1 (ru) | Производные дигидроимидазопиразинона, применимые в лечении рака | |
| TW201613864A (en) | Novel compounds | |
| MY181641A (en) | Amino pyran ring derivative and composition and use thereof | |
| PH12018500378B1 (en) | Novel annelated phenoxyacetamides | |
| MX2016003522A (es) | Derivados de quinazolinas y su uso como inhibidores de la adn metiltransferasa. | |
| PH12018501709A1 (en) | Naphthridinedione derivatives | |
| TR201819805T4 (tr) | Flavaglin türevleri̇. | |
| MX2015013224A (es) | Inhibidores macrociclicos y biciclicos del virus de la hepatitis c. | |
| TR201813294T4 (tr) | N-aril-2-amino-4-aril-pirimidin makrosi̇kli̇k poli̇eter türevleri̇ ve bunlarin flt3 ve jak i̇nhi̇bi̇törleri̇ olarak kullanimlari. | |
| EA201792265A1 (ru) | Способы лечения сердечно-сосудистых заболеваний | |
| MX2015012153A (es) | Inhibidores de la quinasa pirrolopirimidina cdk9. | |
| MX2017002544A (es) | Derivados de isoquinolinona utiles en el tratamiento contra el cancer. | |
| MX2017002747A (es) | Derivados de polieteres macrociclicos de n-aril-triciclopirimidin- 2-amino como inhibidores de ftl3 y jak. |