JP2017529841A5 - - Google Patents
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- Publication number
- JP2017529841A5 JP2017529841A5 JP2017515087A JP2017515087A JP2017529841A5 JP 2017529841 A5 JP2017529841 A5 JP 2017529841A5 JP 2017515087 A JP2017515087 A JP 2017515087A JP 2017515087 A JP2017515087 A JP 2017515087A JP 2017529841 A5 JP2017529841 A5 JP 2017529841A5
- Authority
- JP
- Japan
- Prior art keywords
- region gene
- constant region
- car
- genetically modified
- locus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462052947P | 2014-09-19 | 2014-09-19 | |
| US201462052901P | 2014-09-19 | 2014-09-19 | |
| US62/052,901 | 2014-09-19 | ||
| US62/052,947 | 2014-09-19 | ||
| US201462076836P | 2014-11-07 | 2014-11-07 | |
| US62/076,836 | 2014-11-07 | ||
| US201462094603P | 2014-12-19 | 2014-12-19 | |
| US62/094,603 | 2014-12-19 | ||
| US201562167650P | 2015-05-28 | 2015-05-28 | |
| US62/167,650 | 2015-05-28 | ||
| PCT/US2015/050975 WO2016044745A1 (en) | 2014-09-19 | 2015-09-18 | Chimeric antigen receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017529841A JP2017529841A (ja) | 2017-10-12 |
| JP2017529841A5 true JP2017529841A5 (https=) | 2018-10-25 |
Family
ID=54261082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515087A Pending JP2017529841A (ja) | 2014-09-19 | 2015-09-18 | キメラ抗原受容体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20160081314A1 (https=) |
| EP (1) | EP3193592A1 (https=) |
| JP (1) | JP2017529841A (https=) |
| KR (1) | KR20170083534A (https=) |
| CN (1) | CN107072184A (https=) |
| AU (1) | AU2015317370A1 (https=) |
| BR (1) | BR112017005245A2 (https=) |
| CA (1) | CA2959428A1 (https=) |
| IL (1) | IL250536A0 (https=) |
| MX (1) | MX2017003640A (https=) |
| RU (1) | RU2017113134A (https=) |
| SG (1) | SG11201701040XA (https=) |
| WO (1) | WO2016044745A1 (https=) |
Families Citing this family (65)
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| EP3569313A1 (en) | 2013-03-15 | 2019-11-20 | GPB Scientific, LLC | On-chip microfluidic processing of particles |
| US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
| CN112094347A (zh) * | 2014-03-05 | 2020-12-18 | 奥托路斯有限公司 | 具有针对T细胞受体beta恒定区的抗原结合域的嵌合抗原受体(CAR) |
| US11385233B2 (en) | 2015-03-05 | 2022-07-12 | Autolus Limited | Methods of depleting malignant T-cells |
| US20230027993A1 (en) | 2014-03-05 | 2023-01-26 | Autolus Limited | Methods |
| FR3029449B1 (fr) * | 2014-12-03 | 2017-10-13 | Pole De Plasturgie De Lest | Dispositif de moulage pour la fabrication de pieces en materiau composite a partir de resine polymere liquide. |
| KR102530821B1 (ko) * | 2014-12-19 | 2023-05-10 | 리제너론 파마슈티칼스 인코포레이티드 | 단일 단계 다중 표적화를 통한 표적화된 유전자 변형을 위한 방법 및 조성물 |
| CN107667173A (zh) | 2015-05-06 | 2018-02-06 | 斯尼普技术有限公司 | 改变微生物种群和改善微生物群 |
| US10976232B2 (en) | 2015-08-24 | 2021-04-13 | Gpb Scientific, Inc. | Methods and devices for multi-step cell purification and concentration |
| CN117070468A (zh) | 2015-10-05 | 2023-11-17 | 精密生物科学公司 | 包含经修饰的人T细胞受体α恒定区基因的经遗传修饰的细胞 |
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| KR20200068750A (ko) | 2016-04-01 | 2020-06-15 | 카이트 파마 인코포레이티드 | 키메라 수용체 및 그의 사용 방법 |
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| HUE061619T2 (hu) * | 2016-06-03 | 2023-07-28 | Regeneron Pharma | Exogén terminális dezoxinukleotid-transzferázt expresszáló rágcsálók |
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| JP7500195B2 (ja) | 2016-08-23 | 2024-06-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法 |
| WO2018075586A1 (en) * | 2016-10-18 | 2018-04-26 | Memorial Sloan-Kettering Cancer Center | Antigen-binding proteins targeting melanoma differentiation antigens and uses thereof |
| CN110352068A (zh) | 2016-12-02 | 2019-10-18 | 南加利福尼亚大学 | 合成的免疫受体及其使用方法 |
| AR110424A1 (es) | 2016-12-23 | 2019-03-27 | Macrogenics Inc | Moléculas de unión a adam9 y métodos de uso de las mismas |
| US20190359678A1 (en) | 2017-02-09 | 2019-11-28 | The Regents Of The University Of California | Chimeric t cell antigen receptors and methods of use thereof |
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| CN111182790A (zh) | 2017-07-31 | 2020-05-19 | 瑞泽恩制药公司 | Crispr报告体非人类动物及其用途 |
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| US11851663B2 (en) | 2018-10-14 | 2023-12-26 | Snipr Biome Aps | Single-vector type I vectors |
| KR102840400B1 (ko) | 2018-12-12 | 2025-08-04 | 카이트 파마 인코포레이티드 | 키메라 항원 수용체 및 car-t 세포 및 사용 방법 |
| US20220089672A1 (en) * | 2018-12-27 | 2022-03-24 | Kyoto University | T-cell receptor modified object |
| ES2966625T3 (es) | 2019-04-04 | 2024-04-23 | Regeneron Pharma | Roedores que comprenden un locus del factor de coagulación 12 humanizado |
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| US11622547B2 (en) | 2019-06-07 | 2023-04-11 | Regeneran Pharmaceuticals, Inc. | Genetically modified mouse that expresses human albumin |
| MA56468A (fr) | 2019-07-03 | 2022-05-11 | Regeneron Pharma | Protéines de liaison à l'antigène de carcinome 1 à cellules squameuses de l'oesophage anti-new york (ny-eso-1) et leurs procédés d'utilisation |
| US20220267726A1 (en) | 2019-07-18 | 2022-08-25 | Gpb Scientific, Inc. | Ordered processing of blood products to produce therapeutically active cells |
| CA3154287A1 (en) * | 2019-09-12 | 2021-03-18 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| US20230028754A1 (en) | 2019-12-28 | 2023-01-26 | Gpb Scientific, Inc. | Microfluidic cartridges for processing particles and cells |
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| EP4100027A1 (en) * | 2020-02-04 | 2022-12-14 | Miltenyi Biotec B.V. & Co. KG | Immune cell expressing adapter chimeric antigen receptor for sensing soluble antigens |
| CN111320703A (zh) * | 2020-03-11 | 2020-06-23 | 北京双赢科创生物科技有限公司 | 靶向cd22的嵌合抗原受体及其应用 |
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| CN118632622A (zh) | 2021-12-08 | 2024-09-10 | 瑞泽恩制药公司 | 突变型肌纤蛋白疾病模型及其用途 |
| EP4215042A1 (en) * | 2022-01-21 | 2023-07-26 | Max-Delbrück-Centrum für Molekulare Medizin | A non-human mammal comprising in its genome at least two human leukocyte antigen (hla) class i alleles, methods of making such mammal and uses thereof |
| GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
| CN116138212B (zh) * | 2023-01-11 | 2024-03-05 | 江苏省中医院 | 一种制备细胞因子释放综合征小鼠模型的方法及应用 |
| CN118460446B (zh) * | 2024-07-12 | 2024-11-15 | 内蒙古自治区农牧业科学院 | 一种支原体突变株及其制备方法与应用 |
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2015
- 2015-09-18 CA CA2959428A patent/CA2959428A1/en not_active Abandoned
- 2015-09-18 CN CN201580050602.0A patent/CN107072184A/zh active Pending
- 2015-09-18 US US14/858,597 patent/US20160081314A1/en not_active Abandoned
- 2015-09-18 SG SG11201701040XA patent/SG11201701040XA/en unknown
- 2015-09-18 MX MX2017003640A patent/MX2017003640A/es unknown
- 2015-09-18 AU AU2015317370A patent/AU2015317370A1/en not_active Abandoned
- 2015-09-18 KR KR1020177010023A patent/KR20170083534A/ko not_active Withdrawn
- 2015-09-18 WO PCT/US2015/050975 patent/WO2016044745A1/en not_active Ceased
- 2015-09-18 EP EP15775854.1A patent/EP3193592A1/en not_active Withdrawn
- 2015-09-18 JP JP2017515087A patent/JP2017529841A/ja active Pending
- 2015-09-18 BR BR112017005245A patent/BR112017005245A2/pt not_active Application Discontinuation
- 2015-09-18 RU RU2017113134A patent/RU2017113134A/ru not_active Application Discontinuation
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2017
- 2017-02-09 IL IL250536A patent/IL250536A0/en unknown
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