JP2017537893A5 - - Google Patents
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- JP2017537893A5 JP2017537893A5 JP2017523295A JP2017523295A JP2017537893A5 JP 2017537893 A5 JP2017537893 A5 JP 2017537893A5 JP 2017523295 A JP2017523295 A JP 2017523295A JP 2017523295 A JP2017523295 A JP 2017523295A JP 2017537893 A5 JP2017537893 A5 JP 2017537893A5
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- antibody
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- 229940049595 antibody-drug conjugate Drugs 0.000 claims description 53
- 239000000824 cytostatic agent Substances 0.000 claims description 14
- 231100000433 cytotoxic Toxicity 0.000 claims description 14
- 239000002254 cytotoxic agent Substances 0.000 claims description 14
- 230000001472 cytotoxic effect Effects 0.000 claims description 14
- 108010044540 auristatin Proteins 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 208000034578 Multiple myelomas Diseases 0.000 claims description 6
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 6
- 208000007452 Plasmacytoma Diseases 0.000 claims description 5
- IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 4
- 208000033014 Plasma cell tumor Diseases 0.000 claims description 4
- 239000000611 antibody drug conjugate Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 208000010626 plasma cell neoplasm Diseases 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- MFRNYXJJRJQHNW-DEMKXPNLSA-N (2s)-2-[[(2r,3r)-3-methoxy-3-[(2s)-1-[(3r,4s,5s)-3-methoxy-5-methyl-4-[methyl-[(2s)-3-methyl-2-[[(2s)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 MFRNYXJJRJQHNW-DEMKXPNLSA-N 0.000 claims description 3
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 3
- 229960003957 dexamethasone Drugs 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 3
- 229960004942 lenalidomide Drugs 0.000 claims description 3
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 229960001467 bortezomib Drugs 0.000 claims description 2
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims description 2
- 229930195731 calicheamicin Natural products 0.000 claims description 2
- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical group C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims description 2
- 229960004679 doxorubicin Drugs 0.000 claims description 2
- 229960000688 pomalidomide Drugs 0.000 claims description 2
- UVSMNLNDYGZFPF-UHFFFAOYSA-N pomalidomide Chemical compound O=C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O UVSMNLNDYGZFPF-UHFFFAOYSA-N 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 108010093470 monomethyl auristatin E Proteins 0.000 claims 2
- 108010059074 monomethylauristatin F Proteins 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 description 12
- 238000000034 method Methods 0.000 description 9
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 125000003118 aryl group Chemical group 0.000 description 5
- 230000002132 lysosomal effect Effects 0.000 description 5
- 230000027455 binding Effects 0.000 description 4
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 3
- 125000001931 aliphatic group Chemical group 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 125000003396 thiol group Chemical group [H]S* 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000012875 competitive assay Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 229960004137 elotuzumab Drugs 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 238000009097 single-agent therapy Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 2
- 102000004225 Cathepsin B Human genes 0.000 description 1
- 108090000712 Cathepsin B Proteins 0.000 description 1
- 102000053187 Glucuronidase Human genes 0.000 description 1
- 108010060309 Glucuronidase Proteins 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M Methanesulfonate Chemical compound CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940034982 antineoplastic agent Drugs 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000011301 standard therapy Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462073824P | 2014-10-31 | 2014-10-31 | |
| US62/073,824 | 2014-10-31 | ||
| PCT/US2015/058389 WO2016070089A2 (en) | 2014-10-31 | 2015-10-30 | Anti-cs1 antibodies and antibody drug conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020040783A Division JP2020111583A (ja) | 2014-10-31 | 2020-03-10 | 抗ｃｓ１抗体および抗体薬結合体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017537893A JP2017537893A (ja) | 2017-12-21 |
| JP2017537893A5 true JP2017537893A5 (OSRAM) | 2018-07-26 |
Family
ID=54478286
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017523295A Withdrawn JP2017537893A (ja) | 2014-10-31 | 2015-10-30 | 抗ｃｓ１抗体および抗体薬結合体 |
| JP2020040783A Pending JP2020111583A (ja) | 2014-10-31 | 2020-03-10 | 抗ｃｓ１抗体および抗体薬結合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020040783A Pending JP2020111583A (ja) | 2014-10-31 | 2020-03-10 | 抗ｃｓ１抗体および抗体薬結合体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10011657B2 (OSRAM) |
| EP (1) | EP3212668B1 (OSRAM) |
| JP (2) | JP2017537893A (OSRAM) |
| AU (1) | AU2015339012B2 (OSRAM) |
| BR (1) | BR112017008945A2 (OSRAM) |
| CA (1) | CA2966005C (OSRAM) |
| ES (1) | ES2832711T3 (OSRAM) |
| IL (1) | IL251938A0 (OSRAM) |
| SG (1) | SG11201703446RA (OSRAM) |
| WO (1) | WO2016070089A2 (OSRAM) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130116404A1 (en) | 2011-11-08 | 2013-05-09 | Case Western Reserve University | Targeted non-invasive imaging probes of egfr expressing cells |
| SI3215518T1 (sl) | 2014-10-29 | 2021-08-31 | Bicyclerd Limited | Biciklični peptidni ligandi, značilni za MT1-MMP |
| ES2886657T3 (es) * | 2015-06-29 | 2021-12-20 | Bristol Myers Squibb Co | Regímenes de dosificación inmunoterapéutica que comprenden pomalidomida y un anticuerpo anti-CS1 para el tratamiento de cáncer |
| CA3001941A1 (en) | 2015-10-30 | 2017-05-04 | Nbe-Therapeutics Ag | Anti-ror1 antibodies |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| KR20230114331A (ko) | 2016-09-14 | 2023-08-01 | 애브비 바이오테라퓨틱스 인크. | 항-pd-1 항체 및 이의 용도 |
| BR112019011277A2 (pt) | 2016-12-02 | 2019-10-22 | University Of Southern California | polinucleotídeo, sistema de expressão recombinante, vetor, polipeptídeo, célula recombinante, polipeptídeo de receptor imune sintético isolado ou heterodímero de polipeptídeo, célula efetora imune ou célula-tronco, população de células imunes ou efetoras, métodos de fabricação de uma célula efetora imune que expressa sir, de geração de uma população de células modificadas por rna, de fornecimento de imunidade antidoença e de tratamento ou prevenção de uma doença, composição, uso ou método, kit, e, sequência de aminoácidos. |
| EP3577138A1 (en) * | 2017-02-06 | 2019-12-11 | Innate Pharma | Immunomodulatory antibody drug conjugates binding to a human mica polypeptide |
| EP3601365A4 (en) * | 2017-03-29 | 2021-01-13 | Agency for Science, Technology and Research | ANTI-OLIGOSACCHARIDE ANTIBODIES |
| CN111183147B (zh) | 2017-08-04 | 2024-07-05 | 拜斯科技术开发有限公司 | Cd137特异性的双环肽配体 |
| EP3665193A1 (en) * | 2017-08-07 | 2020-06-17 | NBE Therapeutics AG | Anthracycline-based antibody drug conjugates having high in vivo tolerability |
| SG11202004192XA (en) * | 2017-11-29 | 2020-06-29 | Magenta Therapeutics Inc | Compositions and methods for the depletion of cd2+ cells |
| WO2019162682A1 (en) | 2018-02-23 | 2019-08-29 | Bicycletx Limited | Multimeric bicyclic peptide ligands |
| WO2019183633A1 (en) | 2018-03-23 | 2019-09-26 | Case Western Reserve Univeristy | Psma targeted conjugate compounds and uses thereof |
| US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
| CN111001012A (zh) * | 2018-10-19 | 2020-04-14 | 四川百利药业有限责任公司 | 一种亲水碳酸酯型抗体偶联药物 |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| WO2020128526A1 (en) | 2018-12-21 | 2020-06-25 | Bicycletx Limited | Bicyclic peptide ligands specific for pd-l1 |
| TWI862640B (zh) | 2019-07-30 | 2024-11-21 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| KR20230034957A (ko) * | 2020-06-19 | 2023-03-10 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 캄프토테신 유사체를 갖는 세포-결합 분자의 접합체 |
| WO2022029420A1 (en) * | 2020-08-03 | 2022-02-10 | Bicycletx Limited | Peptide-based linkers |
| EP4257153B1 (en) * | 2020-12-04 | 2025-11-12 | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | Antibody-drug conjugate, and intermediate thereof, preparation method therefor, and application thereof |
| JP7564958B2 (ja) * | 2020-12-18 | 2024-10-09 | シャンハイ フダン－チャンジャン バイオ－ファーマシューティカル カンパニー リミテッド | Ｂ７－ｈ３を標的とする抗体薬物複合体、その製造方法と使用 |
| AU2020482223A1 (en) * | 2020-12-18 | 2023-07-27 | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | Trop2 targeting antibody-drug conjugate, and preparation method and use therefor |
| CN113181373B (zh) * | 2021-05-10 | 2024-03-01 | 深圳安特生物医药科技有限公司 | 一种抗体药物偶联制剂及其制备方法和应用 |
| US20250108124A1 (en) * | 2021-05-19 | 2025-04-03 | Biohaven Therapeutics Ltd. | Antibody drug conjugates using mates technology for delivering cytotoxic agents |
| US20250332265A1 (en) | 2021-11-09 | 2025-10-30 | Case Western Reserve University | Psma targeted conjugate compounds and uses thereof |
| CN114230666B (zh) * | 2021-12-20 | 2022-09-02 | 南京诺唯赞生物科技股份有限公司 | 一种t7 rna聚合酶的单克隆抗体及其制备方法 |
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-
2015
- 2015-10-30 WO PCT/US2015/058389 patent/WO2016070089A2/en not_active Ceased
- 2015-10-30 AU AU2015339012A patent/AU2015339012B2/en not_active Ceased
- 2015-10-30 ES ES15791213T patent/ES2832711T3/es active Active
- 2015-10-30 BR BR112017008945A patent/BR112017008945A2/pt not_active IP Right Cessation
- 2015-10-30 SG SG11201703446RA patent/SG11201703446RA/en unknown
- 2015-10-30 JP JP2017523295A patent/JP2017537893A/ja not_active Withdrawn
- 2015-10-30 EP EP15791213.0A patent/EP3212668B1/en active Active
- 2015-10-30 US US14/928,738 patent/US10011657B2/en active Active
- 2015-10-30 CA CA2966005A patent/CA2966005C/en active Active
-
2017
- 2017-04-26 IL IL251938A patent/IL251938A0/en unknown
- 2017-11-21 US US15/819,153 patent/US10308713B2/en active Active
-
2020
- 2020-03-10 JP JP2020040783A patent/JP2020111583A/ja active Pending
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