JP2017528418A5 - - Google Patents
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- JP2017528418A5 JP2017528418A5 JP2016574072A JP2016574072A JP2017528418A5 JP 2017528418 A5 JP2017528418 A5 JP 2017528418A5 JP 2016574072 A JP2016574072 A JP 2016574072A JP 2016574072 A JP2016574072 A JP 2016574072A JP 2017528418 A5 JP2017528418 A5 JP 2017528418A5
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- JP
- Japan
- Prior art keywords
- linker
- amino acid
- self
- antibody
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462015321P | 2014-06-20 | 2014-06-20 | |
| US62/015,321 | 2014-06-20 | ||
| PCT/US2015/036824 WO2015196167A1 (en) | 2014-06-20 | 2015-06-19 | Anti-folate receptor aplha (fra) antibody-drug conjugates and methods of using thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017528418A JP2017528418A (ja) | 2017-09-28 |
| JP2017528418A5 true JP2017528418A5 (OSRAM) | 2018-08-02 |
Family
ID=54936169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016574072A Pending JP2017528418A (ja) | 2014-06-20 | 2015-06-19 | 抗葉酸受容体アルファ（ｆｒａ）抗体−薬物コンジュゲート及びその使用方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9950077B2 (OSRAM) |
| EP (1) | EP3157960A4 (OSRAM) |
| JP (1) | JP2017528418A (OSRAM) |
| KR (1) | KR20170020868A (OSRAM) |
| CN (1) | CN106661124A (OSRAM) |
| AR (1) | AR100935A1 (OSRAM) |
| AU (1) | AU2015276821A1 (OSRAM) |
| BR (1) | BR112016029860A2 (OSRAM) |
| CA (1) | CA2952876A1 (OSRAM) |
| IL (1) | IL249442A0 (OSRAM) |
| MX (1) | MX2016016490A (OSRAM) |
| PH (1) | PH12016502524A1 (OSRAM) |
| RU (1) | RU2017101662A (OSRAM) |
| SG (1) | SG11201610620UA (OSRAM) |
| TW (1) | TWI654995B (OSRAM) |
| WO (1) | WO2015196167A1 (OSRAM) |
| ZA (1) | ZA201608779B (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI716339B (zh) | 2012-12-21 | 2021-01-21 | 荷蘭商台醫（有限合夥）公司 | 親水性自消耗連接子及彼等之共軛物 |
| AU2015276821A1 (en) | 2014-06-20 | 2017-01-12 | Abgenomics International Inc. | Anti-folate receptor aplha (FRA) antibody-drug conjugates and methods of using thereof |
| PL3313845T3 (pl) | 2015-06-29 | 2021-01-11 | Immunogen, Inc. | Koniugaty przeciwciał modyfikowanych cysteiną |
| ES2880731T3 (es) | 2016-01-08 | 2021-11-25 | Altrubio Inc | Anticuerpos anti-PSGL-1 tetravalentes y usos de los mismos |
| WO2018098258A2 (en) | 2016-11-23 | 2018-05-31 | Immunogen, Inc. | Selective sulfonation of benzodiazepine derivatives |
| CN107446020B (zh) * | 2017-07-28 | 2019-10-01 | 中国药科大学 | 叶酸受体α特异性结合肽2及其应用 |
| US10596270B2 (en) | 2017-09-18 | 2020-03-24 | Sutro Biopharma, Inc. | Anti-folate receptor antibody conjugates, compositions comprising anti-folate receptor antibody conjugates, and methods of making and using anti-folate receptor antibody conjugates |
| KR102808710B1 (ko) | 2018-03-13 | 2025-05-15 | 페인스 테라퓨틱스 인코포레이티드 | 항-폴레이트 수용체 1 항체 및 이의 용도 |
| CA3105415A1 (en) * | 2018-07-09 | 2020-01-23 | Multitude Inc. | Antibodies specific to folate receptor alpha |
| CN109053882B (zh) * | 2018-08-28 | 2019-08-23 | 东莞市朋志生物科技有限公司 | 一种ns1蛋白的结合蛋白以及应用 |
| WO2020060944A1 (en) * | 2018-09-17 | 2020-03-26 | Sutro Biopharma, Inc. | Combination therapies with anti-folate receptor antibody conjugates |
| US20230091510A1 (en) * | 2019-05-20 | 2023-03-23 | Novartis Ag | Antibody drug conjugates having linkers comprising hydrophilic groups |
| CN111393528B (zh) * | 2020-01-19 | 2023-01-31 | 中国药科大学 | 一种靶向叶酸受体α的单链抗体及其应用 |
| US11976120B2 (en) | 2020-06-01 | 2024-05-07 | Boehringer Ingelheim International Gmbh | Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use |
| US10981996B1 (en) | 2020-06-01 | 2021-04-20 | Abexxa Biologics, Inc. | Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use |
| US12036286B2 (en) | 2021-03-18 | 2024-07-16 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| CN112794911B (zh) * | 2021-04-14 | 2021-08-03 | 上海偌妥生物科技有限公司 | 人源化抗叶酸受体1抗体及其应用 |
| CN118696059A (zh) | 2021-11-17 | 2024-09-24 | 美国全心医药生技股份有限公司 | 使用抗psgl-1抗体与jak抑制剂的组合治疗t细胞介导的炎症性疾病或癌症的方法 |
| EP4601703A1 (en) | 2023-04-18 | 2025-08-20 | Astrazeneca AB | Conjugates comprising cleavable linkers |
| WO2025036307A1 (zh) * | 2023-08-11 | 2025-02-20 | 百奥泰生物制药股份有限公司 | 抗frα抗体药物偶联物在治疗疾病中的应用 |
Family Cites Families (88)
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|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5198560A (en) | 1990-04-27 | 1993-03-30 | Bristol-Myers Squibb Company | Cytotoxic bicyclo[7.3.1]tridec-4-ene-2,6-diyne compounds and process for the preparation thereof |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| CA2095633C (en) | 1990-12-03 | 2003-02-04 | Lisa J. Garrard | Enrichment method for variant proteins with altered binding properties |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| WO1996004925A1 (en) | 1994-08-12 | 1996-02-22 | Immunomedics, Inc. | Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells |
| US6548530B1 (en) | 1995-10-03 | 2003-04-15 | The Scripps Research Institute | CBI analogs of CC-1065 and the duocarmycins |
| EP0888301B1 (en) | 1996-03-08 | 2005-08-10 | The Scripps Research Institute | Mcbi analogs of cc-1065 and the duocarmycins |
| US6060608A (en) | 1996-05-31 | 2000-05-09 | The Scripps Research Institute | Analogs of CC-1065 and the duocarmycins |
| WO1998052925A1 (en) | 1997-05-22 | 1998-11-26 | The Scripps Research Institute | Analogs of duocarmycin and cc-1065 |
| NZ503966A (en) | 1997-10-14 | 2002-10-25 | Scripps Research Inst | iso -CBI and iso -CI analogs of CC-1065 and the duocarmycins |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| US20020106728A1 (en) | 2000-06-20 | 2002-08-08 | Genentech, Inc. | NS4 nucleic acids and polypeptides and methods of use for the treatment of body weight disorders |
| US6762020B1 (en) | 1999-03-15 | 2004-07-13 | Protein Design Labs, Inc. | Methods of diagnosing breast cancer |
| DE19926154A1 (de) | 1999-06-09 | 2000-12-14 | Ktb Tumorforschungs Gmbh | Verfahren zur Herstellung einer injizierbaren Arzneimittelzubereitung |
| US20070258987A1 (en) | 2000-11-28 | 2007-11-08 | Seattle Genetics, Inc. | Recombinant Anti-Cd30 Antibodies and Uses Thereof |
| US7090843B1 (en) | 2000-11-28 | 2006-08-15 | Seattle Genetics, Inc. | Recombinant anti-CD30 antibodies and uses thereof |
| EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
| US20030083263A1 (en) | 2001-04-30 | 2003-05-01 | Svetlana Doronina | Pentapeptide compounds and uses related thereto |
| US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US7256257B2 (en) | 2001-04-30 | 2007-08-14 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| KR100628425B1 (ko) | 2001-06-20 | 2006-09-28 | 제넨테크, 인크. | 종양의 진단 및 치료를 위한 방법 및 이를 위한 조성물 |
| US7091186B2 (en) | 2001-09-24 | 2006-08-15 | Seattle Genetics, Inc. | p-Amidobenzylethers in drug delivery agents |
| US7591994B2 (en) | 2002-12-13 | 2009-09-22 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
| US8877901B2 (en) | 2002-12-13 | 2014-11-04 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
| CA2481507A1 (en) | 2002-04-16 | 2003-10-30 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| PT2371392E (pt) | 2002-05-02 | 2015-10-07 | Wyeth Holdings Llc | Conjugados de derivado da caliqueamicina - transportador |
| US20090068178A1 (en) | 2002-05-08 | 2009-03-12 | Genentech, Inc. | Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin |
| SI2357006T1 (sl) | 2002-07-31 | 2016-01-29 | Seattle Genetics, Inc. | Konjugati zdravil in njihova uporaba za zdravljenje raka, avtoimunske bolezni ali infekcijske bolezni |
| AU2003282624A1 (en) | 2002-11-14 | 2004-06-03 | Syntarga B.V. | Prodrugs built as multiple self-elimination-release spacers |
| US8420086B2 (en) | 2002-12-13 | 2013-04-16 | Immunomedics, Inc. | Camptothecin conjugates of anti-CD22 antibodies for treatment of B cell diseases |
| US7332164B2 (en) | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
| BR122018071808B8 (pt) | 2003-11-06 | 2020-06-30 | Seattle Genetics Inc | conjugado |
| AU2005214331B2 (en) * | 2004-02-12 | 2011-09-15 | Eisai, Inc. | Monoclonal antibodies that specifically bind to folate receptor alpha |
| AU2005216251B2 (en) | 2004-02-23 | 2011-03-10 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
| EP2087910B1 (en) | 2004-03-23 | 2022-05-04 | Ascendis Pharma GmbH | Polymeric prodrugs |
| EP1740954B1 (en) | 2004-04-07 | 2015-08-19 | Genentech, Inc. | Mass spectrometry of antibody conjugates |
| RU2402548C2 (ru) | 2004-05-19 | 2010-10-27 | Медарекс, Инк. | Химические линкеры и их конъюгаты |
| CN101065151B (zh) | 2004-09-23 | 2014-12-10 | 健泰科生物技术公司 | 半胱氨酸改造的抗体和偶联物 |
| WO2008020827A2 (en) | 2005-08-01 | 2008-02-21 | Biogen Idec Ma Inc. | Altered polypeptides, immunoconjugates thereof, and methods related thereto |
| WO2007103288A2 (en) | 2006-03-02 | 2007-09-13 | Seattle Genetics, Inc. | Engineered antibody drug conjugates |
| HRP20140172T1 (hr) * | 2006-05-30 | 2014-03-28 | Genentech, Inc. | Protutijela i imunokonjugati kao i njihove uporabe |
| RU2461572C2 (ru) | 2006-06-07 | 2012-09-20 | Биоэллаенс К.В. | Антитела, распознающие содержащий углеводы эпитоп на cd-43 и сеа, экспрессируемых на злокачественных клетках, и способы их применения |
| CA2663375A1 (en) | 2006-09-15 | 2008-03-20 | Onconova Therapeutics, Inc. | Activated cytotoxic compounds for attachment to targeting molecules for the treatment of mammalian disease conditions |
| GB0619291D0 (en) | 2006-09-29 | 2006-11-08 | Ucb Sa | Altered antibodies |
| CA2699837C (en) | 2006-12-01 | 2017-06-13 | Seattle Genetics, Inc. | Variant target binding agents and uses thereof |
| TWI412367B (zh) | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
| EP2606911A1 (en) | 2007-02-16 | 2013-06-26 | KTB Tumorforschungsgesellschaft mbH | Receptor And Antigen Targeted Prodrug |
| RU2528738C2 (ru) | 2007-12-18 | 2014-09-20 | Биоэллаенс К.В. | Антитела, узнающие углеводсодержащий эпитоп на cd43 и сеа, экспрессируемых на раковых клетках и способы их применения |
| CN102083460A (zh) | 2008-01-18 | 2011-06-01 | 米迪缪尼有限公司 | 用于位点特异性偶联的半胱氨酸工程化抗体 |
| US8742076B2 (en) | 2008-02-01 | 2014-06-03 | Genentech, Inc. | Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods |
| CA2754531A1 (en) | 2009-03-06 | 2010-09-30 | Seattle Genetics, Inc. | Antibody drug conjugates (adc) that bind to 24p4c12 proteins |
| BRPI1013016A2 (pt) | 2009-06-04 | 2016-03-29 | Massachusetts Inst Technology | "métodos para identificação de locais para conjugação de igg" |
| CN102802661B (zh) | 2009-06-22 | 2016-01-13 | 米迪缪尼有限公司 | 用于位点特异性偶联的工程改造的Fc区 |
| GB0920127D0 (en) | 2009-11-17 | 2009-12-30 | Ucb Pharma Sa | Antibodies |
| KR20230044026A (ko) * | 2010-02-24 | 2023-03-31 | 이뮤노젠 아이엔씨 | 엽산염 수용체 1 항체와 면역접합체 및 이들의 용도 |
| BR112012026213B1 (pt) | 2010-04-15 | 2021-12-28 | Medimmune Limited | Compostos de pirrolobenzodiazepinas, conjugado das mesmas, composição farmacêutica compreendendo o conjugado e uso do mesmo para o tratamento de uma doença proliferativa |
| HUE030846T2 (en) | 2010-04-21 | 2017-06-28 | Syntarga Bv | Conjugates of cc-1065 analogs and bifunctional linkers |
| WO2011156328A1 (en) | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| EP2675479B1 (en) | 2011-02-15 | 2016-01-13 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives |
| UA125636C2 (uk) | 2011-04-01 | 2022-05-11 | Іммуноджен, Інк. | Способи ідентифікації раку, який може реагувати на анти-folr1 антитіло або анти-folr1 імунокон'югат |
| US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| EA029797B1 (ru) | 2011-06-21 | 2018-05-31 | Иммуноджен, Инк. | Новые производные майтанзиноида с пептидным линкером и их конъюгаты |
| CA2859755C (en) | 2011-12-23 | 2021-04-20 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
| TW201333040A (zh) | 2012-01-06 | 2013-08-16 | Bioalliance Cv | 抗－輸鐵蛋白受器之抗體及其使用方法 |
| CN104662000B (zh) | 2012-05-15 | 2018-08-17 | 索伦托医疗有限公司 | 药物偶联物及其偶联方法和用途 |
| WO2013181597A2 (en) | 2012-05-31 | 2013-12-05 | Synchem, Inc. | Thiol-ene click chemistry for drug conjugates |
| AR091701A1 (es) | 2012-07-09 | 2015-02-25 | Genentech Inc | Anticuerpos anti-cd22 e inmunoconjugados |
| PT3210627T (pt) | 2012-07-12 | 2023-03-23 | Hangzhou Dac Biotech Co Ltd | Conjugados de moléculas de ligação celular com agentes citotóxicos |
| CN112587658A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| WO2014057118A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sarl | Pyrrolobenzodiazepine-anti-cd22 antibody conjugates |
| US9107960B2 (en) | 2012-12-13 | 2015-08-18 | Immunimedics, Inc. | Antibody-SN-38 immunoconjugates with a CL2A linker |
| BR112015013444B1 (pt) | 2012-12-13 | 2022-11-01 | Immunomedics, Inc | Uso de um imunoconjugado |
| TWI716339B (zh) * | 2012-12-21 | 2021-01-21 | 荷蘭商台醫（有限合夥）公司 | 親水性自消耗連接子及彼等之共軛物 |
| JP6262768B2 (ja) | 2013-01-03 | 2018-01-17 | セルトリオン， インク． | 抗体−リンカー−薬物結合体、その製造方法およびそれを含む抗癌剤組成物 |
| SI2953976T1 (sl) | 2013-02-08 | 2021-08-31 | Novartis Ag | Specifična mesta z modificiranje protiteles za izdelavo imunokonjugatov |
| EA038512B1 (ru) | 2013-03-15 | 2021-09-08 | Регенерон Фармасьютикалз, Инк. | Конъюгаты майтанзиноидов и их терапевтическое применение |
| US20140363454A1 (en) | 2013-06-06 | 2014-12-11 | Igenica Biotherapeutics, Inc. | Antibody-Drug Conjugates, Compositions and Methods of Use |
| EP2948184B1 (en) | 2014-01-10 | 2016-03-23 | Synthon Biopharmaceuticals B.V. | Duocarmycin adcs showing improved in vivo antitumor activity |
| KR20170063507A (ko) | 2014-06-20 | 2017-06-08 | 어브게노믹스 인터내셔널 인코포레이티드 | Her2 항체-약물 접합체 |
| SG11201610624WA (en) | 2014-06-20 | 2017-01-27 | Bioalliance Cv | Anti-cd22 antibody-drug conjugates and methods of using thereof |
| AU2015276821A1 (en) | 2014-06-20 | 2017-01-12 | Abgenomics International Inc. | Anti-folate receptor aplha (FRA) antibody-drug conjugates and methods of using thereof |
| ES2880731T3 (es) | 2016-01-08 | 2021-11-25 | Altrubio Inc | Anticuerpos anti-PSGL-1 tetravalentes y usos de los mismos |
-
2015
- 2015-06-19 AU AU2015276821A patent/AU2015276821A1/en not_active Abandoned
- 2015-06-19 JP JP2016574072A patent/JP2017528418A/ja active Pending
- 2015-06-19 SG SG11201610620UA patent/SG11201610620UA/en unknown
- 2015-06-19 CN CN201580044557.8A patent/CN106661124A/zh active Pending
- 2015-06-19 US US14/745,336 patent/US9950077B2/en active Active
- 2015-06-19 BR BR112016029860A patent/BR112016029860A2/pt not_active Application Discontinuation
- 2015-06-19 WO PCT/US2015/036824 patent/WO2015196167A1/en not_active Ceased
- 2015-06-19 EP EP15810153.5A patent/EP3157960A4/en not_active Withdrawn
- 2015-06-19 KR KR1020177001294A patent/KR20170020868A/ko not_active Withdrawn
- 2015-06-19 CA CA2952876A patent/CA2952876A1/en not_active Abandoned
- 2015-06-19 MX MX2016016490A patent/MX2016016490A/es unknown
- 2015-06-19 RU RU2017101662A patent/RU2017101662A/ru not_active Application Discontinuation
- 2015-06-22 TW TW104120020A patent/TWI654995B/zh not_active IP Right Cessation
- 2015-06-22 AR ARP150101993A patent/AR100935A1/es unknown
-
2016
- 2016-12-07 IL IL249442A patent/IL249442A0/en unknown
- 2016-12-16 PH PH12016502524A patent/PH12016502524A1/en unknown
- 2016-12-20 ZA ZA2016/08779A patent/ZA201608779B/en unknown
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