JP2017531430A5 - - Google Patents
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- JP2017531430A5 JP2017531430A5 JP2017518478A JP2017518478A JP2017531430A5 JP 2017531430 A5 JP2017531430 A5 JP 2017531430A5 JP 2017518478 A JP2017518478 A JP 2017518478A JP 2017518478 A JP2017518478 A JP 2017518478A JP 2017531430 A5 JP2017531430 A5 JP 2017531430A5
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- Prior art keywords
- car
- imp
- inhibitory
- dimerization
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- Prior art date
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- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 25
- 238000006471 dimerization reaction Methods 0.000 claims 23
- 210000002865 immune cell Anatomy 0.000 claims 20
- 230000002401 inhibitory effect Effects 0.000 claims 19
- 238000000034 method Methods 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 8
- 230000009977 dual effect Effects 0.000 claims 7
- 230000011664 signaling Effects 0.000 claims 6
- 102000018697 Membrane Proteins Human genes 0.000 claims 5
- 108010052285 Membrane Proteins Proteins 0.000 claims 5
- 230000003834 intracellular effect Effects 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 230000004913 activation Effects 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 108010089791 Eukaryotic Initiation Factor-2 Proteins 0.000 claims 2
- 102100027327 Eukaryotic translation initiation factor 2 subunit 2 Human genes 0.000 claims 2
- -1 SMAD10 Proteins 0.000 claims 2
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- CDKIEBFIMCSCBB-UHFFFAOYSA-N 1-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)-3-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one;hydrochloride Chemical compound Cl.C1C=2C=C(OC)C(OC)=CC=2CCN1C(=O)C=CC(C1=CC=CN=C1N1C)=C1C1=CC=CC=C1 CDKIEBFIMCSCBB-UHFFFAOYSA-N 0.000 claims 1
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 1
- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 claims 1
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 1
- 102100022970 Basic leucine zipper transcriptional factor ATF-like Human genes 0.000 claims 1
- 101000964894 Bos taurus 14-3-3 protein zeta/delta Proteins 0.000 claims 1
- 102100024263 CD160 antigen Human genes 0.000 claims 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 108090000397 Caspase 3 Proteins 0.000 claims 1
- 102100026549 Caspase-10 Human genes 0.000 claims 1
- 102100029855 Caspase-3 Human genes 0.000 claims 1
- 102100038918 Caspase-6 Human genes 0.000 claims 1
- 102100038902 Caspase-7 Human genes 0.000 claims 1
- 102100026548 Caspase-8 Human genes 0.000 claims 1
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 1
- 102100027816 Cytotoxic and regulatory T-cell molecule Human genes 0.000 claims 1
- 101000809594 Escherichia coli (strain K12) Shikimate kinase 1 Proteins 0.000 claims 1
- 102100026693 FAS-associated death domain protein Human genes 0.000 claims 1
- 102100027581 Forkhead box protein P3 Human genes 0.000 claims 1
- 102100040754 Guanylate cyclase soluble subunit alpha-1 Human genes 0.000 claims 1
- 102100040735 Guanylate cyclase soluble subunit alpha-2 Human genes 0.000 claims 1
- 102100040739 Guanylate cyclase soluble subunit beta-1 Human genes 0.000 claims 1
- 102100028963 Guanylate cyclase soluble subunit beta-2 Human genes 0.000 claims 1
- 101150046249 Havcr2 gene Proteins 0.000 claims 1
- 102100028008 Heme oxygenase 2 Human genes 0.000 claims 1
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 1
- 102100035081 Homeobox protein TGIF1 Human genes 0.000 claims 1
- 101000824278 Homo sapiens Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 claims 1
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 1
- 101000903742 Homo sapiens Basic leucine zipper transcriptional factor ATF-like Proteins 0.000 claims 1
- 101000761938 Homo sapiens CD160 antigen Proteins 0.000 claims 1
- 101000983518 Homo sapiens Caspase-10 Proteins 0.000 claims 1
- 101000741087 Homo sapiens Caspase-6 Proteins 0.000 claims 1
- 101000741014 Homo sapiens Caspase-7 Proteins 0.000 claims 1
- 101000983528 Homo sapiens Caspase-8 Proteins 0.000 claims 1
- 101000911074 Homo sapiens FAS-associated death domain protein Proteins 0.000 claims 1
- 101000861452 Homo sapiens Forkhead box protein P3 Proteins 0.000 claims 1
- 101001038755 Homo sapiens Guanylate cyclase soluble subunit alpha-1 Proteins 0.000 claims 1
- 101001038749 Homo sapiens Guanylate cyclase soluble subunit alpha-2 Proteins 0.000 claims 1
- 101001038731 Homo sapiens Guanylate cyclase soluble subunit beta-1 Proteins 0.000 claims 1
- 101001059095 Homo sapiens Guanylate cyclase soluble subunit beta-2 Proteins 0.000 claims 1
- 101001079615 Homo sapiens Heme oxygenase 2 Proteins 0.000 claims 1
- 101000596925 Homo sapiens Homeobox protein TGIF1 Proteins 0.000 claims 1
- 101001083151 Homo sapiens Interleukin-10 receptor subunit alpha Proteins 0.000 claims 1
- 101001003149 Homo sapiens Interleukin-10 receptor subunit beta Proteins 0.000 claims 1
- 101000599048 Homo sapiens Interleukin-6 receptor subunit alpha Proteins 0.000 claims 1
- 101000599056 Homo sapiens Interleukin-6 receptor subunit beta Proteins 0.000 claims 1
- 101001138062 Homo sapiens Leukocyte-associated immunoglobulin-like receptor 1 Proteins 0.000 claims 1
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 1
- 101001091194 Homo sapiens Peptidyl-prolyl cis-trans isomerase G Proteins 0.000 claims 1
- 101000692259 Homo sapiens Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Proteins 0.000 claims 1
- 101001068027 Homo sapiens Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Proteins 0.000 claims 1
- 101001068019 Homo sapiens Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Proteins 0.000 claims 1
- 101000836954 Homo sapiens Sialic acid-binding Ig-like lectin 10 Proteins 0.000 claims 1
- 101000863882 Homo sapiens Sialic acid-binding Ig-like lectin 7 Proteins 0.000 claims 1
- 101000863883 Homo sapiens Sialic acid-binding Ig-like lectin 9 Proteins 0.000 claims 1
- 101000688930 Homo sapiens Signaling threshold-regulating transmembrane adapter 1 Proteins 0.000 claims 1
- 101000863692 Homo sapiens Ski oncogene Proteins 0.000 claims 1
- 101000688996 Homo sapiens Ski-like protein Proteins 0.000 claims 1
- 101000740162 Homo sapiens Sodium- and chloride-dependent transporter XTRP3 Proteins 0.000 claims 1
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 1
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims 1
- 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 claims 1
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims 1
- 101001135589 Homo sapiens Tyrosine-protein phosphatase non-receptor type 22 Proteins 0.000 claims 1
- 101000617285 Homo sapiens Tyrosine-protein phosphatase non-receptor type 6 Proteins 0.000 claims 1
- 102100030236 Interleukin-10 receptor subunit alpha Human genes 0.000 claims 1
- 102100020788 Interleukin-10 receptor subunit beta Human genes 0.000 claims 1
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 claims 1
- 102100037795 Interleukin-6 receptor subunit beta Human genes 0.000 claims 1
- 102000017578 LAG3 Human genes 0.000 claims 1
- 102100020943 Leukocyte-associated immunoglobulin-like receptor 1 Human genes 0.000 claims 1
- 102100025751 Mothers against decapentaplegic homolog 2 Human genes 0.000 claims 1
- 101710143123 Mothers against decapentaplegic homolog 2 Proteins 0.000 claims 1
- 102100025748 Mothers against decapentaplegic homolog 3 Human genes 0.000 claims 1
- 101710143111 Mothers against decapentaplegic homolog 3 Proteins 0.000 claims 1
- 102100025725 Mothers against decapentaplegic homolog 4 Human genes 0.000 claims 1
- 101710143112 Mothers against decapentaplegic homolog 4 Proteins 0.000 claims 1
- 102100024894 PR domain zinc finger protein 1 Human genes 0.000 claims 1
- 102100026066 Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Human genes 0.000 claims 1
- 108010009975 Positive Regulatory Domain I-Binding Factor 1 Proteins 0.000 claims 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 1
- 102100034464 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Human genes 0.000 claims 1
- 102100034470 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Human genes 0.000 claims 1
- 102100027164 Sialic acid-binding Ig-like lectin 10 Human genes 0.000 claims 1
- 102100029946 Sialic acid-binding Ig-like lectin 7 Human genes 0.000 claims 1
- 102100029965 Sialic acid-binding Ig-like lectin 9 Human genes 0.000 claims 1
- 102100024453 Signaling threshold-regulating transmembrane adapter 1 Human genes 0.000 claims 1
- 102100029969 Ski oncogene Human genes 0.000 claims 1
- 102100024451 Ski-like protein Human genes 0.000 claims 1
- 101000987219 Sus scrofa Pregnancy-associated glycoprotein 1 Proteins 0.000 claims 1
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 1
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 108091007178 TNFRSF10A Proteins 0.000 claims 1
- 102000018679 Tacrolimus Binding Proteins Human genes 0.000 claims 1
- 108010027179 Tacrolimus Binding Proteins Proteins 0.000 claims 1
- 102100040113 Tumor necrosis factor receptor superfamily member 10A Human genes 0.000 claims 1
- 102100040112 Tumor necrosis factor receptor superfamily member 10B Human genes 0.000 claims 1
- 102100033138 Tyrosine-protein phosphatase non-receptor type 22 Human genes 0.000 claims 1
- 102100021657 Tyrosine-protein phosphatase non-receptor type 6 Human genes 0.000 claims 1
- 108010072917 class-I restricted T cell-associated molecule Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000005931 immune cell recruitment Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201470623 | 2014-10-07 | ||
| DKPA201470623 | 2014-10-07 | ||
| PCT/EP2015/073197 WO2016055551A1 (en) | 2014-10-07 | 2015-10-07 | Method for modulating car-induced immune cells activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017531430A JP2017531430A (ja) | 2017-10-26 |
| JP2017531430A5 true JP2017531430A5 (cg-RX-API-DMAC7.html) | 2018-11-08 |
Family
ID=51730284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518478A Pending JP2017531430A (ja) | 2014-10-07 | 2015-10-07 | Ｃａｒによって誘導される免疫細胞の活性を調節するための方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10472613B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3204491A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2017531430A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20170068539A (cg-RX-API-DMAC7.html) |
| CN (1) | CN107109368A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015330017A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112017007003A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2963327A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL251429A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2017004603A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2017115808A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016055551A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (77)
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| PL3300745T3 (pl) | 2013-02-15 | 2020-03-31 | The Regents Of The University Of California | Chimeryczny receptor antygenowy i sposoby jego zastosowania |
| EP4400516A1 (en) | 2014-12-15 | 2024-07-17 | The Regents of the University of California | Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20 |
| JP6895380B2 (ja) | 2015-02-06 | 2021-06-30 | ナショナル ユニバーシティ オブ シンガポール | 治療免疫細胞の有効性を改良するための方法 |
| US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
| CN114634943A (zh) | 2015-05-18 | 2022-06-17 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
| SG10202002131PA (en) | 2015-05-21 | 2020-05-28 | Harpoon Therapeutics Inc | Trispecific binding proteins and methods of use |
| TW202444897A (zh) * | 2015-06-25 | 2024-11-16 | 美商生物細胞基因治療有限公司 | 嵌合抗原受體(car)、組合物及其使用方法 |
| US20210206826A1 (en) * | 2015-11-19 | 2021-07-08 | The Regents Of The University Of California | Conditionally repressible immune cell receptors and methods of use thereof |
| SG10201913805RA (en) * | 2016-01-08 | 2020-03-30 | Univ California | Conditionally active heterodimeric polypeptides and methods of use thereof |
| WO2017192536A1 (en) | 2016-05-02 | 2017-11-09 | University Of Kansas | Eliminating mhc restriction from the t cell receptor as a strategy for immunotherapy |
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| US20190038733A1 (en) | 2017-08-10 | 2019-02-07 | National University Of Singapore | T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof |
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| US12433954B2 (en) | 2020-05-01 | 2025-10-07 | Massachusetts Institute Of Technology | Methods of activating anti-CD19 chimeric antigen receptor (CAR) T cells using amphiphilic ligand conjugates comprising CAR-targeting protein sequence motifs |
| US12286465B2 (en) | 2020-05-28 | 2025-04-29 | Miltenyi Biotec B.V. & Co. KG | Chimeric antigen receptor with a spacer comprising C2-set Ig-like domains |
| CN112080527A (zh) * | 2020-09-16 | 2020-12-15 | 南京市第一医院 | 重组表达载体、耗竭减少的嵌合抗原受体t细胞及其应用 |
| GB2617474A (en) | 2020-11-04 | 2023-10-11 | Myeloid Therapeutics Inc | Engineered chimeric fusion protein compositions and methods of use thereof |
| WO2022096664A1 (en) | 2020-11-09 | 2022-05-12 | Miltenyi Biotec B.V. & Co. KG | Methods and compositions for eliminating engineered immune cells |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス，インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
| WO2022165378A1 (en) * | 2021-01-29 | 2022-08-04 | Outpace Bio, Inc. | Small molecule-regulated cell signaling expression system |
| GB2623191A (en) | 2021-03-17 | 2024-04-10 | Myeloid Therapeutics Inc | Engineered chimeric fusion protein compositions and methods of use thereof |
| GB2623653A (en) | 2021-05-11 | 2024-04-24 | Myeloid Therapeutics Inc | Methods and compositions for genomic integration |
| US20250235477A1 (en) | 2021-10-06 | 2025-07-24 | Miltenyi Biotec B.V. & Co. KG | Method for targeted gene insertion into immune cells |
| WO2023081715A1 (en) | 2021-11-03 | 2023-05-11 | Viracta Therapeutics, Inc. | Combination of car t-cell therapy with btk inhibitors and methods of use thereof |
| WO2024078995A1 (en) | 2022-10-15 | 2024-04-18 | Miltenyi Biotec B.V. & Co. KG | Transduction of gammadelta t cells with pseudotyped retroviral vectors |
| JP2025535365A (ja) * | 2022-10-18 | 2025-10-24 | カイト ファーマ インコーポレイテッド | Ｉｌ１８と結合した新規ｃｄ１９結合体を含むｃａｒ－ｔ構築物およびその使用方法 |
| CN116023507A (zh) * | 2022-10-25 | 2023-04-28 | 中国医学科学院基础医学研究所 | 嵌合抗原受体巨噬细胞在实体肿瘤免疫治疗中的应用 |
| WO2024227145A1 (en) * | 2023-04-27 | 2024-10-31 | Memorial Sloan-Kettering Cancer Center | Enhanced fusion polypeptide for immunotherapy |
| KR102764613B1 (ko) * | 2024-03-28 | 2025-02-12 | 한양대학교 에리카산학협력단 | NaPi2b 특이적 CAR-T를 포함하는 난소암 치료용 약학 조성물 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| PL3300745T3 (pl) * | 2013-02-15 | 2020-03-31 | The Regents Of The University Of California | Chimeryczny receptor antygenowy i sposoby jego zastosowania |
| CN105339498A (zh) | 2013-03-07 | 2016-02-17 | 贝勒医学院 | 癌症中靶向cd138 |
| AU2014240083C1 (en) | 2013-03-15 | 2019-10-24 | Celgene Corporation | Modified T lymphocytes |
| EP2970426B1 (en) | 2013-03-15 | 2019-08-28 | Michael C. Milone | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| UY35468A (es) * | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
-
2015
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- 2015-10-07 RU RU2017115808A patent/RU2017115808A/ru not_active Application Discontinuation
- 2015-10-07 JP JP2017518478A patent/JP2017531430A/ja active Pending
- 2015-10-07 CN CN201580066604.9A patent/CN107109368A/zh active Pending
- 2015-10-07 MX MX2017004603A patent/MX2017004603A/es unknown
- 2015-10-07 KR KR1020177012493A patent/KR20170068539A/ko not_active Withdrawn
- 2015-10-07 BR BR112017007003A patent/BR112017007003A2/pt not_active IP Right Cessation
- 2015-10-07 US US15/517,708 patent/US10472613B2/en active Active
- 2015-10-07 AU AU2015330017A patent/AU2015330017A1/en not_active Abandoned
- 2015-10-07 WO PCT/EP2015/073197 patent/WO2016055551A1/en not_active Ceased
- 2015-10-07 EP EP15778276.4A patent/EP3204491A1/en not_active Withdrawn
-
2017
- 2017-03-28 IL IL251429A patent/IL251429A0/en unknown
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